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1. 发明申请

WO2012165914A2 NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS 审中-公开
标题翻译：新型二苯甲基衍生物作为SGLT2抑制剂
公开(公告)号：WO2012165914A2
公开(公告)日：2012-12-06
申请号：PCT/KR2012/004366
申请日：2012-06-01
申请人： GREEN CROSS CORPORATION , CHOI, Soongyu , SONG, Kwang-Seop , LEE, Suk Ho , KIM, Min Ju , SEO, Hee Jeong , PARK, Eun-Jung , KONG, Younggyu , PARK, So Ok , KANG, Hyunku , JUNG, Myung Eun , LEE, Kinam , KIM, Hyun Jung , LEE, Jun Sung , LEE, Min Woo , KIM, Mi-Soon , HONG, Dong Ho , KANG, Misuk
发明人： CHOI, Soongyu , SONG, Kwang-Seop , LEE, Suk Ho , KIM, Min Ju , SEO, Hee Jeong , PARK, Eun-Jung , KONG, Younggyu , PARK, So Ok , KANG, Hyunku , JUNG, Myung Eun , LEE, Kinam , KIM, Hyun Jung , LEE, Jun Sung , LEE, Min Woo , KIM, Mi-Soon , HONG, Dong Ho , KANG, Misuk
IPC分类号： A61K31/357 , A61K31/343 , A61K31/35 , A61K31/015 , A61P3/00
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
摘要翻译：本发明涉及具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物和包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。

2. 发明申请

WO2011005052A3 NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：新的含芳基哌嗪的咪唑4-羧酰胺衍生物和包含它们的药物组合物
公开(公告)号：WO2011005052A3
公开(公告)日：2011-05-26
申请号：PCT/KR2010004479
申请日：2010-07-09
申请人： GREEN CROSS CORP , LEE JINHWA , SEO HEE JEONG , KANG SUK YOUN , PARK EUN-JUNG , KIM MIN JU , LEE SUK HO , KIM JONG YUP , KIM JEONGMIN , JUNG MYUNG EUN , KIM HYUN JUNG , KIM MI-SOON , HAN HO KYUN , AHN KWANG WOO , LEE MIN WOO , LEE KI-NAM , PAE AE NIM , PARK WOO-KYU
发明人： LEE JINHWA , SEO HEE JEONG , KANG SUK YOUN , PARK EUN-JUNG , KIM MIN JU , LEE SUK HO , KIM JONG YUP , KIM JEONGMIN , JUNG MYUNG EUN , KIM HYUN JUNG , KIM MI-SOON , HAN HO KYUN , AHN KWANG WOO , LEE MIN WOO , LEE KI-NAM , PAE AE NIM , PARK WOO-KYU
IPC分类号： C07D403/12 , A61K31/497 , A61P25/24
CPC分类号： C07D417/14 , A61K31/496 , C07D233/88 , C07D401/12 , C07D403/06 , C07D405/04
摘要： A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.
摘要翻译：提供了一种新的含芳基哌嗪的咪唑-4-甲酰胺衍生物或其药学上可接受的盐，以及包含其作为用于预防或治疗抑郁症的活性成分的药物组合物。

3. 发明申请

WO2011005052A2 NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：新颖的含有阿维菌素的咪唑烷四羧酰胺衍生物和包含其的药物组合物
公开(公告)号：WO2011005052A2
公开(公告)日：2011-01-13
申请号：PCT/KR2010/004479
申请日：2010-07-09
申请人： GREEN GROSS CORPORATION , LEE, Jinhwa , SEO, Hee Jeong , KANG, Suk Youn , PARK, Eun-Jung , KIM, Min Ju , LEE, Suk Ho , KIM, Jong Yup , KIM, Jeongmin , JUNG, Myung Eun , KIM, Hyun Jung , KIM, Mi-Soon , HAN, Ho Kyun , AHN, Kwang Woo , LEE, Min Woo , LEE, Ki-Nam , PAE, Ae Nim , PARK, Woo-Kyu
发明人： LEE, Jinhwa , SEO, Hee Jeong , KANG, Suk Youn , PARK, Eun-Jung , KIM, Min Ju , LEE, Suk Ho , KIM, Jong Yup , KIM, Jeongmin , JUNG, Myung Eun , KIM, Hyun Jung , KIM, Mi-Soon , HAN, Ho Kyun , AHN, Kwang Woo , LEE, Min Woo , LEE, Ki-Nam , PAE, Ae Nim , PARK, Woo-Kyu
IPC分类号： C07D403/12 , A61K31/497 , A61P25/24
CPC分类号： C07D417/14 , A61K31/496 , C07D233/88 , C07D401/12 , C07D403/06 , C07D405/04
摘要： A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.
摘要翻译：提供了一种新型含芳基哌嗪的咪唑-4-甲酰胺衍生物或其药学上可接受的盐，以及包含其作为预防或治疗抑郁障碍的活性成分的药物组合物。

4. 发明申请

WO2012165914A3 NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS 审中-公开
标题翻译：新型二苯甲基衍生物作为SGLT2抑制剂
公开(公告)号：WO2012165914A3
公开(公告)日：2013-03-28
申请号：PCT/KR2012004366
申请日：2012-06-01
申请人： GREEN CROSS CORP , CHOI SOONGYU , SONG KWANG-SEOP , LEE SUK HO , KIM MIN JU , SEO HEE JEONG , PARK EUN-JUNG , KONG YOUNGGYU , PARK SO OK , KANG HYUNKU , JUNG MYUNG EUN , LEE KINAM , KIM HYUN JUNG , LEE JUN SUNG , LEE MIN WOO , KIM MI-SOON , HONG DONG HO , KANG MISUK
发明人： CHOI SOONGYU , SONG KWANG-SEOP , LEE SUK HO , KIM MIN JU , SEO HEE JEONG , PARK EUN-JUNG , KONG YOUNGGYU , PARK SO OK , KANG HYUNKU , JUNG MYUNG EUN , LEE KINAM , KIM HYUN JUNG , LEE JUN SUNG , LEE MIN WOO , KIM MI-SOON , HONG DONG HO , KANG MISUK
IPC分类号： A61K31/357 , A61K31/015 , A61K31/343 , A61K31/35 , A61P3/00
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
摘要翻译：本发明涉及具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物和包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。

5. 发明申请

WO2011059207A3 ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：含有阿维A的嘌呤衍生物及其用途
公开(公告)号：WO2011059207A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010007804
申请日：2010-11-05
申请人： GREEN CROSS CORP , LEE JINHWA , PARK EUN-JUNG , KANG SUK YOUN , KONG YOUNGGYU , LEE JUNWON , KIM HYUN JUNG , JUNG MYUNG EUN , LEE KI-NAM , KIM JEONGMIN , PAE AE NIM , PARK WOO-KYU
发明人： LEE JINHWA , PARK EUN-JUNG , KANG SUK YOUN , KONG YOUNGGYU , LEE JUNWON , KIM HYUN JUNG , JUNG MYUNG EUN , LEE KI-NAM , KIM JEONGMIN , PAE AE NIM , PARK WOO-KYU
IPC分类号： C07D473/34 , A61K31/52 , A61P25/24 , C07D403/12
CPC分类号： C07D473/34
摘要： A novel arylpiperazine-containing purine derivatives and a pharmaceutical composition comprising the same as an active ingredient, which are useful for preventing or treating depressive disorders, are provided.
摘要翻译：提供了一种新的含有芳基哌嗪的嘌呤衍生物和包含其作为活性成分的药物组合物，其可用于预防或治疗抑郁障碍。

6. 发明申请

WO2011136501A3 DUAL-TYPE TUBE VESSEL AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：双型管式船及其制造方法
公开(公告)号：WO2011136501A3
公开(公告)日：2012-03-01
申请号：PCT/KR2011002883
申请日：2011-04-21
申请人： LEE KANG JOON , PARK EUN JUNG
发明人： LEE KANG JOON , PARK HO KYUNG
IPC分类号： B65D35/22 , B29C45/17 , B29C45/26 , B65D35/08
CPC分类号： B29D22/003 , B29C53/40 , B29C65/3644 , B29C65/3656 , B29C65/368 , B29C66/112 , B29C66/131 , B29C66/43123 , B29C66/432 , B29C66/4322 , B29C66/5412 , B29C66/547 , B29C66/71 , B29C66/72321 , B29C67/0014 , B29D23/20 , B29L2023/20 , B29L2031/601 , B65B3/027 , B65B2220/16 , B65B2230/02 , B65D35/10 , B65D35/22 , Y10T156/1054 , B29K2023/06
摘要： The present invention relates to a dual-type tube vessel in which partitioning plates are arranged respectively in a tube body and in a neck portion to divide the space in the tube body into two parts and the space in the neck portion into two parts, respectively, such that each space of the tube body is filled with contents different from each other, and the contents are discharged at a predetermined ratio. The present invention also relates to a method for manufacturing the dual-type tube vessel. The dual-type tube vessel comprises a cylindrical tube body; a neck portion formed integrally with the tube body; an S-shaped or corrugated tube body partitioning plate which is arranged within the tube body to divide the space in the tube body into two areas, and which has a width same as the length of the inner circumferential surface of the larger area of the two areas of the tube body; and a neck partitioning plate arranged within the neck portion to divide the neck portion into two areas, wherein the tube body and the tube body partitioning plate are made of one or three sheets of materials. The interior of the tube body is divided into two areas so as to enable two different contents to be injected into a single tube vessel such that the contents are not mixed together. The tube body partitioning plate is formed integrally with the single tube vessel such that the contents can be easily discharged from the tube vessel even when small pressure is applied to the tube vessel. The tube body and the tube body portioning plate are made of three sheets of laminate films of polyethylene/aluminum/polyethylene to contain a wide variety of contents. The tube body and the tube body partitioning plate are coupled integrally with the neck portion and the neck partitioning plate when the neck portion and the neck partitioning plate are integrally injection-molded, thus simplifying manufacturing processes and improving joining strength among the neck portion, the neck partitioning plate, the tube body and the tube body partitioning plate.
摘要翻译：本发明涉及一种双管式容器，其中分隔板分别布置在管体和颈部中，以将管体中的空间分成两部分，将颈部部分的空间分成两部分使得管体的每个空间填充彼此不同的内容物，并以预定的比例排出内容物。本发明还涉及一种用于制造双型管式容器的方法。双管式管容器包括圆柱形管体; 与所述管体一体形成的颈部; S形或波纹管体分隔板，其布置在管体内，以将管体中的空间分成两个区域，其宽度与两个较大面积的较大面积的内周表面的长度相同管体的区域; 以及颈部分隔板，其设置在颈部内，以将颈部分割成两个区域，其中管体和管体分隔板由一片或三片材料制成。管体的内部被分成两个区域，以便能够将两个不同的内容物注入单个管式容器中，使得内容物不混合在一起。管体分隔板与单管容器一体地形成，即使在对管容器施加小的压力时，容纳物也容易从管容器排出。管体和管体分配板由三层聚乙烯/铝/聚乙烯层叠膜制成，容纳各种内容物。当颈部和颈部分隔板被一体地注射成型时，管体和管体分隔板与颈部和颈部分隔板一体地联接在一起，从而简化了颈部，颈部和颈部分隔板之间的接合强度颈部分隔板，管体和管体分隔板。

7. 发明申请

WO2011159067A2 THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：作为SGLT2抑制剂和包含其的药物组合物的噻唑衍生物
公开(公告)号：WO2011159067A2
公开(公告)日：2011-12-22
申请号：PCT/KR2011/004273
申请日：2011-06-10
申请人： GREEN CROSS CORPORATION , LEE, Jinhwa , KIM, Jeongmin , LEE, Suk Ho , LEE, Junwon , SONG, Kwang-Seop , PARK, Eun-Jung , KIM, Min Ju , SEO, Hee Jeong , LEE, Sung-Han , SON, Eun Jung , KIM, Jong Yup , KANG, Suk Youn , KONG, Younggyu
发明人： LEE, Jinhwa , KIM, Jeongmin , LEE, Suk Ho , LEE, Junwon , SONG, Kwang-Seop , PARK, Eun-Jung , KIM, Min Ju , SEO, Hee Jeong , LEE, Sung-Han , SON, Eun Jung , KIM, Jong Yup , KANG, Suk Youn , KONG, Younggyu
IPC分类号： C07D417/14 , C07D309/10 , C07D417/10 , A61K31/427 , A61K31/351 , A61P3/10
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译：本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。

8. 发明申请

WO2011059207A2 ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：含芳基哌嗪的嘌呤衍生物及其用途
公开(公告)号：WO2011059207A2
公开(公告)日：2011-05-19
申请号：PCT/KR2010/007804
申请日：2010-11-05
申请人： GREEN CROSS CORPORATION , LEE, Jinhwa , PARK, Eun-Jung , KANG, Suk Youn , KONG, Younggyu , LEE, Junwon , KIM, Hyun Jung , JUNG, Myung Eun , LEE, Ki-Nam , KIM, Jeongmin , PAE, Ae Nim , PARK, Woo-Kyu
发明人： LEE, Jinhwa , PARK, Eun-Jung , KANG, Suk Youn , KONG, Younggyu , LEE, Junwon , KIM, Hyun Jung , JUNG, Myung Eun , LEE, Ki-Nam , KIM, Jeongmin , PAE, Ae Nim , PARK, Woo-Kyu
CPC分类号： C07D473/34
摘要： A novel arylpiperazine-containing purine derivatives and a pharmaceutical composition comprising the same as an active ingredient, which are useful for preventing or treating depressive disorders, are provided.
摘要翻译：提供了一种新的含芳基哌嗪的嘌呤衍生物和包含其作为活性成分的药物组合物，其可用于预防或治疗抑郁症。

9. 发明申请

WO2010038948A2 ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS 审中-公开
标题翻译：含芳基哌嗪的吡咯3-甲酰胺衍生物用于治疗抑郁症
公开(公告)号：WO2010038948A2
公开(公告)日：2010-04-08
申请号：PCT/KR2009005415
申请日：2009-09-23
申请人： GREEN CROSS CORP , LEE JINHWA , KANG SUK YOUN , PARK EUN-JUNG , SONG KWANG-SEOP , KIM MIN JU , SEO HEE JEONG , LEE SUK HO , KIM JEONGMIN , PAE AE NIM , PARK WOO-KYU
发明人： LEE JINHWA , KANG SUK YOUN , PARK EUN-JUNG , SONG KWANG-SEOP , KIM MIN JU , SEO HEE JEONG , LEE SUK HO , KIM JEONGMIN , PAE AE NIM , PARK WOO-KYU
IPC分类号： C07D403/14 , A61K31/495 , A61K31/496 , A61P25/24 , C07D403/12
CPC分类号： C07D207/34 , C07D207/36 , C07D207/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.
摘要翻译：本发明涉及式（I）的新的含芳基哌嗪的吡咯3-甲酰胺衍生物或其药学上可接受的盐，其可用于预防或治疗抑郁症。本发明还提供了制备含芳基哌嗪的吡咯3-甲酰胺衍生物或其药学上可接受的盐的方法，含有它们的药物组合物，以及预防或治疗抑郁症的方法。

10. 发明申请

WO2011159067A3 THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：作为SGLT2抑制剂和包含其的药物组合物的噻唑衍生物
公开(公告)号：WO2011159067A3
公开(公告)日：2012-04-19
申请号：PCT/KR2011004273
申请日：2011-06-10
申请人： GREEN CROSS CORP , LEE JINHWA , KIM JEONGMIN , LEE SUK HO , LEE JUNWON , SONG KWANG-SEOP , PARK EUN-JUNG , KIM MIN JU , SEO HEE JEONG , LEE SUNG-HAN , SON EUN JUNG , KIM JONG YUP , KANG SUK YOUN , KONG YOUNGGYU
发明人： LEE JINHWA , KIM JEONGMIN , LEE SUK HO , LEE JUNWON , SONG KWANG-SEOP , PARK EUN-JUNG , KIM MIN JU , SEO HEE JEONG , LEE SUNG-HAN , SON EUN JUNG , KIM JONG YUP , KANG SUK YOUN , KONG YOUNGGYU
IPC分类号： C07D417/14 , A61K31/351 , A61K31/427 , A61P3/10 , C07D309/10 , C07D417/10
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译：本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。

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