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1. 发明申请

WO1996038101A1 IMPLANTABLE INTRALUMINAL PROSTHESIS 审中-公开
标题翻译：可植入的内镜治疗
公开(公告)号：WO1996038101A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008174
申请日：1996-05-31
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , PINHEIRO, Orlando, S.
IPC分类号： A61F02/06
CPC分类号： A61F2/86 , A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2002/825 , A61F2002/826 , A61F2002/828 , A61F2002/8486 , A61F2220/0016 , A61F2220/0075 , A61F2230/006 , A61F2250/006
摘要： An implantable intraluminal prosthesis assembly is provided for use in repairing or replacing damaged or diseased portions of a blood vessel or other like vessel. The prosthesis includes an expandable stent/graft combination, with a pair of stents at either end of the graft, and further includes a plurality of struts extending between and interconnecting the stents, and radial spaced about the inner surface of the graft. As such, the implantable prosthesis is provided with internal support for the graft when in a compressed state during implantation and is further provided with radial support along the length of the graft after implantation.
摘要翻译：提供可植入的腔内假体组件，用于修复或替换血管或其他类似血管的受损或患病部分。假体包括可扩张的支架/移植物组合，在移植物的任一端具有一对支架，并且还包括在支架之间延伸并互连的多个支柱，并且围绕移植物的内表面径向间隔开。因此，当在植入期间处于压缩状态时，可植入假体设置有用于移植物的内部支撑，并且在植入后还沿着移植物的长度进一步设置径向支撑。

2. 发明申请

WO1998023307A1 PROCESS FOR PREPARING POLYURETHANE-PEO-HEPARIN COATING COMPOSITIONS 审中-公开
标题翻译：制备聚氨酯 - PEO-HEPARIN涂料组合物的方法
公开(公告)号：WO1998023307A1
公开(公告)日：1998-06-04
申请号：PCT/US1997021212
申请日：1997-11-18
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , PATNAIK, Birendra, K.
IPC分类号： A61L27/00
CPC分类号： C08G81/00 , A61L27/34 , A61L29/085 , A61L33/0029 , C08G18/10 , C08G18/44 , C08G18/6755 , C08G18/7671 , C08G18/833 , C09D5/1637 , C09D175/06 , Y10S128/22 , A61L27/54 , C08L75/04 , C08L71/02 , A61L29/16
摘要： A bio-active coating composition is described which is the reaction product of two different reactions. The first reaction includes reacting a bio-compatible polymer backbone having alpha , beta -unsaturated carbonyl functionality with a hydrophilic spacer having at least one reactive functional group at its first and second ends. In this reaction, one of the reactive functional groups of the spacer reacts with a beta -carbon of the carbonyl functionality to bond the spacer to the polymer backbone. The second reaction includes reacting a bio-active agent with a remaining unreacted reactive functional group of the spacer in the presence of an optional catalyst to covalently bind the bio-active agent to the spacer.
摘要翻译：描述了两种不同反应的反应产物的生物活性涂料组合物。第一反应包括使具有α，β-不饱和羰基官能团的生物相容性聚合物骨架与其第一和第二末端具有至少一个反应性官能团的亲水间隔基反应。在该反应中，间隔基中的一个反应性官能团与羰基官能团的β-碳酸酯反应以将间隔基键合到聚合物主链上。第二反应包括在任选的催化剂存在下使生物活性剂与间隔基的剩余未反应的官能团反应，以将生物活性剂共价结合到间隔物上。

3. 发明申请

WO1995033422A1 A CATHETER WITH STENT AND METHOD FOR THE PRODUCTION OF A CATHETER WITH STENT 审中-公开
标题翻译：一种用于制造带有电导体的导体的电极和方法
公开(公告)号：WO1995033422A1
公开(公告)日：1995-12-14
申请号：PCT/IB1995000492
申请日：1995-06-06
申请人： MEADOX MEDICALS, INC. , MEADOX SURGIMED A/S , STOLTZE, Jacob , KAMSTRUP-LARSEN, Jorgen
发明人： MEADOX MEDICALS, INC. , MEADOX SURGIMED A/S
IPC分类号： A61F02/06
CPC分类号： A61F2/958 , A61F2/88 , A61F2002/9583 , A61M25/104
摘要： The present invention relates to a catheter system for introducing and implanting an expandable stent member in a body. The catheter includes a catheter member having first and second ends, the first end having an inflatable portion, a lumen in fluid communication with the inflatable portion and the second end to provide means for inflating said inflatable portion. The expandable stent member is capable of permanent deformation when expanded. At least a portion of the stent member is attached to the inflatable portion by a bond and whereby upon inflation of the inflatable portion the bond is released from the stent member to permit deployment of the stent member and removal of the catheter member. The bond may be formed by the same or different material than the balloon surface. For example, an adhesive may be used. Additionally the surface of the ballon may be softened and the stent member may be embedded into the softened portion and allowed to return to its original unsoftened state, thereby adhesively connecting the stent to the inflatable balloon.
摘要翻译：本发明涉及一种用于在体内引入和植入可扩张支架构件的导管系统。导管包括具有第一端和第二端的导管构件，第一端具有可充气部分，与可充气部分流体连通的内腔和第二端，以提供用于使所述可充气部分充气的装置。可扩展支架构件在膨胀时能够永久变形。支架构件的至少一部分通过接合附接到可充气部分，并且由此在充气部分膨胀时，粘结从支架构件释放以允许展开支架构件并移除导管构件。该接合可以由与气球表面相同或不同的材料形成。例如，可以使用粘合剂。此外，气囊的表面可以软化，并且支架构件可以嵌入软化部分中并允许返回到其原始未软化状态，从而将支架粘合地连接到可充气气囊。

4. 发明申请

WO1994015548A1 RADIALLY EXPANDABLE TUBULAR PROSTHESIS 审中-公开
标题翻译：放射性可扩展的管状体
公开(公告)号：WO1994015548A1
公开(公告)日：1994-07-21
申请号：PCT/US1994000632
申请日：1994-01-13
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , SCHMITT, Peter, J.
IPC分类号： A61F02/04
CPC分类号： D04C1/06 , A61F2/06 , A61F2/07 , A61F2/90 , A61F2240/001 , A61F2250/001 , A61F2250/0082 , D10B2509/06
摘要： A radially expandable tubular prosthesis (16) which allows for controlled expansion in a circumferential direction following implantation while limiting expansion in a longitudinal direction. The prosthesis (16) is particularly suited to intraluminal implantation via a catheter and is also particularly suited for percutaneous implantation in children.
摘要翻译：一种可径向膨胀的管状假体（16），其允许在植入之后沿圆周方向受控地膨胀，同时限制纵向方向的扩张。假体（16）特别适合于通过导管进行腔内植入，并且还特别适用于儿童经皮植入。

5. 发明申请

WO1994006373A1 THREE-DIMENSIONAL BRAIDED SOFT TISSUE PROSTHESIS 审中-公开
标题翻译：三维BRAIDED软组织展现
公开(公告)号：WO1994006373A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008658
申请日：1993-09-14
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , SCHMITT, Peter, J.
IPC分类号： A61F02/06
CPC分类号： A61F2/06 , D04C1/06 , D10B2403/023 , D10B2403/02411 , D10B2509/06
摘要： The present invention provides a soft tissue prosthesis which is formed from a three-dimensional braided structure having an inner surface (22) and an outer surface (24). The three-dimensional braided structure preferably may be made in the form of a solid three-dimensional braid, a three-dimensional braid having at least one interlocking yarn coupling contiguous layers or in the form of a plurality of two-dimensional braided layers adhesively laminated, separately sewn or otherwise connected together to form the three-dimensional braided prosthesis.
摘要翻译：本发明提供一种由具有内表面（22）和外表面（24）的三维编织结构形成的软组织假体。三维编织结构优选地可以制成固体三维编织物的形式，三维编织物具有至少一个连接连续层的互锁纱线或以多个二维编织层的形式粘合层压，分别缝合或以其他方式连接在一起以形成三维编织假体。

6. 发明申请

WO1994006372A1 A RADIALLY SELF-EXPANDING IMPLANTABLE INTRALUMINAL DEVICE 审中-公开
标题翻译：一种可自由扩张的可植入式内窥镜装置
公开(公告)号：WO1994006372A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008649
申请日：1993-09-14
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , SCHMITT, Peter, J. , LENTZ, David, J.
IPC分类号： A61F02/04
CPC分类号： A61F2/90 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2002/077 , A61F2002/30065 , A61F2002/3008 , A61F2002/30461 , A61F2002/9534 , A61F2210/0071 , A61F2220/0025 , A61F2220/0075 , A61F2250/0098 , D04C1/06 , D10B2509/06 , Y10S623/903
摘要： A radially self-expanding implantable intraluminal device (10) formed from a hollow tubular braid. The intra-luminal device may be used in a variety of medical procedures which require a passageway to be maintained in an open position or which require reinforcement, support or a bypass conduit such as in blood vessels weakened by disease. The intra-luminal device is longitudinally expanded or radially collapsed for ease of insertion into a lumen and upon alignment within the lumen, the intra-luminal device (10) radially self-expands to come into intimate contact with the inner surface of the lumen.
摘要翻译：由中空管状编织物形成的径向自扩张可植入管腔内装置（10）。腔内装置可以用于需要将通道保持在打开位置或需要加强，支撑或旁路导管（例如由疾病削弱的血管）中的各种医疗程序。腔内装置纵向膨胀或径向收缩，以便容易地插入管腔中并且在腔内对准时，腔内装置（10）径向自我扩张以与内腔的内表面紧密接触。

7. 发明申请

WO1998010805A1 PROCESS FOR PREPARING POLYURETHANES GRAFTED WITH POLYETHYLENE OXIDE CHAINS CONTAINING COVALENTLY BONDED HEPARIN 审中-公开
标题翻译：制备含有共价键合的聚氨酯氧化链的聚氨酯的方法
公开(公告)号：WO1998010805A1
公开(公告)日：1998-03-19
申请号：PCT/US1997016162
申请日：1997-09-11
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , PATNAIK, Birendra, K. , ZDRAHALA, Richard, J.
IPC分类号： A61L33/00
CPC分类号： A61L33/0047 , A61L27/34 , A61L33/0029 , A61L33/0094
摘要： Disclosed are bio-active polymer coatings. More particularly, improved bio-active polymer coatings are disclosed which include bio-active molecules attached to polyurethane backbones via amine-terminated spacers. Also disclosed are novel reaction schemes for producing same.
摘要翻译：公开了生物活性聚合物涂层。更具体地，公开了改进的生物活性聚合物涂层，其包括通过胺封端的间隔物连接到聚氨酯主链上的生物活性分子。还公开了用于制备其的新型反应方案。

8. 发明申请

WO1997025938A1 IMPROVED PTFE VASCULAR GRAFT AND METHOD OF MANUFACTURE 审中-公开
标题翻译：改进的聚四氟乙烯瓦斯碎片及其制造方法
公开(公告)号：WO1997025938A1
公开(公告)日：1997-07-24
申请号：PCT/US1997001720
申请日：1997-01-22
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , LENTZ, David, J. , HENDERSON, Jamie , DORMIER, Edward, J. , ZDRAHALA, Richard, J.
IPC分类号： A61F02/06
CPC分类号： A61L27/56 , A61F2/06 , A61F2002/0086 , A61F2002/072 , A61L27/16 , A61L27/507 , Y10S623/901 , C08L27/18
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译：可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。

9. 发明申请

WO1996040350A1 HIGH STRENGTH LOW COMPLIANCE COMPOSITE BALLOON FOR BALLOON CATHETERS 审中-公开
标题翻译：高强度低合金气球用于气球导管
公开(公告)号：WO1996040350A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009379
申请日：1996-06-07
申请人： MEADOX MEDICALS, INC.
发明人： MEADOX MEDICALS, INC. , JORGENSEN, Ole
IPC分类号： A61M29/02
CPC分类号： A61M25/104 , A61M25/0052 , A61M2025/1084 , A61M2025/1086
摘要： An improved dilation balloon for securement to a catheter. The balloon includes an elastomeric skin having a constraining structure affixed thereto. The constraining structure allows radial expansion between an uninflated diameter Ddefl and an inflated diameter Dinfl. The minimum inflation pressure can be calculated based on the chosen elastomer Dinfl and Ddefl.
摘要翻译：用于固定到导管的改进的扩张气囊。气囊包括具有固定在其上的约束结构的弹性体皮肤。约束结构允许未膨胀直径Ddefl和膨胀直径Dinfl之间的径向膨胀。最小充气压力可以根据所选择的弹性体Dinfl和Ddefl计算。

10. 发明申请

WO1996025125A1 ENDOPROSTHESIS STENT/GRAFT DEPLOYMENT SYSTEM 审中-公开
标题翻译：内部控制/骨架部署系统
公开(公告)号：WO1996025125A1
公开(公告)日：1996-08-22
申请号：PCT/US1996002048
申请日：1996-02-14
申请人： MEADOX MEDICALS, INC. , SLATER, Andrea, T. , BYRNE, Brian
发明人： MEADOX MEDICALS, INC.
IPC分类号： A61F02/06
CPC分类号： A61F2/95
摘要： A deployment system (10) for transcutaneous insertion of an implantable tubular prosthesis (30) is provided. The deployment system includes a flexible, elongated, tubular, delivery catheter (20) with at least one inner lumen (26a), and an opening (24) extending through the catheter to the inner lumen (26a). Positioned over the catheter (20) is an implantable endoprosthesis (30) capable of radial expansion and having a proximal (35) and a distal end extent (33). A support assembly (44, 48) removably maintains the endoprosthesis (30) in a compressed state, and is located at a position adjacent the catheter opening (24). The support assembly (44, 48) includes an arm (46) which extends through the catheter opening (24) into the inner lumen (26a). A release mechanism (16) is insertable through the inner lumen (26a) and includes a distal tip (13) engageable with the arm (46) of the support assembly (44, 48). The release mechanism (16) is manipulatable within the inner lumen (26a) so as to remove the support assembly (44, 48) from the endoprosthesis (30), permitting radial expansion of the endoprosthesis (30) for implantation.
摘要翻译：提供了一种用于经皮插入可植入管状假体（30）的部署系统（10）。所述展开系统包括具有至少一个内腔（26a）的柔性细长管状输送导管（20），以及通过所述导管延伸到所述内腔（26a）的开口（24）。定位在导管（20）上方的是可径向膨胀并具有近端（35）和远端范围（33）的可植入内置假体（30）。支撑组件（44,48）可拆卸地将内用假体（30）保持在压缩状态，并且位于邻近导管开口（24）的位置。支撑组件（44,48）包括臂（46），其延伸穿过导管开口（24）进入内腔（26a）。释放机构（16）可插入穿过内腔（26a）并且包括可与支撑组件（44,48）的臂（46）接合的远侧末端（13）。释放机构（16）可在内腔（26a）内操作，从而从内假体（30）移除支撑组件（44,48），允许用于植入的内用假体（30）的径向膨胀。

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