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1. 发明申请

WO2020072653A1 METHODS AND COMPOSITIONS FOR TREATING IGG4-RELATED DISEASES 审中-公开
公开(公告)号：WO2020072653A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054304
申请日：2019-10-02
申请人： ZACK, Debra , STONE, John H. , FOSTER, Paul
发明人： ZACK, Debra , STONE, John H. , FOSTER, Paul
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28
摘要： The present disclosure relates to immunoglobulins that bind Fc ϒ RIIb+ B cells and coengage CD19 on the cell's surface and an Fc ϒ RIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.

2. 发明申请

WO2015195498A1 TREATMENT FOR CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) 审中-公开
标题翻译：慢性淋巴细胞白血病（CLL）治疗
公开(公告)号：WO2015195498A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/035722
申请日：2015-06-15
申请人： XENCOR, INC. , FOSTER, Paul , BYRD, John
发明人： FOSTER, Paul , BYRD, John
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/72 , C07K2317/94
摘要： The present disclosure relates to the treatment of chronic lymphocytic leukemia. Monoclonal antibody XmAb5574 is efficacious when administered to patient at certain dosage regimens. Further disclosed are regimens including said antibody is administered at least once weekly over at least eight weeks; or/and said antibody is administered at a level that achieves a total exposure to said patient measured by area under the curve (AUG) of 14,500 ug *day/ml or more.
摘要翻译：本公开涉及慢性淋巴细胞性白血病的治疗。单克隆抗体XmAb5574在以某种剂量方案给予患者时是有效的。进一步公开的方案包括在至少8周内每周至少施用一次抗体; 或/和所述抗体以达到总共暴露于所述患者的水平，以14,500ug /天或更多的曲线下面积（AUG）测量。

3. 发明申请

WO2010129651A2 COOKING DEVICE 审中-公开
标题翻译：烹饪设备
公开(公告)号：WO2010129651A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033692
申请日：2010-05-05
申请人： SPINFRY, INC. , FOSTER, Paul Lincoln , MILLIKIN, Rory C.P. , THORNOCK, Del Moffat
发明人： FOSTER, Paul Lincoln , MILLIKIN, Rory C.P. , THORNOCK, Del Moffat
IPC分类号： F24C15/20
CPC分类号： A47J37/1271 , A47J37/1219 , A47J37/1223 , A47J37/129 , A47J37/1295
摘要： A cooking device comprises a rotatable food basket disposed within the cooking device. The cooking device may comprise various basket configurations that facilitate cooking various types of foods. Additionally the cooking device may comprise a damping mechanism configured to reduce a vibration generated by the rotatable food basket rotating within the cooking device. Further the cooking device may comprise a retrofit apparatus for retrofitting an existing fryer. The cooking device may include a tube heating element to facilitate heating the cooking liquid and/or the cooked food. A hood gear may be utilized to couple the basket to a motor to facilitate spinning the liquid from the food. Also, the cooking device may include a drawer that facilitates loading and unloading the food into and out of the cooking device. A controller may be utilized to control various aspects of the cooking device and cooking process.
摘要翻译：烹饪装置包括设置在烹饪装置内的可旋转食物篮。烹饪装置可以包括便于烹饪各种类型的食物的各种篮状结构。另外，烹饪装置可以包括阻尼机构，其被配置为减少由烹饪装置内旋转的旋转食物篮产生的振动。此外，烹饪装置可以包括用于改装现有油炸锅的改型装置。烹饪装置可以包括管加热元件，以便于加热烹饪液体和/或烹饪食物。可以使用罩齿轮将篮子连接到马达以便于从食物中纺出液体。此外，烹饪装置可以包括便于将食物装载和卸载进出烹饪装置的抽屉。可以使用控制器来控制烹饪设备的各个方面和烹饪过程。

4. 发明申请

WO2008113993A1 DATA TRIPLE USER ACCESS 审中-公开
标题翻译：数据三用户访问
公开(公告)号：WO2008113993A1
公开(公告)日：2008-09-25
申请号：PCT/GB2008/000929
申请日：2008-03-14
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , MENDIS, Venura, Chakri , FOSTER, Paul, William
发明人： MENDIS, Venura, Chakri , FOSTER, Paul, William
IPC分类号： G06F21/24 , G06F17/30
CPC分类号： G06F17/30958 , G06F21/6227
摘要： A computerized data processing method for providing access to data triples (270, 770) in the form subject (255, 755) - predicate (260, 760) - object (265, 765), the method comprising persisting first data triples (270) associated with a first data triples directed graph (447, 625) in a datastore (120), persisting second data triples (770) associated with a second data triples directed graph (449, 630a) in the datastore (120) together with user access control information (635a, 806), merging the first data triples directed graph (447, 625) and the second data triples directed graph (449, 630a) to provide a merged data triples directed graph (780, 952) in response to a user request (903) having user request access control information corresponding to the user access control information (635a, 806) associated with the second data triples directed graph (449, 630a), and providing access to the merged data triples directed graph (780, 952) to a user (105) associated with the user request.
摘要翻译：一种用于提供对形式主体（255,755） - 谓词（260,760） - 对象（265,765））中的数据三元组（270,770）的访问的计算机化数据处理方法，所述方法包括保持第一数据三元组（270）与数据存储区（120）中的第一数据三倍体有向图（447,625）相关联，持续与数据存储区（120）中的第二数据三倍体有向图（449,630a）相关联的第二数据三元组（770）以及用户访问控制信息（635a，806），合并第一数据三倍体有向图（447,625）和第二数据三倍体有向图（449,630a），以响应于用户提供合并的数据三倍体有向图（780,952）请求（903）具有与与第二数据三倍体有向图（449,630a）相关联的用户访问控制信息（635a，806）对应的用户请求访问控制信息，并且提供对合并的数据三倍体有向图（780,952）的访问）到与用户请求相关联的用户（105）。

5. 发明申请

WO2008065428A3 STEROID SULPHATASE INHIBITORS FOR TREATING HORMONE DEPENDENT CANCER 审中-公开
标题翻译：用于治疗依赖于雄激素的癌症的甾体硫酸酯酶抑制剂
公开(公告)号：WO2008065428A3
公开(公告)日：2008-07-31
申请号：PCT/GB2007004612
申请日：2007-11-30
申请人： STERIX LTD , REED MICHAEL JOHN , PUROHIT ATUL , FOSTER PAUL ALEXANDER , NEWMAN SIMON PAUL , WOO LOK WAI LAWRENCE , POTTER BARRY VICTOR LLOYD
发明人： REED MICHAEL JOHN , PUROHIT ATUL , FOSTER PAUL ALEXANDER , NEWMAN SIMON PAUL , WOO LOK WAI LAWRENCE , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K31/37 , A61P35/00
CPC分类号： A61K31/37
摘要： There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for the treatment of cancer, wherein the cancer is of a type in which the cancer cells overexpress aromatase enzyme.
摘要翻译：提供能够抑制类固醇硫酸酯酶（E.C.3.1.6.2）的化合物在制备用于治疗癌症的药物中的用途，其中癌症是癌细胞过度表达芳香酶的类型。

6. 发明申请

WO2004084094A1 CONVERSION OF STRUCTURED INFORMATION 审中-公开
标题翻译：结构化信息转换
公开(公告)号：WO2004084094A1
公开(公告)日：2004-09-30
申请号：PCT/GB2004/000938
申请日：2004-03-05
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , MENDIS, Venura, Chakri , KEGAL, Ian, Christopher , FOSTER, Paul, William
发明人： MENDIS, Venura, Chakri , KEGAL, Ian, Christopher , FOSTER, Paul, William
IPC分类号： G06F17/30
CPC分类号： G06F17/30569
摘要： A method and apparatus (400) are provided for carrying out conversion of structured information data sets structured according to a first predefined structure (405) into data sets structured according to a second predefined structure (410) by way of an intermediate data structure (300). Conversion rules (420) are defined to convert from each of the first (405) and second (410) predefined structures into the intermediate data structure (300) and from the intermediate data structure (300) into each of the first (405) and second (410) predefined structures. A pre-processor (435) is provided to carry out initial processing tasks (425) on a received data set (405) to make it more susceptible to structural processing (440) according to the conversion rules (420), and a post-processor (445) is provided to carry out tasks (430) such as vocabulary and data type conversion.
摘要翻译：提供一种方法和装置（400），用于根据第一预定义结构（405）将结构化信息数据集转换为根据第二预定义结构（410）通过中间数据结构（300）结构化的数据集）。转换规则（420）被定义为将第一（405）和第二（410）预定义结构中的每一个转换成中间数据结构（300），并从中间数据结构（300）转换成第一（405）和第二（410）预定义结构。提供了一种预处理器（435），用于在接收到的数据集（405）上执行初始处理任务（425），以使其更容易根据转换规则（420）进行结构处理（440）提供处理器（445）以执行诸如词汇和数据类型转换的任务（430）。

7. 发明申请

WO1990002201A1 METHOD AND KIT FOR DIAGNOSIS OF MALIGNANT HYPERPYREXIA 审中-公开
标题翻译：用于诊断恶性高血压的方法和试剂盒
公开(公告)号：WO1990002201A1
公开(公告)日：1990-03-08
申请号：PCT/AU1989000366
申请日：1989-08-30
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , DENBOROUGH, Michael, Anthony , FOSTER, Paul, Stephen
发明人： THE AUSTRALIAN NATIONAL UNIVERSITY
IPC分类号： C12Q01/42
CPC分类号： C12Q1/42 , C12Q1/6876 , C12Q1/6886
摘要： A method for detecting in a human or animal patient the muscle membrane defect leading to the susceptibility of the patient to malignant hyperpyrexia (MH) and/or non-anaesthetic complications, comprises the step of determining the level of inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) or nucleotide sequence encoding same or part thereof in a sample taken from the patient, and comparing the level so determined with the corresponding level in a control sample. A diagnostic kit is also disclosed.
摘要翻译：用于在人或动物患者中检测导致患者对恶性高热（MH）和/或非麻醉并发症的易感性的肌肉膜缺陷的方法包括测定肌醇1,4,5-三三磷酸磷酸酶（InsP35-ase）或从取自患者的样品中编码其相同或部分的核苷酸序列，并将如此确定的水平与对照样品中的相应水平进行比较。还公开了诊断试剂盒。

8. 发明申请

WO2017214452A1 TREATMENT OF IGG4-RELATED DISEASES WITH ANTI-CD19 ANTIBODIES CROSSBINDING TO CD32B 审中-公开
标题翻译：用与CD32B交叉的抗CD19抗体治疗与IGG4有关的疾病
公开(公告)号：WO2017214452A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036635
申请日：2017-06-08
申请人： XENCOR, INC. , ZACK, Debra , STONE, John H. , PATEL, Shiv , FOSTER, Paul
发明人： ZACK, Debra , STONE, John H. , PATEL, Shiv , FOSTER, Paul
IPC分类号： C07K16/28 , A61P37/06 , A61K39/00
摘要： The present disclosure relates to immunoglobulins that bind FcγRIIb+ B cells and coengage CD19 on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.
摘要翻译：本发明涉及与FcγRIIb+ B细胞结合并且使细胞表面上的CD19和细胞表面上的FcγRIIb共同结合的免疫球蛋白，其产生方法以及使用该免疫球蛋白治疗 IgG4相关疾病。

9. 发明申请

WO2010129651A3 COOKING DEVICE 审中-公开
标题翻译：烹饪器具
公开(公告)号：WO2010129651A3
公开(公告)日：2011-11-10
申请号：PCT/US2010033692
申请日：2010-05-05
申请人： SPINFRY INC , FOSTER PAUL LINCOLN , MILLIKIN RORY C P , THORNOCK DEL MOFFAT
发明人： FOSTER PAUL LINCOLN , MILLIKIN RORY C P , THORNOCK DEL MOFFAT
IPC分类号： A47J37/12
CPC分类号： A47J37/1271 , A47J37/1219 , A47J37/1223 , A47J37/129 , A47J37/1295
摘要： A cooking device comprises a rotatable food basket disposed within the cooking device. The cooking device may comprise various basket configurations that facilitate cooking various types of foods. Additionally the cooking device may comprise a damping mechanism configured to reduce a vibration generated by the rotatable food basket rotating within the cooking device. Further the cooking device may comprise a retrofit apparatus for retrofitting an existing fryer. The cooking device may include a tube heating element to facilitate heating the cooking liquid and/or the cooked food. A hood gear may be utilized to couple the basket to a motor to facilitate spinning the liquid from the food. Also, the cooking device may include a drawer that facilitates loading and unloading the food into and out of the cooking device. A controller may be utilized to control various aspects of the cooking device and cooking process.
摘要翻译：烹饪装置包括设置在烹饪装置内的可旋转食物篮。烹饪装置可以包括便于烹饪各种类型的食物的各种篮状结构。另外，烹饪装置可以包括阻尼机构，其被配置为减少由烹饪装置内旋转的旋转食物篮产生的振动。此外，烹饪装置可以包括用于改装现有油炸锅的改装装置。烹饪装置可以包括管加热元件，以便于加热烹饪液体和/或烹饪食物。可以使用罩齿轮将篮子连接到马达以便于从食物中旋转液体。此外，烹饪装置可以包括便于将食物装载和卸载进出烹饪装置的抽屉。可以使用控制器来控制烹饪设备的各个方面和烹饪过程。

10. 发明申请

WO2008116267A1 THERAPEUTIC TARGETS AND MOLECULES 审中-公开
标题翻译：治疗目标和分子
公开(公告)号：WO2008116267A1
公开(公告)日：2008-10-02
申请号：PCT/AU2008/000430
申请日：2008-03-26
申请人： CRC FOR ASTHMA AND AIRWAYS LTD , FOSTER, Paul Stephen , MATTES, Joerg
发明人： FOSTER, Paul Stephen , MATTES, Joerg
IPC分类号： A61K48/00 , C12N15/11
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention provides methods and compositions for treating or preventing inflammation or an inflammatory condition in a subject, comprising administering to the subject an effective amount of at least one antagonist of one or more miRNA upregulated in inflammatory disease conditions and response to allergen challenge. The invention also provides methods for diagnosing inflammatory conditions based on miRNA expression profile signatures.
摘要翻译：本发明提供用于治疗或预防受试者的炎症或炎性病症的方法和组合物，其包括向所述受试者施用有效量的一种或多种在炎性疾病病症中上调的miRNA的至少一种拮抗剂和对变应原攻击的反应。本发明还提供了基于miRNA表达谱特征来诊断炎性病症的方法。

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