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1. 发明申请

WO2014186692A1 COMPUTER-IMPLEMENTED METHODS OF DETERMINING PROTEIN VISCOSITY 审中-公开
标题翻译：计算机实施的测定蛋白质粘度的方法
公开(公告)号：WO2014186692A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/038368
申请日：2014-05-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NOVARTIS PHARMA AG
发明人： TROUT, Bernhardt, Levy , HELK, Bernard , AGRAWAL, Neerah, Jagdish
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G06F19/16 , G01N11/00 , G01N33/6803 , G01N33/6854 , G01N2011/006
摘要： The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three- dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained.
摘要翻译：本发明提供了用于基于粘度特性筛选诸如抗体的蛋白质的计算机实施的方法。该方法涉及制作抗体或蛋白质的三维结构的空间电荷图（SCM），并根据诸如例如血管生成的状况确定SCM分数。 pH值，该评分与粘度相关。因此可以获得粘度的定量测量值。

2. 发明申请

WO2015179461A1 PLASTICITY INDUCED BONDING 审中-公开
标题翻译：塑性诱导结合
公开(公告)号：WO2015179461A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031666
申请日：2015-05-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： PADHYE, Nikhil , PARKS, David Moore , TROUT, Bernhardt, Levy , SLOCUM, Alexander H.
IPC分类号： B29C65/02 , B32B37/06 , C09J5/02 , G05G15/08
CPC分类号： B29C65/02 , B29C65/004 , B29C65/006 , B29C65/1432 , B29C65/72 , B29C65/8215 , B29C65/8223 , B29C65/8253 , B29C66/1122 , B29C66/341 , B29C66/43 , B29C66/45 , B29C66/71 , B29C66/723 , B29C66/73117 , B29C66/73121 , B29C66/73151 , B29C66/73161 , B29C66/73921 , B29C66/8161 , B29C66/8223 , B29C66/8227 , B29C66/83411 , B29C66/83413 , B29C66/91945 , B29C66/9221 , B29C66/9261 , B29K2105/0038 , B32B37/06 , B32B37/10 , B32B2037/0092 , B32B2309/02 , C09J5/00 , C09J2400/226 , G05G15/08 , B29K2001/00 , B29K2023/06 , B29K2023/18 , B29K2025/06 , B29K2031/04 , B29K2033/12 , B29K2039/06 , B29K2069/00 , B29K2083/00
摘要： Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.
摘要翻译：公开了用于粘合聚合物部件的方法和装置。具体地说，在一个实施方案中，聚合物部分在它们低于玻璃化转变温度时彼此通过塑性变形而结合。一种方法包括：将第一聚合物部分放置成与第二聚合物部分接触; 并且使第一聚合物部分和第二聚合物部分彼此相对地塑性变形以将第一聚合物部分结合到第二聚合物部分。此外，在塑性变形期间，第一聚合物部分的温度小于第一聚合物部分的玻璃化转变温度，第二聚合物部分的温度小于第二聚合物部分的玻璃化转变温度。

3. 发明申请

WO2013165604A1 ELECTROPROCESSING OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：活性药物成分的电化学研究
公开(公告)号：WO2013165604A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/031983
申请日：2013-03-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： TROUT, Bernhardt, Levy , BRETTMANN, Blair, Kathryn , MYERSON, Allan, Stuart
IPC分类号： A01N25/34
CPC分类号： A61J3/00 , A61K9/2027 , A61K9/2095 , A61K9/70 , D01D5/0069 , D01F1/10
摘要： Electro spinning of crystalline particles comprising active pharmaceutical ingredients (API) from suspensions yields fibrous compositions comprising the API. The morphology and size of the crystalline particles may be preserved. The particles may be predominantly retained by fibers and distributed throughout the fibrous mesh. Tablet forms of the APIs prepared from the fibrous compositions demonstrate higher dissolution rates than tablets prepared from compacted powders of the APIs.
摘要翻译：包含悬浮液的活性药物成分（API）的结晶颗粒的电纺产生包含API的纤维组合物。可以保留结晶颗粒的形态和尺寸。颗粒可以主要由纤维保留并分布在整个纤维网中。由纤维组合物制备的片剂的片剂形式比从API的压实粉末制备的片剂显示更高的溶解速率。

4. 发明申请

WO2012027398A2 COMPOSITIONS, METHODS, AND SYSTEMS RELATING TO CONTROLLED CRYSTALLIZATION AND/OR NUCLEATION OF MOLECULAR SPECIES 审中-公开
标题翻译：与控制分子结构和/或分子结构相关的组成，方法和系统
公开(公告)号：WO2012027398A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048851
申请日：2011-08-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TROUT, Bernhardt, Levy , DOYLE, Patrick, S. , HATTON, Trevor, Alan , MYERSON, Allan, Stuart , DIAO, Ying , HELGESON, Matthew, E.
发明人： TROUT, Bernhardt, Levy , DOYLE, Patrick, S. , HATTON, Trevor, Alan , MYERSON, Allan, Stuart , DIAO, Ying , HELGESON, Matthew, E.
IPC分类号： B01D9/00
CPC分类号： A61K31/616 , A61K9/14 , A61K9/146 , A61K31/167 , B01D9/00 , B82Y5/00
摘要： The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).
摘要翻译：本发明一般涉及与分子物质的受控结晶和/或成核有关的组合物，方法和系统。在一些实施方案中，分子种类的结晶和/或成核可以通过调整结晶底物的表面化学性质和/或形态来控制。在一些实施方案中，分子种类是小的有机分子（例如药物活性剂）。

5. 发明申请

WO2017070460A1 VEGF-A-BINDING PROTEINS AND HER2-BINDING PROTEINS WITH ENHANCED STABILITY AGAINST AGGREGATION 审中-公开
标题翻译： VEGF-A-结合蛋白和HER2-结合蛋白具有增强的抗凝聚稳定性
公开(公告)号：WO2017070460A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058093
申请日：2016-10-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： TROUT, Bernhardt, Levy , AGRAWAL, Neeraj, Jagdish , COURTOIS, Fabienne
IPC分类号： C07K16/22 , C07K16/32
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/567 , C07K2317/92 , C07K2317/94
摘要： The present disclosure provides VEGF-A-binding proteins and HER-2-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.
摘要翻译：本公开提供具有降低的聚集趋势的VEGF-A结合蛋白和HER-2结合蛋白。还提供了使用的组成和使用方法。

6. 发明申请

WO2016138503A1 METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION 审中-公开
标题翻译：连续异质结晶的方法与系统
公开(公告)号：WO2016138503A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019976
申请日：2016-02-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MYERSON, Allan, Stuart , TROUT, Bernhardt, Levy , JENSEN, Keith, Dale , PERALA, Siva, Rama Krishna , TESTA, Christopher, James
IPC分类号： B01D9/00
CPC分类号： A61K47/26 , A61K31/167 , B01D9/0036 , B01D9/0059
摘要： Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the dissolved agent. Crystallization may occur on the surface of the heteronucleant with little or no bulk crystallization and/or secondary nucleation. In some embodiments, a crystallizer may be configured to inhibit secondary nucleation and/or bulk crystallization, for example, by reducing the formation of free crystals that may serve as nucleation surfaces while allowing for adequate mass and heat transfer. In some such embodiments, the crystallizer may be designed to flow (e.g., continuously) a suspension comprising a heteronucleant and an agent in a fluidized state. The methods and systems of the present invention may be used in a wide variety of applications, including the crystallization of pharmaceutically active agents.
摘要翻译：提供了异相结晶和相关系统的方法。在一些实施方案中，一种方法包括使包含异源核苷酸和溶解试剂的悬浮液中的试剂结晶。结晶可能发生在异源核的表面上，很少或没有本体结晶和/或二次成核。在一些实施方案中，结晶器可以被配置为抑制二次成核和/或体积结晶，例如通过减少可用作成核表面的自由晶体的形成，同时允许足够的质量和热传递。在一些这样的实施方案中，结晶器可以被设计成流动（例如，连续地）流态化的包含异源核苷酸和试剂的悬浮液。本发明的方法和系统可以用于各种应用，包括药物活性剂的结晶。

7. 发明申请

WO2015095533A1 POLYMER MATRICES FOR CONTROLLING CRYSTALLIZATION 审中-公开
标题翻译：用于控制结晶的聚合物矩阵
公开(公告)号：WO2015095533A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071182
申请日：2014-12-18
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ERAL, Huseyin, Burak , LOPEZ-MEJIAS, Vilmali , MYERSON, Allan, Stuart , TROUT, Bernhardt, Levy , DOYLE, Patrick, S. , O'MAHONY, Marcus
IPC分类号： A61K9/14
CPC分类号： A61K31/216 , A61K9/1617 , A61K9/1652
摘要： Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.
摘要翻译：通常描述用于控制试剂结晶的组合物，方法和系统。在一些实施方案中，试剂在聚合物基质如聚合物颗粒存在下结晶。聚合物基质可能影响结晶过程的至少一部分和/或所得组合物。在一些这样的实施方案中，聚合物基质允许控制和/或改变方法和/或组合物的一个或多个方面。例如，聚合物基质可以作为结晶剂的结晶促进剂和/或可接受的载体。在某些实施方案中，本文所述的聚合物基质可以与任何试剂一起使用，而不管其化学和/或物理性质。

8. 发明申请

WO2014052717A2 CD20-AND EGFR-BINDING PROTEINS ENHANCED STABILITY 审中-公开
标题翻译： CD20和EGFR结合蛋白增强稳定性
公开(公告)号：WO2014052717A2
公开(公告)日：2014-04-03
申请号：PCT/US2013/062114
申请日：2013-09-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： TROUT, Bernhardt, Levy , SCHNEIDER, Curtiss, Paul , AGRAWAL, Neeraj, Jagdish
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61J1/065 , A61K39/395 , C07K16/2863 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/92
摘要： The invention provides CD20-binding proteins and EGFR-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.
摘要翻译：本发明提供具有降低的聚集趋势的CD20结合蛋白和EGFR结合蛋白。还提供了使用的组成和使用方法。

9. 发明申请

WO2014052713A3 HER2-AND VEGF-A-BINDING PROTEINS WITH ENHANCED STABILITY 审中-公开
公开(公告)号：WO2014052713A3
公开(公告)日：2014-04-03
申请号：PCT/US2013/062108
申请日：2013-09-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： TROUT, Bernhardt, Levy , SCHNEIDER, Curtiss, Paul , AGRAWAL, Neeraj, Jagdish
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00
摘要： The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.

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