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1. 发明申请

WO2007103204A3 INJECTION DEVICES FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：注射装置用于未定义的目标位置测试
公开(公告)号：WO2007103204A3
公开(公告)日：2008-01-24
申请号：PCT/US2007005428
申请日：2007-03-01
申请人： UNIV SOUTHERN CALIFORNIA , KAPLAN HILTON M , LOEB GERALD E
发明人： KAPLAN HILTON M , LOEB GERALD E
IPC分类号： A61N1/30
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2090/034 , A61B2090/035 , A61B2090/3987 , A61N1/37205
摘要： Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.
摘要翻译：用于将植入物定位在体内目标位置的装置和方法。所述方法包括在目标位置的注射装置内测试植入物以确定植入物是否有效地起作用。所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。该装置可以被配置为允许在植入期间相对于注射装置保持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。还可以包括配置用于注射装置中的植入物。

2. 发明申请

WO2003105668A2 INJECTION DEVICES AND METHODS FOR TESTING IMPLANTS AND FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：注入装置和测试植入物和无缝目标位置测试的方法
公开(公告)号：WO2003105668A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018771
申请日：2003-06-12
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , KAPLAN, Hilton, M. , LOEB, Gerald, E.
发明人： KAPLAN, Hilton, M. , LOEB, Gerald, E.
IPC分类号： A61B
CPC分类号： A61B17/3468 , A61B2090/3987 , A61N1/05 , A61N1/08 , A61N1/37205
摘要： The invention relates to devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. The invention also may include implants configured for use in the injection devices.
摘要翻译：本发明涉及用于将植入物定位在体内目标位置的装置和方法。所述方法包括在目标位置的注射装置内测试植入物以确定植入物是否有效地起作用。所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。该装置可以被配置为允许在植入期间相对于注射装置保持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。本发明还可以包括被配置用于注射装置中的植入物。

3. 发明申请

WO2009046366A1 METHOD AND APPARATUS FOR PRESSURE ULCER PREVENTION AND TREATMENT 审中-公开
标题翻译：压力预防和治疗的方法和装置
公开(公告)号：WO2009046366A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078839
申请日：2008-10-03
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA , KAPLAN, Hilton, M. , LOEB, Gerald, E.
发明人： KAPLAN, Hilton, M. , LOEB, Gerald, E.
IPC分类号： A61N1/00
CPC分类号： A61N1/36003 , A61N1/37205
摘要： Disclosed are methods and system of using wireless neuromuscular electrical stimulation of appropriate muscles to shift immobile patients from any posture. The methods and apparatus are extended to any immobile person, be it due to spinal cord injury, stroke, dementia, or from any other cause. Accordingly, generated pressure ulcers can be avoided or treated in any anatomic locations of the body based on the electrical stimulations of effective muscles relative to said location. Neuromuscular electrical stimulations of muscles would enable the immobile persons to shift their weight. Full body pressure ulcer prevention protocols using plurality of microstimulators that are implanted at plurality of target locations within the patient's body i.e. locations that are particularly at risk.
摘要翻译：公开了使用适当肌肉的无线神经肌肉电刺激从任何姿势移动不动的患者的方法和系统。方法和装置延伸到任何不动的人，无论是由于脊髓损伤，中风，痴呆或任何其他原因。因此，基于有效肌肉相对于所述位置的电刺激，可以在身体的任何解剖位置避免或治疗产生的压力性溃疡。肌肉的神经肌肉电刺激将使移动人员能够改变体重。使用多个微刺激器的全身压力溃疡预防方案，其植入患者身体内的多个目标位置，即特别处于危险中的位置。

4. 发明申请

WO2009059064A1 A LONG-ACTING, WATERPROOF OR WATER-RESISTANT, TOPICAL SUN PROTECTION AGENT WITH ACTIVITY UP TO WEEKS 审中-公开
标题翻译：长效，防水或防水，具有活性的季节性防晒剂
公开(公告)号：WO2009059064A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/081876
申请日：2008-10-30
申请人： SPHJK, INC. , KAPLAN, Hilton, M. , KENNER, Julie, R.
发明人： KAPLAN, Hilton, M. , KENNER, Julie, R.
IPC分类号： A61K8/81 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/8152 , A61K8/8158
摘要： Disclosed herein are compositions for use as a sunscreen or sunblock which, in some embodiments, may provide long-acting, waterproof or water-resistant, broad spectrum topical sun protection with activity up to weeks without reappli cation. In some embodiments, the compositions may include a base and one or more active ingredients. In some embodiments, the base may include an adhesive component, which upon application to a user's skin, adheres the base to the user's skin. In some embodiments, the adhesive component is adapted to hold the active ingredients on the user's skin for at least about 8 hours, such as at least about 24 hours, such as at least about 3 days, or even at least about 2 weeks. Furthermore, in some embodiments, the composition may be waterproof or water-resistant, In some embodiments, the one or more active ingredients may include a photodamage protective ingredient, and/or a photodamage reparative ingredient.
摘要翻译：本文公开了用作防晒剂或防晒剂的组合物，其在一些实施方案中可以提供长效，防水或防水的广谱局部防晒剂，其活性高达数周，无需重新施用。在一些实施方案中，组合物可以包括碱和一种或多种活性成分。在一些实施方案中，基底可以包括粘合剂组分，其在施用于使用者的皮肤时将基底粘附到使用者的皮肤上。在一些实施方案中，粘合剂组分适于将活性成分保持在使用者的皮肤上至少约8小时，例如至少约24小时，例如至少约3天，或甚至至少约2周。此外，在一些实施方案中，组合物可以是防水的或防水的。在一些实施方案中，一种或多种活性成分可以包括光损伤保护成分和/或光损伤修复成分。

5. 发明申请

WO2005007237A1 METHOD AND APPARATUS FOR THE TREATMENT OF URINARY TRACT DYSFUNCTION 审中-公开
标题翻译：治疗尿路性功能障碍的方法和装置
公开(公告)号：WO2005007237A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/022587
申请日：2004-07-12
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , LOEB, Gerald, E. , KAPLAN, Hilton, M.
发明人： LOEB, Gerald, E. , KAPLAN, Hilton, M.
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： The subject invention teaches the use of electrical stimulation of specific sensory nerves to control the filling and/or emptying of the urinary bladder. A wireless, injectable microstimulator (9) is implanted into the soft tissues through which the sensory nerves pass. The sensory nerves supplying the proximal urethra are stimulated by a microstimulator implanted adjacent to the prostatic urethra within the substance of the prostate gland in males, and distal to the bladder neck in females. The activity induced in these nerves causes the spinal cord to generate reflex responses that result in contractions of the detrusor muscle and relaxation of the sphincter, emptying the bladder.
摘要翻译：本发明教导了使用特定感觉神经的电刺激来控制膀胱的填充和/或排空。将无线注射微型刺激器（9）植入到感觉神经通过的软组织中。供应近端尿道的感觉神经通过在雄性前列腺的物质内和雌性膀胱颈远端的前列腺尿道附近植入的微型刺激器来刺激。在这些神经中诱导的活动导致脊髓产生反射反应，导致逼尿肌的收缩和括约肌的松弛，排空膀胱。

6. 发明申请

WO2007103204A2 INJECTION DEVICES FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：用于未定义目标位置测试的注射装置
公开(公告)号：WO2007103204A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005428
申请日：2007-03-01
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , KAPLAN, Hilton, M. , LOEB, Gerald, E.
发明人： KAPLAN, Hilton, M. , LOEB, Gerald, E.
IPC分类号： A61M25/14
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2090/034 , A61B2090/035 , A61B2090/3987 , A61N1/37205
摘要： Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.
摘要翻译：用于将植入物定位在身体中的目标位置的装置和方法。所述方法包括在目标位置的注射装置内测试植入物，以确定植入物是否有效地起作用。这些方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。该装置可以被配置为允许在植入期间相对于注射装置维持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。还可以包括配置用于注射装置中的植入物。

7. 发明申请

WO03105668A3 INJECTION DEVICES AND METHODS FOR TESTING IMPLANTS AND FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：注入装置和测试植入物和无缝目标位置测试的方法
公开(公告)号：WO03105668A3
公开(公告)日：2004-03-25
申请号：PCT/US0318771
申请日：2003-06-12
申请人： ALFRED E MANN INST BIOMED ENG , KAPLAN HILTON M , LOEB GERALD E
发明人： KAPLAN HILTON M , LOEB GERALD E
IPC分类号： A61B17/34 , A61B19/00 , A61N1/05 , A61N1/08 , A61N1/372 , A61N1/04
CPC分类号： A61B17/3468 , A61B2090/3987 , A61N1/05 , A61N1/08 , A61N1/37205
摘要： The invention relates to devices and methods for positioning an implant (902) at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine if it is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device (900) may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. The invention also may include implants configured for use in the injection devices.
摘要翻译：本发明涉及用于将植入物（902）定位在体内目标位置的装置和方法。这些方法包括在目标位置的注射装置内测试植入物以确定其是否有效地起作用。所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。装置（900）可以被配置为允许在植入期间相对于注射装置维持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。本发明还可以包括被配置用于注射装置中的植入物。

8. 发明申请

WO2012138368A1 DEVICES, COMPOSITIONS AND METHODS UTILIZING EP4 AND EP2 RECEPTOR AGONISTS FOR PREVENTING, REDUCING OR TREATING CAPSULAR CONTRACTURE 审中-公开
标题翻译：使用EP4和EP2受体激动剂的装置，组合物和方法，用于预防，减少或治疗CAPSULAR合同
公开(公告)号：WO2012138368A1
公开(公告)日：2012-10-11
申请号：PCT/US2011/045855
申请日：2011-07-29
申请人： ALLERGAN, INC. , JIANG, Guang-Liang , IM, Wha Bin , BEDDINGFIELD, Frederick C. , WHEELER, Larry A. , WHITCUP, Scott M. , AHLUWALIA, Gurpreet , KAPLAN, Hilton M.
发明人： JIANG, Guang-Liang , IM, Wha Bin , BEDDINGFIELD, Frederick C. , WHEELER, Larry A. , WHITCUP, Scott M. , AHLUWALIA, Gurpreet , KAPLAN, Hilton M.
IPC分类号： A61L15/40 , A61L27/34 , A61L27/54
CPC分类号： A61L15/44 , A61L15/40 , A61L27/34 , A61L27/54 , A61L2300/436 , A61L2430/04 , C08L89/00
摘要： Provided are devices, compositions and methods utilizing EP 4 and EP 2 receptor agonists for preventing, reducing, or treating capsular contracture occurring in response to the implantation of breast prostheses.
摘要翻译：提供了利用EP4和EP2受体激动剂预防，减少或治疗响应于乳房假体植入而发生的荚膜挛缩的装置，组合物和方法。

9. 发明申请

WO2007103204A9 INJECTION DEVICES FOR UNIMPEDED TARGET LOCATION TESTING 审中-公开
标题翻译：用于无人目标位置测试的注射装置
公开(公告)号：WO2007103204A9
公开(公告)日：2007-11-01
申请号：PCT/US2007005428
申请日：2007-03-01
申请人： UNIV SOUTHERN CALIFORNIA , KAPLAN HILTON M , LOEB GERALD E
发明人： KAPLAN HILTON M , LOEB GERALD E
IPC分类号： A61M25/14
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2090/034 , A61B2090/035 , A61B2090/3987 , A61N1/37205
摘要： Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.
摘要翻译：用于将植入物定位在身体中的目标位置的装置和方法。该方法包括在目标位置处的注射装置内测试植入物以确定植入物是否有效地起作用。该方法还包括在植入期间从目标位置测试材料或将材料递送到目标位置，并加载注射装置以供使用。该装置可以构造成允许在植入期间相对于注射装置保持植入物的纵向和/或轴向位置。该装置也可以被配置成允许测试植入物。也可以包括配置用于注射装置的植入物。

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