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1. 发明申请

WO2005092346A1 USING COMBINATION OF ESTROGEN AND PROGESTIN WITH ULTRA LOW DOSE FOR LONG TERM ORAL CONTRACEPTION 审中-公开
标题翻译：使用雌激素和孕激素与超低剂量长期口服合同的联合
公开(公告)号：WO2005092346A1
公开(公告)日：2005-10-06
申请号：PCT/CN2004/000348
申请日：2004-04-14
申请人： DONG, Kejuan , DONG, Kewen
发明人： DONG, Kewen
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K31/565 , A61K31/567
摘要： A method for female oral contraception involves administering a combination of estrogen and progestin for 180-364 consecutive days following by non-administration for a period of 3-5 days maximum. An ultra low dose of the estrogen and progestin will be used. The daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.050 to 0.150 mg of levonorgestrel respectively. The advantages of this method include less anaemia, less menstrual bleeding, less total exposure to medication, more convenience and higher compliance rates for patients.
摘要翻译：一种女性口服避孕方法，包括连续180-364天连续施用雌激素和孕激素的组合，然后通过非给药持续3-5天的时间。将使用超低剂量的雌激素和孕激素。雌激素和孕激素的每日量分别等于约5-35mcg的乙炔雌二醇和约0.050至0.150mg的左炔诺孕酮。这种方法的优点包括贫血少，月经量少，药物总暴露少，患者更容易和更高的依从性。

2. 发明申请

WO03011118A3 HUMAN ZONA PELLUCIDA PROTEINS AND METHODS OF THEIR USE IN DIAGNOSING MALE INFERTILITY 审中-公开
标题翻译：人类ZONA PELLUCIDA蛋白及其在诊断男性不孕症中的用途
公开(公告)号：WO03011118A3
公开(公告)日：2003-07-31
申请号：PCT/US0224360
申请日：2002-08-01
申请人： TRINITY BIOMEDICAL TECHNOLOGY , CHI TING-FUNG , LIN ZHIYONG , DONG KEWEN , HSU MING-I , CHENG JR-GANG , ZHENG HEMING
发明人： CHI TING-FUNG , LIN ZHIYONG , DONG KEWEN , HSU MING-I , CHENG JR-GANG , ZHENG HEMING
IPC分类号： A61K38/17 , C07K14/705 , C07K17/00 , G01N33/50 , G01N33/533 , G01N33/569 , G01N33/68 , C07K1/00 , C07H21/04 , C07K4/00 , C12P21/06
CPC分类号： C07K14/705 , G01N33/56966 , G01N33/689 , G01N2800/367
摘要： Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2-ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.
摘要翻译：描述了对生育力测试有用的试剂，方法和试剂盒，并且在许多情况下提供了更快，更方便和更快捷地测定男性不育的方法。所述试剂包括适当糖基化的人ZP3，ZP2，ZP1，其糖基化肽，融合蛋白例如绿色荧光蛋白ZP3，ZP2与ZP3的非共价复合物，ZP2-ZP3的融合蛋白，固相材料例如琼脂糖珠用结合剂如ZP3和其他人工透明带。提供的方法在许多情况下将复杂的生物事件转化为基于一种或多种试剂的定义明确的生物化学结合事件。这种方法更容易设置和监测，从而为男性生育提供更方便和便宜的诊断测试。顶体反应在其他实施方案中通过定量一种或多种释放物质来检测。还提供了包含一种或多种可用于在诊断实验室或其他设施进行检测的试剂的试剂盒。

3. 发明申请

WO2003011118A2 HUMAN ZONA PELLUCIDA PROTEINS AND METHODS OF THEIR USE IN DIAGNOSING MALE INFERTILITY 审中-公开
标题翻译：人类ZONA PELLUCIDA蛋白及其用于诊断男性感染的方法
公开(公告)号：WO2003011118A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024360
申请日：2002-08-01
申请人： TRINITY BIOMEDICAL TECHNOLOGY CORPORATION , CHI, Ting-Fung , LIN, Zhiyong , DONG, Kewen , HSU, Ming-I , CHENG, Jr-Gang , ZHENG, Heming
发明人： CHI, Ting-Fung , LIN, Zhiyong , DONG, Kewen , HSU, Ming-I , CHENG, Jr-Gang , ZHENG, Heming
IPC分类号： A61B
CPC分类号： C07K14/705 , G01N33/56966 , G01N33/689 , G01N2800/367
摘要： Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2-ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.
摘要翻译：描述了可用于生殖力测试的试剂，方法和试剂盒，并且在许多情况下提供更快，更方便和快速测定男性不育症。所述试剂包括适当的糖基化人ZP3，ZP2，ZP1，其糖基化肽，融合蛋白如绿色荧光蛋白ZP3，ZP2与ZP3的非共价复合物，ZP2-ZP3的融合蛋白，固相物质如琼脂糖珠涂覆具有粘合剂如ZP3和其他人造Zona。提供的方法是，在许多情况下，基于一种或多种试剂将复杂生物事件转化为明确定义的生物化学结合事件。这种方法更易于建立和监测，为男性生育提供更方便和便宜的诊断测试。在其它实施方案中，通过定量一种或多种释放物质来检测顶体反应。还提供了包含一种或多种可用于在诊断实验室或其他设施进行测试的试剂的试剂盒。

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