发明申请
WO0178706A3 TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY AND RELATED MUCOCUTANEOUS DISORDERS USING INHIBITORS OF MEVALONATE SYNTHESIS AND METABOLISM
审中-公开
基本信息:
- 专利标题： TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY AND RELATED MUCOCUTANEOUS DISORDERS USING INHIBITORS OF MEVALONATE SYNTHESIS AND METABOLISM
- 专利标题（中）：使用抑制剂合成和代谢的治疗高血压，炎症和相关的神经系统疾病
- 申请号：PCT/US0112175 申请日：2001-04-12
- 公开(公告)号：WO0178706A3 公开(公告)日：2002-03-28
- 发明人： PARKS THOMAS P , GRAYSON STEPHEN
- 申请人： CELLEGY PHARMA INC , PARKS THOMAS P , GRAYSON STEPHEN
- 专利权人： CELLEGY PHARMA INC,PARKS THOMAS P,GRAYSON STEPHEN
- 当前专利权人： CELLEGY PHARMA INC,PARKS THOMAS P,GRAYSON STEPHEN
- 优先权： US19735700 2000-04-13
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K31/015 ; A61K31/045 ; A61K31/047 ; A61K31/19 ; A61K31/22 ; A61K31/235 ; A61K31/366 ; A61K31/40 ; A61K31/4418 ; A61K31/56 ; A61K31/575 ; A61K31/60 ; A61K38/00 ; A61K45/06 ; A61K47/10 ; A61K47/12 ; A61K47/14 ; A61K47/18 ; A61K47/28 ; A61K47/32 ; A61K31/00 ; A61K31/196 ; A61K31/216 ; A61K31/404 ; A61P17/00 ; A61P29/00
摘要：
The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs.
摘要（中）：
本发明提供了使用胆固醇代谢抑制剂治疗各种过度增生和炎症性皮肤病的方法，包括基底细胞癌，鳞状细胞癌，牛皮癣和特应性皮炎，以及与皮肤老化和皮肤光损伤相关的皮肤刺激和疾病 。 本发明进一步涉及到几种胆固醇代谢抑制剂的组合使用产生协同效应的发现。 此外，本发明涉及使用胆固醇代谢抑制剂作为赋形剂来增强抗炎药物的作用。
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |