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1. 发明申请

WO2017084683A1 METHOD FOR EXTRACORPOREAL LUNG SUPPORT 审中-公开
标题翻译：用于体外肺支持的方法
公开(公告)号：WO2017084683A1
公开(公告)日：2017-05-26
申请号：PCT/EP2015/002331
申请日：2015-11-20
申请人： HEPA WASH GMBH
发明人： KREYMANN, Bernhard , HÜSSTEGE, Christoph
IPC分类号： A61M1/16 , A61M1/32 , A61M1/36
CPC分类号： A61M1/1698 , A61M1/1676 , A61M1/1696 , A61M1/32 , A61M1/369 , A61M2202/0208 , A61M2202/0225 , A61M2202/03 , A61M2202/0476 , A61M2230/202 , A61M2230/205 , A61M2230/208
摘要： The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid. In contrast to extracorporeal carbon dioxide removal methods of the prior art (ECCO 2 R), the present invention employs a versatile dialysis liquid that allows to adjust the pH and buffering capacity of the dialysis liquid, to add fluids to the dialysis liquid and/or to the blood and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. The present invention also provides regeneration and recycling of the dialysis liquid, and thus for its repeated use. The present invention is suitable for treating human or animal subjects suffering from lung failure or lung disorders.
摘要翻译：本发明总体上涉及适用于体外肺部支持的方法。该方法包括使血液与通过半透膜分离的透析液接触。在血液和透析液被半透膜分离之前，将氧气引入血液和/或透析液中。该过程是通用的并且允许血液氧合以及从血液中去除血液中存在的至少一种不需要的物质，所述物质选自二氧化碳，碳酸氢盐和氢阳离子。由此，本发明利用了体外接触步骤中的霍尔丹效应。不需要的物质可以有效地通过半透膜传送到透析液。与现有技术（ECCO 2R）的体外二氧化碳去除方法相反，本发明采用多功能透析液，其允许调节透析液的pH和缓冲能力，以添加流体透析液和/或血液，并根据条件和需要从体外回路中的血液中去除物质。本发明还提供了透析液的再生和再循环，并因此用于其重复使用。本发明适用于治疗患有肺衰竭或肺病的人或动物受试者。

2. 发明申请

WO2016190794A3 CARTRIDGE AND APPARATUS FOR PERFORMING ADSORPTION DIALYSIS 审中-公开
标题翻译：用于执行吸附分析的盒子和装置
公开(公告)号：WO2016190794A3
公开(公告)日：2016-12-29
申请号：PCT/SE2016000026
申请日：2016-05-27
申请人： TRIOMED AB
发明人： WALLENÅS ANDERS , MEINANDER NINA , MALMBORG CARIN , LANDHOLM STEFAN , BENGTSSON HANS
IPC分类号： A61M1/28 , A61J1/00 , A61M1/16 , B01J20/22
CPC分类号： B01J20/22 , A61M1/1696 , A61M1/288 , A61M2202/0498 , A61M2205/15 , A61M2205/3331 , A61M2205/50
摘要： A cartridge to be used for adsorption dialysis. A container having flexible walls are arranged to provide an inner space enclosing adsorption powder, comprising activated carbon, a phosphate adsorbent and a potassium ion adsorbent and other adsorbents. A sufficient amount of activated carbon is provided for adsorption of urea by the activated carbon. The cartridge forms a vacuum-packed transportation cartridge by generating a sub-pressure in the inner space, whereby the powder particles are immobilized and the cartridge becomes stiff. Before use, the cartridge is primed by introducing a liquid into the inner space, which introduction takes place at a low pressure. During use, dialysis solution is circulated through the cartridge, which is still exposed to a sub-pressure, whereby the flexible walls are sucked against the powder material. A peritoneal dialysis circuit comprises a filter, in which a primary circuit is formed with the filter and the peritoneal cavity and a secondary circuit is formed with the filter and the adsorbent cartridge.
摘要翻译：用于吸附透析的药筒。布置具有柔性壁的容器，以提供封闭吸附粉末的内部空间，其包括活性炭，磷酸盐吸附剂和钾离子吸附剂以及其它吸附剂。提供足够量的活性炭用于通过活性炭吸附尿素。筒体通过在内部空间中产生副压力而形成真空包装的输送筒，由此粉末颗粒被固定并且盒变硬。在使用之前，通过将液体引入内部空间来引导盒，该介质在低压下进行。在使用期间，透析溶液循环通过筒，其仍然暴露于次压力，由此柔性壁被吸入粉末材料。腹膜透析电路包括过滤器，其中初级回路由过滤器和腹膜腔形成，次级回路由过滤器和吸附剂药筒形成。

3. 发明申请

WO2016191041A1 ZIRCONIUM PHOSPHATE AND ZIRCONIUM OXIDE RECHARGING FLOW PATHS 审中-公开
标题翻译：磷酸锆和氧化锆填充流程图（ZIRCONIUM OXIDE RECHARGING FLOW PATHS）
公开(公告)号：WO2016191041A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/030319
申请日：2016-04-29
申请人： MEDTRONIC, INC.
发明人： MENON, Kanjimpuredathil, Muralikrishna , JEYACHANDRAN, Ramkumar , PATIL, Kaustubh, R. , DUTTA, Sukalyan , PRABHU, Gokul, L. , LURA, David, B. , PUDIL, Bryant, J. , HOBOT, Christopher, M.
IPC分类号： A61M1/16 , B01J20/06 , B01J20/34 , B01J20/02
CPC分类号： A61M1/1696 , A61M2230/207 , A61M2230/65 , B01J20/0211 , B01J20/0292 , B01J20/06 , B01J20/28052 , B01J20/3475 , B01J2220/62
摘要： Systems and methods for recharging zirconium phosphate and zirconium oxide are provided. The systems and methods provide for recharging of the zirconium phosphate and zirconium oxide in reusable sorbent modules. The systems and methods include recharging flow paths for recharging zirconium phosphate independently or concurrently.
摘要翻译：提供了对磷酸锆和氧化锆再充电的系统和方法。该系统和方法提供了可重复使用的吸附剂模块中的磷酸锆和氧化锆的再充电。这些系统和方法包括为独立地或同时地对磷酸锆充电的流路。

4. 发明申请

WO2016190853A1 MULTI-USE SORBENT CARTRIDGE 审中-公开
标题翻译：多用途SORBENT CARTRIDGE
公开(公告)号：WO2016190853A1
公开(公告)日：2016-12-01
申请号：PCT/US2015/032492
申请日：2015-05-26
申请人： MEDTRONIC, INC.
发明人： PUDIL, Bryant, J. , HOBOT, Christopher, M.
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/1696
摘要： A sorbent cartridge comprising one or more detachable modules. The sorbent cartridge can have one or more modules contained therein having connectors connecting eachof the modules. One or more of the modules can be reusable and the sorbent materials therein recharged. The sorbent cartridge can include a module containing an anion exchange resin, such as zirconium oxide, downstream of zirconium phosphate in the sorbent cartridge to recapture phosphate anions that leach out of the zirconium phosphate.
摘要翻译：一种吸附剂盒，包括一个或多个可分离模块。吸附剂盒可以具有一个或多个包含连接模块的模块的模块。一个或多个模块可以是可重复使用的，并且其中的吸附剂材料被再充电。吸附剂盒可以包括在吸附剂筒中含有阴离子交换树脂（例如氧化锆）在磷酸锆下游的模块，以重新吸收从磷酸锆中浸出的磷酸盐阴离子。

5. 发明申请

WO2016190794A2 CARTRIDGE, METHOD AND APPARATUS FOR PERFORMING ADSORPTION DIALYSIS 审中-公开
标题翻译：用于执行吸附透析的盒，方法和装置
公开(公告)号：WO2016190794A2
公开(公告)日：2016-12-01
申请号：PCT/SE2016/000026
申请日：2016-05-27
申请人： TRIOMED AB
发明人： WALLENÅS, Anders , MEINANDER, Nina , MALMBORG, Carin , LANDHOLM, Stefan , BENGTSSON, Hans
IPC分类号： A61M1/28 , A61J1/00 , A61M1/16 , B01J20/22
CPC分类号： A61M1/288 , A61M1/1696 , A61M1/287 , A61M2202/0498 , A61M2205/15 , A61M2205/3331 , A61M2205/50 , B01J20/22
摘要： A cartridge to be used for adsorption dialysis. A container having flexible walls are arranged to provide an inner space enclosing adsorption powder, comprising activated carbon, a phosphate adsorbent and a potassium ion adsorbent and other adsorbents. A sufficient amount of activated carbon is provided for adsorption of urea by the activated carbon. The cartridge forms a vacuum-packed transportation cartridge by generating a sub-pressure in the inner space, whereby the powder particles are immobilized and the cartridge becomes stiff. Before use, the cartridge is primed by introducing a liquid into the inner space, which introduction takes place at a low pressure. During use, dialysis solution is circulated through the cartridge, which is still exposed to a sub-pressure, whereby the flexible walls are sucked against the powder material. A peritoneal dialysis circuit comprises a filter, in which a primary circuit is formed with the filter and the peritoneal cavity and a secondary circuit is formed with the filter and the adsorbent cartridge.
摘要翻译：用于吸附透析的药筒。布置具有柔性壁的容器，以提供封闭吸附粉末的内部空间，其包括活性炭，磷酸盐吸附剂和钾离子吸附剂以及其它吸附剂。提供足够量的活性炭用于通过活性炭吸附尿素。筒体通过在内部空间中产生副压力而形成真空包装的输送筒，由此粉末颗粒被固定并且盒变硬。在使用之前，通过将液体引入内部空间来引导盒，该介质在低压下进行。在使用期间，透析溶液循环通过筒，其仍然暴露于次压力，由此柔性壁被吸入粉末材料。腹膜透析电路包括过滤器，其中初级回路由过滤器和腹膜腔形成，次级回路由过滤器和吸附剂药筒形成。

6. 发明申请

WO2016126596A3 UREA SEQUESTRATION COMPOSITIONS AND METHODS 审中-公开
标题翻译：尿素排序组合物和方法
公开(公告)号：WO2016126596A3
公开(公告)日：2016-10-06
申请号：PCT/US2016015935
申请日：2016-02-01
申请人： CABOT CORP
发明人： NATAN MICHAEL J , KYRLIDIS AGATHAGELOS
IPC分类号： A61M1/14 , B01D15/08 , B01D53/04 , B01D53/06 , B01J20/24 , C01B31/04 , C02F1/28 , C07C275/02
CPC分类号： A61M1/1696 , A61M1/3486 , A61M1/3679 , B01D15/08 , B01D53/04 , B01D2253/102 , B01D2253/306 , B01D2257/40 , B01J20/20 , B01J20/205 , B01J20/28057 , B01J2220/42 , C01B32/182 , C01B32/23 , C02F1/281 , C02F1/283 , C02F1/286 , C02F2101/38 , C07C273/16 , C07C275/02
摘要： Graphene-based materials for sequestering urea from aqueous solutions are provided. The graphene-based materials include graphene aggregates as well as graphene oxides.
摘要翻译：提供了用于从水溶液中螯合尿素的石墨烯基材料。石墨烯材料包括石墨烯聚集体以及石墨烯氧化物。

7. 发明申请

WO2016094015A1 DEGASSING SYSTEM FOR DIALYSIS 审中-公开
标题翻译：脱水脱水系统
公开(公告)号：WO2016094015A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/060090
申请日：2015-11-11
申请人： MEDTRONIC, INC.
发明人： MEYER, Thomas, E. , HAJKO, William, P. , BLOOMBERG, Daniel, Jordan
IPC分类号： A61M1/16 , B01D19/00
CPC分类号： A61M1/1658 , A61M1/1696 , A61M2202/0225 , A61M2205/3382 , A61M2205/3386 , B01D19/0036 , B01D19/0047 , B01D19/0063 , B01D19/0068
摘要： The degassing system can include a degassing vessel and can utilize a vacuum pump and a fluid pump located downstream of the degassing vessel to control the pressure within the degassing vessel in order to control the concentration of gases in fluid exiting the degassing system. The degassing system can further comprise sensors in communication with the pumps to control the rate of flow and pressure through the degassing system. The degassing system may be placed in a dialysate flow path to remove dissolved gases including carbon dioxide from the dialysate.
摘要翻译：脱气系统可以包括脱气容器，并且可以利用位于脱气容器下游的真空泵和流体泵来控制脱气容器内的压力，以便控制离开脱气系统的流体中的气体浓度。脱气系统还可以包括与泵连通的传感器，以控制通过脱气系统的流量和压力的速率。脱气系统可以放置在透析液流动路径中以从透析液中除去包括二氧化碳的溶解气体。

8. 发明申请

WO2016039838A1 PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE WITH FLOW SENSOR 审中-公开
标题翻译：便携式HEMODIALYSIS机器和可拆卸的盒子与流量传感器
公开(公告)号：WO2016039838A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/038530
申请日：2015-06-30
申请人： EASYDIAL, INC.
发明人： GIORDANO, Renato , CORDER, Rodney
IPC分类号： A61M1/10 , A61M1/14 , A61M1/16
CPC分类号： A61M1/1605 , A61M1/16 , A61M1/1601 , A61M1/1603 , A61M1/1609 , A61M1/1621 , A61M1/1645 , A61M1/1654 , A61M1/1658 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/3626 , A61M1/3661 , A61M2205/125 , A61M2205/126 , A61M2205/127 , A61M2205/15 , A61M2205/27 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3327 , A61M2205/3334 , A61M2205/3337 , A61M2205/3368 , A61M2205/3379 , A61M2205/3653 , A61M2205/50 , A61M2205/75
摘要： A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge further includes a filter for removing waste products from the dialysate as well as one or more flow sensors for measuring the flow of dialysate in the dialysate flow path. The preferred flow sensor includes a rotatable spoked wheel in the dialysate flow path which is rotated by the flow of dialysate. The spoked wheel includes one or more magnets which are rotated with the rotation of the spoked wheel. The flow sensor further includes a magnetic field sensor in the reused dialysis machine which is connected to a processor for monitoring the rotation of the spoked wheel to determine flow of fluid in the dialysate flow path.
摘要翻译：提供便携式血液透析系统，其包括一次性药筒和再次使用的透析机。一次性药筒包括透析液流动路径和通过透析器沿相反方向流动的血液流路。一次性药筒还包括用于从透析液中除去废物的过滤器以及用于测量透析液流动路径中透析液流的一个或多个流量传感器。优选的流量传感器包括通过透析液流旋转的透析液流动路径中的可旋转的轮辐。辐条轮包括一个或多个随着轮胎转动而旋转的磁体。流量传感器还包括在再利用透析机中的磁场传感器，该磁场传感器连接到处理器，用于监测辐条轮的旋转以确定透析液流动路径中的流体流动。

9. 发明申请

WO2015199765A1 METHOD OF ZIRCONIUM PHOSPHATE RECHARGING 审中-公开
标题翻译：磷酸锌补充方法
公开(公告)号：WO2015199765A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/019901
申请日：2015-03-11
申请人： MEDTRONIC, INC. , PUDIL, Bryant, J. , LYU, Suping , GROVENDER, Eric , HOBOT, Christopher, M. , GERBER, Martin, T.
发明人： PUDIL, Bryant, J. , LYU, Suping , GROVENDER, Eric , HOBOT, Christopher, M. , GERBER, Martin, T.
IPC分类号： A61M1/14
CPC分类号： A61M1/1696 , B01J39/09 , C01B25/45
摘要： Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.
摘要翻译：提供吸附剂再充电的方法和相关设备。用于再充电的方法和相关装置可以对吸附剂盒中的吸附剂材料例如磷酸锆的特定可再充电层进行再充电。所述方法和装置包括通过含有可再充电的吸附剂材料如磷酸锆的模块来传递含有酸，碱和盐的组合的溶液，以便用氢和钠离子代替与磷酸锆结合的离子。该方法允许可定制的磷酸锆，控制再充电的磷酸锆上钠与氢的比例。

10. 发明申请

WO2015184033A2 METHOD FOR TREATING DIALYSATE, DIALYSIS SYSTEM, AND METHOD FOR PRE-EVALUATING DIALYSIS PATIENTS FOR TREATMENT WITH SAME 审中-公开
标题翻译：用于治疗DIALYSATE的方法，DIALYSIS系统以及用于预测用于治疗的DIALYSIS患者的方法
公开(公告)号：WO2015184033A2
公开(公告)日：2015-12-03
申请号：PCT/US2015/032778
申请日：2015-05-28
申请人： FRESENIUS MEDICAL CARE HOLDINGS, INC.
发明人： MERCHANT, Stephen
IPC分类号： A61M1/16
CPC分类号： A61M1/14 , A61M1/1666 , A61M1/1696 , A61M2205/3334 , A61M2209/06 , G06F19/00 , G16H10/60
摘要： A method for treating dialysate solutions used in dialysis wherein dialysate is treated in an early part of a dialysis treatment session by external infusion of bicarbonate solution into the dialysate circuit to eliminate the need for bicarbonate requirements in concentrates used for preparation of precursor dialysate (priming) solutions and/or for a solid bicarbonate layer in a sorbent cartridge. Dialysate is treated in a latter part of a dialysis treatment session by introduction of sterile dilution water to reduce sodium concentration in the dialysate. The method provides a more efficient and reduced use of dialysate fluids, electrolytes, sorbent cartridge materials, equipment scale, or any combinations of these, while maintaining purity standards and applicable physiological ranges for bicarbonate, sodium, and other dialysate solution components over the course of a dialysis treatment session.
摘要翻译：用于治疗透析中使用的透析液的方法，其中在透析治疗期的早期部分通过将碳酸氢盐溶液外部输入到透析液回路中来处理透析液，以消除用于制备前体透析液（起泡）的浓缩物中碳酸氢盐需求，溶液和/或用于吸附剂盒中的固体碳酸氢盐层。通过引入无菌稀释水以减少透析液中的钠浓度，在透析治疗期的后期部分处理透析液。该方法提供了更有效和更少的使用透析液，电解质，吸附剂盒材料，设备规模或这些的任何组合，同时保持了碳酸氢盐，钠和其它透析液组分在过程中的纯度标准和适用的生理范围透析治疗会议。

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