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1. 发明申请

WO2012145263A3 HIGH EFFICIENCY COOLING SYSTEM 审中-公开
标题翻译：高效冷却系统
公开(公告)号：WO2012145263A3
公开(公告)日：2013-01-24
申请号：PCT/US2012033740
申请日：2012-04-16
申请人： LIEBERT CORP , JUDGE JOHN F , SCHRADER TIMOTHY J , SILLATO STEPHEN , NOLL ROGER , HELMINK GARY A , BARBATO PIERPAOLO , MANA GIUSEPPE DALLA , MONNIER LOU , LIN ZHIYONG , DOLCICH BENEDICT J , SCHUTTE DANIEL J , HAGGY GREG , HARVEY THOMAS , LU ZONGTAO
发明人： JUDGE JOHN F , SCHRADER TIMOTHY J , SILLATO STEPHEN , NOLL ROGER , HELMINK GARY A , BARBATO PIERPAOLO , MANA GIUSEPPE DALLA , MONNIER LOU , LIN ZHIYONG , DOLCICH BENEDICT J , SCHUTTE DANIEL J , HAGGY GREG , HARVEY THOMAS , LU ZONGTAO
IPC分类号： H05K7/20
CPC分类号： H05K7/20836 , F24F1/022 , F24F3/044 , F24F11/46 , F25B25/00 , F25B41/00 , F25B41/043 , F25B45/00 , F25B49/02 , F25B49/022 , F25B2400/06 , F25B2400/0751 , F25B2500/31 , F25D17/06 , H05K7/20827
摘要： A cooling system has a cabinet and a plurality of separate cooling stages including an upstream cooling stage and a downstream cooling stage. At least the upstream cooling state is a variable capacity cooling stage. Each cooling stage has a cooling circuit. Evaporators of the cooling circuits are arranged in the cabinet so that air passes over them in serial fashion. A controller when a Call for Cooling first reaches a point where cooling is needed, operating the upstream cooling circuit to provide cooling and not the downstream cooling circuit. When the Call for Cooling has increased to a second point, the controller additionally operates the downstream cooling circuit to provide cooling. The cooling capacity at which the upstream cooling circuit is being operated is less than its full capacity when the Call for Cooling reaches the second point.
摘要翻译：冷却系统具有机柜和多个单独的冷却级，其包括上游冷却级和下游冷却级。至少上游冷却状态是可变容量冷却阶段。每个冷却阶段都有一个冷却回路。冷却回路的蒸发器布置在机柜中，使得空气以串联方式通过它们。当冷却呼叫首先到达需要冷却的点时，控制器操作上游冷却回路以提供冷却而不是下游冷却回路。当冷却呼叫增加到第二点时，控制器另外操作下游冷却回路以提供冷却。上游冷却回路正在运行的制冷量小于其致冷要求到达第二点的满容量。

2. 发明申请

WO2006069000A3 KLF2 AS A MEDIATOR OF STATIN ACTIVITY 审中-公开
标题翻译： KLF2作为人体活动的中介者
公开(公告)号：WO2006069000A3
公开(公告)日：2007-08-09
申请号：PCT/US2005045946
申请日：2005-12-20
申请人： BRIGHAM & WOMENS HOSPITAL , JAIN MUKESH K , SENBANERJEE SUCHARITA , BANERJEE PALLAB , LIN ZHIYONG , GARCIA-CARDENA GILLERMO , GIMBRONE MICHAEL A JR
发明人： JAIN MUKESH K , SENBANERJEE SUCHARITA , BANERJEE PALLAB , LIN ZHIYONG , GARCIA-CARDENA GILLERMO , GIMBRONE MICHAEL A JR
IPC分类号： C12Q1/68 , A61K38/00 , C12N15/00
CPC分类号： C12Q1/6876 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5064 , G01N33/6875
摘要： The present invention is directed to methods for identifying compounds that mimic or inhibit the therapeutic effect of statins. The compounds are identified using assays of the transcription factor KLF2. The invention also includes methods for creating or identifying endothelial cells with low KLF2 activity which will be resistant to statin treatment and for increasing KLF2 activity by transfecting cells with expression vectors.
摘要翻译：本发明涉及用于鉴定模仿或抑制他汀类药物治疗效果的化合物的方法。使用转录因子KLF2的测定法鉴定化合物。本发明还包括用于产生或鉴定具有低的他汀类药物治疗抗性的KLF2活性低的内皮细胞和通过用表达载体转染细胞增加KLF2活性的方法。

3. 发明申请

WO2006069000A2 KLF2 AS A MEDIATOR OF STATIN ACTIVITY 审中-公开
标题翻译： KLF2作为人体活动的中介者
公开(公告)号：WO2006069000A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/045946
申请日：2005-12-20
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , JAIN, Mukesh K. , SENBANERJEE, Sucharita , BANERJEE, Pallab , LIN, Zhiyong , GARCIA-CARDENA, Gillermo , GIMBRONE, Michael A. Jr.
发明人： JAIN, Mukesh K. , SENBANERJEE, Sucharita , BANERJEE, Pallab , LIN, Zhiyong , GARCIA-CARDENA, Gillermo , GIMBRONE, Michael A. Jr.
CPC分类号： C12Q1/6876 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5064 , G01N33/6875
摘要： The present invention is directed to methods for identifying compounds that mimic or inhibit the therapeutic effect of statins. The compounds are identified using assays of the transcription factor KLF2. The invention also includes methods for creating or identifying endothelial cells with low KLF2 activity which will be resistant to statin treatment and for increasing KLF2 activity by transfecting cells with expression vectors.
摘要翻译：本发明涉及用于鉴定模仿或抑制他汀类药物治疗效果的化合物的方法。使用转录因子KLF2的测定法鉴定化合物。本发明还包括用于产生或鉴定具有低的他汀类药物治疗抗性的KLF2活性低的内皮细胞和通过用表达载体转染细胞增加KLF2活性的方法。

4. 发明申请

WO2012145263A2 HIGH EFFICIENCY COOLING SYSTEM 审中-公开
标题翻译：高效冷却系统
公开(公告)号：WO2012145263A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/033740
申请日：2012-04-16
申请人： LIEBERT CORPORATION , JUDGE, John F. , SCHRADER, Timothy J. , SILLATO, Stephen , NOLL, Roger , HELMINK, Gary A. , BARBATO, Pierpaolo , MANA, Giuseppe Dalla , MONNIER, Lou , LIN, Zhiyong , DOLCICH, Benedict J. , SCHUTTE, Daniel J. , HAGGY, Greg , HARVEY, Thomas , LU, Zongtao
发明人： JUDGE, John F. , SCHRADER, Timothy J. , SILLATO, Stephen , NOLL, Roger , HELMINK, Gary A. , BARBATO, Pierpaolo , MANA, Giuseppe Dalla , MONNIER, Lou , LIN, Zhiyong , DOLCICH, Benedict J. , SCHUTTE, Daniel J. , HAGGY, Greg , HARVEY, Thomas , LU, Zongtao
IPC分类号： H05K7/20
CPC分类号： H05K7/20836 , F24F1/022 , F24F3/044 , F24F11/46 , F25B25/00 , F25B41/00 , F25B41/043 , F25B45/00 , F25B49/02 , F25B49/022 , F25B2400/06 , F25B2400/0751 , F25B2500/31 , F25D17/06 , H05K7/20827
摘要： A cooling system has a cabinet and a plurality of separate cooling stages including an upstream cooling stage and a downstream cooling stage. At least the upstream cooling state is a variable capacity cooling stage. Each cooling stage has a cooling circuit. Evaporators of the cooling circuits are arranged in the cabinet so that air passes over them in serial fashion. A controller when a Call for Cooling first reaches a point where cooling is needed, operating the upstream cooling circuit to provide cooling and not the downstream cooling circuit. When the Call for Cooling has increased to a second point, the controller additionally operates the downstream cooling circuit to provide cooling. The cooling capacity at which the upstream cooling circuit is being operated is less than its full capacity when the Call for Cooling reaches the second point.
摘要翻译：冷却系统具有机柜和多个单独的冷却级，包括上游冷却级和下游冷却级。至少上游冷却状态是可变容量冷却阶段。每个冷却阶段都有一个冷却回路。冷却回路的蒸发器布置在机柜中，使得空气以串联的方式穿过它们。当冷却呼叫首先到达需要冷却的点时，控制器操作上游冷却回路以提供冷却而不是下游冷却回路。当冷却呼叫增加到第二点时，控制器另外操作下游冷却回路以提供冷却。上游冷却回路正在运行的冷却能力小于其致冷要求达到第二点的全部容量。

5. 发明申请

WO03011118A3 HUMAN ZONA PELLUCIDA PROTEINS AND METHODS OF THEIR USE IN DIAGNOSING MALE INFERTILITY 审中-公开
标题翻译：人类ZONA PELLUCIDA蛋白及其在诊断男性不孕症中的用途
公开(公告)号：WO03011118A3
公开(公告)日：2003-07-31
申请号：PCT/US0224360
申请日：2002-08-01
申请人： TRINITY BIOMEDICAL TECHNOLOGY , CHI TING-FUNG , LIN ZHIYONG , DONG KEWEN , HSU MING-I , CHENG JR-GANG , ZHENG HEMING
发明人： CHI TING-FUNG , LIN ZHIYONG , DONG KEWEN , HSU MING-I , CHENG JR-GANG , ZHENG HEMING
IPC分类号： A61K38/17 , C07K14/705 , C07K17/00 , G01N33/50 , G01N33/533 , G01N33/569 , G01N33/68 , C07K1/00 , C07H21/04 , C07K4/00 , C12P21/06
CPC分类号： C07K14/705 , G01N33/56966 , G01N33/689 , G01N2800/367
摘要： Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2-ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.
摘要翻译：描述了对生育力测试有用的试剂，方法和试剂盒，并且在许多情况下提供了更快，更方便和更快捷地测定男性不育的方法。所述试剂包括适当糖基化的人ZP3，ZP2，ZP1，其糖基化肽，融合蛋白例如绿色荧光蛋白ZP3，ZP2与ZP3的非共价复合物，ZP2-ZP3的融合蛋白，固相材料例如琼脂糖珠用结合剂如ZP3和其他人工透明带。提供的方法在许多情况下将复杂的生物事件转化为基于一种或多种试剂的定义明确的生物化学结合事件。这种方法更容易设置和监测，从而为男性生育提供更方便和便宜的诊断测试。顶体反应在其他实施方案中通过定量一种或多种释放物质来检测。还提供了包含一种或多种可用于在诊断实验室或其他设施进行检测的试剂的试剂盒。

6. 发明申请

WO2003011118A2 HUMAN ZONA PELLUCIDA PROTEINS AND METHODS OF THEIR USE IN DIAGNOSING MALE INFERTILITY 审中-公开
标题翻译：人类ZONA PELLUCIDA蛋白及其用于诊断男性感染的方法
公开(公告)号：WO2003011118A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024360
申请日：2002-08-01
申请人： TRINITY BIOMEDICAL TECHNOLOGY CORPORATION , CHI, Ting-Fung , LIN, Zhiyong , DONG, Kewen , HSU, Ming-I , CHENG, Jr-Gang , ZHENG, Heming
发明人： CHI, Ting-Fung , LIN, Zhiyong , DONG, Kewen , HSU, Ming-I , CHENG, Jr-Gang , ZHENG, Heming
IPC分类号： A61B
CPC分类号： C07K14/705 , G01N33/56966 , G01N33/689 , G01N2800/367
摘要： Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2-ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.
摘要翻译：描述了可用于生殖力测试的试剂，方法和试剂盒，并且在许多情况下提供更快，更方便和快速测定男性不育症。所述试剂包括适当的糖基化人ZP3，ZP2，ZP1，其糖基化肽，融合蛋白如绿色荧光蛋白ZP3，ZP2与ZP3的非共价复合物，ZP2-ZP3的融合蛋白，固相物质如琼脂糖珠涂覆具有粘合剂如ZP3和其他人造Zona。提供的方法是，在许多情况下，基于一种或多种试剂将复杂生物事件转化为明确定义的生物化学结合事件。这种方法更易于建立和监测，为男性生育提供更方便和便宜的诊断测试。在其它实施方案中，通过定量一种或多种释放物质来检测顶体反应。还提供了包含一种或多种可用于在诊断实验室或其他设施进行测试的试剂的试剂盒。

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