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1. 发明申请

WO2019070500A1 MAGNETICALLY SUSPENDED BLOOD DRIVING PISTON CIRCULATORY ASSIST DEVICE 审中-公开
公开(公告)号：WO2019070500A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/053089
申请日：2018-09-27
申请人： HEARTWARE, INC.
发明人： SHAFIR, David A.
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1081 , A61M1/1005 , A61M1/1055 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/122 , A61M2205/3334 , F04B35/045
摘要： A pulsatile blood pump including a chamber having an upstream portion, a downstream portion, and a wall coupling the upstream portion to the downstream portion, the upstream portion defining an inlet sized to fit within a ventricle of a heart, the downstream portion defining an outlet, and the wall defining a bore; a piston disposed within the bore of the wall, the piston including a first side in continuous fluid communication with the ventricle of the heart when the inlet is within the ventricle of the heart and defining a travel path within the bore including an upstream direction toward the inlet and a downstream direction toward the outlet; and a valve coupled to the piston and defining a one-way fluid flow path within the chamber through the first side of the piston in the downstream direction.

2. 发明申请

WO2018005525A1 ELECTRICALLY CONDUCTIVE MEMBRANE PUMP SYSTEMS 审中-公开
标题翻译：导电膜泵系统
公开(公告)号：WO2018005525A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039543
申请日：2017-06-27
申请人： CLEAN ENERGY LABS, LLC
发明人： PINKERTON, Joseph, F.
IPC分类号： F04B43/02 , F04B43/04 , B06B1/02 , G01H11/06 , G10K9/12 , H04R19/00 , A61B5/00 , H04W4/00 , G06F1/16
CPC分类号： B06B1/02 , A61M1/1053 , A61M1/1087 , A61M1/12 , F04B43/0054 , F04B43/02 , F04B43/04 , G01H11/06 , G06F1/163 , G06F1/1688 , G10K9/12 , H04R7/045 , H04R19/02 , H04R2307/023 , H04W4/00 , H04W4/80
摘要： Pump systems having electrically conductive membranes are described. In embodiments of the invention, the electrically conductive membranes can be utilized as speakers to produce ultrasonic and audible sounds. The electrically conductive membranes are made from materials such as graphene, graphene oxide, and polymer films having a thin conductive coating.
摘要翻译：描述了具有导电膜的泵系统。在本发明的实施例中，导电膜可以用作扬声器以产生超声波和可听见的声音。导电膜由诸如石墨烯，氧化石墨烯和具有薄导电涂层的聚合物膜的材料制成。

3. 发明申请

WO2015188154A8 SYSTEM FOR CALCULATING A CHANGE IN FLUID VOLUME IN A PUMPING CHAMBER 审中-公开
标题翻译：计算泵送液体流量变化的系统
公开(公告)号：WO2015188154A8
公开(公告)日：2017-01-19
申请号：PCT/US2015034570
申请日：2015-06-05
申请人： DEKA PRODUCTS LP
发明人： NORRIS MICHAEL G , SCARPACI JACOB W , BRYANT ROBERT J , SPENCER GEOFFREY P , GIROUARD PAUL G , KAROL DANIEL S , SINGER DANIEL B , RUSHLOW JOSEPH P , HIBBARD DAVID J , DALE JAMES D , KERWIN JOHN M , COLL ANDREW S , BEAVERS DAVID A , MCGILL DAVID W , HELMORE SIMON C , DOHERTY DAVID B , BOLTON EDGAR J , YOO JINSUN
IPC分类号： A61M1/10 , A61M1/28 , A61M1/30
CPC分类号： A61M39/22 , A61M1/1006 , A61M1/1012 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/166 , A61M1/28 , A61M1/282 , A61M1/288 , A61M2205/12 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/3396 , A61M2205/6063
摘要： Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control the amount of intraperitoneal fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.
摘要翻译：一般来说，对气动驱动的隔膜泵公开了流体体积测量系统的改进，特别是使用泵盒的腹膜透析循环仪。泵流体体积测量基于泵室控制室中的压力测量和双室模型中的参考室，其中该设备的不同部分使用绝热，等温和多变过程的组合进行建模。还公开了在隔膜泵的泵室中的实时或瞬时流体流量测量，在这种情况下使用单室理想气体模型并且使用高速处理器在流体流入或流出期间获得和处理泵控制室压力的泵室。还公开了改进的加热器控制电路，以在加热器的脉冲宽度调制控制期间提供附加的或冗余的安全措施，或减少来自加热器元件的电流泄漏。在腹膜透析治疗期间在排水阶段中施加负压并且在治疗期间控制腹膜内液体积累的量也公开了改进。流体进出腹膜透析循环仪的双泵盒和加热袋，以及在腹膜透析循环仪或其他流体处理中两个或多个泵的操作的同步中也公开了效率的改善使用多泵排列的装置。

4. 发明申请

WO2015092732A1 ARTIFICIAL HEART 审中-公开
标题翻译：人造心脏
公开(公告)号：WO2015092732A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/067068
申请日：2014-12-18
申请人： GALLUCCI, Stefano , SCURI, Silvia Teresa Giustina , TOMASI, Enzo , MANTOVANI, Felice , PERLATO, Tiziano , GEROSA, Gino
发明人： SCURI, Silvia Teresa Giustina , MANTOVANI, Felice , PERLATO, Tiziano , GEROSA, Gino , SUSIN, Francesca Maria
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1037 , A61F2/04 , A61M1/1046 , A61M1/1049 , A61M1/106 , A61M1/1087 , A61M1/1096 , A61M1/12
摘要： An artificial heart (1) comprises two deformable lateral ventricles (11, 12) and a central ventricle (10), arranged in such a way that: - the central ventricle (10) is connected to the first lateral ventricle (11) and to the second lateral ventricle (12) by means of a first and a second one-way valve (21, 22), respectively, mounted so as to be able to be crossed by a hydraulic flow (B) from the first lateral ventricle (11) to the central ventricle (10) and then to the second lateral ventricle (12), respectively, - the first lateral ventricle (11) is connected to an inlet opening (31) and to the first one-way valve (21) and - the second lateral ventricle (12) is connected to the second one-way valve (22) and to a second outlet opening (32), - a mechanical and/or hydraulic actuator for alternately: - expanding the central ventricle (10) and compressing the lateral ventricles (11, 12). - compressing the central ventricle (10) and expanding the lateral ventricles (11, 12).
摘要翻译：人造心脏（1）包括两个可变形的侧脑室（11,12）和中央心室（10），所述中心心室（10）以如下方式设置： - 所述中央心室（10）连接到所述第一侧脑室（11）所述第二侧脑室（12）分别通过第一和第二单向阀（21,22）安装，以便能够被来自所述第一侧脑室（11）的液压流（B）穿过）分别连接到中央心室（10），然后到第二侧脑室（12），第一侧脑室（11）连接到入口开口（31）和第一单向阀（21），并且 - 所述第二侧脑室（12）连接到所述第二单向阀（22）和第二出口开口（32）， - 机械和/或液压致动器，用于交替地： - 扩张所述中心心室（10）和压缩侧脑室（11,12）。 - 压缩所述中心心室（10）并扩张所述侧脑室（11,12）。

5. 发明申请

WO2012161744A2 BLOOD TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：血液处理系统和方法
公开(公告)号：WO2012161744A2
公开(公告)日：2012-11-29
申请号：PCT/US2012000257
申请日：2012-05-24
申请人： DEKA PRODUCTS LP , WILT MICHAEL J , VAN DER MERWE DIRK A , BALLANTYNE TODD A , GRANT KEVIN L , ROSSE JONATHAN P , FLYNN CATHARINE N , YEE BRIAN K
发明人： WILT MICHAEL J , VAN DER MERWE DIRK A , BALLANTYNE TODD A , GRANT KEVIN L , ROSSE JONATHAN P , FLYNN CATHARINE N , YEE BRIAN K
IPC分类号： A61M1/10 , A61M1/16 , A61M1/34 , A61M1/36 , G06F1/16
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/3481
摘要： There is disclosed herein dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.

6. 发明申请

WO2012041525A1 VALVE, PUMP SYSTEM AND METHOD FOR OPERATION OF A PUMP SYSTEM 审中-公开
标题翻译：泵，泵系统和泵系统的操作方法
公开(公告)号：WO2012041525A1
公开(公告)日：2012-04-05
申请号：PCT/EP2011/005078
申请日：2011-09-30
申请人： BERLIN HEART GMBH , HERING, Jörg , SCHWIERTZ, Norbert
发明人： HERING, Jörg , SCHWIERTZ, Norbert
IPC分类号： F16K11/085 , A61M1/10
CPC分类号： F16K11/085 , A61M1/1037 , A61M1/106 , A61M1/1087 , A61M1/12 , A61M1/122 , F04B49/22 , F16K11/0856
摘要： The invention relates to a valve for the control of a fluid flow, with a connection block (24) which comprises a cylinder-symmetrical recess (25), wherein at least one first and a second entry channel (20, 22, 30, 35) as well as a first and a second exit channel (21, 23, 32, 37) run out in the peripheral surface of the recess, as well as with a control pin (29) which is fitted into the recess, is rotatable about a rotation axis (29a), comprises at least two through-channels (38, 39, 40, 41, 42) and connects different ones of the entry and exit channels of the connection block to one another depending on its angular position. In order to create a valve which may advantageously be applied with dual blood pump systems and with a low flow resistance and low wear, with a rapid and reliable switching capability, according to the invention, one envisages a first through-channel (38, 41) in the pin, with respect to the rotation axis, exclusively connecting channels (30, 31, 32) running out at a first axial height, to one another, and a second through-channel (40, 42) exclusively connecting channels (35, 36, 37) running out at a second axial height, to one another. The invention further relates to a corresponding pump system and to a method for operating the system.
摘要翻译：本发明涉及一种用于控制流体流动的阀，其中连接块（24）包括圆柱体对称的凹部（25），其中至少一个第一和第二进入通道（20,22,30,35 ）以及在凹部的外周表面中延伸的第一和第二出口通道（21,23,32,37）以及装配到凹部中的控制销（29）可围绕旋转轴线（29a）包括至少两个通道（38,39,40,41,42），并且根据其角度位置将连接块的进入和离开通道中的不同的通道彼此连接。根据本发明，为了创建可有利地应用双血液泵系统并具有低流动阻力和低磨损的阀门，根据本发明，设计了一种第一通道（38,41 ）相对于旋转轴线在第一轴向高度处相互独立地连接通道（30,31,32），并且仅将连接通道（35,42）连接到第二通道（40,42），36,37）在第二轴向高度上彼此延伸。本发明还涉及相应的泵系统和用于操作该系统的方法。

7. 发明申请

WO2008146144A8 KIT FOR THE EXTRACORPOREAL TREATMENT OF A BIOLOGICAL FLUID OF A PATIENT, AND UNIT PROVIDED WITH SAID KIT 审中-公开
标题翻译：用于对患者的生物流体进行真空处理的工具包，以及提供的工具包的单元
公开(公告)号：WO2008146144A8
公开(公告)日：2009-06-04
申请号：PCT/IB2008001361
申请日：2008-05-29
申请人： HAEMOTRONIC ADVANCED MEDICAL T , GOLDONI MARCO , RAVIZZA ALICE
发明人： GOLDONI MARCO , RAVIZZA ALICE
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/34 , A61M1/10 , A61M1/1006 , A61M1/1037 , A61M1/1087 , A61M1/1096 , A61M1/367 , A61M39/24 , A61M2039/242 , A61M2039/2433 , A61M2039/2453 , A61M2039/2473 , A61M2039/2486 , A61M2205/3331
摘要： A kit for the treatment in a sterile environment of a biological fluid of a patient comprises: an intake branch (7) designed to be connected to the haematic circuit of a patient; an activation assembly (8) designed to co-operate with a device for generating pulsating pressure for controlling a flow of the biological fluid at least in the intake branch (7); a delivery- branch (9) set downstream of the intake branch (7) and of the activation assembly (8); and a connection outlet element (50) fluidically connected to the delivery branch (9) and designed to be connected to the haematic circuit of the patient, the delivery branch (9) being designed to co-operate with a means of treatment (5) of said biological fluid. In particular, the kit comprises a first non- return valve (13) and a second non¬ return valve (17) set in line, respectively, on the intake branch (7) and on the delivery branch (9), the portion of activation (8) being set between the first and second non¬ return valves (13, 17).
摘要翻译：用于在患者的生物流体的无菌环境中治疗的试剂盒包括：设计成连接到患者的运动回路的进气分支（7）; 激活组件（8），其被设计成与用于产生脉动压力的装置协作，用于至少在所述进气分支（7）中控制所述生物流体的流动; 设置在进气分支（7）和激活组件（8）下游的输送支路（9）; 以及连接出口元件（50），其流体地连接到所述输送支路（9）并被设计成连接到所述患者的所述运动回路，所述输送支路（9）设计成与治疗装置（5）协作，的所述生物流体。特别地，该套件包括分别设置在进气支路（7）和输送支路（9）上的第一止回阀（13）和第二止回阀（17），该第一止回阀（13）和第二止回阀激活（8）被设置在第一和第二止回阀（13,17）之间。

8. 发明申请

WO2008106538A2 CASSETTE SYSTEM INTEGRATED APPARATUS 审中-公开
标题翻译： CASSETTE系统集成设备
公开(公告)号：WO2008106538A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055168
申请日：2008-02-27
申请人： DEKE PRODUCTS LIMITED PARTNERSHIP , DEMERS, Jason, A. , WILT, Michael, J. , GRANT, Kevin, L. , DALE, James, D. , TRACEY, Brian
发明人： DEMERS, Jason, A. , WILT, Michael, J. , GRANT, Kevin, L. , DALE, James, D. , TRACEY, Brian
IPC分类号： A61M1/10 , A61M1/16
CPC分类号： F04B53/10 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/16 , A61M1/1605 , A61M1/1639 , A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/287 , A61M2205/12 , A61M2205/128 , A61M2205/3317 , A61M2205/3324 , A61M2205/3368 , F04B7/02 , F04B9/109 , F04B13/02 , F04B23/06 , F04B41/06 , F04B43/00 , F04B43/02 , F04B43/06 , F04B43/073 , F04B43/0733 , F04B43/0736 , F04B45/02 , F04B45/0536 , F04B49/22 , F04B53/06 , F04B53/16 , F17D3/00 , Y10T137/0324 , Y10T137/0379 , Y10T137/2521 , Y10T137/85978 , Y10T137/86139
摘要： Pumping cassettes are disclosed. Each cassette includes a housing, at least one fluid inlet and at least one fluid outlet as well as at least one reciprocating pressure displacement membrane pomp in fluid relation to the cassette. The balancing cassette includes at least one balancing pod in fluid connection. The mixing cassette includes at least one mixing chamber in fluid connection. The system includes a mixing cassette, a balancing cassette, and an outer or middle cassette fluid! y connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is flαidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidiy connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.
摘要翻译：公开了抽吸盒。每个盒包括壳体，至少一个流体入口和至少一个流体出口以及至少一个与盒相关的流体相互作用的往复压力移动膜。平衡盒包括至少一个流体连接的平衡盒。混合盒包括至少一个流体连接的混合室。该系统包括混合盒，平衡盒和外部或中间盒式流体！ y连接到混合盒和平衡盒和至少一个盒。混合盒通过至少一个流体管线与中间盒子有弹性地连接，并且中间盒通过至少一个流体管线流体连接到平衡盒。至少一个容器连接到盒中的至少两个盒，其中盒位于盒之间的区域中。

9. 发明申请

WO2003055541A1 INTRAVASCULAR PUMP 审中-公开
标题翻译：血管内泵
公开(公告)号：WO2003055541A1
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005935
申请日：2002-12-30
申请人： HENEIN, Michael , KHIR, Ashraf
发明人： HENEIN, Michael , KHIR, Ashraf
IPC分类号： A61M1/10
CPC分类号： A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1081 , A61M1/1087 , A61M1/122 , A61M1/125 , A61M1/127 , A61M2205/8243
摘要： An intravascular bi-directional pump is disclosed which is adapted to be located in the upper aorta, whereby it can assist the left ventricle to eject in the forward direction during systole, so as to off-load the heart, and also pump an adequate amount in the reverse direction, during diastole, to secure coronary flow.
摘要翻译：公开了一种血管内双向泵，其适于位于上主动脉中，由此其可以帮助左心室在收缩期间向前方向弹出，以便使心脏脱离，并且还泵送足够的量在舒张期，在相反的方向，以确保冠状动脉血流。

10. 发明申请

WO01017604A1 FLUID PRESSURE ACTUATED BLOOD PUMPING SYSTEMS AND METHODS WITH CONTINUOUS INFLOW AND PULSATILE OUTFLOW CONDITIONS 审中-公开
标题翻译：流体压力驱动的血液泵送系统和连续流量和脉搏流出条件的方法
公开(公告)号：WO01017604A1
公开(公告)日：2001-03-15
申请号：PCT/US2000/023675
申请日：2000-08-29
IPC分类号： A61M1/02 , A61M1/10 , A61M1/30 , A61M1/36 , A61M37/00 , F04B13/02 , F04B43/02 , F04B49/06 , B01D37/00 , B01D61/00 , B01D63/00 , C02F1/00 , C02F1/44 , F04B9/08 , F04B17/00 , F04B35/00 , F04B49/00
CPC分类号： A61M1/3696 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M2205/128 , A61M2205/331 , A61M2205/3334 , A61M2205/3393 , F04B13/02 , F04B43/026 , F04B49/065 , F04B2205/09
摘要： Blood processing systems (10) and related methods place first (PP1) and second (PP2) fluid actuated pump stations in in-line communication between a source and a destination. The systems and methods apply fluid pressure pump strokes to the first and second pump stations to convey fluid from the source to the destination. The systems and methods switch between a first flow mode and a second flow mode. The first flow draws a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination. In the second flow mode, the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination. The pump strokes are synchronized so that flow from the source is essentially continuous while fluid flow to the destination is pulsatile.
摘要翻译：血液处理系统（10）和相关方法将首先（PP1）和第二（PP2）流体致动泵站放置在源和目的地之间的在线通信中。系统和方法将流体压力泵冲程施加到第一和第二泵站以将流体从源传送到目的地。系统和方法在第一流模式和第二流模式之间切换。第一流将来自源的流体体积从第二泵站抽出到第一泵站中，并将流体体积从第二泵站排出到目的地。在第二流动模式中，泵冲程从源将流体体积从第二泵站抽出到第二泵站，并将流体体积从第一泵站排出到目的地。泵冲程是同步的，使得来自源的流动基本上是连续的，而流到目的地的流体是脉动的。

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