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    • 4. 发明申请
    • INTELLIGENT LIGHTING CONTROL SYSTEM
    • 智能照明控制系统
    • WO2010116283A2
    • 2010-10-14
    • PCT/IB2010051358
    • 2010-03-29
    • KONINKL PHILIPS ELECTRONICS NVKLUSMANN DONALD LOUISMURPHY MICHAEL SHAWN
    • KLUSMANN DONALD LOUISMURPHY MICHAEL SHAWN
    • H05B37/02
    • H05B37/0254H05B37/0218H05B37/0227H05B37/0245H05B37/0263H05B37/0272Y02B20/44Y02B20/46Y02B20/48
    • Multiple control modules (14, 16, 18) provide various power control functions including occupancy sensing, ambient light level sensing, manual touch switch (push button) preset stations, light dimming and power control relay switching. The control modules (14, 16, 18) are interconnected in a conventional four-wire local area network for executing different power control functions in response to remote wireless commands as well as preset manual switch commands at the wall box level. The local area network (12) supplies DC operating power and communicates programming command and control module status information signals to all network control modules (14, 16, 18). One or more control modules (14, 16, 18) include an infrared signal sensor, a laser signal sensor, a signal decoder, a data microcontroller, a parameter lookup table and multiple light emitting diodes (LEDs). The LED diodes are used individually or in combination, in one or more colors and blink rate, to indicate the programming mode, or provide sensor feedback, or indicate device status, according to information contained in a command signal transmitted by a remote programming unit (58).
    • 多个控制模块(14,16,18)提供各种功率控制功能,包括占用感测,环境光电平感测,手动触摸开关(按钮)预设电台,光调光和功率控制继电器切换。 控制模块(14,16,18)在传统的四线局域网中相互连接,用于响应于远程无线命令执行不同的功率控制功能以及在壁盒级别上预设的手动切换命令。 局域网(12)提供直流工作电源,并向所有网络控制模块(14,16,18)传送编程命令和控制模块状态信息信号。 一个或多个控制模块(14,16,18)包括红外信号传感器,激光信号传感器,信号解码器,数据微控制器,参数查找表和多个发光二极管(LED)。 根据由远程编程单元发送的命令信号中包含的信息,LED二极管可以以一种或多种颜色和眨眼速率单独使用或组合使用,以指示编程模式,或提供传感器反馈或指示设备状态( 58)。
    • 6. 发明申请
    • A METHOD FOR GENERATING REFERENCE CONTROLS FOR PHARMACOGENOMIC TESTING
    • 一种用于产生用于药物生物学测试的参考控制的方法
    • WO2009135180A3
    • 2010-03-18
    • PCT/US2009042608
    • 2009-05-01
    • PARAGONMURPHY MICHAEL PCLARK L SCOTTNAKHLE PAMELA JBUTZ KENNETH G
    • MURPHY MICHAEL PCLARK L SCOTTNAKHLE PAMELA JBUTZ KENNETH G
    • C12N15/02A61K48/00A61P35/00C12N5/10C12N15/52
    • C12Q1/6858C12N9/0071C12Q2545/113
    • Reference controls for use with pharmacogenomic testing, and methods for their identification, preparation, and use, are disclosed. The reference controls can confirm that pharmacogenomic testing correctly identifies individuals that do or do not have the mutation of interest, in both clinical trial and patient treatment settings. The reference controls can be selected to include one or more mutations to be identified, and prescreened to confirm that they bind to one or more of the primers used in the pharmacogenomic testing. The reference controls are human genomic DNA that includes certain identified polymorphisms (mutations) of interest, ideally derived from individuals, pre-selected and optionally properly consented, which have one or more of the polymorphism(s) of interest. The reference controls can be prepared by targeted pre-screening of human patients, by examining the genotype or genetic profile of the patients, isolating cells with the desired mutation, optionally immortalizing the cells, and obtaining DNA from the cells. The prescreening of prospective donors can be targeted based on any of a number of factors, such as genes of interest, mutations within the genes of interest, and membership in a specific ethnic or disease state population. The genomic DNA can be pre-screened for its ability to be detected, using a standard pharmacogenomic test, as including a specific mutation. Examples of mutations of interest include those present in a Phase I or Phase Il metabolic enzyme such as CYP2D6, CYP2C 19, CYP2C9, CYP2C8, and CYP3A5, CYP3A4, CYP2A6, CYP2B6, UGT1A1, DPD, ERCC1, MDR1, ADH2, NAT1 and NAT2 or any other metabolic or disease gene.
    • 公开了用于药物基因组测试的参考对照及其鉴定,制备和使用的方法。 在临床试验和患者治疗环境中,参照对照可以证实药物基因组检测正确地识别出有或没有感兴趣突变的个体。 可以选择参考对照以包括待鉴定的一个或多个突变,并进行预筛选以确认它们与药物基因组测试中使用的一种或多种引物结合。 参考对照是人基因组DNA,其包括某些鉴定的目的多态性(突变),理想地衍生自预先选择的和任选正确同意的个体,其具有一个或多个感兴趣的多态性。 通过检查患者的基因型或遗传概况,分离具有所需突变的细胞,任选地使细胞永生化,以及从细胞中获得DNA,可以通过靶向预筛选人类患者来制备参照对照。 可以基于许多因素,如感兴趣的基因,感兴趣的基因内的突变以及特定种族或疾病状态群体的成员中的任何一个因素来预先预先筛选前瞻性供体。 可以使用标准药物基因组测试将基因组DNA的筛选能力进行预筛选,作为包括特异性突变。 感兴趣的突变的实例包括存在于I期或II期代谢酶如CYP2D6,CYP2C19,CYP2C9,CYP2C8和CYP3A5,CYP3A4,CYP2A6,CYP2B6,UGT1A1,DPD,ERCC1,MDR1,ADH2,NAT1和NAT2中的那些 或任何其他代谢或疾病基因。