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1. 发明申请

WO2009034464A2 INDOLE RELATED COMPOUNDS WITH PHYSIOLOGICAL ACTIVITY 审中-公开
标题翻译：包含生理活动的相关化合物
公开(公告)号：WO2009034464A2
公开(公告)日：2009-03-19
申请号：PCT/IB2008002387
申请日：2008-09-12
申请人： NEWCASTLE INNOVATION LTD , CHILDREN S MEDICAL RES INST , ROBINSON PHILLIP J , MCCLUSKEY ADAM
发明人： ROBINSON PHILLIP J , MCCLUSKEY ADAM
CPC分类号： C07D209/18
摘要： The invention relates to compounds of Formula I or Ia having dynamin protein inhibitory activity. Compounds embodied by the invention have application in inhibiting cellular endocytosis and cytokinesis, and may be used in the prophylaxis or treatment of various diseases and conditions involving endocytosis or cell proliferation, such as seizures, epilepsy and cancer. Particularly preferred compounds provided by Formula I and Ia are indoles.
摘要翻译：本发明涉及具有Dynamin蛋白抑制活性的式I或Ia化合物。本发明体现的化合物可用于抑制细胞内吞和胞质分裂，并可用于预防或治疗涉及内吞作用或细胞增殖的各种疾病和病症，例如癫痫发作，癫痫和癌症。由式I和Ia提供的特别优选的化合物是吲哚。

2. 发明申请

WO2015143070A1 IDENTIFYING DIFFERENT TYPES OF PAIN USING MAGNETIC RESONANCE SPECTROSCOPY 审中-公开
标题翻译：使用磁共振光谱鉴别不同类型的疼痛
公开(公告)号：WO2015143070A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/021312
申请日：2015-03-18
申请人： NEWCASTLE INNOVATION LTD , MOUNTFORD, Carolyn , RAMADAN, Saadallah , LIN, Alexander , DIMITRAKOFF, Jordan
发明人： MOUNTFORD, Carolyn , RAMADAN, Saadallah , LIN, Alexander , DIMITRAKOFF, Jordan
IPC分类号： A61B5/055 , G01R33/48 , G01R33/54
CPC分类号： A61B5/4824 , A61B5/0042 , A61B5/055 , A61B5/4255 , A61B5/4571 , A61B5/4839 , A61B5/4848 , A61B5/742 , G01R33/4633 , G01R33/4806
摘要： The present invention relates to a method and system for using neurochemical markers to identify different types of pain, including chronic and acute, and providing the capacity to monitor response to therapy on an individual basis. The present invention relates to a method and system for using neuro biomarkers to identify pain of different types and origins, and the capacity to monitor response to therapy on a personalized basis.
摘要翻译：本发明涉及一种使用神经化学标记物鉴别不同类型疼痛（包括慢性和急性）并提供监测个体治疗反应能力的方法和系统。本发明涉及一种使用神经生物标志物鉴别不同类型和来源的疼痛的方法和系统，以及在个性化基础上监测对治疗反应的能力。

3. 发明申请

WO2014199228A3 DETECTION OF BRCA CARRIERS IN BREAST TISSUE 审中-公开
标题翻译：检测BRCA携带者在乳腺组织
公开(公告)号：WO2014199228A3
公开(公告)日：2015-05-21
申请号：PCT/IB2014001593
申请日：2014-03-17
申请人： NEWCASTLE INNOVATION LTD
发明人： RAMADAN SAADALLAH , SANTAMARIA GORANE , MALYCHA PETER , MOUNTFORD CAROLYN , CLARKE DAVID
IPC分类号： A61B5/055 , G01N24/00 , G01R33/20
CPC分类号： A61B5/4312 , A61B5/055 , A61B5/7282 , A61B5/742 , A61B2576/02 , C12Q1/6886 , C12Q2563/143 , C12Q2565/601 , G01N33/4833 , G01N2405/00 , G01R33/46 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/485
摘要： A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.
摘要翻译：一种用于检测乳腺组织中BRCS载体的存在的方法和系统，包括使用磁共振光谱装置从乳腺组织获得光谱数据，并通过所述装置产生光谱数据，所述装置提供化学标记，以检测乳腺组织是否含有BRCA载体。

4. 发明申请

WO2014199228A2 DETECTION OF BRCA CARRIERS IN BREAST TISSUE 审中-公开
标题翻译：检测BRCA携带者在乳腺组织
公开(公告)号：WO2014199228A2
公开(公告)日：2014-12-18
申请号：PCT/IB2014/001593
申请日：2014-03-17
申请人： NEWCASTLE INNOVATION LTD
发明人： RAMADAN, Saadallah , SANTAMARIA, Gorane , MALYCHA, Peter , MOUNTFORD, Carolyn , CLARKE, David
CPC分类号： A61B5/4312 , A61B5/055 , A61B5/7282 , A61B5/742 , A61B2576/02 , C12Q1/6886 , C12Q2563/143 , C12Q2565/601 , G01N33/4833 , G01N2405/00 , G01R33/46 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/485
摘要： A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.
摘要翻译：一种用于检测乳腺组织中BRCS载体的存在的方法和系统，包括使用磁共振光谱仪从乳腺组织获得光谱数据，并通过所述装置产生光谱数据，所述装置提供化学标记，以检测乳腺组织是否含有BRCA载体。

5. 发明申请

WO2012021944A1 METHODS AND KITS FOR PREDICTING THE ONSET OF LABOUR 审中-公开
标题翻译：用于预测劳动力的方法和工具
公开(公告)号：WO2012021944A1
公开(公告)日：2012-02-23
申请号：PCT/AU2011/001072
申请日：2011-08-22
申请人： NEWCASTLE INNOVATION LTD , SMITH, Roger
发明人： SMITH, Roger
IPC分类号： G01N33/50 , G01N33/74
CPC分类号： G01N33/743
摘要： The present invention relates to methods and kits useful for predicting the time of onset of or the susceptibility of a subject to the onset of labour in a pregnant subject. Also disclosed are methods of determining the susceptibility of a subject to successful induction of labour. In particular, the invention relates to methods and kits for predicting or assessing the susceptibility of a subject to the onset of labour wherein the levels of at least two hormones, selected from estriol, estradiol and progesterone, are determined and a ratio of said levels is calculated, and wherein the susceptibility to the onset of labour is predicted by comparison of said ratio with a predetermined ratio. The invention further contemplates methods for preventing preterm delivery of an infant/offspring and for predicting whether a subject is likely to respond to induction of labour at or post term.
摘要翻译：本发明涉及可用于预测受试者在怀孕受试者中开始劳动的时间或易感性的方法和试剂盒。还公开了确定受试者成功诱导劳动的易感性的方法。特别地，本发明涉及用于预测或评估受试者对劳动者开始的易感性的方法和试剂盒，其中确定选自雌三醇，雌二醇和孕酮中的至少两种激素的水平，并且所述水平的比例为并且其中通过将所述比例与预定比例进行比较来预测对劳动发生的敏感性。本发明进一步考虑了用于预防婴儿/子代早产的预防方法以及用于预测受试者是否可能对期间或之后的劳动诱导作出反应。

6. 发明申请

WO2009006688A1 REGULATING IL-4 AND IL- 13 LEVELS BY BLOCKING HIGH AFFINITY BINDING BY IL-3, IL-5 AND GM-CSF TO THEIR COMMON RECEPTOR 审中-公开
标题翻译：通过阻断IL-3，IL-5和GM-CSF对其共同受体的高亲和性结合来调节IL-4和IL-13水平
公开(公告)号：WO2009006688A1
公开(公告)日：2009-01-15
申请号：PCT/AU2008/001005
申请日：2008-07-10
申请人： MEDVET SCIENCE PTY LTD , NEWCASTLE INNOVATION LTD , LOPEZ, Angel , FOSTER, Paul
发明人： LOPEZ, Angel , FOSTER, Paul
IPC分类号： A61K39/395 , A61P11/00 , A61P11/06
CPC分类号： C07K16/2866 , A61K31/00 , A61K31/57 , A61K39/3955 , A61K45/06
摘要： A method of reducing IL-4 and/or IL- 13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a βc receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM- CSF to the βc common chain to thereby reduce the IL-4 and/or IL-13 levels.
摘要翻译：降低具有升高水平的哺乳动物的肺中的IL-4和/或IL-13水平的方法包括向哺乳动物施用有效量的能够阻断所有三种结合的β受体阻断剂的步骤 IL-3，IL-5和GM-CSF至ßc共同链，从而降低IL-4和/或IL-13水平。

7. 发明申请

WO2007131281A8 A METHOD AND SYSTEM FOR GENERATING POWER FROM A HEAT SOURCE 审中-公开
标题翻译：用于从热源产生电力的方法和系统
公开(公告)号：WO2007131281A8
公开(公告)日：2008-12-04
申请号：PCT/AU2007000646
申请日：2007-05-14
申请人： NEWCASTLE INNOVATION LTD , MOGHTADERI BEHDAD , DOROODCHI ELHAM
发明人： MOGHTADERI BEHDAD , DOROODCHI ELHAM
IPC分类号： F01K25/10 , F03G7/04 , F24J3/08
CPC分类号： F01K25/08 , F01K3/06 , F01K25/10 , F02C1/06 , F02C1/10
摘要： A method of generating power from a heat source, said method including: compressing (10) a working fluid to increase its temperature; exchanging (11) heat between said working fluid and said heat source to superheat said working fluid; expanding (12) said superheated working fluid to drive a turbine, thereby reducing its temperature; condensing (13) said working fluid to further reduce its temperature; and returning said working fluid to said compressing step (10), the method further including the step (14) of regenerating the heat of said working fluid wherein working fluid passing between said compressing step (10) and said heat exchanging step (11) exchanges heat with working fluid passing between said expanding step (12) and said condensing step (13); wherein said steps are performed in a thermodynamic cycle (S1-S1'-S2-S3- S3'-S4) within a supercritical region (SC) above the saturation dome (A) of said working fluid, and wherein said heat regenerating step (14) is performed under isenthalpic conditions to induce continuous heat exchange. A system for generating power from a heat source is also provided.
摘要翻译：一种从热源发电的方法，所述方法包括：压缩（10）工作流体以增加其温度; 在所述工作流体和所述热源之间交换（11）热量以使所述工作流体过热; 膨胀（12）所述过热工作流体以驱动涡轮，从而降低其温度; 冷凝（13）所述工作流体以进一步降低其温度; 并且将所述工作流体返回到所述压缩步骤（10），所述方法还包括使所述工作流体的热量再生的步骤（14），其中在所述压缩步骤（10）和所述热交换步骤（11）之间通过的工作流体交换工作流体在所述膨胀步骤（12）和所述冷凝步骤（13）之间通过的热量; 其中所述步骤在所述工作流体的饱和圆顶（A）上方的超临界区域（SC）内的热力循环（S1-S1'-S2-S3-S3'-S4）中进行，并且其中所述热再生步骤 14）在等焓条件下进行以诱导连续热交换。还提供了一种用于从热源发电的系统。

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