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    • 6. 发明申请
    • FORMULATIONS AND METHODS FOR SOLID CHITOSAN-CONTAINING BLENDS
    • 含固体含酒石酸的配方及方法
    • WO2010148357A1
    • 2010-12-23
    • PCT/US2010/039259
    • 2010-06-18
    • HALOSOURCE, INC.NICHOLS, Everett, J.SCOTT, James, R.
    • NICHOLS, Everett, J.SCOTT, James, R.
    • A01N43/04
    • C02F1/5263C02F1/66
    • Chitosan-containing blends and methods of dissolving and using chitosan are disclosed. A blend includes a solid acid or a solid agent that generates a proton in situ in the presence of water mixed together with a dry solid chitosan, and may optionally contain other components. The blends are in a dry, free-flowing, particulate form. Methods of dissolving a blend typically comprise adding a quantity of the blend to a low volume of water and mixing until the chitosan and solid acid or solid agent are dissolved and then further diluting this mixture by the addition of water, or used as-is. Devices containing the blends are also described along with methods of using the devices, such as for controlled release of solubilized chitosan in a body of water, such as a stream, containing impurities (e.g., particles, sediment, or suspended matter or dissolved substances) to cause flocculation or precipitation of such impurities.
    • 公开了含壳聚糖的共混物和溶解和使用壳聚糖的方法。 共混物包括固体酸或固体剂,其在与干燥固体壳聚糖混合在一起的水的存在下原位产生质子,并且可任选地含有其它组分。 混合物为干燥,自由流动的颗粒形式。 溶解共混物的方法通常包括将一定量的共混物加入到低体积的水中并混合直到壳聚糖和固体酸或固体剂溶解,然后通过加入水进一步稀释该混合物,或按原样使用。 还描述了含有共混物的装置以及使用装置的方法,例如用于控制释放水体中的溶解的壳聚糖,例如含有杂质的流(例如,颗粒,沉积物或悬浮物质或溶解物质) 引起这种杂质的絮凝或沉淀。
    • 8. 发明申请
    • ABSORBING FAT CHITOSAN
    • 吸收脂肪的CHITOSAN
    • WO0147372A3
    • 2001-12-27
    • PCT/US0034604
    • 2000-12-15
    • VANSON INCNICHOLS EVERETT J
    • NICHOLS EVERETT J
    • A23L29/275A61K47/48C08B37/08C08L5/08A23L1/056C08B37/00
    • C08B37/003A23L29/275A61K47/61A61K47/69C08L5/08
    • In one aspect, the present invention provides kits for reducing absorption of lipids by the gastrointestinal tract of a mammalian body. The kits include chitosan, packaging, and instructions indicating that the chitosan may be consumed with food. Chitosan useful for incorporation into kits of the present invention dissolves sufficiently rapidly in gastric juice that it does not have to be consumed in advance of a meal in order to dissolve within the stomach and thereafter effectively entrap lipids in the gastrointestinal tract of the consumer. In a particular embodiment of the kits of the present invention, the chitosan possesses the property of dissolving in a 100-fold (w/w) excess of 0.16N hydrochloric acid, at a temperature in the range of from 16 DEG C to 25 DEG C, so that the maximum viscosity of the dissolved chitosan solution is reached within 5 minutes after the acid contacts the chitosan. It is desirable to utilize chitosan having a high tap density and/or high bulk density in the kits of the present invention. In another aspect, the present invention provides methods for reducing absorption of lipids by the gastrointestinal tract of a mammalian body. The methods include the step of providing a consumer with a kit including chitosan, packaging, and instructions indicating that the chitosan may be consumed with food. The kits of the present invention are useful in the practice of the methods of the present invention. By utilizing the kits and/or methods for lipid absorption reduction of the present invention a consumer does not have to remember to consume lipid-absorbing chitosan in advance of food consumption.
    • 一方面,本发明提供了用于减少哺乳动物体的胃肠道吸收脂质的试剂盒。 试剂盒包括壳聚糖,包装和说明,表明壳聚糖可能与食物一起食用。 用于掺入本发明试剂盒中的壳聚糖在胃液中足够快地溶解,其不必在饭前提前消费,以便在胃中溶解,然后有效地将脂质捕获到消费者的胃肠道中。 在本发明的试剂盒的一个具体实施方案中,壳聚糖具有在16℃至25℃的温度范围内溶解于100倍(w / w)过量的0.16N盐酸的性质。 C,使得在酸接触壳聚糖后5分钟内达到溶解的壳聚糖溶液的最大粘度。 希望在本发明的试剂盒中使用具有高振实密度和/或高堆积密度的壳聚糖。 另一方面,本发明提供了减少哺乳动物体的胃肠道吸收脂质的方法。 所述方法包括向消费者提供包括壳聚糖,包装和说明壳聚糖可能被食物消耗的说明书的步骤。 本发明的试剂盒可用于实施本发明的方法。 通过利用本发明的用于减少脂质吸收的试剂盒和/或方法,消费者不必记住在食物消耗之前消耗脂质吸收壳聚糖。