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1. 发明申请

WO2007092349A2 LOW INTENSITY LIGHT THERAPY FOR TREATMENT OF RETINAL, MACULAR, AND VISUAL PATHWAY DISORDERS 审中-公开
标题翻译：治疗视神经，视觉途径障碍的低强度光疗法
公开(公告)号：WO2007092349A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002958
申请日：2007-02-02
申请人： LIGHT BIOSCIENCE, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
CPC分类号： A61N5/0616 , A61N5/0601 , A61N5/0613 , A61N2005/0605 , A61N2005/0609 , A61N2005/0652 , A61N2005/0653 , A61N2005/0654 , A61N2005/0662 , A61N2005/067
摘要： Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.
摘要翻译：公开了用于治疗细胞，特别是视觉途径障碍的系统和方法。更具体地，所公开的发明涉及视网膜上皮细胞的光调节和/或光老化，以治疗各种视力障碍。治疗视网膜细胞以减少或逆转视觉途径障碍的作用的过程使用应用于视网膜细胞的窄带光源来提供非常低的能量注量。

2. 发明申请

WO2007103132A3 METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY 审中-公开
公开(公告)号：WO2007103132A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005288
申请日：2007-03-02
申请人： LIGHT BIOSCIENCE, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： C12N13/00 , A61N5/06
摘要： Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

3. 发明申请

WO2011079212A2 METHODS AND COMPOSITIONS FOR IDENTIFYING, PRODUCING AND USING PLANT-DERIVED PRODUCTS MODULATING CELL FUNCTION AND AGING 审中-公开
标题翻译：用于鉴定，生产和使用调节细胞功能和老化的植物衍生产品的方法和组合物
公开(公告)号：WO2011079212A2
公开(公告)日：2011-06-30
申请号：PCT/US2010/061849
申请日：2010-12-22
申请人： LIFESPAN EXTENSION, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： A01H3/02
CPC分类号： G01N33/5023 , A23L2/52 , A23L33/105 , A61K8/97 , A61K36/14 , A61K36/45 , A61K36/51 , A61K36/63 , A61K36/87 , A61K36/889 , A61Q19/00 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N2333/195 , G01N2333/37 , G01N2333/405 , G01N2333/415 , G01N2500/00
摘要： Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.
摘要翻译：本文提供了在体外培养细胞的方法，以利用细胞的生物化学生产能力来制备由于其生物学效应而被评估和收获的代谢物。还提供了用于评估来自这种培养细胞的提取物以表征其生物活性的系统，特别是在对健康，健康，长寿，DNA维持，线粒体健康和/或生物发生等方面的影响方面。还提供了生物活性提取物，其组分，以及包含这些物质的组合物（如化妆品或药物制剂）。

4. 发明申请

WO2010065567A2 METHODS AND COMPOSITIONS FOR ALTERING HEALTH, WELLBEING, AND LIFESPAN 审中-公开
标题翻译：改变健康，健康和寿命的方法和组合物
公开(公告)号：WO2010065567A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/066294
申请日：2009-12-01
申请人： LIFESPAN EXTENSION LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： A61K36/889 , A61K36/736 , A61K31/166 , A61K31/16 , A61K31/05 , A61P5/00
CPC分类号： A61K36/74 , A61K31/05 , A61K31/122 , A61K31/16 , A61K31/166 , A61K36/13 , A61K2300/00
摘要： Described herein are the results of comprehensive genetic expression and other molecular analysis of the effect of antioxidants on biological systems, including specifically different human cells. Based on these analyses, methods and compositions are described for modifying or influencing the lifespan of cells, tissues, organs, and organisms. In various embodiments, there are provided methods for modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells, as well as methods for modulating the rate/efficiency of the cellular respiration provided by the mitochondria, mitochondrial biogenesis, and maintenance of the mitochondrial membrane potential. Exemplary lifespan altering compounds include natural and synthetic antioxidants, such as plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone, idebenone, or a synthetic form or derivatives thereof.
摘要翻译：本文描述了抗氧化剂对生物系统（包括特别不同的人类细胞）的综合基因表达和其他分子分析的结果。基于这些分析，描述了用于修饰或影响细胞，组织，器官和生物体寿命的方法和组合物。在各种实施方案中，提供了用于调节基因维持过程的活性以便影响活细胞中端粒的长度和/或结构完整性的方法，以及调节所提供的细胞呼吸的速率/效率的方法通过线粒体，线粒体生物发生和维持线粒体膜电位。示例性寿命改变化合物包括天然和合成的抗氧化剂，例如来源于咖啡樱桃，茶，浆果等的植物抗氧化剂和多酚化合物，包括但不限于咖啡酸，绿原酸，阿魏酸，奎尼酸，原花色素，泛醌，艾地苯醌或其合成形式或其衍生物。

5. 发明申请

WO2003086215A1 LOW INTENSITY LIGHT THERAPY FOR THE MANIPULATION OF FIBROBLAST-DERIVED MAMMALIAN CELLS AND COLLAGEN 审中-公开
标题翻译：用于控制FIBROBLAST衍生的MAMMALIAN细胞和胶原的低强度光疗法
公开(公告)号：WO2003086215A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/010509
申请日：2003-04-08
申请人： LIGHT BIOSCIENCE, INC. , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： A61B18/18
CPC分类号： A61K8/35 , A61B18/203 , A61B2018/00023 , A61B2018/00452 , A61B2018/0047 , A61B2018/00702 , A61B2018/00791 , A61B2090/395 , A61K8/19 , A61K8/31 , A61K8/347 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/49 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K8/67 , A61K8/671 , A61K8/676 , A61K8/678 , A61K8/97 , A61K8/9706 , A61K41/0057 , A61K41/0071 , A61K2800/58 , A61K2800/782 , A61K2800/81 , A61N5/0617 , A61N5/062 , A61N2005/0652 , A61Q19/08
摘要： Disclosed is a method for treating various dermatological conditions using electromagnetic radiation. Particularly preferred are narrowband, multichromatic electromagnetic radiation emitters having a dominant emissive wavelength corresponding to the peak absorption wavelength of the mammalian tissue targetted for treatment. Topical compositions are disclosed for pretreating the targetted tissue to alter the peak absorption wavelength of the tissue.
摘要翻译：公开了一种使用电磁辐射治疗各种皮肤病学病症的方法。特别优选的是具有对应于针对治疗的哺乳动物组织的峰值吸收波长的主要发射波长的窄带多色电磁辐射发射器。公开了用于预处理靶组织以改变组织的峰值吸收波长的局部组合物。

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