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1. 发明申请

WO2004108719A9 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A9
公开(公告)日：2005-07-28
申请号：PCT/KR2004001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/14 , C07D213/74
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R1 and R2 represent respectively C1-C4 straight or branched alkyl group, C1-C4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

2. 发明申请

WO2004108719A1 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A1
公开(公告)日：2004-12-16
申请号：PCT/KR2004/001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： C07D413/14
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R 1 and R 2 represent respectively C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

3. 发明申请

WO2003084953A1 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 6-（4-取代的苯胺基）吡嗪衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2003084953A1
公开(公告)日：2003-10-16
申请号：PCT/KR2003/000588
申请日：2003-03-25
申请人： B & C BIOPHARM , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： C07D413/14
CPC分类号： C07D239/48 , C07D401/12
摘要： The present invention relates to 6(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; (HCV), represented by the following formula (I) in which R represents a C 1 -C 4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的6（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的新颖的6（4-取代苯胺基）嘧啶衍生物; （I）的R代表C1-C4直链或支链烷氧基羰基，杂环羰基或羧基烷基表示的（HCV）及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的6（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

4. 发明申请

WO2006011719A1 N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N-取代的磺酰苯甲酸衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2006011719A1
公开(公告)日：2006-02-02
申请号：PCT/KR2005/002257
申请日：2005-07-13
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
发明人： KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
IPC分类号： C07D413/12
CPC分类号： C07D295/135 , C07D413/12 , C07D413/14
摘要： The present invention relates to N -substituted-sulfamoylbenzoic acid derivatives useful as an antiviral agent, and more particularly the present invention relates to novel N -substituted-sulfamoylbenzoic acid derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The N -substituted-sulfamoylbenzoic acid derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的N-取代氨磺酰基苯甲酸衍生物，更具体地说，本发明涉及对丙型肝炎病毒（HCV）和药学上复制具有优异抑制作用的新型N-取代氨磺酰基苯甲酸衍生物其可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的N-取代氨磺酰基苯甲酸衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

5. 发明申请

WO2001038306A1 NOVEL 3-NITROPYRIDINE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES 审中-公开
标题翻译：新型3-硝基吡啶衍生物和含有衍生物的药物组合物
公开(公告)号：WO2001038306A1
公开(公告)日：2001-05-31
申请号：PCT/KR2000/001365
申请日：2000-11-27
申请人： DONG WHA PHARM. IND. CO., LTD , YOON, Sung, June , LEE, Sang, Wook , KIM, Nam, Doo , PARK, Yong, Kyun , LEE, Geun, Hyung , KIM, Jong, Woo , PARK, Sang, Jin , PARK, Hee, Jeoung , SHIN, Dong, Hyuk
发明人： YOON, Sung, June , LEE, Sang, Wook , KIM, Nam, Doo , PARK, Yong, Kyun , LEE, Geun, Hyung , KIM, Jong, Woo , PARK, Sang, Jin , PARK, Hee, Jeoung , SHIN, Dong, Hyuk
IPC分类号： C07D213/16
CPC分类号： C07D401/12
摘要： The present invention relates to novel 3-nitropyridine derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 3-nitropyridine derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的3-硝基吡啶衍生物和含有所述衍生物，更具体地涉及3-硝基吡啶衍生物及其药学上可接受的盐的药物组合物，其制备方法和含有所述化合物作为活性成分的药物组合物。特别地，本发明的所述3-硝基吡啶衍生物由于其对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）的增殖的抑制活性可用作治疗剂以及预防性乙型肝炎的代理人和获得性免疫缺陷综合征（AIDS）。

6. 发明申请

WO0138306A9 NOVEL 3-NITROPYRIDINE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES 审中-公开
标题翻译：新型3-硝基吡啶衍生物和含有衍生物的药物组合物
公开(公告)号：WO0138306A9
公开(公告)日：2003-06-19
申请号：PCT/KR0001365
申请日：2000-11-27
申请人： DONG WHA PHARM IND CO LTD , YOON SUNG JUNE , LEE SANG WOOK , KIM NAM DOO , PARK YONG KYUN , LEE GEUN HYUNG , KIM JONG WOO , PARK SANG JIN , PARK HEE JEOUNG , SHIN DONG HYUK
发明人： YOON SUNG JUNE , LEE SANG WOOK , KIM NAM DOO , PARK YONG KYUN , LEE GEUN HYUNG , KIM JONG WOO , PARK SANG JIN , PARK HEE JEOUNG , SHIN DONG HYUK
IPC分类号： C07D401/12 , C07D213/16
CPC分类号： C07D401/12
摘要： The present invention relates to novel 3-nitropyridine derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 3-nitropyridine derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的3-硝基吡啶衍生物和含有所述衍生物，更具体地涉及3-硝基吡啶衍生物及其药学上可接受的盐的药物组合物，其制备方法和含有所述化合物作为活性成分的药物组合物。特别地，本发明的所述3-硝基吡啶衍生物由于其对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）的增殖的抑制活性可用作治疗剂以及预防性乙型肝炎的代理人和获得性免疫缺陷综合征（AIDS）。

7. 发明申请

WO2006137706A1 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 6-（4-取代的苯胺基）吡嗪衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2006137706A1
公开(公告)日：2006-12-28
申请号：PCT/KR2006/002416
申请日：2006-06-22
申请人： B & C BIOPHARM. CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
发明人： KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
IPC分类号： C07D413/14 , A61K31/00 , A61P31/12
CPC分类号： C07D239/48 , C07D403/12 , C07D417/12
摘要： 6-(4-substituted-anilino)pyrimidine derivatives represented by Formula 1 having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) or pharmaceutically acceptable salts thereof, a method for preparing thereof and an antiviral pharmaceutical composition comprising the same. The novel 6-(4-substituted- anilino)pyrimidine derivatives represented by Formula 1 have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and low toxicity thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：具有对丙型肝炎病毒（HCV）复制的抑制作用优异的式1表示的6-（4-取代苯胺基）嘧啶衍生物或其药学上可接受的盐，其制备方法和含有该丙烯酰胺的抗病毒药物组合物。由式1表示的新型6-（4-取代 - 苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，低毒性，因此可有利地用作丙型肝炎的治疗或预防剂。

8. 发明申请

WO2004108068A3 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A3
公开(公告)日：2005-02-17
申请号：PCT/KR2004001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/12 , A61K20060101
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R1 represents C1-C4 straight or branched alkoxy group, -NR2R3 group or 4-(R4)-piperazin-l-yl group; R2 represents hydrogen or C1-C4 straight or branched alkyl group; R3 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C1-C4 straight or branched alkyl group substituted by C2-C6 straight or branched dialkylamino group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; R4 represents C1-C4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH2-CO-NH-R5 group; and R5 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C3-C6 cycloalkyl group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

9. 发明申请

WO2004108068A2 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A2
公开(公告)日：2004-12-16
申请号：PCT/KR2004/001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： A61K
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R 1 represents C 1 -C 4 straight or branched alkoxy group, -NR 2 R 3 group or 4-(R 4 )-piperazin-l-yl group; R 2 represents hydrogen or C 1 -C 4 straight or branched alkyl group; R 3 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 1 -C 4 straight or branched alkyl group substituted by C 2 -C 6 straight or branched dialkylamino group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; R 4 represents C 1 -C 4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH 2 -CO-NH-R 5 group; and R 5 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 3 -C 6 cycloalkyl group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

10. 发明申请

WO0178648A3 6-METHYLNICOTINAMIDE DERIVATIVES AS ANTIVIRAL AGENTS 审中-公开
标题翻译： 6-甲基吗啉衍生物作为抗病毒剂
公开(公告)号：WO0178648A3
公开(公告)日：2003-12-18
申请号：PCT/KR0100613
申请日：2001-04-13
申请人： DONG WHA PHARM IND CO LTD , YOON SUNG-JUNE , LEE SANG-WOOK , LEE JIN-SOO , KIM NAM-DOO , LEE GEUN-HYUNG , LEE HAK-DONG , KIM JONG-WOO , PARK SANG-JIN , PARK HEE-JEONG
发明人： YOON SUNG-JUNE , LEE SANG-WOOK , LEE JIN-SOO , KIM NAM-DOO , LEE GEUN-HYUNG , LEE HAK-DONG , KIM JONG-WOO , PARK SANG-JIN , PARK HEE-JEONG
IPC分类号： A61P31/18 , C07D213/82 , C07D401/12 , C07D401/14 , C07D521/00
CPC分类号： C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The 6-methylnicotinamide derivatives of the present invention exhibit their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV) and Hepatitis C virus (HCV), such that they can be used for hepatitis B, hepatitis C and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的6-甲基烟酰胺衍生物及其药学上可接受的盐，其制备方法和含有所述化合物作为活性成分的药物组合物。本发明的6-甲基烟酰胺衍生物对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的增殖具有抑制活性，从而可用于乙型肝炎，丙型肝炎和获得性免疫缺陷综合征（AIDS）。

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