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1. 发明申请

WO2012144790A1 CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME 审中-公开
标题翻译：非生产菌株的循环肽，其生产方法和用于预防或治疗包含其的MYCOBACTERIA相关疾病的药物组合物
公开(公告)号：WO2012144790A1
公开(公告)日：2012-10-26
申请号：PCT/KR2012/002933
申请日：2012-04-18
申请人： B&C BIOPHARM CO., LTD. , MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KIM, Jong Woo , LEE, Sang Wook , PARK, Sang Jin , SUH, Joo Won , LEE, In Ae , YOON, Tae Mi , CHOI, Jong Keun , LEE, Ji Ean , KIM, Jin Yong , JIN, Ying Yu , FRANZBLAU, Scott , CHO, Sanghyun , GAO, Wei , PAULI, Guido , McALPINE, James , NAPOLITANO, Jose , JAKI, Birgit , FRIESEN, Brent , RODRIGUEZ BRASCO, Maria Florencia , LANKIN, David
发明人： KIM, Jong Woo , LEE, Sang Wook , PARK, Sang Jin , SUH, Joo Won , LEE, In Ae , YOON, Tae Mi , CHOI, Jong Keun , LEE, Ji Ean , KIM, Jin Yong , JIN, Ying Yu , FRANZBLAU, Scott , CHO, Sanghyun , GAO, Wei , PAULI, Guido , McALPINE, James , NAPOLITANO, Jose , JAKI, Birgit , FRIESEN, Brent , RODRIGUEZ BRASCO, Maria Florencia , LANKIN, David
IPC分类号： C07K7/64
CPC分类号： C07K7/54 , A61K38/00 , C07K7/08
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis , including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译：本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。

2. 发明申请

WO2016153262A3 PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF PLATYCODON GRANDIFLORUM ENHANCED EFFECTIVE SAPONIN CONTENTS FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：包含高效液相色谱法提取有效柚苷含量的药物组合物，用于治疗恶病质
公开(公告)号：WO2016153262A3
公开(公告)日：2017-03-23
申请号：PCT/KR2016002906
申请日：2016-03-23
申请人： B&C BIOPHARM CO LTD
发明人： RYU DONG SEOUNG , LEE SANG WOOK , SOHN WEE YONG
IPC分类号： A61K36/34 , A61K9/20
CPC分类号： A61K36/346 , A23L33/105 , A61K9/0056 , A61K9/5047 , A61K9/5073 , A61K2236/00
摘要： The present invention relates to a pharmaceutical composition comprising the Platycodon grandiflorum extract containing the enhanced effective saponin content as an active ingredient for the treatment of rheumatoid arthritis. The Platycodon grandiflorum extract of the present invention displays a significant therapeutic effect on rheumatoid arthritis. In particular, when the extract was administered as being coated specifically with the enteric coating agent that can be released in the intestines, in order for the extract to show the maximum effect with the minimum dose with minimum damage and side effects in the stomach by not being released in the stomach but being released and absorbed in the intestines, a significant therapeutic effect on rheumatoid arthritis was observed. Therefore, the Platycodon grandiflorum extract of the present invention can be effectively used for the treatment of rheumatoid arthritis.
摘要翻译：本发明涉及一种药物组合物，其包含含有增强的有效皂苷含量的桔梗提取物作为治疗类风湿性关节炎的活性成分。本发明的桔梗提取物对类风湿性关节炎显示出显着的治疗作用。特别是当将提取物特异性地涂敷于能够在肠中释放的肠溶衣时，为了提取物以最小的剂量显示出最大的效果，而不是在胃中具有最小的损伤和副作用在胃中释放并释放并吸收肠道，观察到对类风湿性关节炎的显着治疗作用。因此，本发明的桔梗提取物可以有效地用于治疗类风湿性关节炎。

3. 发明申请

WO2010085091A3 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C, COMPRISING THE ROOTS EXTRACT OF PLATYCODON GRANDIFLORUM OR PLATYCODON GRANDIFLORUM SAPONIN COMPONENTS 审中-公开
标题翻译：用于预防或治疗丙型肝炎的药物组合物，包含巨大葛根或巨大葛根素皂苷元组份的根提取物
公开(公告)号：WO2010085091A3
公开(公告)日：2010-11-25
申请号：PCT/KR2010000376
申请日：2010-01-21
申请人： B & C BIOPHARM CO LTD , KIM JONG WOO , LEE SANG WOOK , HAN JAE JIN , PARK SANG JIN , SHIN JUNG CHEUL , YANG JAE WON , LEE YOUNG CHUN , PARK BYOUNG KEUN
发明人： KIM JONG WOO , LEE SANG WOOK , HAN JAE JIN , PARK SANG JIN , SHIN JUNG CHEUL , YANG JAE WON , LEE YOUNG CHUN , PARK BYOUNG KEUN
IPC分类号： A61K36/346 , A61P31/12
CPC分类号： A61K36/346 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition for preventing or treating Hepatitis C, comprising the roots extract of Platycodon grandiflorum and/or saponin components in Platycodon grandiflorum useful as an antiviral agent. The composition of the present invention has no harm to human and inhibits the proliferation of Hepatitis C virus, so that it can be effectively used as a preventive or therapeutic agent for Hepatitis C.
摘要翻译：本发明涉及用于预防或治疗丙型肝炎的药物组合物，其包含可用作抗病毒剂的桔梗中的桔梗和/或皂苷成分的根提取物。本发明的组合物对人体无害并且抑制丙型肝炎病毒的增殖，因此可以有效地用作丙型肝炎的预防或治疗剂。

4. 发明申请

WO2004108068A3 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A3
公开(公告)日：2005-02-17
申请号：PCT/KR2004001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/12 , A61K20060101
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R1 represents C1-C4 straight or branched alkoxy group, -NR2R3 group or 4-(R4)-piperazin-l-yl group; R2 represents hydrogen or C1-C4 straight or branched alkyl group; R3 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C1-C4 straight or branched alkyl group substituted by C2-C6 straight or branched dialkylamino group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; R4 represents C1-C4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH2-CO-NH-R5 group; and R5 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C3-C6 cycloalkyl group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

5. 发明申请

WO2004108068A2 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A2
公开(公告)日：2004-12-16
申请号：PCT/KR2004/001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： A61K
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R 1 represents C 1 -C 4 straight or branched alkoxy group, -NR 2 R 3 group or 4-(R 4 )-piperazin-l-yl group; R 2 represents hydrogen or C 1 -C 4 straight or branched alkyl group; R 3 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 1 -C 4 straight or branched alkyl group substituted by C 2 -C 6 straight or branched dialkylamino group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; R 4 represents C 1 -C 4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH 2 -CO-NH-R 5 group; and R 5 represents C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched hydroxyalkyl group, C 3 -C 6 cycloalkyl group or C 1 -C 4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

6. 发明申请

WO2010085091A2 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C, COMPRISING THE ROOTS EXTRACT OF PLATYCODON GRANDIFLORUM OR PLATYCODON GRANDIFLORUM SAPONIN COMPONENTS 审中-公开
标题翻译：用于预防或治疗HEPATITIS C的药物组合物，包括平板ON ON UM UM THE THE THE ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS ENTS
公开(公告)号：WO2010085091A2
公开(公告)日：2010-07-29
申请号：PCT/KR2010/000376
申请日：2010-01-21
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , HAN, Jae Jin , PARK, Sang Jin , SHIN, Jung Cheul , YANG, Jae Won , LEE, Young Chun , PARK, Byoung Keun
发明人： KIM, Jong Woo , LEE, Sang Wook , HAN, Jae Jin , PARK, Sang Jin , SHIN, Jung Cheul , YANG, Jae Won , LEE, Young Chun , PARK, Byoung Keun
IPC分类号： A61K36/346 , A61P31/12
CPC分类号： A61K36/346 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition for preventing or treating Hepatitis C, comprising the roots extract of Platycodon grandiflorum and/or saponin components in Platycodon grandiflorum useful as an antiviral agent. The composition of the present invention has no harm to human and inhibits the proliferation of Hepatitis C virus, so that it can be effectively used as a preventive or therapeutic agent for Hepatitis C.
摘要翻译：本发明涉及一种用于预防或治疗丙型肝炎的药物组合物，其包含用作抗病毒剂的桔梗中的桔梗和/或皂角苷组分的根提取物。本发明的组合物对人体无害，抑制丙型肝炎病毒的增殖，因此可有效地用作丙型肝炎的预防或治疗剂。

7. 发明申请

WO2004108719A9 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A9
公开(公告)日：2005-07-28
申请号：PCT/KR2004001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/14 , C07D213/74
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R1 and R2 represent respectively C1-C4 straight or branched alkyl group, C1-C4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

8. 发明申请

WO2004108719A1 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A1
公开(公告)日：2004-12-16
申请号：PCT/KR2004/001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
发明人： KIM, Jong-Woo , LEE, Sang-Wook , LEE, Geun-Hyung , HAN, Jae-Jin , PARK, Sang-Jin , PARK, Eul-Yong , SHIN, Joong-Chul
IPC分类号： C07D413/14
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R 1 and R 2 represent respectively C 1 -C 4 straight or branched alkyl group, C 1 -C 4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

9. 发明申请

WO2016153262A2 PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF PLATYCODON GRANDIFLORUM ENHANCED EFFECTIVE SAPONIN CONTENTS FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：包含高效液相色谱法提取有效柚苷含量的药物组合物，用于治疗恶病质
公开(公告)号：WO2016153262A2
公开(公告)日：2016-09-29
申请号：PCT/KR2016/002906
申请日：2016-03-23
申请人： B&C BIOPHARM CO., LTD.
发明人： RYU, Dong Seoung , LEE, Sang Wook , SOHN, Wee Yong
IPC分类号： A61K36/34 , A23L1/30 , A61K9/20
CPC分类号： A61K36/346 , A23L33/105 , A61K9/0056 , A61K9/5047 , A61K9/5073 , A61K2236/00
摘要： The present invention relates to a pharmaceutical composition comprising the Platycodon grandiflorum extract containing the enhanced effective saponin content as an active ingredient for the treatment of rheumatoid arthritis. The Platycodon grandiflorum extract of the present invention displays a significant therapeutic effect on rheumatoid arthritis. In particular, when the extract was administered as being coated specifically with the enteric coating agent that can be released in the intestines, in order for the extract to show the maximum effect with the minimum dose with minimum damage and side effects in the stomach by not being released in the stomach but being released and absorbed in the intestines, a significant therapeutic effect on rheumatoid arthritis was observed. Therefore, the Platycodon grandiflorum extract of the present invention can be effectively used for the treatment of rheumatoid arthritis.
摘要翻译：本发明涉及一种药物组合物，其包含含有增强的有效皂苷含量的桔梗提取物作为治疗类风湿性关节炎的活性成分。本发明的桔梗提取物对类风湿性关节炎显示出显着的治疗作用。特别是当将提取物特异性地涂敷于能够在肠中释放的肠溶衣时，为了提取物以最小的剂量显示出最大的效果，而不是在胃中具有最小的损伤和副作用在胃中释放并释放并吸收肠道，观察到对类风湿性关节炎的显着治疗作用。因此，本发明的桔梗提取物可以有效地用于治疗类风湿性关节炎。

10. 发明申请

WO2006011719A1 N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N-取代的磺酰苯甲酸衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2006011719A1
公开(公告)日：2006-02-02
申请号：PCT/KR2005/002257
申请日：2005-07-13
申请人： B & C BIOPHARM CO., LTD. , KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
发明人： KIM, Jong Woo , LEE, Sang Wook , LEE, Geun Hyung , HAN, Jae Jin , PARK, Sang Jin , PARK, Eul Yong , SHIN, Joong Chul
IPC分类号： C07D413/12
CPC分类号： C07D295/135 , C07D413/12 , C07D413/14
摘要： The present invention relates to N -substituted-sulfamoylbenzoic acid derivatives useful as an antiviral agent, and more particularly the present invention relates to novel N -substituted-sulfamoylbenzoic acid derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The N -substituted-sulfamoylbenzoic acid derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的N-取代氨磺酰基苯甲酸衍生物，更具体地说，本发明涉及对丙型肝炎病毒（HCV）和药学上复制具有优异抑制作用的新型N-取代氨磺酰基苯甲酸衍生物其可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的N-取代氨磺酰基苯甲酸衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

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