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1. 发明申请

WO0200232A9 METHODS AND COMPOSITIONS FOR DEVELOPING SPORE DISPLAY SYSTEMS FOR MEDICINAL AND INDUSTRIAL APPLICATIONS 审中-公开
标题翻译：用于开发用于医药和工业应用的SPORE显示系统的方法和组合
公开(公告)号：WO0200232A9
公开(公告)日：2004-05-13
申请号：PCT/US0120372
申请日：2001-06-26
申请人： MAXYGEN INC , GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
发明人： GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
IPC分类号： A61K39/385 , A61K48/00 , A61P37/00 , C07K14/14 , C07K14/24 , C12Q1/02 , G01N33/532 , A61K39/00 , A61K35/72 , A61K35/74
CPC分类号： C07K14/005 , A61K39/385 , A61K48/00 , A61K2039/523 , A61K2039/541 , A61K2039/6006 , A61K2039/6031 , C07K14/24 , C12N2720/12322 , C12Q1/02 , G01N33/532
摘要： Compositions and methods for utilizing spore systems for medicinal and industrial protein applications are provided. Compositions comprise spores that produce and/or display carbohydrates, proteins, and nucleic acids of interest. Such spores are useful as therapeutic or prophylactic agents or vaccines against a broad spectrum of immunogens and bacterial and viral pathogens. Additionally, spore systems are useful in production, packaging, delivery, and presentation of polypeptides and/or nucleic acids for industrial catalysts, medical applications, and diagnostic applications.
摘要翻译：提供了用于药用和工业蛋白质应用的孢子体系的组合物和方法。组合物包含产生和/或显示目标碳水化合物，蛋白质和核酸的孢子。这样的孢子可用作针对广谱免疫原和细菌和病毒病原体的治疗或预防剂或疫苗。此外，孢子系统在生产，包装，递送和呈递用于工业催化剂，医疗应用和诊断应用的多肽和/或核酸方面是有用的。

2. 发明申请

WO2018191733A1 BELT PRE-TENSIONING AND POSITIONING SYSTEM FOR TRAINING A MUSCLE 审中-公开
公开(公告)号：WO2018191733A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027683
申请日：2018-04-14
申请人： WHALEN, Robert tremaine
发明人： WHALEN, Robert tremaine
IPC分类号： A63B21/008 , A61F13/00 , A61H9/00 , A61H11/00 , A63B21/00 , A63B21/02
CPC分类号： A63B21/0085 , A61B17/135 , A61F13/085 , A61H9/0092 , A61H11/00 , A61H2011/005 , A61H2201/0103 , A61H2201/0157 , A61H2201/1261 , A61H2201/1638 , A61H2201/1645 , A61H2201/165 , A61H2205/06 , A61H2230/00 , A61H2230/30 , A61H2230/305 , A63B21/00069 , A63B21/4025 , A63B69/0059 , A63B2208/053 , A63B2213/006 , A63B2225/62
摘要： A belt for use in a BFR system with an outer belt material hermetically sealed to an inner belt material along a perimeter, thereby forming at least one inflatable chamber, the inflatable chamber having an input port for accepting a gas into the chamber, the belt further comprising a first fastening means in communication with the outer belt material, for attaching to a second fastening means in communication with the outer belt material, thereby locking a circumference of the belt, when wrapped around a user's limb, and the belt further comprising a pre-tensioning system for prescribing and applying a known amount of initial compression to the limb by the belt.

3. 发明申请

WO2010118417A2 FOLDING PET STAIRCASE 审中-公开
标题翻译：折叠PET站
公开(公告)号：WO2010118417A2
公开(公告)日：2010-10-14
申请号：PCT/US2010030720
申请日：2010-04-12
申请人： WHALEN ROBERT F
发明人： WHALEN ROBERT F
IPC分类号： A01K29/00 , A61G1/013 , E04F11/06
CPC分类号： A01K1/035 , E06C1/383 , E06C1/387 , E06C1/52 , E06C1/54
摘要： A method and apparatus are provided, for allowing pets to ascend and descend on a foldable staircase having a plurality of stair treads operatively connected by articulating links in such a manner that the treads can be pivoted in unison from a stowed position of the staircase, in which the treads are substantially stacked upon one another, to a plurality of extended positions, in which the links position the treads in a spaced and parallel relationship to one another. A latch selectively secures the staircase in a selected one of the extended positions. The latch is configured for preventing further pivoting of the treads in either direction between the stowed and extended positions of the staircase, when the latch is engaged.
摘要翻译：提供了一种方法和装置，用于允许宠物上升和下降在具有多个阶梯踏板的可折叠楼梯上，所述多个阶梯踏板通过铰接连杆可操作地连接，使得踏板能够与楼梯的收起位置一致地枢转，胎面基本上彼此堆叠在一起的多个延伸位置，在该多个延伸位置中，连杆将胎面彼此间隔开并且平行的关系定位。闩锁选择性地将楼梯固定在所选择的一个延伸位置中。闩锁被构造成用于在闩锁接合时防止踏板在楼梯的收起位置和延伸位置之间沿任一方向的进一步枢转。

4. 发明申请

WO2006069086A2 FOLDING PET STAIRCASE 审中-公开
标题翻译：折叠PET站
公开(公告)号：WO2006069086A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046228
申请日：2005-12-21
申请人： WHALEN, Robert F.
发明人： WHALEN, Robert F.
IPC分类号： E04F11/00
CPC分类号： E06C1/52 , A01K1/035
摘要： A method and apparatus are provided, for allowing pets to ascend to and descend thereupon, through use of a foldable staircase having a plurality of stair treads operatively connected by articulating links in such a manner that the treads can be pivoted in unison from a stowed position of the staircase, in which the treads are substantially stacked upon one another, to a plurality of extended positions, in which the links position the treads in a spaced and parallel relationship to one another. A latch selectively secures the staircase in a selected one of the extended positions. The latch is configured for preventing further pivoting of the treads in either direction between the stowed and extended positions of the staircase, when the latch is engaged.
摘要翻译：提供了一种方法和装置，用于允许宠物通过使用具有多个阶梯踏板的可折叠楼梯上升和下降，所述可折叠楼梯通过铰接连杆可操作地连接，使得胎面可以从收起位置一致地枢转其中胎面基本上彼此堆叠在一起的多个延伸位置，在该多个延伸位置中，连接件使胎面彼此间隔开并且平行的关系。闩锁选择性地将楼梯固定在所选择的一个延伸位置中。闩锁被构造成用于在闩锁接合时防止踏板在楼梯的收起位置和延伸位置之间沿任一方向的进一步枢转。

5. 发明申请

WO0132712A3 ANTIBODY DIVERSITY GENERATION 审中-公开
标题翻译：抗体多样性生成
公开(公告)号：WO0132712A3
公开(公告)日：2002-03-21
申请号：PCT/US0030247
申请日：2000-11-01
申请人： MAXYGEN INC , KARRER ERIK , BASS STEVEN H , WHALEN ROBERT , PATTEN PHILLIP A
发明人： KARRER ERIK , BASS STEVEN H , WHALEN ROBERT , PATTEN PHILLIP A
IPC分类号： C07K16/00 , C07K16/12 , C12N1/21 , C12N15/13 , C12N15/49 , A61K39/21 , A61K39/42 , C07K14/16 , C07K16/10 , C07K16/46 , C12N15/62 , G06F17/30
CPC分类号： C07K16/1271 , C07K16/00 , C07K16/1275 , C07K2317/24
摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigencity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
摘要翻译：提供了通过多种DNA多样化和选择程序改进抗体的方法。改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。人性化。提供重组抗体序列的文库，以及表达这些文库成员的细胞。提供了新的噬菌体展示载体。提供了抗体及其同源抗原共转化方法。共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。提供了改进用于检测生物战剂的抗体的方法。

6. 发明申请

WO2006069086A3 FOLDING PET STAIRCASE 审中-公开
标题翻译：折叠PET站
公开(公告)号：WO2006069086A3
公开(公告)日：2008-01-24
申请号：PCT/US2005046228
申请日：2005-12-21
申请人： WHALEN ROBERT F
发明人： WHALEN ROBERT F
IPC分类号： E04F11/06
CPC分类号： E06C1/52 , A01K1/035
摘要： A method and apparatus are provided, for allowing pets to ascend to and descend thereupon, through use of a foldable staircase having a plurality of stair treads operatively connected by articulating links in such a manner that the treads can be pivoted in unison from a stowed position of the staircase, in which the treads are substantially stacked upon one another, to a plurality of extended positions, in which the links position the treads in a spaced and parallel relationship to one another. A latch selectively secures the staircase in a selected one of the extended positions. The latch is configured for preventing further pivoting of the treads in either direction between the stowed and extended positions of the staircase, when the latch is engaged.
摘要翻译：提供了一种方法和装置，用于允许宠物通过使用具有多个阶梯踏板的可折叠楼梯上升和下降，所述可折叠楼梯通过铰接连杆可操作地连接，使得胎面可以从收起位置一致地枢转其中胎面基本上彼此堆叠在一起的多个延伸位置，在该多个延伸位置中，连接件使胎面彼此间隔开并且平行的关系。闩锁选择性地将楼梯固定在所选择的一个延伸位置中。闩锁被构造成用于在闩锁接合时防止踏板在楼梯的收起位置和延伸位置之间沿任一方向进一步枢转。

7. 发明申请

WO2004007664A3 NUCLEIC ACID VECTORS 审中-公开
标题翻译：核酸载体
公开(公告)号：WO2004007664A3
公开(公告)日：2004-07-15
申请号：PCT/US0316688
申请日：2003-05-28
申请人： MAXYGEN INC , PUNNONEN JUHA , APT DORIS , WHALEN ROBERT G
发明人： PUNNONEN JUHA , APT DORIS , WHALEN ROBERT G
IPC分类号： C07H21/04 , C07K14/18 , C12N15/85 , C12Q1/68 , C12N15/63 , A61K48/00 , C12N15/64
CPC分类号： C07K14/005 , A61K2039/53 , C12N15/85 , C12N2770/24122 , C12N2830/00 , C12N2830/15 , C12N2830/38 , C12N2840/20 , C12N2840/203
摘要： The invention relates to nucleic acid vectors useful for expression and production of polypeptides, compositions comprising vectors, and methods for the production and use of vectors and polypeptides.
摘要翻译：本发明涉及用于表达和产生多肽的核酸载体，包含载体的组合物，以及用于生产和使用载体和多肽的方法。

8. 发明申请

WO0200232A3 METHODS AND COMPOSITIONS FOR DEVELOPING SPORE DISPLAY SYSTEMS FOR MEDICINAL AND INDUSTRIAL APPLICATIONS 审中-公开
标题翻译：开发用于药物和工业应用的孢子展示系统的方法和组合物
公开(公告)号：WO0200232A3
公开(公告)日：2002-06-20
申请号：PCT/US0120372
申请日：2001-06-26
申请人： MAXYGEN INC , GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
发明人： GOLDMAN STANLEY , LATHROP STEPHANIE J , LONGCHAMP PASCAL F , WHALEN ROBERT G
IPC分类号： A61K39/385 , A61K48/00 , A61P37/00 , C07K14/14 , C07K14/24 , C12Q1/02 , G01N33/532 , A61K39/00 , A61K35/72 , A61K35/74
CPC分类号： C07K14/005 , A61K39/385 , A61K48/00 , A61K2039/523 , A61K2039/541 , A61K2039/6006 , A61K2039/6031 , C07K14/24 , C12N2720/12322 , C12Q1/02 , G01N33/532
摘要： Compositions and methods for utilizing spore systems for medicinal and industrial protein applications are provided. Compositions comprise spores that produce and/or display carbohydrates, proteins, and nucleic acids of interest. Such spores are useful as therapeutic or prophylactic agents or vaccines against a broad spectrum of immunogens and bacterial and viral pathogens. Additionally, spore systems are useful in production, packaging, delivery, and presentation of polypeptides and/or nucleic acids for industrial catalysts, medical applications, and diagnostic applications.
摘要翻译：提供了用于医药和工业蛋白质应用的孢子系统的组合物和方法。组合物包含产生和/或展示感兴趣的碳水化合物，蛋白质和核酸的孢子。这种孢子可用作针对广谱免疫原和细菌和病毒病原体的治疗剂或预防剂或疫苗。此外，孢子系统可用于工业催化剂，医学应用和诊断应用的多肽和/或核酸的生产，包装，递送和递呈。

9. 发明申请

WO2010118417A3 FOLDING PET STAIRCASE 审中-公开
公开(公告)号：WO2010118417A3
公开(公告)日：2010-10-14
申请号：PCT/US2010/030720
申请日：2010-04-12
申请人： WHALEN, Robert F.
发明人： WHALEN, Robert F.
IPC分类号： A01K29/00 , E04F11/06 , A61G1/013
摘要： A method and apparatus are provided, for allowing pets to ascend and descend on a foldable staircase having a plurality of stair treads operatively connected by articulating links in such a manner that the treads can be pivoted in unison from a stowed position of the staircase, in which the treads are substantially stacked upon one another, to a plurality of extended positions, in which the links position the treads in a spaced and parallel relationship to one another. A latch selectively secures the staircase in a selected one of the extended positions. The latch is configured for preventing further pivoting of the treads in either direction between the stowed and extended positions of the staircase, when the latch is engaged.

10. 发明申请

WO2009051750A1 SYSTEMS, METHODS AND APPARATUS FOR CALIBRATING DIFFERENTIAL AIR PRESSURE DEVICES 审中-公开
标题翻译：用于校准差压空气压力装置的系统，方法和装置
公开(公告)号：WO2009051750A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011807
申请日：2008-10-15
申请人： ALTERG, INC. , WHALEN, Sean, Tremaine , SHUGHART, Mark, Alan , SCHWANDT, Douglas, Frank , WHALEN, Robert, Tremaine , LIOU, Edward , MOORE, Fritz
发明人： WHALEN, Sean, Tremaine , SHUGHART, Mark, Alan , SCHWANDT, Douglas, Frank , WHALEN, Robert, Tremaine , LIOU, Edward , MOORE, Fritz
IPC分类号： A61H1/02
CPC分类号： A61H9/00 , A61F2007/0239 , A61H2009/0035 , A61H2201/5058 , A63B21/00181 , A63B22/0023 , A63B22/0056 , A63B22/0076 , A63B22/02 , A63B22/0605 , A63B22/18 , A63B2022/002 , A63B2071/0072 , A63B2208/0204 , A63B2208/0228 , A63B2208/0242 , A63B2208/053 , A63B2209/10 , A63B2220/20 , A63B2220/40 , A63B2220/805 , A63B2230/01 , A63B2230/06 , A63B2230/062 , A63B2230/30
摘要： Methods, apparatus, and systems for calibrating differential air pressure systems are described. The methods, apparatus, and systems may be adapted for physical training of an individual, e.g. as a training tool to improve performance or as a physical therapy tool for rehabilitation or strengthening. The differential air pressure systems comprise a chamber for receiving at least a portion of a user's body. In one embodiment, a method for calibrating a differential air pressure system for predicting effective body weight of a user versus system pressure is described. In certain variations, the methods, apparatus and systems may comprise adjusting pressure in the system until one or more force values are reached. The methods described herein may comprise determining a relationship between body weight force and pressure, allowing the user to set a pressure or a parameter correlated with pressure to achieve a desired effective body weight.
摘要翻译：描述用于校准差压气压系统的方法，装置和系统。方法，装置和系统可以适于个体的体育训练，例如，作为提高绩效或作为康复或加强的物理治疗工具的培训工具。差动空气压力系统包括用于容纳使用者身体的至少一部分的腔室。在一个实施例中，描述了用于校准用于预测用户的有效体重与差异系统压力的差分气压系统的方法。在某些变型中，方法，装置和系统可以包括调整系统中的压力，直到达到一个或多个力值。本文描述的方法可以包括确定体重力和压力之间的关系，允许使用者设定压力或与压力相关的参数以实现期望的有效体重。

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