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1. 发明申请

WO0178706A3 TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY AND RELATED MUCOCUTANEOUS DISORDERS USING INHIBITORS OF MEVALONATE SYNTHESIS AND METABOLISM 审中-公开
标题翻译：使用抑制剂合成和代谢的治疗高血压，炎症和相关的神经系统疾病
公开(公告)号：WO0178706A3
公开(公告)日：2002-03-28
申请号：PCT/US0112175
申请日：2001-04-12
申请人： CELLEGY PHARMA INC , PARKS THOMAS P , GRAYSON STEPHEN
发明人： PARKS THOMAS P , GRAYSON STEPHEN
IPC分类号： A61K9/00 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/366 , A61K31/40 , A61K31/4418 , A61K31/56 , A61K31/575 , A61K31/60 , A61K38/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/32 , A61K31/00 , A61K31/196 , A61K31/216 , A61K31/404 , A61P17/00 , A61P29/00
CPC分类号： A61K31/404 , A61K9/0014 , A61K9/0043 , A61K9/0073 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/366 , A61K31/40 , A61K31/4418 , A61K31/56 , A61K31/575 , A61K31/60 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/32 , A61K2300/00
摘要： The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs.
摘要翻译：本发明提供了使用胆固醇代谢抑制剂治疗各种过度增生和炎症性皮肤病的方法，包括基底细胞癌，鳞状细胞癌，牛皮癣和特应性皮炎，以及与皮肤老化和皮肤光损伤相关的皮肤刺激和疾病。本发明进一步涉及到几种胆固醇代谢抑制剂的组合使用产生协同效应的发现。此外，本发明涉及使用胆固醇代谢抑制剂作为赋形剂来增强抗炎药物的作用。

2. 发明申请

WO2003075851A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS 审中-公开
公开(公告)号：WO2003075851A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/007106
申请日：2003-03-05
申请人： CELLEGY PHARMACEUTICALS, INC. , PARKS, Thomas, P. , MAK, Vivien, H., W. , LEE, Jung-Chung , LEE, Charles , GRAYSON, Stephen
发明人： PARKS, Thomas, P. , MAK, Vivien, H., W. , LEE, Jung-Chung , LEE, Charles , GRAYSON, Stephen
IPC分类号： A61K31/35 , A61K31/56 , A61K31/165
摘要： Compositions and methods for the treatment of patients with anorectal disorders including colostomy are provided in which certain compounds including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators (including acetylcholine storage blocking agents and acetylcholine vesicle storage blocking agents), α-adrenergic receptor antagonists (including α 1 -adrenergic antagonists and α 2 -adrenergic antagonists), β-adrenergic receptor agonists (including β 2 -adrenergic antagonists and β 3 -adrenergic antagonists), phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators (including ATP-sensitive potassium channel activators and activators of the Maxi-K channels), estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates, cGMP-dependent protein kinase activators (e.g., cGMP mimetics), and combinations thereof are used.

3. 发明申请

WO2003075851A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS 审中-公开
标题翻译：用于治疗异位性疾病的组合物和方法
公开(公告)号：WO2003075851A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/007106
申请日：2003-03-05
申请人： CELLEGY PHARMACEUTICALS, INC. , PARKS, Thomas, P. , MAK, Vivien, H., W. , LEE, Jung-Chung , LEE, Charles , GRAYSON, Stephen
发明人： PARKS, Thomas, P. , MAK, Vivien, H., W. , LEE, Jung-Chung , LEE, Charles , GRAYSON, Stephen
IPC分类号： A61K
CPC分类号： A61K31/00
摘要： Compositions and methods for the treatment of patients with anorectal disorders including colostomy are provided in which certain compounds including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators (including acetylcholine storage blocking agents and acetylcholine vesicle storage blocking agents), $g(a)-adrenergic receptor antagonists (including $g(a)¿1?-adrenergic antagonists and $g(a)¿2?-adrenergic antagonists), $g(b)-adrenergic receptor agonists (including $g(b)¿2?-adrenergic antagonists and $g(b)¿3?-adrenergic antagonists), phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators (including ATP-sensitive potassium channel activators and activators of the Maxi-K channels), estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates, cGMP-dependent protein kinase activators (e.g., cGMP mimetics), and combinations thereof are used.
摘要翻译：提供了用于治疗包括结肠造口术在内的肛门直肠疾病患者的组合物和方法，其中某些化合物包括但不限于NO供体，钙通道阻断剂，胆碱能调节剂（包括乙酰胆碱储存阻断剂和乙酰胆碱泡囊阻滞剂），$ g（a） - 肾上腺素受体拮抗剂（包括$ g（a）1 - 肾上腺素能拮抗剂和$ g（a）2'-肾上腺素能拮抗剂），$ g（b） - 肾上腺素能受体激动剂（包括$ g ）2'-肾上腺素能拮抗剂和$ g（b）3'-肾上腺素能拮抗剂），磷酸二酯酶抑制剂，cAMP依赖性蛋白激酶激活剂（例如cAMP模拟物），超氧化物清除剂，钾通道激活剂（包括ATP敏感钾通道 Maxi-K通道的激活剂和激活剂），雌激素样化合物，睾酮样化合物，苯并二氮杂，肾上腺素能神经抑制剂，止泻药，HMG-CoA还原酶抑制剂，平滑肌松弛剂，腺苷受体调节剂，腺苷酸环化酶激活剂，内皮素受体拮抗剂，双膦酸盐，cGMP依赖性蛋白激酶激活剂（例如，cGMP模拟物）及其组合。

4. 发明申请

WO0209714A9 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS 审中-公开
标题翻译：用于治疗异位性疾病的组合物和方法
公开(公告)号：WO0209714A9
公开(公告)日：2003-03-06
申请号：PCT/US0123971
申请日：2001-07-30
申请人： CELLEGY PHARMA INC , PARKS THOMAS P , MAK VIVIEN , LEE JUNG-CHUNG , LEE CHARLES
发明人： PARKS THOMAS P , MAK VIVIEN , LEE JUNG-CHUNG , LEE CHARLES
IPC分类号： A61K45/00 , A61K31/04 , A61K31/137 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/554 , A61P1/00 , A61P9/14 , A61K31/52 , A61K31/135 , A61K31/335
CPC分类号： A61K31/137 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/554
摘要： Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2 ) scavengers, beta -adrenergic agonists, cAMP-dependent protein kinase activators, alpha 1-adrenergic antagonists, L-type Ca channel blockers, estrogens, ATP-sensitive channel activators and smooth muscle relaxants are used.
摘要翻译：提供了治疗肛门直肠疾病的组合物和方法，其中NO供体，PDE抑制剂，超氧化物（O 2 - ）清除剂，β-肾上腺素能激动剂，cAMP依赖性蛋白激酶激活剂，α1-肾上腺素能拮抗剂L 型Ca 2+通道阻滞剂，雌激素，ATP敏感性通道激活剂和平滑肌松弛剂。

5. 发明申请

WO2009079607A1 APPLICATOR FOR APPLYING POWDER FORMULATIONS AND USES THEREOF 审中-公开
标题翻译：适用于粉末制剂及其用途的申请人
公开(公告)号：WO2009079607A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/087288
申请日：2008-12-17
申请人： OSEL, INC. , PARKS, Thomas P. , JUST, Troy
发明人： PARKS, Thomas P. , JUST, Troy
IPC分类号： A61M31/00 , B05B11/02
CPC分类号： A61M31/00 , B05B11/02
摘要： The present invention relates to applicators for applying powders to the vaginal mucosa.
摘要翻译：本发明涉及将粉末施用于阴道粘膜的施用器。

6. 发明申请

WO0178706A9 TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY AND RELATED MUCOCUTANEOUS DISORDERS USING INHIBITORS OF MEVALONATE SYNTHESIS AND METABOLISM 审中-公开
标题翻译：用茉莉酮酸合成和代谢抑制剂治疗过度增殖，炎性和相关性皮肤病
公开(公告)号：WO0178706A9
公开(公告)日：2002-12-27
申请号：PCT/US0112175
申请日：2001-04-12
申请人： CELLEGY PHARMA INC , PARKS THOMAS P , GRAYSON STEPHEN
发明人： PARKS THOMAS P , GRAYSON STEPHEN
IPC分类号： A61K9/00 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/366 , A61K31/40 , A61K31/4418 , A61K31/56 , A61K31/575 , A61K31/60 , A61K38/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/32 , A61K31/00 , A61K31/196 , A61K31/216 , A61K31/404 , A61P17/00 , A61P29/00
CPC分类号： A61K31/404 , A61K9/0014 , A61K9/0043 , A61K9/0073 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/366 , A61K31/40 , A61K31/4418 , A61K31/56 , A61K31/575 , A61K31/60 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/32 , A61K2300/00
摘要： The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs.
摘要翻译：本发明提供了使用胆固醇代谢抑制剂治疗多种过度增殖性和炎症性皮肤粘膜疾病，包括基底细胞癌，鳞状细胞癌，牛皮癣和特应性皮炎，以及与皮肤老化和皮肤光损伤有关的皮肤刺激和病症。本发明还涉及几种胆固醇代谢抑制剂的组合使用产生协同效应的发现。此外，本发明涉及使用胆固醇代谢抑制剂作为赋形剂来增强抗炎药的作用。

7. 发明申请

WO2002096416A1 STORE OPERATED CALCIUM INFLUX INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： STORE OPERATED CALCIUM INFLUX抑制剂及其使用方法
公开(公告)号：WO2002096416A1
公开(公告)日：2002-12-05
申请号：PCT/US2002/017112
申请日：2002-05-31
申请人： CELLEGY PHARMACEUTICALS, INC. , PARKS, Thomas, P. , BAKER, Don, R.
发明人： PARKS, Thomas, P. , BAKER, Don, R.
IPC分类号： A61K31/405
CPC分类号： A61K31/00 , A61K31/366 , A61K31/403 , A61K31/405 , A61K31/435
摘要： The present invention provides store operated calcium influx inhibitor compounds, pharmaceutical compositions, and methods of use. The compounds are useful for treating an inflammatory disease or treating an inflammatory reaction. Preferably, compounds, compositions and methods of this invention are used for treatment of inflammatory skin, pulmonary, musculoskeletal, and gastrointestinal diseases, as well as autoimmune disorders, transplantation treatment, and osteoporosis.
摘要翻译：本发明提供商店操作的钙流入抑制剂化合物，药物组合物和使用方法。该化合物可用于治疗炎性疾病或治疗炎性反应。优选地，本发明的化合物，组合物和方法用于治疗炎性皮肤，肺，肌肉骨骼和胃肠道疾病，以及自身免疫性疾病，移植治疗和骨质疏松症。

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