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    • 6. 发明申请
    • HUMAN ZONA PELLUCIDA PROTEINS AND METHODS OF THEIR USE IN DIAGNOSING MALE INFERTILITY
    • 人类ZONA PELLUCIDA蛋白及其用于诊断男性感染的方法
    • WO2003011118A2
    • 2003-02-13
    • PCT/US2002/024360
    • 2002-08-01
    • TRINITY BIOMEDICAL TECHNOLOGY CORPORATIONCHI, Ting-FungLIN, ZhiyongDONG, KewenHSU, Ming-ICHENG, Jr-GangZHENG, Heming
    • CHI, Ting-FungLIN, ZhiyongDONG, KewenHSU, Ming-ICHENG, Jr-GangZHENG, Heming
    • A61B
    • C07K14/705G01N33/56966G01N33/689G01N2800/367
    • Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2-ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.
    • 描述了可用于生殖力测试的试剂,方法和试剂盒,并且在许多情况下提供更快,更方便和快速测定男性不育症。 所述试剂包括适当的糖基化人ZP3,ZP2,ZP1,其糖基化肽,融合蛋白如绿色荧光蛋白ZP3,ZP2与ZP3的非共价复合物,ZP2-ZP3的融合蛋白,固相物质如琼脂糖珠涂覆 具有粘合剂如ZP3和其他人造Zona。 提供的方法是,在许多情况下,基于一种或多种试剂将复杂生物事件转化为明确定义的生物化学结合事件。 这种方法更易于建立和监测,为男性生育提供更方便和便宜的诊断测试。 在其它实施方案中,通过定量一种或多种释放物质来检测顶体反应。 还提供了包含一种或多种可用于在诊断实验室或其他设施进行测试的试剂的试剂盒。