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1. 发明申请

WO2005112792A3 LOCKING MECHANISMS FOR FIXATION DEVICES AND METHODS OF ENGAGING TISSUE 审中-公开
标题翻译：用于固定装置的锁定机构和接合组织的方法
公开(公告)号：WO2005112792A3
公开(公告)日：2006-03-23
申请号：PCT/US2005017178
申请日：2005-05-16
申请人： EVALVE INC , GOLDFARB ERIC A , SARABIA JAIME E , RASCHDORF ALFRED H , MADDEN JOHN P
发明人： GOLDFARB ERIC A , SARABIA JAIME E , RASCHDORF ALFRED H , MADDEN JOHN P
IPC分类号： A61B17/00 , A61B17/04 , A61B17/08 , A61B17/10 , A61B17/28
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供设备，系统和方法用于组织近似和修复治疗部位。特别地，提供了固定装置，其包括一对固定元件，每个固定元件具有第一端，与第一端相对的自由端和用于接合组织的接合表面，第一端可移动地联接在一起，使得固定元件在其中自由端间隔开的打开位置和闭合位置之间可移动，其中自由端通常彼此面对的接合表面更靠近在一起。固定装置还包括联接到固定元件的锁定机构，用于将固定元件锁定就位。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放性外科手术，并可用于各种解剖学领域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。

2. 发明申请

WO2005112792A2 LOCKING MECHANISMS FOR FIXATION DEVICES AND METHODS OF ENGAGING TISSUE 审中-公开
标题翻译：用于固定装置的锁定机构和接合组织的方法
公开(公告)号：WO2005112792A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017178
申请日：2005-05-16
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , SARABIA, Jaime, E. , RASCHDORF, Alfred, H. , MADDEN, John, P.
发明人： GOLDFARB, Eric, A. , SARABIA, Jaime, E. , RASCHDORF, Alfred, H. , MADDEN, John, P.
IPC分类号： A61B17/10
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供了设备，系统和方法用于治疗部位的组织近似和修复。特别地，提供固定装置，其包括一对固定元件，每个固定元件具有第一端，与第一端相对的自由端以及用于接合组织的接合表面，第一端可移动地联接在一起，使得固定元件在其中自由端间隔开的打开位置和闭合位置之间可移动，其中自由端与通常彼此面对的接合表面更靠近在一起。固定装置还包括联接到固定元件的锁定机构，用于将固定元件锁定就位。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放手术，并可用于各种解剖区域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。

3. 发明申请

WO1994003781A2 LIQUID VOLUME MEASURING APPARATUS 审中-公开
标题翻译：液体体积测量装置
公开(公告)号：WO1994003781A2
公开(公告)日：1994-02-17
申请号：PCT/IE1993000043
申请日：1993-07-30
申请人： BURGEE LIMITED , SISK, Henry, Benjamin , MADDEN, John, James , O'SULLIVAN, Niall, Anthony , COMERFORD, Kieran, Anthony , HOOD, Oliver, St. Clair
发明人： BURGEE LIMITED
IPC分类号： G01F19/00
CPC分类号： G01F17/00 , G01F19/00 , G01F23/0053 , G01F23/02 , G01F25/0084
摘要： Apparatus for determining deviation of a volume of liquid from a predetermined volume comprises a main vessel (4) for receiving the liquid and a measuring vessel (5) from which the deviation is determined from the meniscus of the liquid in the measuring vessel (5). A communicating tube (49) extending from a neck (32) of the main vessel (4) communicates the main vessel (4) with the secondary vessel (5) through a ball valve (56). Liquid above a weir (55) in the neck (32) flows into the measuring vessel (5). The deviation of the liquid volume is read from a scale (26) adjacent the measuring vessel (5). A variable volume bladder (71) completely filled with liquid alcohol is mounted in the main vessel (4) for compensating for volume changes in the main vessel (4) due to temperature variations.
摘要翻译：用于确定液体体积与预定体积的偏差的装置包括用于接收液体的主容器（4）和测量容器（5），从测量容器（5）中的液体的弯液面确定偏差，。从主容器（4）的颈部（32）延伸的连通管（49）通过球阀（56）将主容器（4）与次级容器（5）连通。颈部（32）中的堰（55）上方的液体流入测量容器（5）。从与测量容器（5）相邻的刻度（26）读取液体体积的偏差。完全充满液体醇的可变体积囊（71）安装在主容器（4）中，用于补偿主容器（4）中由于温度变化引起的体积变化。

4. 发明申请

WO2011113154A1 ELECTROCHEMICAL PHOTOVOLTAIC CELLS 审中-公开
标题翻译：电化学光电池
公开(公告)号：WO2011113154A1
公开(公告)日：2011-09-22
申请号：PCT/CA2011/000296
申请日：2011-03-18
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , TAKSHI, Arash , MADDEN, John D.W. , BEATTY, John T.
发明人： TAKSHI, Arash , MADDEN, John D.W. , BEATTY, John T.
IPC分类号： H01M14/00
CPC分类号： H01L51/424 , B82Y10/00 , H01G9/2059 , H01L51/0093 , H01M8/16 , H01M14/005 , Y02E10/542 , Y02E60/527
摘要： The invention provides a bio-photovoltaic device, in which a photoelectric center, exemplified by a biological photosynthetic reaction center (RC), is dispersed and mobile in a medium, such as an aqueous solution. The charges generated by the illuminated RC are transferred to electrodes via one or more mediators. In selected embodiments, the difference between the reaction rates of two types of mediator at the electrode surfaces, in conjunction with other charge transfer reaction equilibria, determines the direction of the photocurrent in the device. In an exemplified embodiment, the magnitude of the photocurrent is proportional to the incident light intensity, and the current increases nonlinearly with an increase in the RC concentration in the medium.
摘要翻译：本发明提供了一种生物光伏器件，其中由生物光合反应中心（RC）示例的光电中心在诸如水溶液的介质中分散和移动。由照明的RC产生的电荷通过一个或多个介质转移到电极。在选择的实施方案中，两种类型的介质在电极表面的反应速率与其它电荷转移反应平衡的反应速率之间的差异决定了器件中光电流的方向。在示例性实施例中，光电流的大小与入射光强成比例，并且电流随着介质中RC浓度的增加而非线性增加。

5. 发明申请

WO2006099744A1 THIN FILM FIELD EFFECT TRANSISTORS HAVING SCHOTTKY GATE-CHANNEL JUNCTIONS 审中-公开
标题翻译：具有肖特基通道通道的薄膜场效应晶体管
公开(公告)号：WO2006099744A1
公开(公告)日：2006-09-28
申请号：PCT/CA2006/000445
申请日：2006-03-24
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , TAKSHI, Arash , MADDEN, John
发明人： TAKSHI, Arash , MADDEN, John
IPC分类号： H01L29/47 , H01L51/10 , H01L29/786 , H01L29/772
CPC分类号： H01L51/0508 , H01L29/812
摘要： An active electronic device has drain and source electrodes that make ohmic conduct with a layer of a semiconductor. The semiconductor layer may be a thin layer of an organic or amorphous semiconductor. The drain and source electrodes are on a first face of the layer of semiconductor at locations that are spaced apart on either side of a channel. The device has a gate electrode on a second face of the layer of semiconductor adjacent to the channel. The gate electrode makes a Schottky contact with the semiconductor to produce a depletion region in the channel. The gate electrode may encapsulate the channel so that the channel is protected from contact with oxygen, water molecules or other materials in the environment. In some embodiments, the device has an additional gate electrode separated from the semiconductor layer by an insulating layer. Such embodiments combine features of OFETs and MESFETs.
摘要翻译：有源电子器件具有用半导体层形成欧姆导体的漏极和源极。半导体层可以是有机或非晶半导体的薄层。漏极和源电极位于半导体层的第一面上，在沟道的任一侧间隔开。器件在与沟道相邻的半导体层的第二面上具有栅电极。栅电极与半导体形成肖特基接触，以在沟道中产生耗尽区。栅电极可以封装通道，使得通道被保护以免与氧气，水分子或环境中的其它材料接触。在一些实施例中，器件具有通过绝缘层与半导体层分离的附加栅电极。这样的实施例组合OFET和MESFET的特征。

6. 发明申请

WO2006037073A3 METHODS AND DEVICES FOR TISSUE GRASPING AND ASSESSMENT 审中-公开
公开(公告)号：WO2006037073A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/034902
申请日：2005-09-27
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , THORNTON, Troy, L. , RASCHDORF, Alfred, H. , SARABIA, Jaime, E. , MADDEN, John, P. , POWELL, Ferolyn, T. , MARTIN, Brian, B. , WEN-CHIN FAN, Sylvia , KOMTEBEDDE, Jan , LIAO, Yen, C.
发明人： GOLDFARB, Eric, A. , THORNTON, Troy, L. , RASCHDORF, Alfred, H. , SARABIA, Jaime, E. , MADDEN, John, P. , POWELL, Ferolyn, T. , MARTIN, Brian, B. , WEN-CHIN FAN, Sylvia , KOMTEBEDDE, Jan , LIAO, Yen, C.
IPC分类号： A61F2/00
摘要： Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.

7. 发明申请

WO2008127514A1 BATTERY INCLUDING A FLUID MANAGER 审中-公开
标题翻译：电池包括流体管理器
公开(公告)号：WO2008127514A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/002671
申请日：2008-02-28
申请人： EVEREADY BATTERY COMPANY, INC. , BAILEY, John, C. , JONES, Steven, D. , LANGAN, Richard, A. , COLE, Matthew , MADDEN, John David, Wyndham
发明人： BAILEY, John, C. , JONES, Steven, D. , LANGAN, Richard, A. , COLE, Matthew , MADDEN, John David, Wyndham
IPC分类号： H01M12/06
CPC分类号： H01M8/04201 , H01M8/04089 , H01M12/065
摘要： An electrochemical cell having a fluid consuming electrode and a fluid regulating system for controlling the rate of entry of fluids into the cell. The fluid regulating system may include a valve for controlling the rate of entry of fluids into the cell and an actuator for operating the valve. The actuator comprises an ionic polymer that responds to changes in a potential applied across the actuator to open or close the valve. In one embodiment, the actuator comprises at least one conducting polymer. In one embodiment, the actuator comprises polypyrrole, at least one polypyrrole derivative, or mixtures of two of more thereof.
摘要翻译：一种具有流体消耗电极和流体调节系统的电化学电池，用于控制流体进入电池的速率。流体调节系统可以包括用于控制流体进入电池的速率的阀和用于操作阀的致动器。致动器包括离子聚合物，其响应施加在致动器上的电位的变化以打开或关闭阀。在一个实施例中，致动器包括至少一个导电聚合物。在一个实施方案中，致动器包括聚吡咯，至少一种聚吡咯衍生物，或其中两个以上的混合物。

8. 发明申请

WO2006037073A2 METHODS AND DEVICES FOR TISSUE GRASPING AND ASSESSMENT 审中-公开
标题翻译：用于组织成像和评估的方法和装置
公开(公告)号：WO2006037073A2
公开(公告)日：2006-04-06
申请号：PCT/US2005034902
申请日：2005-09-27
申请人： EVALVE INC , GOLDFARB ERIC A , THORNTON TROY L , RASCHDORF ALFRED H , SARABIA JAIME E , MADDEN JOHN P , POWELL FEROLYN T , MARTIN BRIAN B , WEN-CHIN FAN SYLVIA , KOMTEBEDDE JAN , LIAO YEN C
发明人： GOLDFARB ERIC A , THORNTON TROY L , RASCHDORF ALFRED H , SARABIA JAIME E , MADDEN JOHN P , POWELL FEROLYN T , MARTIN BRIAN B , WEN-CHIN FAN SYLVIA , KOMTEBEDDE JAN , LIAO YEN C
CPC分类号： A61B17/0401 , A61B17/08 , A61B17/29 , A61B17/3478 , A61B2017/00243 , A61B2017/00783 , A61B2017/081 , A61B2017/22088 , A61B2017/22089 , A61B2017/22098 , A61B2017/2825 , A61B2017/2926 , A61B2017/2931 , A61B2017/306 , A61B2090/3908 , A61B2090/3925
摘要： Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.
摘要翻译：提供的装置，系统和方法用于稳定和抓握诸如瓣叶的组织，评估这些组织的抓握，近似和固定组织，以及评估组织的固定以治疗心脏瓣膜反流，特别是二尖瓣反流。

9. 发明申请

WO2011143766A1 SYSTEM AND METHOD FOR GENERATING SUBNETS AND USING SUCH SUBNETS FOR CONTROLLING ACCESS TO WEB CONTENT 审中-公开
标题翻译：用于生成子网和使用这样的子网控制访问WEB内容的系统和方法
公开(公告)号：WO2011143766A1
公开(公告)日：2011-11-24
申请号：PCT/CA2011/000596
申请日：2011-05-20
申请人： SZETO, Timothy , MADDEN, John William
发明人： SZETO, Timothy , MADDEN, John William
IPC分类号： H04L12/24
CPC分类号： G06Q30/00 , G06F21/62 , G06F2221/2119
摘要： A system and a method are provided for generating a subnet and using the subnet to control access to web content. An Open Subnet (OSN) server is provided to receive proposed web pages to be added to a white list on the subnet, as well as votes from one or more users whether or not to add one or more of the web pages to the white list. A sync server is connected to the OSN through an intermediary. The sync server obtains a copy of the white list and, based on a user's license to the subnet, a user is allowed access to web pages on the white list.
摘要翻译：提供了一种用于生成子网并使用子网来控制对web内容的访问的系统和方法。提供开放子网（OSN）服务器以接收要添加到子网上的白名单的建议网页，以及来自一个或多个用户的投票，无论是否将一个或多个网页添加到白名单中。同步服务器通过中介连接到OSN。同步服务器获取白名单的副本，并且根据用户对该子网的许可，允许用户访问白名单上的网页。

10. 发明申请

WO2013116380A1 TISSUE NECROSIS METHODS AND APPARATUS 审中-公开
标题翻译：组织损伤方法和装置
公开(公告)号：WO2013116380A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/023915
申请日：2013-01-30
申请人： VYTRONUS, INC. , PEDERSON, Michael, J. , PHILLIPS, Patrick, J. , MADDEN, John, P. , HORZEWSKI, Michael, J.
发明人： PEDERSON, Michael, J. , PHILLIPS, Patrick, J. , MADDEN, John, P. , HORZEWSKI, Michael, J.
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B17/2202 , A61B17/3478 , A61B2017/22021 , A61B2018/00011 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61N7/022 , A61N2007/0043 , A61N2007/0052 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091 , A61N2007/0095
摘要： Apparatus and methods for creating tissue necrosis include an energy delivery apparatus that can be positioned adjacent a target treatment site such as a vessel without direct contact with the treatment site tissue. Collimated energy is then directed to the vessel to create necrotic regions in the tissue. Exemplary use in renal vessels creates necrotic regions in adjacent nerves which can alleviate hypertension in a patient.
摘要翻译：用于产生组织坏死的装置和方法包括能量输送装置，其能够定位在诸如血管的目标治疗部位附近而不与治疗部位组织直接接触。然后将准直的能量引导到血管以在组织中产生坏死区域。在肾血管中的示例性用途在相邻神经中产生可以减轻患者高血压的坏死区域。

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