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1. 发明申请

WO2007103132A2 METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY 审中-公开
标题翻译：使用低强度光疗法进行ACNE治疗的方法和装置
公开(公告)号：WO2007103132A2
公开(公告)日：2007-09-13
申请号：PCT/US2007005288
申请日：2007-03-02
申请人： LIGHT BIOSCIENCE LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61B18/18 , A61B18/20 , A61B17/00 , A61B17/22 , A61B18/00 , A61H21/00 , A61K31/409 , A61K31/555 , A61K41/00 , A61K47/10 , A61K47/22 , A61M37/00 , A61N5/06 , A61P17/10
CPC分类号： A61N5/0616 , A61B18/203 , A61B2017/00765 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807 , A61K41/0057 , A61K41/0071 , A61N5/0617 , A61N5/062 , A61N5/0624 , A61N2005/0606 , A61N2005/0642 , A61N2005/0644 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662
摘要： Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.
摘要翻译：公开了一种用于治疗皮肤疾病的系统和方法。更具体地，所公开的发明涉及使用低强度光疗法减少痤疮和痤疮相关细菌。在说明性实施例中，含有痤疮细菌的皮肤用来自发光二极管的一系列光脉冲进行处理。 LED具有约660nm的主要发射波长和约4mW的能量输出。含有痤疮细菌的组织暴露于来自光源的脉冲约100次，每脉冲约250毫秒，脉冲间隔约为100毫秒。

2. 发明申请

WO2005011606A2 SYSTEM AND METHOD FOR THE PHOTODYNAMIC TREATMENT OF BURNS, WOUNDS, AND RELATED SKIN DISORDERS 审中-公开
标题翻译： BURNS，WOUNDS和相关皮肤病症的光动力治疗系统及方法
公开(公告)号：WO2005011606A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024879
申请日：2004-08-02
申请人： LIGHT BIOSCIENCE, LLC , McDANIEL, David, H.
发明人： McDANIEL, David, H.
IPC分类号： A61K
CPC分类号： A61N5/0616 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662 , A61N2005/0663 , A61N2005/0667
摘要： Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.
摘要翻译：人类和哺乳动物的皮肤经历与时间老化相关的各种变化。各种环境因素，疾病状态和遗传疾病都可能加速老化皮肤的出现，以及与老化皮肤相关的结构和功能变化。来自太阳的紫外线辐射是加速或恶化皮肤老化的经典已知和明确定义的手段之一，这通常被称为光老化。其他环境因素，如氧化应激，自由基，环境毒素如臭氧和文化习俗或习惯，如吸烟是其他已知的摄影老化皮肤的探针加速剂。已知和未知的各种其他因素有助于皮肤的加速或过早老化。本发明讨论了电磁辐射，特别是光线可用于光生物调节活细胞的活性以延缓，减少，延迟或甚至逆转皮肤和其它活细胞和组织老化的结构和功能效应的方法。具体描述用于改善皮肤老化的外观，结构，功能的方法，包括上调和下调老化皮肤表型的基因型标记。

3. 发明申请

WO2007092349A3 LOW INTENSITY LIGHT THERAPY FOR TREATMENT OF RETINAL, MACULAR, AND VISUAL PATHWAY DISORDERS 审中-公开
标题翻译：治疗视神经，视觉途径障碍的低强度光疗法
公开(公告)号：WO2007092349A3
公开(公告)日：2008-10-09
申请号：PCT/US2007002958
申请日：2007-02-02
申请人： LIGHT BIOSCIENCE LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61N5/0601 , A61N5/0613 , A61N2005/0605 , A61N2005/0609 , A61N2005/0652 , A61N2005/0653 , A61N2005/0654 , A61N2005/0662 , A61N2005/067
摘要： Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.
摘要翻译：公开了用于治疗细胞，特别是视觉途径障碍的系统和方法。更具体地，所公开的发明涉及视网膜上皮细胞的光调节和/或光老化，以治疗各种视力障碍。治疗视网膜细胞以减少或逆转视觉途径障碍的作用的过程使用应用于视网膜细胞的窄带光源来提供非常低的能量注量。

4. 发明申请

WO2007092349A2 LOW INTENSITY LIGHT THERAPY FOR TREATMENT OF RETINAL, MACULAR, AND VISUAL PATHWAY DISORDERS 审中-公开
标题翻译：治疗视神经，视觉途径障碍的低强度光疗法
公开(公告)号：WO2007092349A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002958
申请日：2007-02-02
申请人： LIGHT BIOSCIENCE, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
CPC分类号： A61N5/0616 , A61N5/0601 , A61N5/0613 , A61N2005/0605 , A61N2005/0609 , A61N2005/0652 , A61N2005/0653 , A61N2005/0654 , A61N2005/0662 , A61N2005/067
摘要： Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.
摘要翻译：公开了用于治疗细胞，特别是视觉途径障碍的系统和方法。更具体地，所公开的发明涉及视网膜上皮细胞的光调节和/或光老化，以治疗各种视力障碍。治疗视网膜细胞以减少或逆转视觉途径障碍的作用的过程使用应用于视网膜细胞的窄带光源来提供非常低的能量注量。

5. 发明申请

WO2007103132A3 METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY 审中-公开
公开(公告)号：WO2007103132A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005288
申请日：2007-03-02
申请人： LIGHT BIOSCIENCE, LLC , MCDANIEL, David, H.
发明人： MCDANIEL, David, H.
IPC分类号： C12N13/00 , A61N5/06
摘要： Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

6. 发明申请

WO2005011606A3 SYSTEM AND METHOD FOR THE PHOTODYNAMIC TREATMENT OF BURNS, WOUNDS, AND RELATED SKIN DISORDERS 审中-公开
标题翻译： BURNS，WOUNDS和相关皮肤病症的光动力治疗系统及方法
公开(公告)号：WO2005011606A3
公开(公告)日：2006-12-28
申请号：PCT/US2004024879
申请日：2004-08-02
申请人： LIGHT BIOSCIENCE LLC , MCDANIEL DAVID H
发明人： MCDANIEL DAVID H
IPC分类号： A61B18/18 , A61K20060101 , A61N1/00 , A61N5/06
CPC分类号： A61N5/0616 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662 , A61N2005/0663 , A61N2005/0667
摘要： Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.
摘要翻译：人类和哺乳动物的皮肤经历与时间老化相关的各种变化。各种环境因素，疾病状态和遗传疾病都可能加速老化皮肤的出现，以及与老化皮肤相关的结构和功能变化。来自太阳的紫外线辐射是加速或恶化皮肤老化的经典已知和明确定义的手段之一，这通常被称为光老化。其他环境因素，如氧化应激，自由基，环境毒素如臭氧和文化习俗或习惯，如吸烟是其他已知的摄影老化皮肤的探针加速剂。已知和未知的各种其他因素有助于皮肤的加速或过早老化。本发明讨论了电磁辐射，特别是光线可用于光生物调节活细胞的活性以延迟，减少，延迟或甚至逆转皮肤和其它活细胞和组织老化的结构和功能效应的方法。具体描述用于改善皮肤老化的外观，结构，功能的方法，包括上调和下调老化皮肤表型的基因型标记。

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