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1. 发明申请

WO2008020365A2 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：WO2008020365A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/053117
申请日：2007-08-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DURIC, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , DE BOER, Bart Michiel
发明人： DURIC, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , DE BOER, Bart Michiel
IPC分类号： G01N33/543 , G01N27/72 , G01N15/10 , G01N35/00
CPC分类号： G01N33/54366 , G01N27/745 , G01N33/54326 , G01N33/54373 , G01N35/0098
摘要： The present invention provides a magnetic sensor device (20) comprising at least one sensor surface lying in a first plane, a first magnetic field generating means (12) for attracting magnetic or magnetizable objects (15) toward a sensor surface (13), the first magnetic field generating means (12) lying in a second plane different from and substantially parallel to the first plane, and a second magnetic field generating means (14) for magnetizing magnetic or magnetizable objects (15) which are bond to the sensor. The spacing between the first magnetic field generating means (12) and the at least one sensor element (11) is smaller than 2 μm down to optionally overlapping. The present invention furthermore provides a method for determining the presence and/or amount of magnetic or magnetizable objects (15) in a sample fluid using the magnetic sensor device (20) according to embodiments of the invention.
摘要翻译：本发明提供了一种包括位于第一平面中的至少一个传感器表面的磁传感器装置（20），用于将磁性或可磁化物体（15）吸引到传感器表面（13）的第一磁场产生装置（12）第一磁场产生装置（12），其位于与第一平面不同并且基本上平行的第二平面中;以及第二磁场产生装置（14），用于磁化磁性或可磁化物体（15），所述第二磁场产生装置结合到传感器。第一磁场产生装置（12）和至少一个传感器元件（11）之间的间隔小于2μm，直到可选地重叠。本发明还提供一种用于使用根据本发明的实施例的磁传感器装置（20）来确定样品流体中的磁性或可磁化物体（15）的存在和/或量的方法。

2. 发明申请

WO2008020365A3 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁性传感器装置
公开(公告)号：WO2008020365A3
公开(公告)日：2008-04-24
申请号：PCT/IB2007053117
申请日：2007-08-07
申请人： KONINKL PHILIPS ELECTRONICS NV , DURIC HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , DE BOER BART MICHIEL
发明人： DURIC HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , DE BOER BART MICHIEL
IPC分类号： G01N33/543 , G01N15/10 , G01N27/72 , G01N35/00
CPC分类号： G01N33/54366 , G01N27/745 , G01N33/54326 , G01N33/54373 , G01N35/0098
摘要： The present invention provides a magnetic sensor device (20) comprising at least one sensor surface lying in a first plane, a first magnetic field generating means (12) for attracting magnetic or magnetizable objects (15) toward a sensor surface (13), the first magnetic field generating means (12) lying in a second plane different from and substantially parallel to the first plane, and a second magnetic field generating means (14) for magnetizing magnetic or magnetizable objects (15) which are bond to the sensor. The spacing between the first magnetic field generating means (12) and the at least one sensor element (11) is smaller than 2 µm down to optionally overlapping. The present invention furthermore provides a method for determining the presence and/or amount of magnetic or magnetizable objects (15) in a sample fluid using the magnetic sensor device (20) according to embodiments of the invention.
摘要翻译：本发明提供一种磁性传感器装置（20），其包括位于第一平面中的至少一个传感器表面，用于朝向传感器表面（13）吸引磁性或可磁化对象（15）的第一磁场产生装置（12），所述位于与第一平面不同且基本上平行的第二平面内的第一磁场发生装置（12），以及用于磁化与传感器结合的磁性或可磁化物体（15）的第二磁场发生装置（14）。第一磁场产生装置（12）和至少一个传感器元件（11）之间的间隔小于2μm，直至可选地重叠。本发明还提供了一种使用根据本发明实施例的磁传感器装置（20）来确定样本流体中的磁性或可磁化对象（15）的存在和/或数量的方法。

3. 发明申请

WO2007132366A3 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007051505
申请日：2007-04-24
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
发明人： NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域之外或之内的单个事件。

4. 发明申请

WO2007034408A2 MAGNETIC SENSOR SEVICE WITH FILTERING MEANS 审中-公开
标题翻译：带滤波器的磁性传感器设备
公开(公告)号：WO2007034408A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053361
申请日：2006-09-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
CPC分类号： G01R33/12
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency fls a GMR sensor (12) operated with an input current of a second frequency f2, and an amplifier (26) for amplifying the output of the GMR sensor (12). A first filter (24) is used to prevent noise of the current source (23) from reaching the GMR sensor (12), and to prevent magnetic signals from the GMR sensor (12) from reaching the current source (23). Moreover, a second filter (25) is used to prevent the second frequency f2 from reaching the amplifier (26).
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有以第二频率f2的输入电流操作的GMR传感器（12）的第一频率的磁场的导线（11,13）和放大器（26），用于放大GMR传感器（12）的输出。第一滤波器（24）用于防止电流源（23）的噪声到达GMR传感器（12），并且防止来自GMR传感器（12）的磁信号到达电流源（23）。此外，第二滤波器（25）用于防止第二频率f2到达放大器（26）。

5. 发明申请

WO2007034358A2 SENSOR DEVICE WITH GENERATOR AND SENSOR CURRENT SOURCES 审中-公开
标题翻译：具有发电机和传感器电流源的传感器装置
公开(公告)号：WO2007034358A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006053226
申请日：2006-09-12
申请人： KONINKL PHILIPS ELECTRONICS NV , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
发明人： DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field and a magnetic sensor element (12), for example a GMR (12), for sensing changes of the generated magnetic field caused by magnetic particles (2). The wires (11, 13) and the magnetic sensor element (12) are supplied with alternating currents (I1, I2) of high frequencies fl and f2. Said frequencies are chosen such that their difference ?f = æf2-f1æ is low and lies in a range of thermal white noise above the 1/f noise of an amplifier (24) and below the 1/f noise of the GMR (12). In this way it is possible to use a high-frequency magnetic field while only low frequency signals have to be processed.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生磁场的导线（11,13）和用于感测所产生的磁场的变化的磁传感器元件（12），例如GMR（12）由磁性颗粒（2）引起。电线（11,13）和磁性传感器元件（12）被提供有高频f1和f2的交流电流（I1，I2）。选择所述频率使得它们的差Δf=æf2-f1æ为低，并且位于高于放大器（24）的1 / f噪声并低于GMR（12）的1 / f噪声的热白噪声范围内，。以这种方式，可以使用高频磁场，而只需要处理低频信号。

6. 发明申请

WO2011007292A1 ELECTRO-PHYSIOLOGICAL MEASUREMENT WITH REDUCED MOTION ARTIFACTS 审中-公开
标题翻译：电生理测量与减少运动文学
公开(公告)号：WO2011007292A1
公开(公告)日：2011-01-20
申请号：PCT/IB2010/053089
申请日：2010-07-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VEEN, Jeroen , MEFTAH, Mohammed , LAMBERT, Nicolaas , DE BOER, Bart, Michiel , FEDDES, Bastiaan , GOURMELON, Lena , RIETMAN, Ronald , HUSEN, Sri, Andari
发明人： VEEN, Jeroen , MEFTAH, Mohammed , LAMBERT, Nicolaas , DE BOER, Bart, Michiel , FEDDES, Bastiaan , GOURMELON, Lena , RIETMAN, Ronald , HUSEN, Sri, Andari
IPC分类号： A61B5/0428
CPC分类号： A61B5/04284 , A61B5/7214 , A61B2562/0209 , A61B2562/046
摘要： The present invention relates to an apparatus and method (4,5,6,7,2) for capacitive measurement of electrophysiological signals (1) wherein motion artifacts are suppressed or reduced by providing a feedback mechanism. An average voltage between a capacitive sensor electrode (1) and the body (3) is controlled so as to reduce or minimize motion- induced signals.
摘要翻译：本发明涉及一种用于电生理信号（1）的电容测量的装置和方法（4,5,6,7,2）（1），其中通过提供反馈机制来抑制或减少运动伪影。控制电容传感器电极（1）和主体（3）之间的平均电压，以便减少或最小化运动引起的信号。

7. 发明申请

WO2007132366A2 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A2
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051505
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3）和参数结合曲线，例如， Langmuir等温线可以适应于取样的测量信号，以确定样品中所需的颗粒浓度。此外，在正在进行的采样过程中，可以动态地拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数对应于目标颗粒移动到，移出或在敏感区域内的单个事件。

8. 发明申请

WO2007042959A3 MAGNETIC SENSOR DEVICE WITH DIFFERENT INTERNAL OPERATING FREQUENCIES 审中-公开
标题翻译：具有不同内部操作频率的磁性传感器装置
公开(公告)号：WO2007042959A3
公开(公告)日：2007-08-16
申请号：PCT/IB2006053561
申请日：2006-09-29
申请人： KONINKL PHILIPS ELECTRONICS NV , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
发明人： KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
IPC分类号： G01N15/06 , G01N33/543 , G01N35/00 , G01R33/09 , G01R33/12
CPC分类号： G01R33/09 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f 1 a GMR sensor (12) operated with an input current of a second frequency f 2 , and a demodulator (26) operated at a third frequency f 3 . In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency f ref . Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.
摘要翻译：本发明涉及一种磁传感器装置（10），包括用于产生具有第一频率的磁场的导线（11,13），GMR传感器（12）以输入电流第二频率f _{2和以第三频率f _{3 运行的解调器（26）。为了避免由相位噪声造成的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f _{ref 。所述推导可以例如在数字分频器的帮助下实现。此外，可以在反馈控制回路中使用相位检测器（PD1，PD2）以确保三个频率的相位之间的预定关系。在本发明的另一个实施例中，用于处理传感器输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）跟踪。}}}

9. 发明申请

WO2007077498A1 MICROELECTRONIC DEVICE WITH MAGNETIC EXCITATION WIRES 审中-公开
标题翻译：具有磁性激发线的微电子器件
公开(公告)号：WO2007077498A1
公开(公告)日：2007-07-12
申请号：PCT/IB2006/053926
申请日：2006-10-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , JOHNSON, Mark Thomas , IMMINK, Albert Hendrik Jan , PONJEE, Marc Wilhelmus Gijsbert , REIJME, Mirielle Ann , KAHLMAN, Josephus Arnoldus Henricus Maria , NIEUWENHUIS, Jeroen Hans , DE BOER, Bart Michiel
发明人： JOHNSON, Mark Thomas , IMMINK, Albert Hendrik Jan , PONJEE, Marc Wilhelmus Gijsbert , REIJME, Mirielle Ann , KAHLMAN, Josephus Arnoldus Henricus Maria , NIEUWENHUIS, Jeroen Hans , DE BOER, Bart Michiel
IPC分类号： G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

10. 发明申请

WO2007042959A2 MAGNETIC SENSOR DEVICE WITH DIFFERENT INTERNAL OPERATING FREQUENCIES 审中-公开
标题翻译：具有不同内部操作频率的磁传感器装置
公开(公告)号：WO2007042959A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053561
申请日：2006-09-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
CPC分类号： G01R33/09 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f 1 a GMR sensor (12) operated with an input current of a second frequency f 2 , and a demodulator (26) operated at a third frequency f 3 . In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency f ref . Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有第一频率f 1的磁场的导线（11,13），GMR传感器（12）用输入电流第二频率f 2 2和在第三频率f 3 3处操作的解调器（26）。为了避免相位噪声的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f ref 。所述推导可以例如在数字分频器的帮助下实现。此外，相位检测器（PD1，PD2）可用于反馈控制回路中以确保三个频率的相位之间的预定关系。在本发明的另一个实施例中，用于处理传感器的输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）来跟踪。

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