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1. 发明申请

WO2011137456A9 METHODS AND MECHANISMS INVOLVING HYPERPIGMENTATION PARTICULARLY FOR AFRICAN AMERICAN SKIN 审中-公开
标题翻译：涉及非洲裔美国人皮肤特异性高的方法和机制
公开(公告)号：WO2011137456A9
公开(公告)日：2012-03-01
申请号：PCT/US2011034856
申请日：2011-05-02
申请人： UNIV HAMPTON , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61K31/573 , A61K9/06 , A61K9/70 , A61K31/56 , A61P17/00 , C12Q1/68 , G01N33/15
CPC分类号： A61K31/56 , A61K31/573 , A61K45/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , A61K2300/00

2. 发明申请

WO2011079212A2 METHODS AND COMPOSITIONS FOR IDENTIFYING, PRODUCING AND USING PLANT-DERIVED PRODUCTS MODULATING CELL FUNCTION AND AGING 审中-公开
标题翻译：用于鉴定，生产和使用调节细胞功能和老化的植物衍生产品的方法和组合物
公开(公告)号：WO2011079212A2
公开(公告)日：2011-06-30
申请号：PCT/US2010/061849
申请日：2010-12-22
申请人： LIFESPAN EXTENSION, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： A01H3/02
CPC分类号： G01N33/5023 , A23L2/52 , A23L33/105 , A61K8/97 , A61K36/14 , A61K36/45 , A61K36/51 , A61K36/63 , A61K36/87 , A61K36/889 , A61Q19/00 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N2333/195 , G01N2333/37 , G01N2333/405 , G01N2333/415 , G01N2500/00
摘要： Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.
摘要翻译：本文提供了在体外培养细胞的方法，以利用细胞的生物化学生产能力来制备由于其生物学效应而被评估和收获的代谢物。还提供了用于评估来自这种培养细胞的提取物以表征其生物活性的系统，特别是在对健康，健康，长寿，DNA维持，线粒体健康和/或生物发生等方面的影响方面。还提供了生物活性提取物，其组分，以及包含这些物质的组合物（如化妆品或药物制剂）。

3. 发明申请

WO2007103132A3 METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY 审中-公开
公开(公告)号：WO2007103132A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005288
申请日：2007-03-02
申请人： LIGHT BIOSCIENCE, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： C12N13/00 , A61N5/06
摘要： Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

4. 发明申请

WO2005011606A3 SYSTEM AND METHOD FOR THE PHOTODYNAMIC TREATMENT OF BURNS, WOUNDS, AND RELATED SKIN DISORDERS 审中-公开
标题翻译： BURNS，WOUNDS和相关皮肤病症的光动力治疗系统及方法
公开(公告)号：WO2005011606A3
公开(公告)日：2006-12-28
申请号：PCT/US2004024879
申请日：2004-08-02
申请人： LIGHT BIOSCIENCE LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61B18/18 , A61K20060101 , A61N1/00 , A61N5/06
CPC分类号： A61N5/0616 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662 , A61N2005/0663 , A61N2005/0667
摘要： Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.
摘要翻译：人类和哺乳动物的皮肤经历与时间老化相关的各种变化。各种环境因素，疾病状态和遗传疾病都可能加速老化皮肤的出现，以及与老化皮肤相关的结构和功能变化。来自太阳的紫外线辐射是加速或恶化皮肤老化的经典已知和明确定义的手段之一，这通常被称为光老化。其他环境因素，如氧化应激，自由基，环境毒素如臭氧和文化习俗或习惯，如吸烟是其他已知的摄影老化皮肤的探针加速剂。已知和未知的各种其他因素有助于皮肤的加速或过早老化。本发明讨论了电磁辐射，特别是光线可用于光生物调节活细胞的活性以延迟，减少，延迟或甚至逆转皮肤和其它活细胞和组织老化的结构和功能效应的方法。具体描述用于改善皮肤老化的外观，结构，功能的方法，包括上调和下调老化皮肤表型的基因型标记。

5. 发明申请

WO9737602A3 ALEXANDRITE LASER SYSTEM FOR TREATMENT OF DERMATOLOGICAL SPECIMENS 审中-公开
标题翻译：用于治疗皮肤样本的ALEXANDRITE激光系统
公开(公告)号：WO9737602A3
公开(公告)日：1997-12-24
申请号：PCT/US9705560
申请日：1997-04-04
申请人： CYNOSURE INC , FURUMOTO HORACE W , CHO GEORGE , MCDANIEL DAVID H , KOSCHMANN ERIC , RIZZO ANTONIO G
发明人： FURUMOTO HORACE W , CHO GEORGE , MCDANIEL DAVID H , KOSCHMANN ERIC , RIZZO ANTONIO G
IPC分类号： A61B17/00 , A61B17/22 , A61B18/20 , A61N5/06 , H01S3/08 , H01S3/092 , H01S3/16 , A61B17/41
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A long pulse alexandrite laser for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm2. A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The invention is also directed to a hair removal system. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. This provides the operator with a record of those parts of the skin that have already been treated. Finally, the invention is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins. Substantially increased success, in the range of 90-100 % has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Preferably, the light-based therapy is performed before the sclerotherapy. Success can be achieved by performing the sclerotherapy followed by the light-based therapy after the dwell time, however.

6. 发明申请

WO1997037602A2 ALEXANDRITE LASER SYSTEM FOR TREATMENT OF DERMATOLOGICAL SPECIMENS 审中-公开
标题翻译：用于治疗皮肤样本的ALEXANDRITE激光系统
公开(公告)号：WO1997037602A2
公开(公告)日：1997-10-16
申请号：PCT/US1997005560
申请日：1997-04-04
申请人： CYNOSURE, INC. , FURUMOTO, Horace, W. , CHO, George , McDANIEL, David, H. , KOSCHMANN, Eric , RIZZO, Antonio, G.
发明人： CYNOSURE, INC.
IPC分类号： A61B17/41
CPC分类号： H01S3/092 , A61B18/203 , A61B2017/00172 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , H01S3/08072 , H01S3/1633 , H01S2301/08
摘要： A long pulse alexandrite laser for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm . A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The invention is also directed to a hair removal system. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. This provides the operator with a record of those parts of the skin that have already been treated. Finally, the invention is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins. Substantially increased success, in the range of 90-100 % has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Preferably, the light-based therapy is performed before the sclerotherapy. Success can be achieved by performing the sclerotherapy followed by the light-based therapy after the dwell time, however.
摘要翻译：公开了用于治疗皮肤病学标本的长脉冲亚历山大激光。使用alexandrite可以在近红外线中进行操作，特别是在围绕755的50nm范围内。在该范围内的红外线允许良好的穿透，同时仍然达到可接受的血红蛋白与黑色素吸收比。在操作中，激光产生持续时间在5和100毫秒之间的脉冲，并且在10和50J / cm 2之间的通量。提供了一种光输送系统，其将激光输出脉冲发送到患者的皮肤病学靶标。本发明还涉及一种脱毛系统。这里，期望在要处理的皮肤部分上使用折射率匹配应用，并且视觉指示器是热敏或光敏响应的或以其他方式响应于激光脉冲以产生可见变化。这为操作者提供已经被处理的皮肤部分的记录。最后，本发明涉及用于不需要的静脉的组合的硬化疗法和光治疗方法和试剂盒。通过在光疗法和硬化疗法之间实施12个月至6个月之间的停留时间，在90-100％的范围内大大提高了成功率。优选地，光硬化治疗在硬化治疗之前进行。然而，通过在停留时间之后进行硬化治疗，然后进行基于光的治疗，可以实现成功。

7. 发明申请

WO2011137456A2 METHODS AND MECHANISMS INVOLVING HYPERPIGMENTATION PARTICULARLY FOR AFRICAN AMERICAN SKIN 审中-公开
标题翻译：涉及非洲裔美国人皮肤特异性高的方法和机制
公开(公告)号：WO2011137456A2
公开(公告)日：2011-11-03
申请号：PCT/US2011/034856
申请日：2011-05-02
申请人： HAMPTON UNIVERSITY , McDANIEL, David, H.
发明人： McDANIEL, David, H.
IPC分类号： A61K31/573 , A61K31/56 , A61K9/06 , A61K9/70 , C12Q1/68 , G01N33/15 , A61P17/00
CPC分类号： A61K31/56 , A61K31/573 , A61K45/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , A61K2300/00
摘要： Sets of genes are identified that show modulated activity in hyperpigmented sun-exposed (HE) and non-hyperpigmented sun-exposed (NHE) skin, when compared to non- hyperpigmented non-exposed (NHNE) skin. The modulated sets of genes reveal important information about the genetic changes that take place in skin as a result of environmental exposure and damage. The modulated sets of genes may be used to fabricate custom DNA microarrays for evaluating patients with skin diseases or disorders. The microarrays may also be used to screen new substances for treating skin diseases and disorders. The modulated gene sets, and substances that target them, may also be used to develop therapies for individuals who suffer from hypopigmentation, such as those with Fitzpatrick type I skin or vitiligo.
摘要翻译：当与非色素沉着的非暴露（NHNE）皮肤相比时，鉴定出一组基因表现出色素沉着的阳光暴露（HE）和非色素沉着的阳光暴露（NHE）皮肤的调节活性。调控的基因组显示关于由于环境暴露和损伤而在皮肤中发生的遗传变化的重要信息。经调制的基因组可用于制备用于评估皮肤疾病或病症患者的定制DNA微阵列。微阵列也可用于筛选用于治疗皮肤疾病和病症的新物质。调控的基因集和靶向它们的物质也可用于为患有色素沉着过度的个体开发治疗，例如具有Fitzpatrick I型皮肤或白癜风的患者。

8. 发明申请

WO2011079212A3 METHODS AND COMPOSITIONS FOR IDENTIFYING, PRODUCING AND USING PLANT-DERIVED PRODUCTS MODULATING CELL FUNCTION AND AGING 审中-公开
标题翻译：鉴定，生产和使用植物衍生产品调节细胞功能和老化的方法和组合物
公开(公告)号：WO2011079212A3
公开(公告)日：2011-11-03
申请号：PCT/US2010061849
申请日：2010-12-22
申请人： LIFESPAN EXTENSION LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A01H3/02 , A01H3/04 , A61K35/74 , A61K36/00 , A61K36/02 , A61K36/05 , A61K36/06 , A61K36/14 , A61K36/20 , A61K36/324 , A61K36/45 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/898 , A61P39/00 , A61P39/06
CPC分类号： G01N33/5023 , A23L2/52 , A23L33/105 , A61K8/97 , A61K36/14 , A61K36/45 , A61K36/51 , A61K36/63 , A61K36/87 , A61K36/889 , A61Q19/00 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N2333/195 , G01N2333/37 , G01N2333/405 , G01N2333/415 , G01N2500/00
摘要： Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.
摘要翻译：本文提供了体外培养细胞的方法，以利用细胞的生物化学生产能力来制备被评估和收获其生物效应的代谢物。还提供了用于评估来自此类培养细胞的提取物以表征它们的生物学活性的系统，特别是关于对健康，福祉，寿命，DNA维持，线粒体健康和/或生物发生等的影响。还提供了生物活性提取物，其组分和其组合物（例如化妆品或药物制剂）。

9. 发明申请

WO2010065567A3 METHODS AND COMPOSITIONS FOR ALTERING HEALTH, WELLBEING, AND LIFESPAN 审中-公开
标题翻译：改善健康，健康和寿命的方法和组合
公开(公告)号：WO2010065567A3
公开(公告)日：2010-11-18
申请号：PCT/US2009066294
申请日：2009-12-01
申请人： LIFESPAN EXTENSION LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61K36/889 , A61K31/05 , A61K31/16 , A61K31/166 , A61K36/736 , A61P5/00
CPC分类号： A61K36/74 , A61K31/05 , A61K31/122 , A61K31/16 , A61K31/166 , A61K36/13 , A61K2300/00
摘要： Described herein are the results of comprehensive genetic expression and other molecular analysis of the effect of antioxidants on biological systems, including specifically different human cells. Based on these analyses, methods and compositions are described for modifying or influencing the lifespan of cells, tissues, organs, and organisms. In various embodiments, there are provided methods for modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells, as well as methods for modulating the rate/efficiency of the cellular respiration provided by the mitochondria, mitochondrial biogenesis, and maintenance of the mitochondrial membrane potential. Exemplary lifespan altering compounds include natural and synthetic antioxidants, such as plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone, idebenone, or a synthetic form or derivatives thereof.
摘要翻译：本文描述了抗氧化剂对生物系统（包括特异性不同的人细胞）的影响的综合遗传表达和其他分子分析的结果。基于这些分析，描述了修饰或影响细胞，组织，器官和生物体的寿命的方法和组合物。在各种实施方案中，提供了调节基因维持过程的活性以便影响活细胞中端粒的长度和/或结构完整性的方法以及调节所提供的细胞呼吸的速率/效率的方法通过线粒体，线粒体生物发生和维持线粒体膜电位。示例性的寿命改变化合物包括天然和合成的抗氧化剂，例如来自咖啡樱桃，茶，浆果等的植物抗氧化剂和多酚化合物，包括但不限于咖啡酸，绿原酸，阿魏酸，奎尼酸，原花青素，泛醌，艾地苯醌或其合成形式或衍生物。

10. 发明申请

WO2007103132A2 METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY 审中-公开
标题翻译：使用低强度光疗法进行ACNE治疗的方法和装置
公开(公告)号：WO2007103132A2
公开(公告)日：2007-09-13
申请号：PCT/US2007005288
申请日：2007-03-02
申请人： LIGHT BIOSCIENCE LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61B18/18 , A61B18/20 , A61B17/00 , A61B17/22 , A61B18/00 , A61H21/00 , A61K31/409 , A61K31/555 , A61K41/00 , A61K47/10 , A61K47/22 , A61M37/00 , A61N5/06 , A61P17/10
CPC分类号： A61N5/0616 , A61B18/203 , A61B2017/00765 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807 , A61K41/0057 , A61K41/0071 , A61N5/0617 , A61N5/062 , A61N5/0624 , A61N2005/0606 , A61N2005/0642 , A61N2005/0644 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662
摘要： Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.
摘要翻译：公开了一种用于治疗皮肤疾病的系统和方法。更具体地，所公开的发明涉及使用低强度光疗法减少痤疮和痤疮相关细菌。在说明性实施例中，含有痤疮细菌的皮肤用来自发光二极管的一系列光脉冲进行处理。 LED具有约660nm的主要发射波长和约4mW的能量输出。含有痤疮细菌的组织暴露于来自光源的脉冲约100次，每脉冲约250毫秒，脉冲间隔约为100毫秒。

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