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1. 发明申请

WO02103030A2 MULTIDIMENSIONAL BIODATA INTEGRATION AND RELATIONSHIP INFERENCE 审中-公开
标题翻译：多元生物多样性整合与关系研究
公开(公告)号：WO02103030A2
公开(公告)日：2002-12-27
申请号：PCT/US0219163
申请日：2002-06-14
申请人： RIGEL PHARMACEUTICALS INC , QU KUNBIN , LIN NAN , LU YANMEI , PAYAN DONALD G
发明人： QU KUNBIN , LIN NAN , LU YANMEI , PAYAN DONALD G
IPC分类号： G06F7/00 , G06F19/12 , G06F19/24 , G06F19/28 , C12Q
CPC分类号： G06F19/28 , G06F19/12 , G06F19/24 , Y10S707/99933 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945 , Y10S707/99948
摘要： This invention provides an advanced platform for the analysis of biological data that emphasizes pathway mapping and relationship inference based upon data acquired from multiple diverse sources. The platform employs a bioinformatic system that integrates data from the diverse sources, connecting related genes and proteins and inferring biological functions in the context of global cellular processes.
摘要翻译：本发明提供了一种基于从多个不同来源获得的数据分析强调路径映射和关系推理的生物数据的先进平台。该平台采用生物信息学系统，整合来自不同来源的数据，连接相关基因和蛋白质，并在全球细胞过程的背景下推断生物学功能。

2. 发明申请

WO9954467A9 SH2 DOMAIN-CONTAINING PEPTIDES 审中-公开
标题翻译： SH2含域蛋白
公开(公告)号：WO9954467A9
公开(公告)日：1999-12-16
申请号：PCT/US9908847
申请日：1999-04-23
申请人： GENENTECH INC , STEWART TIMOTHY A , LU YANMEI
发明人： STEWART TIMOTHY A , LU YANMEI
IPC分类号： G01N33/53 , C07K14/47 , C07K16/18 , C07K16/42 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/68 , C12N15/11 , C12N15/62
CPC分类号： C07K14/47 , C07K2319/02
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypeptides. The invention further relates to compositions and method for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based in part on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain tumors (e.g. cancer) and may act as predictors of the prognosis of tumor treatment.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，拮抗剂和激动剂载体以及表达PRO101，PRO308或PRO309多肽的免疫粘附和抗体的宿主细胞。本发明还涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。本发明部分基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。因此，被扩增的基因编码的蛋白质被认为是用于某些肿瘤（例如癌症）的诊断和/或治疗（包括预防））的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

3. 发明申请

WO1995013092A1 REESTABLISHMENT OF IFN-'gamma' INDUCIBILITY OR CONSTITUTIVE EXPRESSION OF MHC CLASS II IN TUMOR CELLS 审中-公开
标题翻译：肿瘤细胞中MHC II类的IFN-γ诱导或构象表达的研究
公开(公告)号：WO1995013092A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012987
申请日：1994-11-10
申请人： UNIVERSITY OF SOUTH FLORIDA , BLANCK, George , LU, Yanmei , USSERY, DeWayne
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , C07K14/70539
摘要： A process of producing a cancer vaccine against IFN- gamma noninducible-MHC-class II tumor cells with otherwise functional MHC class II genes and which are defective at a DNA sequence other than MHC class II genes. The process includes the steps of isolating IFN- gamma noninducible tumor cells and then transforming IFN- gamma noninducible tumor cells with a DNA sequence controlling the non-MHC class II defect. Once transformed, the cells are treated with IFN- gamma , if needed, and an effective amount of the cells or cell membranes administered to a patient to stimulate the patient's immune system against the tumor cells.
摘要翻译：制备针对具有另外功能性MHC II类基因的IFN-γ不可诱导型MHC-II型肿瘤细胞的癌症疫苗的过程，并且在除MHC II类基因以外的DNA序列处有缺陷。该方法包括分离IFN-γ不可诱导肿瘤细胞，然后用控制非MHC II类缺陷的DNA序列转化IFN-γ不可诱导肿瘤细胞的步骤。一旦转化，如果需要，用IFN-γ处理细胞，以及向患者施用有效量的细胞或细胞膜以刺激患者的免疫系统抵抗肿瘤细胞。

4. 发明申请

WO2002103030A3 MULTIDIMENSIONAL BIODATA INTEGRATION AND RELATIONSHIP INFERENCE 审中-公开
公开(公告)号：WO2002103030A3
公开(公告)日：2002-12-27
申请号：PCT/US2002/019163
申请日：2002-06-14
申请人： RIGEL PHARMACEUTICALS, INC. , QU, Kunbin , LIN, Nan , LU, Yanmei , PAYAN, Donald, G.
发明人： QU, Kunbin , LIN, Nan , LU, Yanmei , PAYAN, Donald, G.
IPC分类号： G06F17/60
摘要： This invention provides an advanced platform for the analysis of biological data that emphasizes pathway mapping and relationship inference based upon data acquired from multiple diverse sources (102). The platform employs a bioinformatic system (100) that integrates data from the diverse sources (102), connecting related genes and proteins and inferring biological functions (108) in the context of global cellular processes.

5. 发明申请

WO0053758A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES 审中-公开
标题翻译：用于治疗免疫相关疾病的组合物和方法
公开(公告)号：WO0053758A3
公开(公告)日：2001-02-08
申请号：PCT/US0005841
申请日：2000-03-02
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P1/16 , A61P3/10 , A61P5/14 , A61P11/00 , A61P11/02 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： C12N15/10 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C12N2799/026 , C12Q1/686 , C12Q2531/113 , C12Q2521/331
摘要： The present invention relates to a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases.
摘要翻译：本发明涉及包含用于诊断和治疗免疫相关疾病的新型蛋白质和方法的组合物。

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