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1. 发明申请

WO2004103162A3 FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE 审中-公开
公开(公告)号：WO2004103162A3
公开(公告)日：2004-12-02
申请号：PCT/US2004/015609
申请日：2004-05-18
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , RASCHDORF, Alfred, H. Jr. , SARABIA, Jaime, E. , FAN, Sylvia Wen Chin , DELL, Kent, D. , KOMTEBEDDE, Jan , POWELL, Ferolyn, T.
发明人： GOLDFARB, Eric, A. , RASCHDORF, Alfred, H. Jr. , SARABIA, Jaime, E. , FAN, Sylvia Wen Chin , DELL, Kent, D. , KOMTEBEDDE, Jan , POWELL, Ferolyn, T.
IPC分类号： A61B17/04
摘要： A fixation device (10) for engaging tissue (LF) comprising: a pair of fixation elements (16,18) each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between a closed position wherein the engagement surfaces face each other to an inverted position wherein the engagement surfaces face away from each other; and an actuation mechanism (12) coupled to the fixation elements adapted to move the fixation elements between the closed position and the inverted position.

2. 发明申请

WO2006047709A2 FIXATION DEVICES FOR VARIATION IN ENGAGEMENT OF TISSUE 审中-公开
标题翻译：用于组织参与变化的固定装置
公开(公告)号：WO2006047709A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038843
申请日：2005-10-25
申请人： EVALVE INC , GOLDFARB ERIC A , RASCHDORF ALFRED H JR , SARABIA JAIME E , FAN SYLVIA WEN CHIN , DELL KENT D , KOMTEBEDDE JAN , POWELL FEROLYN T
发明人： GOLDFARB ERIC A , RASCHDORF ALFRED H JR , SARABIA JAIME E , FAN SYLVIA WEN CHIN , DELL KENT D , KOMTEBEDDE JAN , POWELL FEROLYN T
IPC分类号： A61B17/08
CPC分类号： A61B17/1285 , A61B17/122 , A61B2017/00243 , A61B2017/00783 , A61B2017/081
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites, particularly in those procedures requiring minimally-invasive or endovascular access to remote tissue locations. Fixation devices are provided to fix tissue in approximation with the use of distal elements. In some embodiments, the fixation devices have at least two distal elements and an actuatable feature wherein actuation of the feature varies a dimension of the at least two distal elements. In other embodiments, the fixation devices have at least two pairs of distal elements wherein the pairs of distal elements are moveable to engage tissue between opposed pairs of distal elements. Systems are also provided comprising fixation devices and accessories.
摘要翻译：提供设备，系统和方法用于治疗部位的组织近似和修复，特别是在需要微创或血管内进入远程组织位置的那些程序中。提供固定装置以通过使用远端元件近似地固定组织。在一些实施例中，固定装置具有至少两个远侧元件和可致动特征，其中特征的致动改变至少两个远端元件的尺寸。在其它实施例中，固定装置具有至少两对远侧元件，其中远侧元件组可移动以在相对的远侧元件对之间接合组织。还提供了包括固定装置和附件的系统。

3. 发明申请

WO2006037073A2 METHODS AND DEVICES FOR TISSUE GRASPING AND ASSESSMENT 审中-公开
标题翻译：用于组织成像和评估的方法和装置
公开(公告)号：WO2006037073A2
公开(公告)日：2006-04-06
申请号：PCT/US2005034902
申请日：2005-09-27
申请人： EVALVE INC , GOLDFARB ERIC A , THORNTON TROY L , RASCHDORF ALFRED H , SARABIA JAIME E , MADDEN JOHN P , POWELL FEROLYN T , MARTIN BRIAN B , WEN-CHIN FAN SYLVIA , KOMTEBEDDE JAN , LIAO YEN C
发明人： GOLDFARB ERIC A , THORNTON TROY L , RASCHDORF ALFRED H , SARABIA JAIME E , MADDEN JOHN P , POWELL FEROLYN T , MARTIN BRIAN B , WEN-CHIN FAN SYLVIA , KOMTEBEDDE JAN , LIAO YEN C
CPC分类号： A61B17/0401 , A61B17/08 , A61B17/29 , A61B17/3478 , A61B2017/00243 , A61B2017/00783 , A61B2017/081 , A61B2017/22088 , A61B2017/22089 , A61B2017/22098 , A61B2017/2825 , A61B2017/2926 , A61B2017/2931 , A61B2017/306 , A61B2090/3908 , A61B2090/3925
摘要： Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.
摘要翻译：提供的装置，系统和方法用于稳定和抓握诸如瓣叶的组织，评估这些组织的抓握，近似和固定组织，以及评估组织的固定以治疗心脏瓣膜反流，特别是二尖瓣反流。

4. 发明申请

WO2004103162A2 FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE 审中-公开
标题翻译：固定装置，系统和方法用于组织组织
公开(公告)号：WO2004103162A2
公开(公告)日：2004-12-02
申请号：PCT/US2004015609
申请日：2004-05-18
申请人： EVALVE INC , GOLDFARB ERIC A , RASCHDORF ALFRED H JR , SARABIA JAIME E , FAN SYLVIA WEN CHIN , DELL KENT D , KOMTEBEDDE JAN , POWELL FEROLYN T
发明人： GOLDFARB ERIC A , RASCHDORF ALFRED H JR , SARABIA JAIME E , FAN SYLVIA WEN CHIN , DELL KENT D , KOMTEBEDDE JAN , POWELL FEROLYN T
IPC分类号： A61B20060101 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/128 , A61F2/24 , A61B
CPC分类号： A61B17/122 , A61B8/10 , A61B17/00234 , A61B17/04 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/0625 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/07207 , A61B17/08 , A61B17/10 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B50/30 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/00783 , A61B2017/00867 , A61B2017/0406 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0429 , A61B2017/0435 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/06057 , A61B2017/06076 , A61B2017/061 , A61B2017/06171 , A61B2017/0641 , A61B2017/088 , A61B2017/2908 , A61B2017/2926 , A61F2/24 , A61F2/2442 , A61F2/2445 , A61F2/2466 , A61M25/0136 , A61M25/0138 , A61M25/0147 , A61M25/02 , A61M2025/0161
摘要： The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues
摘要翻译：本发明提供了用于在治疗部位组织近似和修复的装置，系统和方法。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放性外科手术，并可用于各种解剖学领域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。此外，本发明的许多装置和系统适于在任何点处可逆地从患者移除，而不会干扰或损伤内部组织

5. 发明申请

WO2006037073A3 METHODS AND DEVICES FOR TISSUE GRASPING AND ASSESSMENT 审中-公开
公开(公告)号：WO2006037073A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/034902
申请日：2005-09-27
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , THORNTON, Troy, L. , RASCHDORF, Alfred, H. , SARABIA, Jaime, E. , MADDEN, John, P. , POWELL, Ferolyn, T. , MARTIN, Brian, B. , WEN-CHIN FAN, Sylvia , KOMTEBEDDE, Jan , LIAO, Yen, C.
发明人： GOLDFARB, Eric, A. , THORNTON, Troy, L. , RASCHDORF, Alfred, H. , SARABIA, Jaime, E. , MADDEN, John, P. , POWELL, Ferolyn, T. , MARTIN, Brian, B. , WEN-CHIN FAN, Sylvia , KOMTEBEDDE, Jan , LIAO, Yen, C.
IPC分类号： A61F2/00
摘要： Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.

6. 发明申请

WO2006047709A3 FIXATION DEVICES FOR VARIATION IN ENGAGEMENT OF TISSUE 审中-公开
公开(公告)号：WO2006047709A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038843
申请日：2005-10-25
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , RASCHDORF, Alfred, H., Jr. , SARABIA, Jaime, E. , FAN, Sylvia, Wen Chin , DELL, Kent, D. , KOMTEBEDDE, Jan , POWELL, Ferolyn, T.
发明人： GOLDFARB, Eric, A. , RASCHDORF, Alfred, H., Jr. , SARABIA, Jaime, E. , FAN, Sylvia, Wen Chin , DELL, Kent, D. , KOMTEBEDDE, Jan , POWELL, Ferolyn, T.
IPC分类号： A61M29/00
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites, particularly in those procedures requiring minimally-invasive or endovascular access to remote tissue locations. Fixation devices are provided to fix tissue in approximation with the use of distal elements. In some embodiments, the fixation devices have at least two distal elements and an actuatable feature wherein actuation of the feature varies a dimension of the at least two distal elements. In other embodiments, the fixation devices have at least two pairs of distal elements wherein the pairs of distal elements are moveable to engage tissue between opposed pairs of distal elements. Systems are also provided comprising fixation devices and accessories.

7. 发明申请

WO2005112792A3 LOCKING MECHANISMS FOR FIXATION DEVICES AND METHODS OF ENGAGING TISSUE 审中-公开
标题翻译：用于固定装置的锁定机构和接合组织的方法
公开(公告)号：WO2005112792A3
公开(公告)日：2006-03-23
申请号：PCT/US2005017178
申请日：2005-05-16
申请人： EVALVE INC , GOLDFARB ERIC A , SARABIA JAIME E , RASCHDORF ALFRED H , MADDEN JOHN P
发明人： GOLDFARB ERIC A , SARABIA JAIME E , RASCHDORF ALFRED H , MADDEN JOHN P
IPC分类号： A61B17/00 , A61B17/04 , A61B17/08 , A61B17/10 , A61B17/28
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供设备，系统和方法用于组织近似和修复治疗部位。特别地，提供了固定装置，其包括一对固定元件，每个固定元件具有第一端，与第一端相对的自由端和用于接合组织的接合表面，第一端可移动地联接在一起，使得固定元件在其中自由端间隔开的打开位置和闭合位置之间可移动，其中自由端通常彼此面对的接合表面更靠近在一起。固定装置还包括联接到固定元件的锁定机构，用于将固定元件锁定就位。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放性外科手术，并可用于各种解剖学领域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。

8. 发明申请

WO2005112792A2 LOCKING MECHANISMS FOR FIXATION DEVICES AND METHODS OF ENGAGING TISSUE 审中-公开
标题翻译：用于固定装置的锁定机构和接合组织的方法
公开(公告)号：WO2005112792A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017178
申请日：2005-05-16
申请人： EVALVE, INC. , GOLDFARB, Eric, A. , SARABIA, Jaime, E. , RASCHDORF, Alfred, H. , MADDEN, John, P.
发明人： GOLDFARB, Eric, A. , SARABIA, Jaime, E. , RASCHDORF, Alfred, H. , MADDEN, John, P.
IPC分类号： A61B17/10
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供了设备，系统和方法用于治疗部位的组织近似和修复。特别地，提供固定装置，其包括一对固定元件，每个固定元件具有第一端，与第一端相对的自由端以及用于接合组织的接合表面，第一端可移动地联接在一起，使得固定元件在其中自由端间隔开的打开位置和闭合位置之间可移动，其中自由端与通常彼此面对的接合表面更靠近在一起。固定装置还包括联接到固定元件的锁定机构，用于将固定元件锁定就位。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放手术，并可用于各种解剖区域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。

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