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1. 发明申请

WO2014198602A1 NEW SUCCINATE DERIVATIVES 审中-公开
标题翻译：新的成功衍生物
公开(公告)号：WO2014198602A1
公开(公告)日：2014-12-18
申请号：PCT/EP2014/061561
申请日：2014-06-04
申请人： SYMRISE AG , STUHLMANN, Dominik , MEYER, Imke , KOCH, Oskar , OERTLING, Helko , HERRMANN, Martina , GÖMANN, Claudia
发明人： STUHLMANN, Dominik , MEYER, Imke , KOCH, Oskar , OERTLING, Helko , HERRMANN, Martina , GÖMANN, Claudia
IPC分类号： C07C235/74 , A61Q19/00 , A61Q19/02 , A61Q19/08
CPC分类号： A61K8/42 , A61K8/4926 , A61K2800/48 , A61K2800/522 , A61K2800/524 , A61K2800/591 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/04 , A61Q19/08 , C07C235/74
摘要： The invention relates generally to new compounds of formula (I), wherein R 1 , R' 1 , R 2 , R' 2 , R 3 , R' 3 , R 4 R' 4 , R 5 , R' 5 , R 6 , R 7 are independently of one another and denote hydrogen, hydroxyl, C 1 to C 6 -alkyl group or R 6 and R 7 form together a C5-C6 ring system, and wherein n = 0, 1, 2, 3, or 4. Moreover, the invention relates to the use of one or more compounds of formula (I) in cosmetic or pharmaceutical compositions, which are preferably dermatological compositions and are preferably used topically.
摘要翻译：本发明一般涉及新的式（I）化合物，其中R 1，R'1，R 2，R'2，R 3，R'3，R 4'R 4，R 5，R'5，R 6，R 7独立地为另一个表示氢，羟基，C 1至C 6烷基或R 6和R 7一起形成C 5 -C 6环系，并且其中n = 0,1,2,3或4.此外，本发明涉及使用一种或多种化妆品或药物组合物中的式（I）化合物，其优选是皮肤病学组合物，并且优选地局部使用。

2. 发明申请

WO2014170239A1 A COMPOSITION FOR LIGHTENING SKIN AND HAIR 审中-公开
标题翻译：皮肤和头发的组合物
公开(公告)号：WO2014170239A1
公开(公告)日：2014-10-23
申请号：PCT/EP2014/057450
申请日：2014-04-11
申请人： SYMRISE AG , MEYER, Imke , KNUPFER, Mirjam
发明人： MEYER, Imke , KNUPFER, Mirjam
IPC分类号： A61Q5/08 , A61Q19/02 , A61K8/49
CPC分类号： A61K8/4973 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/342 , A61K8/35 , A61K8/37 , A61K8/44 , A61K8/492 , A61K8/498 , A61K8/58 , A61K8/602 , A61K8/675 , A61K8/922 , A61K8/97 , A61K31/365 , A61K2800/592 , A61Q5/00 , A61Q5/08 , A61Q17/04 , A61Q19/00 , A61Q19/02
摘要： Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent. on condition that compound a is present in an amount of from 0.00001 to 0.001 % b.w. - calculated on the total composition.
摘要翻译：建议包括（a）香紫苏内酯和（b1）至少一种酪氨酸酶抑制剂的组合物; 和/或（b2）至少一种防晒因子; 和/或（b3）至少一种抗氧化剂; 和/或（b4）至少一种抗炎剂; 和/或（b5）至少一种脱屑剂。化合物a的存在量为0.00001至0.001％b.w。 - 根据总成分计算。

3. 发明申请

WO2010089421A3 MENTHYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译：戊烯碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010089421A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057117
申请日：2010-05-25
申请人： SYMRISE AG , MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q19/06
CPC分类号： A61K8/42 , A61K8/4973 , A61Q19/06 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2601/14 , C07D307/14 , C07D317/58
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain menthyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and to certain novel compounds of formula (I) wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed.
摘要翻译：本发明涉及以下给出的某些式（I）的薄荷基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性成分。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和某些新颖的其中R 1表示氢或具有1至14个碳原子的有机基团的式（I）化合物，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得形成3〜8元环。

4. 发明申请

WO2010097479A3 CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译： CYCLOHEXYL碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010097479A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010057112
申请日：2010-05-25
申请人： SYMRISE AG , MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
发明人： MEYER IMKE , OERTLING HEIKO , HILLEBRAND NADINE , GOEMANN CLAUDIA , BRODHAGE RAHIM
IPC分类号： A61K8/42 , A61Q19/06
CPC分类号： A61K8/44 , A61K31/00 , A61K31/27 , A61Q19/06
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性物质。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和新的化合物式（I）其中A表示（II），其中X，Y和Z彼此独立地表示氢，C1-C4-烷基或C2-C4-烯基，其中任选地两个基团X，Y和Z共价键合在这样的双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B 表示NR 1 R 2，其中R 1表示氢或具有1至14个碳原子的有机基团，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选为该B为3至8元环。

5. 发明申请

WO2010070152A3 USE OF DIHYDRODEHYDRODIISOEUGENOL AND PREPARATIONS COMPRISING DIHYDRODEHYDRODIISOEUGENOL 审中-公开
标题翻译：二氢二氢叶酸的使用和包含二氢硬脂基菊酯的制剂
公开(公告)号：WO2010070152A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010054667
申请日：2010-04-08
申请人： SYMRISE AG , MEYER IMKE , KOCH OSKAR , KRUTMANN JEAN
发明人： MEYER IMKE , KOCH OSKAR , KRUTMANN JEAN
IPC分类号： A61K8/49 , A61Q19/08
CPC分类号： A61K8/4973 , A61K31/343 , A61K45/06 , A61K2800/59 , A61K2800/782 , A61K2800/92 , A61Q1/10 , A61Q5/004 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61Q17/04 , A61Q19/08
摘要： This invention relates to cosmetic and pharmaceutical preparations comprising (i) a diastereomer or a mixture of two or more diastereomers of the compound of Formula (I), or (ii) a salt of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I) or (iii) a mixture of two or more salts of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I), a diastereomer, salt or a mixture as defined above as a drug for topical application and/or for the treatment of lipoatrophy; the non-therapeutic use of a diastereomer, salt or a mixture as defined above for the prevention, treatment or reduction of skin aging, especially skin wrinkles; the use of a diastereomer, salt or a mixture as defined above for the production of an orally administered non-pharmaceutical preparation.
摘要翻译：本发明涉及化妆品和药物制剂，其包含（i）式（I）化合物的非对映异构体或两种或更多种非对映异构体的混合物，或（ii）非对映异构体的盐或两种或更多种非对映异构体的混合物式（I）化合物或（iii）两种或更多种非对映体盐或两种或更多种式（I）化合物的非对映异构体的混合物的混合物，非对映异构体，盐或如上定义的混合物用于局部应用和/或治疗脂肪萎缩的药物; 如上定义的非对映异构体，盐或混合物的非治疗用途，用于预防，治疗或减少皮肤老化，特别是皮肤皱纹; 使用如上定义的非对映异构体，盐或混合物来生产口服非药物制剂。

6. 发明申请

WO2010097479A2 CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译： CYCLOHEXYL碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010097479A2
公开(公告)日：2010-09-02
申请号：PCT/EP2010/057112
申请日：2010-05-25
申请人： SYMRISE GMBH & CO. KG , MEYER, Imke , OERTLING, Heiko , HILLEBRAND, Nadine , GÖMANN, Claudia , BRODHAGE, Rahim
发明人： MEYER, Imke , OERTLING, Heiko , HILLEBRAND, Nadine , GÖMANN, Claudia , BRODHAGE, Rahim
CPC分类号： A61K8/44 , A61K31/00 , A61K31/27 , A61Q19/06
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR 1 R 2 , wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性物质。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和新的化合物式（I）其中A表示（II），其中X，Y和Z彼此独立地表示氢，C1-C4-烷基或C2-C4-烯基，其中任选地两个基团X，Y和Z共价键合在这样的双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B 表示NR 1 R 2，其中R 1表示氢或具有1至14个碳原子的有机基团，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选为该B为3至8元环。

7. 发明申请

WO2010089421A2 MENTHYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS 审中-公开
标题翻译：戊烯碳酸酯化合物作为活性抗细胞成分
公开(公告)号：WO2010089421A2
公开(公告)日：2010-08-12
申请号：PCT/EP2010/057117
申请日：2010-05-25
申请人： SYMRISE GMBH & CO. KG , MEYER, Imke , OERTLING, Heiko , HILLEBRAND, Nadine , GÖMANN, Claudia , BRODHAGE, Rahim
发明人： MEYER, Imke , OERTLING, Heiko , HILLEBRAND, Nadine , GÖMANN, Claudia , BRODHAGE, Rahim
CPC分类号： A61K8/42 , A61K8/4973 , A61Q19/06 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2601/14 , C07D307/14 , C07D317/58
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain menthyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and to certain novel compounds of formula (I) wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed.
摘要翻译：本发明涉及以下给出的某些式（I）的薄荷基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性成分。本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和某些新颖的其中R 1表示氢或具有1至14个碳原子的有机基团的式（I）化合物，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得形成3〜8元环。

8. 发明申请

WO2007042472A1 SYNERGISTIC MIXTURES OF BISABOLOL AND GINGER EXTRACT 审中-公开
标题翻译：双酚和双羟萘酸的协同混合物
公开(公告)号：WO2007042472A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/067130
申请日：2006-10-06
申请人： SYMRISE GMBH & CO. KG , HERRMANN, Martina , VIELHABER, Gabriele , MEYER, Imke , JOPPE, Holger
发明人： HERRMANN, Martina , VIELHABER, Gabriele , MEYER, Imke , JOPPE, Holger
IPC分类号： A61Q19/00 , A61P17/00 , A61K8/34 , A61K31/045 , A61K8/97
CPC分类号： A61K31/045 , A61K8/34 , A61K8/35 , A61K8/97 , A61K2800/75 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/004 , A61Q19/005 , A61Q19/04
摘要： Described is a formulation having a skin irritation-reducing action consisting of or comprising: bisabolol and a composition or compound chosen from the group consisting of a) substance mixtures obtainable from an extraction of ginger, b) substance mixtures obtainable from a separation of a ginger extract which comprise a compound which is chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and c) compounds obtainable from a separation of a ginger extract which are chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and mixtures thereof, wherein the particular content of bisabolol and of the said composition or compound in the formulation is adjusted such that the skin irritation-reducing action of these contents is increased synergistically.
摘要翻译：描述了具有皮肤刺激减少作用的制剂，其包含或包含：红嘌呤和选自以下的组合物或化合物：a）从姜提取物获得的物质混合物，b）从分离姜获得的物质混合物提取物，其包含选自姜酚，皂醇，姜黄色素，脱氢脱水es啶，间二异吲哚及其衍生物的化合物，和c）可从姜油，姜黄素，姜糖醇，脱水脱水脱水物，paradols及其衍生物及其混合物，其中调节配方中所述组合物或组合物中的红嘌呤醇的特定含量，从而协同地增加这些内容物的皮肤刺激减少作用。

9. 发明申请

WO2010070152A2 USE OF DIHYDRODEHYDRODIISOEUGENOL AND PREPARATIONS COMPRISING DIHYDRODEHYDRODIISOEUGENOL 审中-公开
标题翻译：二氢二氢叶酸的使用和包含二氢硬脂基菊酯的制剂
公开(公告)号：WO2010070152A2
公开(公告)日：2010-06-24
申请号：PCT/EP2010/054667
申请日：2010-04-08
申请人： SYMRISE GMBH & CO. KG , MEYER, Imke , KOCH, Oskar , KRUTMANN, Jean
发明人： MEYER, Imke , KOCH, Oskar , KRUTMANN, Jean
CPC分类号： A61K8/4973 , A61K31/343 , A61K45/06 , A61K2800/59 , A61K2800/782 , A61K2800/92 , A61Q1/10 , A61Q5/004 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61Q17/04 , A61Q19/08
摘要： This invention relates to cosmetic and pharmaceutical preparations comprising (i) a diastereomer or a mixture of two or more diastereomers of the compound of Formula (I), or (ii) a salt of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I) or (iii) a mixture of two or more salts of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I), a diastereomer, salt or a mixture as defined above as a drug for topical application and/or for the treatment of lipoatrophy; the non-therapeutic use of a diastereomer, salt or a mixture as defined above for the prevention, treatment or reduction of skin aging, especially skin wrinkles; the use of a diastereomer, salt or a mixture as defined above for the production of an orally administered non-pharmaceutical preparation.
摘要翻译：本发明涉及化妆品和药物制剂，其包含（i）式（I）化合物的非对映异构体或两种或更多种非对映异构体的混合物，或（ii）非对映异构体的盐或两种或更多种非对映异构体的混合物式（I）化合物或（iii）两种或更多种非对映体盐或两种或更多种式（I）化合物的非对映异构体的混合物的混合物，非对映异构体，盐或如上定义的混合物用于局部应用和/或治疗脂肪萎缩的药物; 如上定义的非对映异构体，盐或混合物的非治疗用途，用于预防，治疗或减少皮肤老化，特别是皮肤皱纹; 使用如上定义的非对映异构体，盐或混合物来生产口服非药物制剂。

10. 发明申请

WO2015044390A1 A COSMETIC COMPOSITION FOR LIGHTENING SKIN AND HAIR 审中-公开
标题翻译：化妆品组合物，用于照射皮肤和头发
公开(公告)号：WO2015044390A1
公开(公告)日：2015-04-02
申请号：PCT/EP2014/070701
申请日：2014-09-26
申请人： SYMRISE AG , MEYER, Imke , KNUPFER, Mirjam , JOPPE, Holger , KÖHLER, Antje , HÖLSCHER, Bernd , MANSFELD, Marc
发明人： MEYER, Imke , KNUPFER, Mirjam , JOPPE, Holger , KÖHLER, Antje , HÖLSCHER, Bernd , MANSFELD, Marc
IPC分类号： A61K8/34 , A61Q19/02 , A61Q5/08
CPC分类号： A61K8/345 , A61K2800/92 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/08 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： Suggested is a composition comprising (a) larixol and at least one of the components (b1) to (b5) selected from (b1) tyrosinase inhibitors; (b2) sun protection factors; (b3) antioxidants; (b4) anti-inflammatory agents; and (b5) desquamating agents.
摘要翻译：建议包括（a）larixol和选自（b1）酪氨酸酶抑制剂的组分（b1）至（b5）中的至少一种的组合物; （b2）防晒因素; （b3）抗氧化剂; （b4）抗炎剂; 和（b5）脱屑剂。

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