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1. 发明申请

WO2013003767A2 CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE 审中-公开
标题翻译： CMP- N-乙酰氨基酸羟化酶和/或谷氨酰胺ALPHA-1,3-糖蛋白酶的细胞缺失
公开(公告)号：WO2013003767A2
公开(公告)日：2013-01-03
申请号：PCT/US2012/045027
申请日：2012-06-29
申请人： SIGMA-ALDRICH CO. LLC , LIN, Nan , GEORGE, Henry J. , MASCARENHAS, Joaquina , COLLINGWOOD, Trevor N. , KAYSER, Kevin J. , ACHTIEN, Katherine
发明人： LIN, Nan , GEORGE, Henry J. , MASCARENHAS, Joaquina , COLLINGWOOD, Trevor N. , KAYSER, Kevin J. , ACHTIEN, Katherine
IPC分类号： C12N5/10 , C12P21/00
CPC分类号： C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
摘要： The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
摘要翻译：本发明提供了缺乏CMP-Neu5Ac羟化酶（Cmah）和/或糖蛋白α-1,3-半乳糖基转移酶（Ggta1）的非人哺乳动物细胞系。还提供了使用本文公开的细胞来生产具有人类糖基化模式的重组蛋白质的方法。

2. 发明申请

WO2007047400A2 SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR IMPLEMENTING RATE 3/4 LOW DENSITY PARITY CHECK CODE 审中-公开
标题翻译：实施速率3/4低密度奇偶校验码的系统，方法和计算机程序产品
公开(公告)号：WO2007047400A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/039970
申请日：2006-10-11
申请人： HUGHES NETWORK SYSTEMS, LLC , EROZ, Mustafa , IYER, Lakshmi , LEE, Lin-Nan
发明人： EROZ, Mustafa , IYER, Lakshmi , LEE, Lin-Nan
IPC分类号： H03M13/00
CPC分类号： H03M13/116 , H03M13/1185 , H03M13/1188 , H03M13/6356 , H03M13/6362
摘要： A method, system, apparatus and computer program product for correcting errors in a signal transmission using a rate 3/4 low density parity check (LDPC) code. At least a portion of a received data message is encoded by using a parity check matrix of the LDPC code. The encoded data message is transmitting in a signal transmission over a communication channel to a receiving device in the communication network. After being received, the encoded portion of the data message is decoded using a parity check matrix of the LDPC code to obtain the data message. For example, the encoding and decoding can be performed using a parity check matrix corresponds to a coded block size (N) equal to 1944 for communicating data in compliance with an 802.11n standard.
摘要翻译：一种用于使用速率3/4低密度奇偶校验（LDPC）码校正信号传输中的错误的方法，系统，装置和计算机程序产品。通过使用LDPC码的奇偶校验矩阵来对接收到的数据消息的至少一部分进行编码。编码数据消息是通过通信信道在信号传输中发送到通信网络中的接收装置。在接收之后，使用LDPC码的奇偶校验矩阵对数据消息的编码部分进行解码以获得数据消息。例如，可以使用对应于等于1944的编码块大小（N）的奇偶校验矩阵来进行编码和解码，以根据802.11n标准传送数据。

3. 发明申请

WO2005047294A1 MACROCYCLIC KINASE INHIBITORS 审中-公开
标题翻译：大环激酶抑制剂
公开(公告)号：WO2005047294A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/036582
申请日：2004-11-03
申请人： ABBOTT LABORATORIES , TAO, Zhi-Fu , LIN, Nan-Horng , WANG, Le , SOWIN, Thomas, J. , SULLIVAN, Gerard M. , TONG, Yunsong , PRZYTULINSKA, Magdalenna , LI, Gaoquan
发明人： TAO, Zhi-Fu , LIN, Nan-Horng , WANG, Le , SOWIN, Thomas, J. , SULLIVAN, Gerard M. , TONG, Yunsong , PRZYTULINSKA, Magdalenna , LI, Gaoquan
IPC分类号： C07D498/08
CPC分类号： C07D498/08 , C07D498/18
摘要： Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds
摘要翻译：具有式（I）的化合物可用于抑制蛋白激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法

4. 发明申请

WO03020006A8 CIRCUIT AND METHOD FOR ACOUSTIC SOURCE DIRECTIONAL PATTERN DETERMINATION UTILIZING TWO MICROPHONES 审中-公开
标题翻译：用于使用两个麦克风的声源方向图确定的电路和方法
公开(公告)号：WO03020006A8
公开(公告)日：2004-10-28
申请号：PCT/US0225580
申请日：2002-08-13
申请人： INNOMEDIA PTE LTD , OUYANG JING ZHENG , LIN NAN-SHENG
发明人： OUYANG JING ZHENG , LIN NAN-SHENG
IPC分类号： H04M9/08 , H04R3/00
CPC分类号： H04M9/08 , H04R3/00 , H04R3/005
摘要： A circuit for determining an angular direction of an acoustic source relative to a reference direction comprises an uni-directional microphone (12), an omni-directional microphone (20), and a background noise suppression circuit (11).
摘要翻译：用于确定声源相对于参考方向的角度方向的电路包括单向麦克风（12），全向麦克风（20）和背景噪声抑制电路（11）。

5. 发明申请

WO02103030A2 MULTIDIMENSIONAL BIODATA INTEGRATION AND RELATIONSHIP INFERENCE 审中-公开
标题翻译：多元生物多样性整合与关系研究
公开(公告)号：WO02103030A2
公开(公告)日：2002-12-27
申请号：PCT/US0219163
申请日：2002-06-14
申请人： RIGEL PHARMACEUTICALS INC , QU KUNBIN , LIN NAN , LU YANMEI , PAYAN DONALD G
发明人： QU KUNBIN , LIN NAN , LU YANMEI , PAYAN DONALD G
IPC分类号： G06F7/00 , G06F19/12 , G06F19/24 , G06F19/28 , C12Q
CPC分类号： G06F19/28 , G06F19/12 , G06F19/24 , Y10S707/99933 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945 , Y10S707/99948
摘要： This invention provides an advanced platform for the analysis of biological data that emphasizes pathway mapping and relationship inference based upon data acquired from multiple diverse sources. The platform employs a bioinformatic system that integrates data from the diverse sources, connecting related genes and proteins and inferring biological functions in the context of global cellular processes.
摘要翻译：本发明提供了一种基于从多个不同来源获得的数据分析强调路径映射和关系推理的生物数据的先进平台。该平台采用生物信息学系统，整合来自不同来源的数据，连接相关基因和蛋白质，并在全球细胞过程的背景下推断生物学功能。

6. 发明申请

WO1995011283A1 LIQUID INK 审中-公开
标题翻译：液体墨水
公开(公告)号：WO1995011283A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011842
申请日：1994-10-17
申请人： THE GILLETTE COMPANY , LIN, Nan-Jae , KLASSMAN, Andrew, R. , NICOLL, Roy , PACKHAM, Charles, Christopher , HULSE, Vliet , THOMPSON, John
发明人： THE GILLETTE COMPANY
IPC分类号： C09D11/18
CPC分类号： C09D11/18 , B43K5/1845 , C09D11/16 , Y10S260/38
摘要： A non-erasable liquid ink for a marking instrument including a colorant and a solvent and having a water content of about 0-15 % by weight and a viscosity of about 15 to 4,500 cps. Also disclosed is a marking instrument filled with an ink of such a viscosity or lower in its reservoir.
摘要翻译：一种用于包括着色剂和溶剂并具有约0-15重量％的水含量和约15至4,500厘泊的粘度的标记仪器的不可擦墨液体油墨。还公开了一种在其储存器中填充有这种粘度或更低的油墨的标记仪器。

7. 发明申请

WO2022133064A1 FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION 审中-公开
公开(公告)号：WO2022133064A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/063761
申请日：2021-12-16
申请人： BIOMEA FUSION, INC. , BUTLER, Thomas , PALMER, James T. , KIRSCHBERG, Thorsten , LIN, Nan-Horng , HUI, Hon , UPASANI, Ravindra , UNGASHE, Solomon B. , SPERANDIO, David
发明人： BUTLER, Thomas , PALMER, James T. , KIRSCHBERG, Thorsten , LIN, Nan-Horng , HUI, Hon , UPASANI, Ravindra , UNGASHE, Solomon B. , SPERANDIO, David
IPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , C07F5/02 , A61P35/00 , A61K31/519
摘要： Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

8. 发明申请

WO2008082839A2 PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS 审中-公开
标题翻译： PIM激酶抑制剂作为癌症化学疗法
公开(公告)号：WO2008082839A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/086472
申请日：2007-12-05
申请人： ABBOTT LABORATORIES , PENNING, Thomas D , HASVOLD, Lisa A , HEXAMER, Laura A , GIRANDA, Vincent L , LIN, Nan-horng , TAO, Zhi-fu , WANG, Le
发明人： PENNING, Thomas D , HASVOLD, Lisa A , HEXAMER, Laura A , GIRANDA, Vincent L , LIN, Nan-horng , TAO, Zhi-fu , WANG, Le
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
摘要翻译：披露了Pim激酶的抑制剂，制备方法以及使用它们治疗患者的方法。

9. 发明申请

WO2007030613A1 CODE DESIGN AND IMPLEMENTATION IMPROVEMENTS FOR LOW DENSITY PARITY CHECK CODES FOR WIRELESS ROUTERS USING 802.11N PROTOCOL 审中-公开
标题翻译：使用802.11N协议的无线路由器的低密度奇偶校验代码的代码设计和实现改进
公开(公告)号：WO2007030613A1
公开(公告)日：2007-03-15
申请号：PCT/US2006/034851
申请日：2006-09-08
申请人： THE DIRECTV GROUP, INC. , EROZ, Mustafa , LEE, Lin-Nan , SUN, Feng-Wen
发明人： EROZ, Mustafa , LEE, Lin-Nan , SUN, Feng-Wen
IPC分类号： H04L27/26 , H04L1/06 , H04L1/00
CPC分类号： H04B7/06 , H03M13/1102 , H03M13/255 , H04B7/04 , H04L1/005 , H04L1/0057 , H04L1/0606 , H04L1/0625 , H04L1/0637 , H04L5/0023 , H04L25/03898
摘要： Method and apparatus for implementing LDPC codes in an EBEE 802.11 standard system configured to operate in a Multiple-Input, Multiple-Output (MIMO) schema. A method in accordance with the present invention comprises defining a base LDPC code, having a length equal to an integer number of data carriers in an ODFM symbol, transmitting the base LDPC code over a plurality of sub-carriers, wherein the base code is transmitted at an expected phase on sub-carriers specified by the IEEE 802.11 standard system, and transmitting the base LDPC code on other sub-carriers than those specified by the IEEE 802.11 standard system, wherein the base LDPC code on the other sub-carriers is transmit offset in phase from the base LDPC code on the specified sub-carriers.
摘要翻译：用于在被配置为在多输入多输出（MIMO）模式中操作的EBEE 802.11标准系统中实现LDPC码的方法和装置。根据本发明的方法包括定义具有等于ODFM符号中的整数数据载波的长度的基本LDPC码，在多个子载波上发送基本LDPC码，其中发送基本码在由IEEE 802.11标准系统指定的子载波上的期望阶段，并且在与由IEEE 802.11标准系统指定的那些子载波之外的其他子载波上发送基本LDPC码，其中其他子载波上的基本LDPC码被发送在指定子载波上与基本LDPC码相位偏移。

10. 发明申请

WO2006020460A3 CODE DESIGN AND IMPLEMENTATION IMPROVEMENTS FOR LOW DENSITY PARITY CHECK CODES FOR MULTIPLE-INPUT MULTIPLE-OUTPUT CHANNELS 审中-公开
标题翻译：用于多输入多输出通道的低密度奇偶校验码的代码设计和实现改进
公开(公告)号：WO2006020460A3
公开(公告)日：2006-05-18
申请号：PCT/US2005027447
申请日：2005-08-03
申请人： DIRECTV GROUP INC , EROZ MUSTAFA , LEE LIN-NAN , SUN FENG-WEN
发明人： EROZ MUSTAFA , LEE LIN-NAN , SUN FENG-WEN
IPC分类号： H03M13/00
CPC分类号： H03M13/1165 , H03M13/1137 , H03M13/1185 , H03M13/15 , H03M13/152 , H03M13/255 , H03M13/2906 , H03M13/6561 , H04B7/0413 , H04L1/0048 , H04L1/005 , H04L1/0057 , H04L1/0625 , H04L1/0643
摘要： Methods and systems for designing LDPC codes (102) are disclosed. A method in accordance with the present invention comprises configuring a plurality of parallel accumulation engines (500), a number of the plurality of parallel accumulation engines (500) equal to M, accumulating a first information bit at a first set of specific parity bit addresses (502) using the plurality of parallel accumulation engines (500), increasing a parity bit address (504) for each member of the first set of specific parity bit addresses by a pre-determined offset for each new information bit, accumulating subsequent information bits at parity bit addresses that are offset from the specific parity bit addresses by a pre-determined offset until an M+1 information bit is reached (506), accumulating the next M information bits at a second set of specific parity bit addresses using the plurality of parallel accumulation engines (508), increasing a parity bit address for each member of the second set of specific parity bit addresses by the pre-determined offset for each new information bit (510); and repeating accumulating and increasing the addresses until the information bits are exhausted (512).
摘要翻译：公开了用于设计LDPC码（102）的方法和系统。根据本发明的方法包括配置多个并行累积引擎（500），多个并行累积引擎（500）的数量等于M，在第一组特定奇偶校验位地址处累积第一信息位（502），使用所述多个并行累积引擎（500），增加所述第一组特定奇偶校验位地址的每个成员的奇偶校验位地址（504），以为每个新的信息比特设置预定的偏移量，累积随后的信息比特在与特定奇偶校验位地址偏移一直到达到M + 1信息位（506）的预定偏移的奇偶校验位地址（506）处，使用多个奇偶校验位地址将第二组特定奇偶校验位地址累积下一个M个信息位并行累积引擎（508），增加第二组特定奇偶校验位地址的每个成员的奇偶校验位地址，形成位（510）; 并重复累积和增加地址直到信息位耗尽（512）。

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