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1. 发明申请

WO2004108068A3 4-[4-(4-MORPHOLINO)ANILINO]PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 4- [4-（4-吗啉基）苯胺基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108068A3
公开(公告)日：2005-02-17
申请号：PCT/KR2004001297
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/12 , A61K20060101
CPC分类号： C07D239/47
摘要： The present invention relates to 4-[4-(4-morpholino)anilino]pyrimidine derivatives useful as an antiviral agent, and more particularly novel 4-[4-(4-morpholino)anilino]pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula I: in which R1 represents C1-C4 straight or branched alkoxy group, -NR2R3 group or 4-(R4)-piperazin-l-yl group; R2 represents hydrogen or C1-C4 straight or branched alkyl group; R3 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C1-C4 straight or branched alkyl group substituted by C2-C6 straight or branched dialkylamino group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; R4 represents C1-C4 straight or branched alkoxycarbonylmethyl group, carboxymethyl group or -CH2-CO-NH-R5 group; and R5 represents C1-C4 straight or branched alkyl group, C1-C4 straight or branched hydroxyalkyl group, C3-C6 cycloalkyl group or C1-C4 straight or branched alkyl group substituted by heterocyclic ring; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 4-[4-(4-morpholino)anilino]pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型4- [4-（4-吗啉代）苯胺基]嘧啶衍生物由下式I表示的丙型肝炎病毒（HCV）：其中R1表示C1-C4直链或支链烷氧基，-NR2R3基或4-（R4） - 哌嗪-1-基; R2表示氢或C1-C4直链或支链烷基; R3表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C2-C6直链或支链二烷基氨基取代的C1-C4直链或支链烷基或被杂环取代的C1-C4直链或支链烷基环; R4表示C1-C4直链或支链烷氧基羰基甲基，羧甲基或-CH2-CO-NH-R5基团; R5表示C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，C3-C6环烷基或被杂环取代的C1-C4直链或支链烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的4- [4-（4-吗啉代）苯胺基]嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

2. 发明申请

WO2004108719A9 2-[2-(4-MORPHOLINO)ETHYLAMINO]PYRIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： 2- [2-（4-吗啉基）乙基氨基]吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：WO2004108719A9
公开(公告)日：2005-07-28
申请号：PCT/KR2004001298
申请日：2004-06-01
申请人： B & C BIOPHARM CO LTD , KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
发明人： KIM JONG-WOO , LEE SANG-WOOK , LEE GEUN-HYUNG , HAN JAE-JIN , PARK SANG-JIN , PARK EUL-YONG , SHIN JOONG-CHUL
IPC分类号： C07D413/14 , C07D213/74
CPC分类号： C07D213/74
摘要： The present invention relates to 2-[2-(4-morpholino)ethylamino]pyridine derivatives useful as an antiviral agent, and more particularly novel 2-[2-(4-morpholino)ethylamino]pyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), represented by the following formula (I) in which R1 and R2 represent respectively C1-C4 straight or branched alkyl group, C1-C4 straight or branched alkoxy group, methylthio group, trifluoromethyl group, halogen atom, or hydrogen atom, and X represents oxygen atom or sulfur atom; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective component. The 2-[2-(4-morpholino)ethylamino]pyridine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的2- [2-（4-吗啉代）乙氨基]吡啶衍生物，更特别地涉及对复制具有优异抑制作用的更具体的新型2- [2-（4-吗啉代）乙氨基]吡啶衍生物由下式（I）表示的丙烯酸类病毒（HCV），其中R1和R2分别表示C1-C4直链或支链烷基，C1-C4直链或支链烷氧基，甲硫基，三氟甲基，卤素原子，或氢原子，X表示氧原子或硫原子; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的2- [2-（4-吗啉代）乙氨基]吡啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

3. 发明申请

WO0178648A3 6-METHYLNICOTINAMIDE DERIVATIVES AS ANTIVIRAL AGENTS 审中-公开
标题翻译： 6-甲基吗啉衍生物作为抗病毒剂
公开(公告)号：WO0178648A3
公开(公告)日：2003-12-18
申请号：PCT/KR0100613
申请日：2001-04-13
申请人： DONG WHA PHARM IND CO LTD , YOON SUNG-JUNE , LEE SANG-WOOK , LEE JIN-SOO , KIM NAM-DOO , LEE GEUN-HYUNG , LEE HAK-DONG , KIM JONG-WOO , PARK SANG-JIN , PARK HEE-JEONG
发明人： YOON SUNG-JUNE , LEE SANG-WOOK , LEE JIN-SOO , KIM NAM-DOO , LEE GEUN-HYUNG , LEE HAK-DONG , KIM JONG-WOO , PARK SANG-JIN , PARK HEE-JEONG
IPC分类号： A61P31/18 , C07D213/82 , C07D401/12 , C07D401/14 , C07D521/00
CPC分类号： C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The 6-methylnicotinamide derivatives of the present invention exhibit their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV) and Hepatitis C virus (HCV), such that they can be used for hepatitis B, hepatitis C and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的6-甲基烟酰胺衍生物及其药学上可接受的盐，其制备方法和含有所述化合物作为活性成分的药物组合物。本发明的6-甲基烟酰胺衍生物对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的增殖具有抑制活性，从而可用于乙型肝炎，丙型肝炎和获得性免疫缺陷综合征（AIDS）。

4. 发明申请

WO2013019038A3 ORIENTED COEXTRUDED FILM HAVING ADHESIVE MULTILAYER 审中-公开
标题翻译：具有粘合多层膜的面向共挤薄膜
公开(公告)号：WO2013019038A3
公开(公告)日：2013-07-11
申请号：PCT/KR2012006027
申请日：2012-07-27
申请人： DAELIM IND CO LTD , LEE SANG-WOOK , KIM HYUN-CHUL , KANG JEON-SEOK
发明人： LEE SANG-WOOK , KIM HYUN-CHUL , KANG JEON-SEOK
IPC分类号： B32B27/08 , B29C47/06 , B32B7/12 , B32B37/12
CPC分类号： B32B27/32 , B32B7/12 , B32B27/08 , B32B2405/00 , C09J7/29
摘要： The present invention relates to an oriented coextruded film having an adhesive multilayer with excellent thermal adhesive properties, and more specifically to an oriented coextruded film having an adhesive multilayer capable of direct adhesion with objects to be adhered such as papers, films, metals, and the like. The oriented coextruded film having an adhesive multilayer according to the invention can avoid additional steps such as an EVA lamination coating, uneven thickness, and contamination of rolls during a manufacturing process, and has excellent adhesive force with objects to be adhered.
摘要翻译：本发明涉及一种具有优异的热粘合性能的粘合剂多层的定向共挤出膜，更具体地涉及一种具有能够与诸如纸，膜，金属等粘合的物体直接粘合的粘合剂多层的定向共挤出膜，并且喜欢。具有根据本发明的粘合剂多层的定向共挤出膜可以避免在制造过程中附加的步骤，例如EVA层压涂层，不均匀的厚度和辊的污染，并且与粘附物体具有优异的粘附力。

5. 发明申请

WO2013019038A2 ORIENTED COEXTRUDED FILM HAVING ADHESIVE MULTILAYER 审中-公开
标题翻译：定向共层复合膜具有粘性多层膜
公开(公告)号：WO2013019038A2
公开(公告)日：2013-02-07
申请号：PCT/KR2012006027
申请日：2012-07-27
申请人： DAELIM IND CO LTD , LEE SANG-WOOK , KIM HYUN-CHUL , KANG JEON-SEOK
发明人： LEE SANG-WOOK , KIM HYUN-CHUL , KANG JEON-SEOK
IPC分类号： B32B27/08 , B29C47/06 , B32B7/12 , B32B37/12
CPC分类号： B32B27/32 , B32B7/12 , B32B27/08 , B32B2405/00 , C09J7/29
摘要： The present invention relates to an oriented coextruded film having an adhesive multilayer with excellent thermal adhesive properties, and more specifically to an oriented coextruded film having an adhesive multilayer capable of direct adhesion with objects to be adhered such as papers, films, metals, and the like. The oriented coextruded film having an adhesive multilayer according to the invention can avoid additional steps such as an EVA lamination coating, uneven thickness, and contamination of rolls during a manufacturing process, and has excellent adhesive force with objects to be adhered.
摘要翻译：本发明涉及一种取向共挤出膜，其具有具有优异热粘合性能的粘合剂多层，并且更具体地涉及一种取向共挤出膜，其具有能够直接粘合诸如纸，膜，金属等的待粘合物体的粘合剂多层膜，并且喜欢。具有根据本发明的粘合剂多层的取向共挤出膜可以避免额外的步骤，例如EVA层压涂覆，厚度不均匀以及在制造过程中辊的污染，并且与待粘合的物体具有优异的粘合力。

6. 发明申请

WO2010117171A2 PET TOILET DEVICE HAVING A NOCTILUCENT FUNCTION 审中-公开
标题翻译：具有命名功能的PET卫生间设备
公开(公告)号：WO2010117171A2
公开(公告)日：2010-10-14
申请号：PCT/KR2010002071
申请日：2010-04-05
申请人： LEE SANG-WOOK
发明人： LEE SANG-WOOK
IPC分类号： A01K23/00
CPC分类号： A01K1/0107
摘要： According to the present invention, a pet toilet device having a noctilucent function comprises: a net on which a pet excretes, and which has a plurality of through-holes; a frame which has a hollow portion into which the net penetrates and a stepped portion with a predetermined height, formed along the outer circumference of the hollow portion; and a base which has a receiving surface for receiving the net, and which is disposed below the frame, wherein either the net or the receiving surface of the base has a noctilucent portion coated with a noctilucent material. The pet toilet device having a noctilucent function according to the present invention enables pets with relatively poor eyesight to easily discriminate the pet toilet device in a dark place or during the night, and thus trains pets to steadily excrete on the device. The pet toilet device of the present invention has an overall round shape to prevent pets from excreting in a specific direction or from wandering around on the toilet device in search of a place to excrete.
摘要翻译：根据本发明，具有夜光功能的宠物厕所装置包括：宠物排泄物并具有多个通孔的网; 沿着中空部的外周形成具有网状物穿过的中空部和具有规定高度的阶梯部的框架，以及具有用于接收网的接收表面并且设置在框架下方的底座，其中底座的网或接收表面具有涂覆有夜光材料的夜视部分。根据本发明的具有夜光功能的宠物厕所装置使得具有较差视力的宠物能够在黑暗的地方或夜间容易地辨别宠物厕所装置，从而训练宠物以稳定地排出在装置上。本发明的宠物厕所装置具有整体圆形，以防止宠物在特定方向上排泄或者在厕所装置上徘徊以寻找排泄物。

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