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1. 发明申请

WO2009046366A1 METHOD AND APPARATUS FOR PRESSURE ULCER PREVENTION AND TREATMENT 审中-公开
标题翻译：压力预防和治疗的方法和装置
公开(公告)号：WO2009046366A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078839
申请日：2008-10-03
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , KAPLAN, Hilton, M. , LOEB, Gerald, E.
发明人： KAPLAN, Hilton, M. , LOEB, Gerald, E.
IPC分类号： A61N1/00
CPC分类号： A61N1/36003 , A61N1/37205
摘要： Disclosed are methods and system of using wireless neuromuscular electrical stimulation of appropriate muscles to shift immobile patients from any posture. The methods and apparatus are extended to any immobile person, be it due to spinal cord injury, stroke, dementia, or from any other cause. Accordingly, generated pressure ulcers can be avoided or treated in any anatomic locations of the body based on the electrical stimulations of effective muscles relative to said location. Neuromuscular electrical stimulations of muscles would enable the immobile persons to shift their weight. Full body pressure ulcer prevention protocols using plurality of microstimulators that are implanted at plurality of target locations within the patient's body i.e. locations that are particularly at risk.
摘要翻译：公开了使用适当肌肉的无线神经肌肉电刺激从任何姿势移动不动的患者的方法和系统。方法和装置延伸到任何不动的人，无论是由于脊髓损伤，中风，痴呆或任何其他原因。因此，基于有效肌肉相对于所述位置的电刺激，可以在身体的任何解剖位置避免或治疗产生的压力性溃疡。肌肉的神经肌肉电刺激将使移动人员能够改变体重。使用多个微刺激器的全身压力溃疡预防方案，其植入患者身体内的多个目标位置，即特别处于危险中的位置。

2. 发明申请

WO1996034508A1 A MULTICHANNEL COCHLEAR PROSTHESIS WITH FLEXIBLE CONTROL OF STIMULUS WAVEFORMS 审中-公开
标题翻译：具有灵活波形控制的多通道耦合
公开(公告)号：WO1996034508A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005854
申请日：1996-04-23
申请人： ADVANCED BIONICS CORPORATION , LOEB, Gerald, E. , FALTYS, Michael, A.
发明人： ADVANCED BIONICS CORPORATION
IPC分类号： H04R25/00
CPC分类号： A61N1/36036
摘要： A method and system provides for a wide range of temporospatial patterns of electrical stimulation waveforms to be readily specified for respective channels of a multichannel cochlear prosthesis. The cochlear prosthesis includes: a speech processor system (10), and a cochlear stimulator (12). The speech processor system typically includes an external headpiece (14), including a microphone (18), coupled to a speech processor (16). The speech processor (16) includes electronic circuitry, typically including a microprocessor, that converts acoustical signals sensed through the microphone to electrical signals, and processes the electrical signals in accordance with a desired speech processing strategy. The definition of simple or complex stimulation waveforms to be used as part of the selected speech processing strategy is facilitated, in a preferred embodiment, through the use of a template table (e.g., Fig. 8) stored in the speech processor. The rows and columns of the template table define time intervals and stimulation channels (and hence stimulation sites). The individual cells of the template table are programmed, e.g., using a laptop computer (17), to contain selected alphanumeric codes or characters, including null characters, that define the polarity and relative magnitude of desired stimulation patterns and waveforms that are applied to the defined stimulation sites at the indicated frame times. Alternatively, the stimulation patterns and waveforms may be specified in a list of spatial/temporal events.
摘要翻译：一种方法和系统提供对多声道耳蜗假体的各个通道容易指定的电刺激波形的多种时空空间模式。耳蜗假体包括：语音处理器系统（10）和耳蜗刺激器（12）。语音处理器系统通常包括耦合到语音处理器（16）的包括麦克风（18）的外部头戴装置（14）。语音处理器（16）包括通常包括微处理器的电子电路，其将通过麦克风感测的声学信号转换为电信号，并根据期望的语音处理策略处理电信号。在优选实施例中，通过使用存储在语音处理器中的模板表（例如，图8），促进要用作所选语音处理策略的一部分的简单或复杂刺激波形的定义。模板表的行和列定义时间间隔和刺激通道（因此也是刺激位置）。模板表的各个单元格被编程，例如使用膝上型计算机（17）来包含所选择的字母数字代码或字符（包括空字符），其定义所期望的刺激模式的极性和相对幅度以及应用于在指定的帧时间定义的刺激位点。或者，可以在空间/时间事件的列表中指定刺激模式和波形。

3. 发明申请

WO2009124209A1 ROBUST MEASUREMENT OF SLIDING FRICTION-INDUCED VIBRATIONS FOR BIOMIMETIC TACTILE SENSING 审中-公开
标题翻译：用于生物动力学触觉的滑动摩擦诱导振动的稳健测量
公开(公告)号：WO2009124209A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039354
申请日：2009-04-02
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , LOEB, Gerald, E. , FISHEL, Jeremy , WETTELS, Nicholas , SANTOS, Veronica, J. , PECK, Raymond
发明人： LOEB, Gerald, E. , FISHEL, Jeremy , WETTELS, Nicholas , SANTOS, Veronica, J. , PECK, Raymond
IPC分类号： G01N21/77 , G01N21/78
CPC分类号： B25J13/084 , A61F2/586 , A61F2/68 , A61F2/76 , A61F2002/5001 , A61F2002/5061 , A61F2002/6827 , A61F2002/704 , A61F2002/745 , A61F2002/7635 , B25J13/083
摘要： Tactile sensors are disclosed that mimic the human fingertip and its touch receptors. The mechanical components are similar to a fingertip, with a rigid core surrounded by a weakly conductive fluid contained within an elastomeric skin. The deformable properties of the finger pad can be used as part of a transduction process. Multiple electrodes can be mounted on the surface of the rigid core and connected to impedance measuring circuitry within the core. External forces deform the fluid path around the electrodes, resulting in a distributed pattern of impedance changes containing information about those forces and the objects that applied them. Strategies are described for extracting features related to the mechanical inputs and using this information for reflexive grip control. Controlling grip force in a prosthetic having sensory feedback information is described. Pressure transducers can provide sensory feedback by measuring micro-vibrations due to sliding friction.
摘要翻译：公开了模仿人类指尖及其触觉受体的触觉传感器。机械部件类似于指尖，刚性芯由包含在弹性体皮肤内的弱导电流体包围。指垫的可变形特性可以用作转导过程的一部分。多个电极可以安装在刚性芯的表面上并连接到芯内的阻抗测量电路。外力使电极周围的流体路径变形，导致阻抗变化的分布式图案包含关于这些力和施加它们的物体的信息。描述了用于提取与机械输入相关的特征的策略，并将该信息用于反身式握持控制。描述了在具有感觉反馈信息的假肢中控制握力。压力传感器可以通过测量由于滑动摩擦引起的微振动来提供感官反馈。

4. 发明申请

WO2009023334A9 BIOMIMETIC TACTILE SENSOR FOR CONTROL OF GRIP 审中-公开
标题翻译：用于控制GRIP的生物触觉传感器
公开(公告)号：WO2009023334A9
公开(公告)日：2009-04-02
申请号：PCT/US2008063985
申请日：2008-05-16
申请人： UNIV SOUTHERN CALIFORNIA , JOHANSSON ROLAND S , LOEB GERALD E , WETTELS NICHOLAS , POPOVIC DJORDJE , SANTOS VERONICA J
发明人： JOHANSSON ROLAND S , LOEB GERALD E , WETTELS NICHOLAS , POPOVIC DJORDJE , SANTOS VERONICA J
IPC分类号： G01D7/00
CPC分类号： G01D5/2417 , B25J13/084 , G01L1/205 , G01L5/228
摘要： Disclosed is a robust tactile sensor array that mimics the human fingertip and its touch receptors. The mechanical components are similar to a fingertip, with a rigid core surrounded by a weakly conductive fluid contained within an elastomeric skin. It uses the deformable properties of the finger pad as part of the transduction process. Multiple electrodes are mounted on the surface of the rigid core and connected to impedance measuring circuitry within the core. External forces deform the fluid path around the electrodes, resulting in a distributed pattern of impedance changes containing information about those forces and the objects that applied them. Strategies for extracting features related to the mechanical inputs and using this information for reflexive grip control.
摘要翻译：公开了一种强大的触觉传感器阵列，其模拟人的指尖及其触觉受体。机械部件类似于指尖，刚性芯由包含在弹性体皮肤内的弱导电流体包围。它使用指垫的可变形特性作为转导过程的一部分。多个电极安装在刚性芯的表面上并连接到芯内的阻抗测量电路。外力使电极周围的流体路径变形，导致阻抗变化的分布式图案包含关于这些力和施加它们的物体的信息。用于提取与机械输入相关的功能的策略，并将此信息用于反身式握持控制。

5. 发明申请

WO2007028123A3 COCHLEAR IMPLANT FITTING 审中-公开
标题翻译： COCHLEAR植物配件
公开(公告)号：WO2007028123A3
公开(公告)日：2007-11-15
申请号：PCT/US2006034418
申请日：2006-09-01
申请人： ALFRED E MANN INST BIOMED ENG , LOEB GERALD E
发明人： LOEB GERALD E
IPC分类号： A61N1/00
CPC分类号： A61N1/36036 , H04R25/606
摘要： Systems and methods for fitting cochlear implants. The cochlear implant fitting systems and methods can be used to generate various stimulus patterns for fitting patients with speech processors for cochlear implants. The fitting systems and methods provide means to identify rapidly which of several speech processing strategies could function effectively in cochlear implant patients.
摘要翻译：适用于人工耳蜗植入的系统和方法。可以使用人工耳蜗植入装置系统和方法来产生各种刺激模式，以用于用耳蜗植入物的语音处理器来适应患者。拟合系统和方法提供了快速识别哪些语音处理策略可以在耳蜗植入患者中有效发挥作用的手段。

6. 发明申请

WO2007126854A3 BIOMIMETIC TACTILE SENSOR 审中-公开
公开(公告)号：WO2007126854A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/007631
申请日：2007-03-28
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , LOEB, Gerald, E. , JOHANSSON, Roland
发明人： LOEB, Gerald, E. , JOHANSSON, Roland
IPC分类号： G01D7/00
摘要： Disclosed is a tactile sensory system consisting of set of sensors that work by measuring impedance among plurality of electrodes. The electrodes are deployed on a substantially rigid structure that is protected form the direct contact with external objects by overlying deformable structures. These mechanical structures have similarities to the biological relationships among the distal phalanx, overlying finger pulp and covering skin and nail. Signal information is extracted form these sensors that is related to canonical physical representations used to describe stimuli to be sensed.

7. 发明申请

WO2007103204A2 INJECTION DEVICES FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：用于未定义目标位置测试的注射装置
公开(公告)号：WO2007103204A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005428
申请日：2007-03-01
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , KAPLAN, Hilton, M. , LOEB, Gerald, E.
发明人： KAPLAN, Hilton, M. , LOEB, Gerald, E.
IPC分类号： A61M25/14
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2090/034 , A61B2090/035 , A61B2090/3987 , A61N1/37205
摘要： Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.
摘要翻译：用于将植入物定位在身体中的目标位置的装置和方法。所述方法包括在目标位置的注射装置内测试植入物，以确定植入物是否有效地起作用。这些方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。该装置可以被配置为允许在植入期间相对于注射装置维持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。还可以包括配置用于注射装置中的植入物。

8. 发明申请

WO2006086581A3 BIOCHEMICAL MARKER DETECTION DEVICE 审中-公开
公开(公告)号：WO2006086581A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/004629
申请日：2006-02-09
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , LOEB, Gerald, E. , MARCU, Laura , KANG, Sanmao , LIAO, Kuo-Chih (Vincent)
发明人： LOEB, Gerald, E. , MARCU, Laura , KANG, Sanmao , LIAO, Kuo-Chih (Vincent)
IPC分类号： A61B5/00 , A61B10/00
摘要： A probe device for detecting chemotherapy effectiveness, and methods of use are disclosed. The device includes a fiber optic probe element that can be injected into a tumor. The probe element is connected to an external controlling/measurement element, which injects a reagent through the probe and into the tumor. The reagent reacts with biological markers indicative of chemotherapy effectiveness.

9. 发明申请

WO2006086578A1 INTERNAL BIOCHEMICAL SENSING DEVICE 审中-公开
标题翻译：内部生物传感装置
公开(公告)号：WO2006086578A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/004626
申请日：2006-02-08
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , LOEB, Gerald, E. , GEORGE, Thomas , BLANCO, Cesar , MARCU, Laura
发明人： LOEB, Gerald, E. , GEORGE, Thomas , BLANCO, Cesar , MARCU, Laura
CPC分类号： A61B5/14542 , A61B5/14532 , A61B5/1459 , A61B5/415 , A61B5/418 , G01N21/7703 , G01N2021/7786
摘要： A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer receives light from the reaction of fluorescent molecules in the biosensing element. The biosensing device can be used to detect and analyze the effectiveness of chemotherapy agents and molecules associated with various diseases.
摘要翻译：公开了用于检测生物分析物的生物传感装置及其使用和制造方法。该装置包括可长时间保持植入的生物传感元件。生物传感元件连接到终端外部的光纤。光纤也连接到信息分析仪。信息分析器从生物传感元件中的荧光分子的反应接收光。生物传感装置可用于检测和分析与各种疾病相关的化疗药物和分子的有效性。

10. 发明申请

WO03105668A3 INJECTION DEVICES AND METHODS FOR TESTING IMPLANTS AND FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：注入装置和测试植入物和无缝目标位置测试的方法
公开(公告)号：WO03105668A3
公开(公告)日：2004-03-25
申请号：PCT/US0318771
申请日：2003-06-12
申请人： ALFRED E MANN INST BIOMED ENG , KAPLAN HILTON M , LOEB GERALD E
发明人： KAPLAN HILTON M , LOEB GERALD E
IPC分类号： A61B17/34 , A61B19/00 , A61N1/05 , A61N1/08 , A61N1/372 , A61N1/04
CPC分类号： A61B17/3468 , A61B2090/3987 , A61N1/05 , A61N1/08 , A61N1/37205
摘要： The invention relates to devices and methods for positioning an implant (902) at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine if it is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device (900) may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. The invention also may include implants configured for use in the injection devices.
摘要翻译：本发明涉及用于将植入物（902）定位在体内目标位置的装置和方法。这些方法包括在目标位置的注射装置内测试植入物以确定其是否有效地起作用。所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。装置（900）可以被配置为允许在植入期间相对于注射装置维持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。本发明还可以包括被配置用于注射装置中的植入物。

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