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1. 发明申请

WO2012128582A3 A COMPOUND FOR INHIBITING HUMAN 11-ß-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：用于抑制人11-β-羟化甾体脱氢酶1型的化合物和包含其的药物组合物
公开(公告)号：WO2012128582A3
公开(公告)日：2012-11-15
申请号：PCT/KR2012002100
申请日：2012-03-23
申请人： HYUNDAI PHARM CO LTD , LEE IN HEE , PARK CHANG MIN , KIM SE HOAN , CHAE HEE IL , PYEON DOO HYEOK , SHIN MYOUNG HYEON , HWANG JEONG UN , MOON SOON YOUNG , HA TAE YOUNG , KIM SO YOUN , CHOI HYUK JOON , YOO MYOUNG HYUN , LEE JONG CHAN , KIM YOUNG SEOK , RHEE JAE KEOL
发明人： LEE IN HEE , PARK CHANG MIN , KIM SE HOAN , CHAE HEE IL , PYEON DOO HYEOK , SHIN MYOUNG HYEON , HWANG JEONG UN , MOON SOON YOUNG , HA TAE YOUNG , KIM SO YOUN , CHOI HYUK JOON , YOO MYOUNG HYUN , LEE JONG CHAN , KIM YOUNG SEOK , RHEE JAE KEOL
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/00 , A61P9/00
CPC分类号： C07D265/30 , C07D413/06
摘要： The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.
摘要翻译：本发明涉及一种新型化合物或其立体异构体或其药学上可接受的盐，以及包含其的人-11-β-羟基类固醇脱氢酶1型（11β-HSD1）的药物组合物。本发明提供了具有优异活性和溶解性并且更有效地配制和递送的化合物，以及包含其的人-11-β-羟基类固醇脱氢酶的药物组合物。

2. 发明申请

WO2015183002A3 NOVEL ANALOG OF HALOCYNTHIA AURANTIUM-DERIVED ANTIMICROBIAL PEPTIDE, AND USE THEREOF 审中-公开
标题翻译： HALOCYNTHIA AURANTIUM衍生的抗微生物肽的新型模拟物及其用途
公开(公告)号：WO2015183002A3
公开(公告)日：2016-01-21
申请号：PCT/KR2015005338
申请日：2015-05-28
申请人： LEE IN HEE
发明人： LEE IN HEE
IPC分类号： C07K7/00 , A61K38/17 , A61P31/02 , A61P31/04
CPC分类号： A61K38/17 , C07K7/00
摘要： The present invention relates to an antimicrobial peptide and, more specifically, to: a mutant antimicrobial peptide in which the resistance against proteases and the activity in the serum are greatly improved by modifying a part of the amino acids of halocidin, which is an antimicrobial peptide isolated from Halocynthia aurantium body fluid cells; and an antimicrobial agent containing the antimicrobial peptide as an active ingredient. The antimicrobial peptide of the present invention is an antimicrobial peptide having strong fungicidal activity against fungi and excellent resistance against gram-positive and gram-negative bacteria, particularly, antibiotic resistant bacteria, overcoming the problems of the hydrolysis by proteases and the loss of antimicrobial activity caused by nonspecific binding with serum proteins, which are large obstacles to the practical use of an antimicrobial peptide, and useful as a novel peptide antibiotic.
摘要翻译：本发明涉及一种抗微生物肽，更具体地说，涉及：通过修饰作为抗微生物肽的卤代核苷酸的一部分氨基酸，其中抗蛋白酶的抗性和血清中的活性大大提高的突变型抗微生物肽从紫穗槐属体液细胞中分离出来; 和含有抗微生物肽作为活性成分的抗微生物剂。本发明的抗微生物肽是对真菌具有强烈杀真菌活性的抗微生物肽，具有抗革兰氏阳性和革兰氏阴性细菌，特别是抗生素抗性细菌的优良抗性，克服蛋白酶水解的问题和抗菌活性丧失由与血清蛋白质的非特异性结合引起的，这是抗微生物肽实际使用的巨大障碍，并且可用作新的肽抗生素。

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