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1. 发明申请

WO2012058415A1 ELECTRODE SHAPES AND POSITIONS FOR REDUCING LOSS OF CONTACT IN AN IMPLANTABLE ECG RECORDER 审中-公开
标题翻译：电极形状和位置，用于减少可移植ECG记录仪中的接触损失
公开(公告)号：WO2012058415A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058067
申请日：2011-10-27
申请人： MEDTRONIC, INC. , GORDON, Charles Robert , LEE, Brian B. , BARROR, Michael William
发明人： GORDON, Charles Robert , LEE, Brian B. , BARROR, Michael William
IPC分类号： A61B5/042 , A61B5/07
CPC分类号： A61B5/0422 , A61B5/0006 , A61B5/076 , A61B5/6861 , A61B2560/0406 , A61B2562/0209
摘要： An improved design for subcutaneous monitors that addresses the problem caused by bubbles of air may remain in the pocket in which the device is implanted. As implantable monitors and their associated electrodes are reduced in size, these bubbles may in some cases cover one or both electrodes, interfering with sensing of the ECG signal. The invention addresses this problem by configuring the electrodes to increase the pressure of the electrodes against the tissue above the electrodes relative to the pressures exerted by the adjacent outer facing surfaces of the device.
摘要翻译：用于解决由空气气泡引起的问题的皮下监测器的改进设计可以保留在装置植入的口袋中。随着植入式监护仪及其相关电极的尺寸减小，这些气泡在某些情况下可能会覆盖一个或两个电极，从而干扰ECG信号的感测。本发明通过配置电极来相对于由相邻的面向外部的表面施加的压力来配置电极以增加电极对电极上方的组织的压力来解决这个问题。

2. 发明申请

WO2008054992A1 METHOD AND APPARATUS FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 审中-公开
标题翻译：基于静脉循环长度的ATRIAL FIBRILLATION检测方法与装置
公开(公告)号：WO2008054992A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/081600
申请日：2007-10-17
申请人： MEDTRONIC, INC. , LEE, Brian, B. , PANKEN, Eric, J.
发明人： LEE, Brian, B. , PANKEN, Eric, J.
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

3. 发明申请

WO2007127714A3 TELEMETRY-SYNCHRONIZED PHYSIOLOGICAL MONITORING AND THERAPY DELIVERY SYSTEMS 审中-公开
标题翻译：电话同步生理监测和治疗传递系统
公开(公告)号：WO2007127714A3
公开(公告)日：2008-01-17
申请号：PCT/US2007067271
申请日：2007-04-24
申请人： MEDTRONIC INC , LEE BRIAN B , PANKEN ERIC J , CINBIS CAN , HILL GERALD J , GREVIOUS JOHN J
发明人： PANKEN ERIC J , CINBIS CAN , HILL GERALD J , GREVIOUS JOHN J
IPC分类号： A61N1/36 , A61N1/365 , A61N1/372
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

4. 发明申请

WO2007127714A2 TELEMETRY-SYNCHRONIZED PHYSIOLOGICAL MONITORING AND THERAPY DELIVERY SYSTEMS 审中-公开
标题翻译：电话同步生理监测和治疗传递系统
公开(公告)号：WO2007127714A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067271
申请日：2007-04-24
申请人： MEDTRONIC, INC. , LEE, Brian B. , PANKEN, Eric J. , CINBIS, Can , HILL, Gerald J. , GREVIOUS, John J.
发明人： PANKEN, Eric J. , CINBIS, Can , HILL, Gerald J. , GREVIOUS, John J.
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

5. 发明申请

WO2005053791A1 MULTI-LEVEL AVERAGING SCHEME FOR ACQUIRING HEMODYNAMIC DATA 审中-公开
标题翻译：用于获取血液动力学数据的多级平均方案
公开(公告)号：WO2005053791A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039412
申请日：2004-11-23
申请人： MEDTRONIC, INC. , LEE, Brian, B. , BENNETT, Tommy, D.
发明人： LEE, Brian, B. , BENNETT, Tommy, D.
IPC分类号： A61N1/37
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/04325 , A61B5/145 , A61B5/14532 , G06F19/00
摘要： A system and method for storing and processing physiological data in a medical recording device that allows continuous data collection and storage of such data in multiple time-resolved levels are provided. The method includes: sampling one or more physiological signals at a selected sampling rate; deriving physiological parameter values from the sampled signal; storing the parameter values as they are determined in a temporary memory buffer for a predetermined storage interval; determining a statistical aspect of the stored parameter values upon expiration of the storage interval; and writing the statistical aspect to a long-term memory buffer. A number of long-term memory buffers may be designated for storing a statistical aspect of a physiological parameter at uniquely different time resolutions. The resolution of each long-term memory buffer is determined by the storage interval defined for an associated temporary memory buffer, which stores parameter values from which statistical aspects are computed.
摘要翻译：提供一种在医疗记录装置中存储和处理生理数据的系统和方法，其允许以多个时间分辨级别连续数据收集和存储这些数据。该方法包括：以选定的采样速率对一个或多个生理信号进行采样; 从采样信号中得到生理参数值; 将其在临时存储器缓冲器中确定的参数值存储在预定的存储间隔中; 在所述存储间隔期满时确定所存储的参数值的统计方面; 并将统计方面写入长期内存缓冲区。可以指定多个长期记忆缓冲器用于以独特的不同时间分辨率存储生理参数的统计方面。每个长期存储器缓冲器的分辨率由为关联的临时存储器缓冲器定义的存储间隔确定，其存储从其计算统计方面的参数值。

6. 发明申请

WO2012057866A1 POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：对生理参数的诱导变化
公开(公告)号：WO2012057866A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/034479
申请日：2011-04-29
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , LEE, Brian, B.
发明人： CORBUCCI, Giorgio , LEE, Brian, B.
IPC分类号： A61B5/024 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/029 , A61B5/1116 , A61B5/686 , A61B5/7246 , A61B5/7282 , A61N1/3627 , A61N1/36535 , A61N1/36585 , A61N1/3702 , A61N1/37247 , G06F19/00
摘要： Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient.
摘要翻译：用于分析姿势引起的对患者的生理参数的变化的方法和装置（例如，射血时间，心率等）以提供对患者的一个或多个状况的评估。

7. 发明申请

WO2010011632A1 VIRTUAL PHYSICIAN ACUTE MYOCARDIAL INFARCTION DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：虚拟医学急性心肌梗死检测系统及方法
公开(公告)号：WO2010011632A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051220
申请日：2009-07-21
申请人： MEDTRONIC, INC. , WENGREEN, Eric, J. , SONG, Zhendong , LEE, Brian, B.
发明人： WENGREEN, Eric, J. , SONG, Zhendong , LEE, Brian, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/0031 , A61B5/02405 , A61B5/0404 , A61B5/0452 , A61B5/04525 , A61B5/076 , A61N1/365
摘要： A system and method for virtually detecting a medical condition, such as acute myocardial infarction (AMI), in a patient using holistic diagnostic procedures implemented in medical devices. Physiological parameters in a patient are monitored in an implantable medical device (IMD) to detect deviations from desired characteristics. When severe physiological parameter deviations exist indicating with a desired certainty that the patient is experiencing a medical condition (e.g., AMI), an alert is generated. If only minor deviations from the desired characteristics exist, additional holistic diagnostic procedures are performed virtually for diagnosing whether the patient is likely to be experiencing the medical condition, such as querying the patient through an external device regarding symptoms the patient is experiencing and analyzing the patient's responses to the questions to determine whether the patient is experiencing the medical condition. When diagnosis is still unclear, additional holistic diagnostic procedures can be performed virtually until diagnosis is certain.
摘要翻译：用于使用在医疗装置中实施的整体诊断程序来虚拟检测医疗状况的系统和方法，例如急性心肌梗塞（AMI）。在可植入医疗器械（IMD）中监测患者的生理参数，以检测与所需特征的偏差。当存在严重的生理参数偏差，指示患者正在经历医疗状况（例如，AMI）的期望确定性时，产生警报。如果仅存在与期望特征的微小偏差，则虚拟地执行附加的整体诊断程序，用于诊断患者是否可能经历医疗状况，例如通过外部设备查询患者所遇到的症状并分析患者的回答问题以确定患者是否正在经历医疗状况。当诊断仍不清楚时，可以进行额外的整体诊断程序，直到诊断确定为止。

8. 发明申请

WO2012106086A1 EXTERNAL CARDIAC MONITOR 审中-公开
标题翻译：外部监护员
公开(公告)号：WO2012106086A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/021154
申请日：2012-01-13
申请人： MEDTRONIC, INC. , CAO, Jian , KRONICH, Christine G. , FUSS, David M. , GOTTLIEB, Rebecca K. , KEHN, Jeffrey L. , KRAUSE, Paul G. , LEE, Brian B. , PATRAS, George
发明人： CAO, Jian , KRONICH, Christine G. , FUSS, David M. , GOTTLIEB, Rebecca K. , KEHN, Jeffrey L. , KRAUSE, Paul G. , LEE, Brian B. , PATRAS, George
IPC分类号： A61B5/0432
CPC分类号： A61B5/0432 , A61B5/6823
摘要： An external physiological monitor continuously senses and monitors cardiac function of a patient to allow detection of cardiac events and the recording of data and signals pre- and post-event. The monitor is connected to and suspended on the patients body solely by the electrode assembly. Stored diagnostic data may be uplinked and evaluated by the patients physician utilizing a programmer via a twoway telemetry link. An external patient activator may optionally allow the patient, or other care provider to manually activate the recording of diagnostic data.
摘要翻译：外部生理监视器连续地感测和监视患者的心脏功能，以允许检测心脏事件以及事件之前和事件之后的数据和信号的记录。显示器仅通过电极组件连接到患者身体并悬挂在患者身上。存储的诊断数据可以由患者医生通过双向遥测链路利用程序员上行和评估。外部患者激活器可以可选地允许患者或其他护理提供者手动激活诊断数据的记录。

9. 发明申请

WO2008039242A1 IMPLANTABLE MEDICAL DEVICE WITH SENSOR SELF-TEST FEATURE 审中-公开
标题翻译：具有传感器自检功能的可植入医疗器械
公开(公告)号：WO2008039242A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/009852
申请日：2007-04-24
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
发明人： PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

10. 发明申请

WO2007065049A1 MEDICAL DEVICE PACKAGING SYSTEM 审中-公开
标题翻译：医疗器械包装系统
公开(公告)号：WO2007065049A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/060640
申请日：2006-11-08
申请人： MEDTRONIC, INC. , PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
发明人： PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
IPC分类号： A61B19/02 , A61N1/372 , A61N1/375
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294
摘要： A system, comprising a sterilizable package (60) ; an implantable medical device (IMD) (10) placed inside the sterilizable package; and an electrical interface (50) electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface in the form of a flexible circuit, may include package contacts (52) electrically coupled to electrode terminals on the implantable medical device, patient terminals (54) and conductors extending between the package contacts and the patient terminals. The packaging system allows to obtain pre-implant test data without compromising the sterility of the IMD within the package.
摘要翻译：一种系统，包括可灭菌包装（60）; 将可植入医疗装置（IMD）（10）放置在可灭菌包装内; 以及电接口（50），其电连接到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，柔性电路形式的接口可以包括电耦合到可植入医疗装置上的电极端子的包装触点（52），患者端子（54）和在包装触头和患者端子之间延伸的导体。包装系统允许获得植入前测试数据，而不会影响包装内IMD的无菌性。

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