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    • 4. 发明申请
    • CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
    • CYCLOHEXYL CARBAMATE化合物作为皮肤和/或头发照明活动
    • WO2010122178A3
    • 2011-04-14
    • PCT/EP2010057115
    • 2010-05-25
    • SYMRISE AGVIELHABER GABRIELEOERTLING HEIKOTITZE NICOLEGOEMANN CLAUDIABRODHAGE RAHIM
    • VIELHABER GABRIELEOERTLING HEIKOTITZE NICOLEGOEMANN CLAUDIABRODHAGE RAHIM
    • A61K8/42A61Q5/08A61Q19/02C08B37/00
    • A61K8/44A61K8/40A61K8/42A61K8/445A61K31/27A61K45/06A61Q17/04A61Q19/02C08L5/00
    • The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
    • 本发明涉及以下给出的某些式(I)环己基氨基甲酸酯化合物的化妆品,皮肤病学或治疗用途,优选作为皮肤和/或发白(增白)活性物质。 本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式(I)化合物的组合物和化妆品,皮肤病学或治疗产品。 本发明还涉及作为药物的式(I)化合物,其用于制备用于减轻人类皮肤和/或头发的药物组合物的用途和新的式(I)化合物,其中A表示其中X,Y和Z 彼此独立地表示氢,C 1 -C 4 - 烷基或C 2 -C 4 - 烯基,其中任选地,两个基团X,Y和Z彼此共价键合形成双环体系,在这种双环体系中 两个基团X,Y和Z一起优选形成具有1至4个碳原子的基团,优选具有1至3个碳原子的烃基,B表示NR1R2,其中R1表示氢或具有1至14个碳原子的有机基团 R 2表示碳原子数为1〜14的有机基团,且R 1和R 2中任选具有共价键,优选为B为3〜8元环。
    • 5. 发明申请
    • MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
    • MENTHYL CARBAMATE化合物作为皮肤和/或头发照明活动
    • WO2010097480A2
    • 2010-09-02
    • PCT/EP2010/057119
    • 2010-05-25
    • SYMRISE GMBH & CO. KGVIELHABER, GabrieleOERTLING, HeikoSCHAPER, KarinGÖMANN, ClaudiaBRODHAGE, Rahim
    • VIELHABER, GabrieleOERTLING, HeikoSCHAPER, KarinGÖMANN, ClaudiaBRODHAGE, Rahim
    • A61K8/40A61K8/44A61K8/4973A61K31/325A61Q5/00A61Q5/08A61Q17/00A61Q19/02
    • The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof, wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).
    • 本发明涉及式(I)化合物或式(I)化合物的化妆品可接受的盐或包含这些化合物中的两种或更多种的混合物或其盐的化妆品,皮肤病学或药学(治疗)用途, 其中R1表示氢或具有1至14个碳原子的有机基团,R2表示具有1至14个碳原子的有机基团,并且其中任选地R 1和R 2彼此共价键合,优选形成3至8元环 ,用于减轻皮肤和/或头发。 本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式(I)化合物的组合物和化妆品,皮肤病学或药物制剂(组合物)。 本发明还涉及作为药物的式(I)化合物,其用于制备用于减轻人类皮肤和/或头发的药物组合物和某些新的式(I)化合物的用途。
    • 8. 发明申请
    • CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS
    • CYCLOHEXYL碳酸酯化合物作为活性抗细胞成分
    • WO2010097479A3
    • 2011-04-14
    • PCT/EP2010057112
    • 2010-05-25
    • SYMRISE AGMEYER IMKEOERTLING HEIKOHILLEBRAND NADINEGOEMANN CLAUDIABRODHAGE RAHIM
    • MEYER IMKEOERTLING HEIKOHILLEBRAND NADINEGOEMANN CLAUDIABRODHAGE RAHIM
    • A61K8/42A61Q19/06
    • A61K8/44A61K31/00A61K31/27A61Q19/06
    • The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
    • 本发明涉及以下给出的某些式(I)环己基氨基甲酸酯化合物的化妆品,皮肤病学或治疗用途,优选作为抗脂肪团活性物质。 本发明还涉及包含这样的式(I)化合物的组合物和化妆品,皮肤病学或治疗产品,其优选适用于预防(预防)和化妆品处理(抗击)人体中的脂肪团,相应的方法和新的化合物 式(I)其中A表示(II),其中X,Y和Z彼此独立地表示氢,C1-C4-烷基或C2-C4-烯基,其中任选地两个基团X,Y和Z共价键合 在这样的双环体系中,基团X,Y和Z中的两个一起优选形成具有1至4个碳原子的基团,优选地具有1至3个碳原子的烃基,B 表示NR 1 R 2,其中R 1表示氢或具有1至14个碳原子的有机基团,R 2表示具有1至14个碳原子的有机基团,并且其中任选地R 1和R 2彼此共价键合,优选为 该B为3至8元环。
    • 9. 发明申请
    • CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS
    • CYCLOHEXYL碳酸酯化合物作为活性抗细胞成分
    • WO2010097479A2
    • 2010-09-02
    • PCT/EP2010/057112
    • 2010-05-25
    • SYMRISE GMBH & CO. KGMEYER, ImkeOERTLING, HeikoHILLEBRAND, NadineGÖMANN, ClaudiaBRODHAGE, Rahim
    • MEYER, ImkeOERTLING, HeikoHILLEBRAND, NadineGÖMANN, ClaudiaBRODHAGE, Rahim
    • A61K8/44A61K31/00A61K31/27A61Q19/06
    • The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR 1 R 2 , wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
    • 本发明涉及以下给出的某些式(I)环己基氨基甲酸酯化合物的化妆品,皮肤病学或治疗用途,优选作为抗脂肪团活性物质。 本发明还涉及包含这样的式(I)化合物的组合物和化妆品,皮肤病学或治疗产品,其优选适用于预防(预防)和化妆品处理(抗击)人体中的脂肪团,相应的方法和新的化合物 式(I)其中A表示(II),其中X,Y和Z彼此独立地表示氢,C1-C4-烷基或C2-C4-烯基,其中任选地两个基团X,Y和Z共价键合 在这样的双环体系中,基团X,Y和Z中的两个一起优选形成具有1至4个碳原子的基团,优选地具有1至3个碳原子的烃基,B 表示NR 1 R 2,其中R 1表示氢或具有1至14个碳原子的有机基团,R 2表示具有1至14个碳原子的有机基团,并且其中任选地R 1和R 2彼此共价键合,优选为 该B为3至8元环。