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1. 发明申请

WO2015183002A3 NOVEL ANALOG OF HALOCYNTHIA AURANTIUM-DERIVED ANTIMICROBIAL PEPTIDE, AND USE THEREOF 审中-公开
标题翻译： HALOCYNTHIA AURANTIUM衍生的抗微生物肽的新型模拟物及其用途
公开(公告)号：WO2015183002A3
公开(公告)日：2016-01-21
申请号：PCT/KR2015005338
申请日：2015-05-28
申请人： LEE IN HEE
发明人： LEE IN HEE
IPC分类号： C07K7/00 , A61K38/17 , A61P31/02 , A61P31/04
CPC分类号： A61K38/17 , C07K7/00
摘要： The present invention relates to an antimicrobial peptide and, more specifically, to: a mutant antimicrobial peptide in which the resistance against proteases and the activity in the serum are greatly improved by modifying a part of the amino acids of halocidin, which is an antimicrobial peptide isolated from Halocynthia aurantium body fluid cells; and an antimicrobial agent containing the antimicrobial peptide as an active ingredient. The antimicrobial peptide of the present invention is an antimicrobial peptide having strong fungicidal activity against fungi and excellent resistance against gram-positive and gram-negative bacteria, particularly, antibiotic resistant bacteria, overcoming the problems of the hydrolysis by proteases and the loss of antimicrobial activity caused by nonspecific binding with serum proteins, which are large obstacles to the practical use of an antimicrobial peptide, and useful as a novel peptide antibiotic.
摘要翻译：本发明涉及一种抗微生物肽，更具体地说，涉及：通过修饰作为抗微生物肽的卤代核苷酸的一部分氨基酸，其中抗蛋白酶的抗性和血清中的活性大大提高的突变型抗微生物肽从紫穗槐属体液细胞中分离出来; 和含有抗微生物肽作为活性成分的抗微生物剂。本发明的抗微生物肽是对真菌具有强烈杀真菌活性的抗微生物肽，具有抗革兰氏阳性和革兰氏阴性细菌，特别是抗生素抗性细菌的优良抗性，克服蛋白酶水解的问题和抗菌活性丧失由与血清蛋白质的非特异性结合引起的，这是抗微生物肽实际使用的巨大障碍，并且可用作新的肽抗生素。

2. 发明申请

WO2006022461A1 DIAGNOSIS KITS FOR HEMORRHAGIC FEVER WITH RENAL SYNDROME COMPRISING NUCLEOCAPSID PROTEIN OF HANTA VIRUS EXPRESSED IN TRANSFORMED PLANT 审中-公开
标题翻译：用于包含转化植物中表达的汉娜病毒核苷酸蛋白的肾综合征的HEMORRHAGIC FEAT诊断试剂盒
公开(公告)号：WO2006022461A1
公开(公告)日：2006-03-02
申请号：PCT/KR2004/002161
申请日：2004-08-27
申请人： NEXGEN BIOTECHNOLOGIES, INC. , LEE, Sun , JU, Yong Gyu , CHUNG, Nam Jun , LEE, In Hee , PARK, Sun Hee , YOO, Je Geun , MACPHERSON, Jim , COLETTE, Jako
发明人： LEE, Sun , JU, Yong Gyu , CHUNG, Nam Jun , LEE, In Hee , PARK, Sun Hee , YOO, Je Geun , MACPHERSON, Jim , COLETTE, Jako
IPC分类号： C07K14/175
CPC分类号： G01N33/56983 , C07K14/005 , C12N15/8257 , C12N15/8258 , C12N2760/12122 , G01N2333/175 , G01N2469/20
摘要： The present invention relates to a novel polynucleotide sequence encoding a nucleocapsid protein of Hanta virus, a plant expression vector comprising the same, a plant transformed with the same, a diagnosis kit for hemorrhagic fever with renal syndrome and a method for detecting an antibody specific to hemorrhagic fever with renal syndrome. The present invention makes it possible to obtain recombinant nucleocapsid proteins with excellent antigenicity of Hanta virus in more cost-effective manner. Furthermore, the recombinant nucleocapsid proteins of this invention permit to diagnose hemorrhagic fever with renal syndrome with excellent specificity and sensitivity.
摘要翻译：本发明涉及一种编码汉坦病毒核衣壳蛋白的新型多核苷酸序列，含有其的植物表达载体，用其转化的植物，具有肾综合征的出血热诊断试剂盒，以及用于检测特异于出血热伴肾综合征。本发明可以以更具成本效益的方式获得具有优异的Hanta病毒抗原性的重组核衣壳蛋白。此外，本发明的重组核衣壳蛋白质能够以良好的特异性和灵敏度诊断具有肾综合征的出血热。

3. 发明申请

WO2006078133A1 A SPEAKER EMBODYING A STEREO SOUND 审中-公开
标题翻译：一个扬声器演奏一个立体声
公开(公告)号：WO2006078133A1
公开(公告)日：2006-07-27
申请号：PCT/KR2006/000222
申请日：2006-01-20
申请人： LEE, In-hee
发明人： LEE, In-hee
IPC分类号： H04R1/02
CPC分类号： H04R1/347 , H04R1/021
摘要： The present invention relates to speakers and, more particularly, to a speaker sound system, characterized in that the speaker, mounted on a speaker housing constituting a sound emission apparatus, has a guide cover to guide sound radiating from the back of the speaker forwards when the sound is output both forwards and backwards because of fluctuations of a cone of the speaker due to electrical signals, that is integrally attached to the surface of the speaker, thereby providing vivid high-fidelity sound.
摘要翻译：本发明涉及扬声器，更具体地说，涉及一种扬声器音响系统，其特征在于，安装在构成声音发射装置的扬声器壳体上的扬声器具有引导盖，用于引导从扬声器背面辐射的声音，由于由于电信号而扬声器的锥体的波动，声音被向前和向后输出，这被整体连接到扬声器的表面，从而提供生动的高保真声音。

4. 发明申请

WO2004048407A1 ANTIMICROBIAL PEPTIDE ISOLATED FROM HALOCYNTHIA AURANTIUM 审中-公开
标题翻译：从HALOCYNTHIA AURANTIUM分离的抗微生物肽
公开(公告)号：WO2004048407A1
公开(公告)日：2004-06-10
申请号：PCT/KR2002/002195
申请日：2002-11-22
申请人： LEE, In-Hee , SON, Seok-Min , JANG, Woong-Sik , KIM, Kyu-Nam
发明人： LEE, In-Hee , SON, Seok-Min , JANG, Woong-Sik , KIM, Kyu-Nam
IPC分类号： C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong acidic and basic environments. Moreover, it also shows strong antimicrobial activity against resistant bacteria. So, it can be used usefully as a natural antimicrobial agent.
摘要翻译：本发明涉及从Halocynthia aurantium分离的抗微生物肽，更具体地说，涉及从Halocynthia aurantium的体液中分离的抗微生物肽，以及含有它们作为活性成分的抗微生物剂。本发明的抗菌肽在强酸性和碱性环境下表现出优异的抗菌活性。此外，它还显示出抗性细菌的强抗微生物活性。因此，它可以有效地用作天然抗菌剂。

5. 发明申请

WO2012128582A3 A COMPOUND FOR INHIBITING HUMAN 11-ß-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：用于抑制人11-β-羟化甾体脱氢酶1型的化合物和包含其的药物组合物
公开(公告)号：WO2012128582A3
公开(公告)日：2012-11-15
申请号：PCT/KR2012002100
申请日：2012-03-23
申请人： HYUNDAI PHARM CO LTD , LEE IN HEE , PARK CHANG MIN , KIM SE HOAN , CHAE HEE IL , PYEON DOO HYEOK , SHIN MYOUNG HYEON , HWANG JEONG UN , MOON SOON YOUNG , HA TAE YOUNG , KIM SO YOUN , CHOI HYUK JOON , YOO MYOUNG HYUN , LEE JONG CHAN , KIM YOUNG SEOK , RHEE JAE KEOL
发明人： LEE IN HEE , PARK CHANG MIN , KIM SE HOAN , CHAE HEE IL , PYEON DOO HYEOK , SHIN MYOUNG HYEON , HWANG JEONG UN , MOON SOON YOUNG , HA TAE YOUNG , KIM SO YOUN , CHOI HYUK JOON , YOO MYOUNG HYUN , LEE JONG CHAN , KIM YOUNG SEOK , RHEE JAE KEOL
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/00 , A61P9/00
CPC分类号： C07D265/30 , C07D413/06
摘要： The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.
摘要翻译：本发明涉及一种新型化合物或其立体异构体或其药学上可接受的盐，以及包含其的人-11-β-羟基类固醇脱氢酶1型（11β-HSD1）的药物组合物。本发明提供了具有优异活性和溶解性并且更有效地配制和递送的化合物，以及包含其的人-11-β-羟基类固醇脱氢酶的药物组合物。

6. 发明申请

WO1998045260A1 PROCESS FOR STEREOSELECTIVE PREPARATION OF AZETIDINONES 审中-公开
标题翻译：方法选择性制备AZETIDINONES的方法
公开(公告)号：WO1998045260A1
公开(公告)日：1998-10-15
申请号：PCT/KR1997000070
申请日：1997-04-30
申请人： CHOONGWAE PHARMACEUTICAL CO., LTD. , LEE, Mi-Jung , YOON, Taek-Hyun , LEE, In-Hee , KWON, Hee-An , HWANG, Tae-Seop
发明人： CHOONGWAE PHARMACEUTICAL CO., LTD.
IPC分类号： C07D205/08
CPC分类号： C07D205/08
摘要： The present invention relates to a process for stereoselective preparation of (3S,4S)-3- [(1R)-hydroxyethyl]-4-acyl-1-p-methoxyphenyl-2-azetidinone which is a useful intermediate for preparing carbapenem and penem type antibiotics.
摘要翻译：本发明涉及立体选择性制备（3S，4S）-3 - [（1R） - 羟基乙基] -4-酰基-1-对甲氧基苯基-2-氮杂环丁酮的方法，其是制备碳青霉烯和青霉烯的有用中间体型抗生素。

7. 发明申请

WO1998007691A1 PROCESS FOR STEREOSELECTIVE PREPARATION OF TRANS-AZETIDINONES 审中-公开
标题翻译：异硫氰酸酯的立体选择性制备方法
公开(公告)号：WO1998007691A1
公开(公告)日：1998-02-26
申请号：PCT/KR1997000072
申请日：1997-04-30
申请人： CHOONGWAE PHARMACEUTICAL CO., LTD. , LEE, Mi-Jung , YOON, Taek-Hyun , LEE, In-Hee , KWON, Hee-An , HWANG, Tae-Seop , LEE, Su-Jin , AHN, Chan-Yong
发明人： CHOONGWAE PHARMACEUTICAL CO., LTD.
IPC分类号： C07D205/08
CPC分类号： C07D303/48 , C07D205/08 , C07F7/1804
摘要： The present invention relates to a process for stereoselective preparation of (3S,4S)-3-[(1'R)-1'-hydroxyethyl]-4-alkoxycarbonyl-2-azetidinone (I) which is a useful intermediate for preparing carbaphenem and phenem type beta -lactam antibiotics. According to the present invention the objective compound can be synthesized with economic advantages as well as high synthetic yield.
摘要翻译：本发明涉及立体选择性制备（3S，4S）-3 - [（1'R）-1'-羟乙基] -4-烷氧基羰基-2-氮杂环丁酮（I）的方法，其是制备碳青霉烯类的有用中间体和phenem型β-内酰胺抗生素。根据本发明，可以合成具有经济优势和高合成产率的目标化合物。

8. 发明申请

WO2012128582A2 A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：一种抑制人类11-β-羟基类固醇脱氢酶1型的化合物和一种含有该化合物的药物组合物
公开(公告)号：WO2012128582A2
公开(公告)日：2012-09-27
申请号：PCT/KR2012/002100
申请日：2012-03-23
申请人： HYUNDAI PHARM CO., LTD. , LEE, In Hee , PARK, Chang Min , KIM, Se Hoan , CHAE, Hee Il , PYEON, Doo Hyeok , SHIN, Myoung Hyeon , HWANG, Jeong Un , MOON, Soon Young , HA, Tae Young , KIM, So Youn , CHOI, Hyuk Joon , YOO, Myoung Hyun , LEE, Jong Chan , KIM, Young Seok , RHEE, Jae Keol
发明人： LEE, In Hee , PARK, Chang Min , KIM, Se Hoan , CHAE, Hee Il , PYEON, Doo Hyeok , SHIN, Myoung Hyeon , HWANG, Jeong Un , MOON, Soon Young , HA, Tae Young , KIM, So Youn , CHOI, Hyuk Joon , YOO, Myoung Hyun , LEE, Jong Chan , KIM, Young Seok , RHEE, Jae Keol
IPC分类号： C07D265/30 , A61K31/5375 , A61P9/00 , A61P3/00
CPC分类号： C07D265/30 , C07D413/06
摘要： The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.
摘要翻译：本发明涉及新型化合物或其立体异构体或其药学上可接受的盐和用于人11-β-羟基类固醇脱氢酶1型（11β-HSD1）的药物组合物，其包含相同。本发明提供一种化合物，其具有优异的活性和溶解性并且更有效地配制和递送，并且提供了一种包含其的人11-β-羟基类固醇脱氢酶1型的药物组合物。

9. 发明申请

WO1998007690A1 PROCESS FOR STEREOSELECTIVE PREPARATION OF 4-ACETOXYAZETIDINONES 审中-公开
标题翻译： 4-乙酰氧基苯乙酮的立体选择性制备方法
公开(公告)号：WO1998007690A1
公开(公告)日：1998-02-26
申请号：PCT/KR1997000071
申请日：1997-04-30
申请人： CHOONGWAE PHARMACEUTICAL CO., LTD. , LEE, Mi-Jung , YOON, Taek-Hyun , LEE, In-Hee , KWON, Hee-An , HWANG, Tae-Seop , LEE, Su-Jin , AHN, Chan-Yong
发明人： CHOONGWAE PHARMACEUTICAL CO., LTD.
IPC分类号： C07D205/08
CPC分类号： C07D303/48 , C07D205/08 , C07F7/1804
摘要： The present invention relates to a process for stereoselective preparation of (3R,4R)-4-acetoxy-3-{[(1'R)-1'-t-butyldimethylsilyloxy]ethyl}-2-azetidinone (I) which is a useful intermediate for preparing carbapenem and penem type beta -lactam antibiotics. According to the present invention the objective compound can be synthesized with economic advantages as well as high synthetic yield.
摘要翻译：本发明涉及立体选择性制备（3R，4R）-4-乙酰氧基-3 - {[（1'R）-1'-叔丁基二甲基甲硅烷氧基]乙基} -2-氮杂环丁酮（I）的方法，其为制备碳青霉烯类和β-内酰胺类抗生素的有用中间体。根据本发明，可以合成具有经济优势和高合成产率的目标化合物。

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