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1. 发明申请

WO2005084263A2 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
标题翻译：试剂递送系统，生物染色装置的分配装置和容器
公开(公告)号：WO2005084263A2
公开(公告)日：2005-09-15
申请号：PCT/US2005006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK AS , FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
发明人： FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
IPC分类号： B01L3/00 , G01N1/31 , G01N35/10
CPC分类号： G01N1/30 , B01L3/508 , G01N1/312 , G01N35/1002 , G01N35/109 , Y10T436/2575
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
摘要翻译：本发明涉及用于处理布置在显微镜载片上的生物样品的装置的试剂递送系统，包括具有一个或多个试剂容器的试剂部分; 其中布置有至少一个显微镜载玻片的滑动部分; 用于将一部分试剂分配到预定显微镜载玻片上的探针和用于处理探针的装置。探针包括连续证明管道元件，其延伸穿过刚性探针构件并将探针尖端连接到气动调压装置。试剂容器适于与探针尖端配合。以这种方式，由于没有组装部件构成探针的内部容积，可以保持流体，所以实现了很高的保持和非常低的流体滞留输送。

2. 发明申请

WO2005016296A1 EMULSIVE COMPOSITION CONTAINING DAPSONE 审中-公开
标题翻译：含有DAPSONE的强力组合物
公开(公告)号：WO2005016296A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/026447
申请日：2004-08-13
申请人： ATRIX LABORATORIES, INC. , LATHROP, Robert , OSBORNE, David, W.
发明人： LATHROP, Robert , OSBORNE, David, W.
IPC分类号： A61K7/00
CPC分类号： A61K8/46 , A61K9/0014 , A61K47/06 , A61K47/10 , A61K47/14 , A61Q17/005 , A61Q19/00 , Y02A50/411
摘要： The present invention relates to a topical, emulsive composition containing Dapsone or its derivative. The inventive composition incorporates emollients and Dapsone or its derivative in a stable emulsion. The stability is achieved through the use of a combination of certain surfactant mixtures and an enhancer providing solubility of the Dapsone.
摘要翻译：本发明涉及含有氨苯砜或其衍生物的局部用乳化组合物。本发明的组合物将柔软剂和氨苯砜或其衍生物掺入稳定的乳液中。通过使用某些表面活性剂混合物和提供氨苯砜的溶解度的增强剂的组合来实现稳定性。

3. 发明申请

WO2003043628A1 ARZNEIMITTEL ZUR BEHANDLUNG VON VIRALEN HAUT- UND TUMORERKRANKUNGEN 审中-公开
标题翻译：药物的病毒性皮肤病和肿瘤疾病的治疗
公开(公告)号：WO2003043628A1
公开(公告)日：2003-05-30
申请号：PCT/EP2002/012919
申请日：2002-11-18
申请人： MEDIGENE AKTIENGESELLSCHAFT , CHANG, Yunik , LATHROP, Robert , BÖHM, Erwin , GANDER-MEISTERERNST, Irene , GREGER, Regina , HOLLDACK, Johanna , MOEBIUS, Ulrich
发明人： CHANG, Yunik , LATHROP, Robert , BÖHM, Erwin , GANDER-MEISTERERNST, Irene , GREGER, Regina , HOLLDACK, Johanna , MOEBIUS, Ulrich
IPC分类号： A61K31/23
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： Die vorliegende Erfindung betrifft ein Arzneimittel, enthaltend eine Verbindung der allgemeinen Formel wobei, R 1 unabhängig voneinander ein unverzweigter oder verzweigter, gesättigter, einfach oder mehrfach ungesättigter, gegebenenfalls substituierter C 11 -C 21 Alkyl-, Alkylen- oder Alkinylrest, vorzugsweise ein C 11 -C 15 - Alkyl-, Alkylen- oder Alkinylrest, insbesondere ein C 11 -C 13 Alkyl-, Alkylen- oder Alkinylrest, vor allem ein C 13 -Alkylrest bedeutet, und R2 unabhängig voneinander ein unverzweigter oder verzweigter C 1 -C 8 Alkyl Alkylen- oder Alkinylrest, vorzugsweise ein C 1 -C 6 - Alkyl-, Alkylen- oder Alkinylrest, insbesondere ein C 2 -C 4 Alkyl-, Alkylen- oder Alkinylrest, vor allem ein C 3 Alkylrest, ein -[CH 2 -(CH 2 ) m -O] n H Rest mit n = 1 bis 10, vorzugsweise n = 1 bis 5, m = 1 bis 5, vorzugsweise m = 1 bis 3, einen -CH 2 -[CH-(OH)] p [CH 2 -(R 3 )]-Rest, wobei R 3 unabhängig voneinander ein Wasserstoff oder ein Hydroxylrest, p = 1 bis 7, vorzugsweise p = 1 bis 4, ein Pentose-Rest oder ein Hexose-Rest bedeutet, als therapeutisch aktiven Wirkstoff alleine oder zusammen mit einem oder mehreren weiteren pharmazeutischen Wirkstoffen als Kombinationspräparat zur Behandlung von viralen Hauterkrankungen und/oder Tumorerkrankungen, hervorgerufen insbesondere durch humane Papilloma Viren (HPV) und/oder Herpes Viren, sowie eine topisch wirkende Arzneimittelformulierung und deren Verwendung.
摘要翻译：本发明涉及含有通式的化合物的药物，其中，R 1彼此独立地直链或支链的，饱和的，单或多不饱和，任选取代的C11-C21烷基，亚烷基或炔基，优选C11-C15烷基指亚烷基或亚炔基，特别是C11-C13烷基，亚烷基或炔基，特别是C13-烷基，和R 2独立地为直链或支链的C1-C8烷基亚烷基或亚炔基，优选为C1-C6 - - 烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，特别是C 3烷基， - [CH 2（CH 2）Mo]的NH基团，其中n = 1至10，优选n = 1至5，M = 1至5，优选M = 1至3，一个-CH 2 [CH（OH）] p [CH 2（R 3）] - 基团，其中R 3独立地是氢或羟基，p = 1至7，优选地，p = 1至4，戊糖基团或一个己糖基团，如单独或与一种或多种另外的药物活性物质，作为病毒性皮肤疾病和/或肿瘤疾病的治疗的组合制剂一起治疗活性成分，由人类乳头状瘤病毒（HPV）和/或疱疹病毒，以及局部作用的药物制剂，并引起了特别它们的使用。

4. 发明申请

WO2006050303A2 INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH METRONIDAZOLE COMPOSITIONS 审中-公开
标题翻译：甲硝唑组合物阴道内治疗阴道感染
公开(公告)号：WO2006050303A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039349
申请日：2005-10-26
申请人： QLT USA INC. , EBMEIER, Mathew , LATHROP, Robert
发明人： EBMEIER, Mathew , LATHROP, Robert
IPC分类号： A61K9/00 , A61K31/4164 , A61P31/04
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供适用于治疗细菌性阴道病的缓冲不流动组合物。该组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝哒唑。甲硝唑与缓冲系统一起存在于生理上可耐受的介质中。缓冲体系为组合物提供约5.0至约6.0的酸性缓冲pH值。本发明还提供了一种抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了治疗人类患者的细菌性阴道病的方法。该方法包括对需要这种治疗的患者进行阴道内给药有效量的本发明组合物。该组合物每天至少一次引入阴道至少一天的时间。

5. 发明申请

WO2005084263A3 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
公开(公告)号：WO2005084263A3
公开(公告)日：2005-09-15
申请号：PCT/US2005/006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK A/S , FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
发明人： FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
IPC分类号： G01N1/10
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

6. 发明申请

WO2005047858A2 ON-LINE APPARATUS AND METHOD FOR DETERMINING ENDOTOXIN LEVELS 审中-公开
标题翻译：在线装置和确定内毒素水平的方法
公开(公告)号：WO2005047858A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037097
申请日：2004-11-08
申请人： CAMBREX BIO SCIENCE WALKERSVILLE, INC. , BONEN, Matthew, Richard , BERZOFSKY, Ronald, Norman , RICHARDSON, Bruce, J. , LATHROP, Robert, L., III , DEN DULK, Bruce, Rodney
发明人： BONEN, Matthew, Richard , BERZOFSKY, Ronald, Norman , RICHARDSON, Bruce, J. , LATHROP, Robert, L., III , DEN DULK, Bruce, Rodney
IPC分类号： G01N
CPC分类号： G01N1/18 , G01N33/5302 , G01N35/1097 , G01N2035/103
摘要： An apparatus and method for on-line testing for the presence of an endotoxin within a fluid sample from a fluid line. The apparatus is positioned in fluid communication with a fluid line to perform the on-line fluid testing for the presence of at least one endotoxin. The apparatus can include a housing and a fluid sampling system positioned in fluid communication with the fluid line. The fluid sampling system can comprise a valve for controlling the fluid flow from the fluid line into the fluid sampling system. A fluid flow well is positioned within the housing and in fluid communication with the fluid sampling system. A removable assembly can also be secured within the housing. The removable assembly comprises a plurality of wells for receiving used and unused fluid carrying members that can receive samples from the fluid flow well, a plurality of fluid sample receiving wells, and a plurality of vessel retention positions comprising recesses for securely receiving portions of respective fluid vessels. A detecting system is provided for testing a control sample and a sample of the fluid from the fluid line. The results of these tests are compared in order to determine if the fluid sample is carrying any endotoxins. In an embodiment, fluorescence testing of the sample is compared to that of the control in order to determine if the sample includes an endotoxin.
摘要翻译：用于在线测试来自流体管线的流体样品内存在内毒素的装置和方法。该装置定位成与流体管线流体连通，以进行在线流体测试以存在至少一种内毒素。该装置可以包括壳体和定位成与流体管线流体连通的流体采样系统。流体采样系统可以包括用于控制从流体管线流入流体采样系统的流体流量的阀。流体流动井位于壳体内并与流体采样系统流体连通。可拆卸的组件也可以固定在壳体内。可移除的组件包括多个井，用于接收可以从流体井接收样品的多余的未使用流体承载构件，多个流体样品接收孔，以及多个容器保持位置，其包括用于牢固地接收各个流体的部分的凹部船只。提供了一种用于从流体管线测试对照样品和流体样品的检测系统。比较这些测试的结果以确定流体样品是否携带任何内毒素。在一个实施方案中，将样品的荧光测试与对照的荧光测试进行比较，以确定样品是否包含内毒素。

7. 发明申请

WO2004057308A1 AN AUTOMATED SAMPLE PROCESSING APPARATUS AND A METHOD OF AUTOMATED TREATING OF SAMPLES AND USE OF SUCH APPARATUS 审中-公开
标题翻译：自动样品处理装置和自动处理样品的方法和使用这种装置
公开(公告)号：WO2004057308A1
公开(公告)日：2004-07-08
申请号：PCT/DK2003/000911
申请日：2003-12-19
申请人： DAKOCYTOMATION DENMARK A/S , LATHROP, Robert , KEY, Marc , FAVUZZI, John
发明人： LATHROP, Robert , KEY, Marc , FAVUZZI, John
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N35/10 , G01N35/1002 , G01N2001/317 , G01N2035/00138 , G01N2035/00326 , G01N2035/00534 , G01N2035/00881
摘要： An automated staining apparatus (1) and a method for treating samples arranged on carrier means (7) is disclosed, in which portions of two or more selected reagents from a first station (2) containing the reagents are collected individually by means of a robot arm (20) handling a probe (10) and dispensed in a mixing station (9) of the apparatus. After mixing the reagents in the mixing station (9) , e.g. by shaking or rotating the mixing cup containing the reagents, the reagent mixture is applied to selected samples by means of the robot arm (20) and a probe.(10) .By providing a staining apparatus having an automated mixer integrated therein, staining or treatment processes requiring a mixture of unmixable reagents, such as a water based and an oil based reagent, or insoluble reagents, can be performed automatically instead of requiring human interaction or manual performance of some process steps in a much more automated process, and the quality of the staining process may be improved as a desired degree of mixing of reagents may be provided or an optimal application time window for a deteriorating mixture may be reached.
摘要翻译：公开了一种自动染色装置（1）和用于处理载体装置（7）上的样品的方法，其中来自含有试剂的第一工位（2）的两种或更多种所选试剂的部分通过机器人分别收集臂（20）处理探针（10）并分配在装置的混合站（9）中。将混合站（9）中的试剂混合后，通过摇动或旋转含有试剂的混合杯，将试剂混合物通过机器人手臂（20）和探针（10）施加到选定的样品上。（10）通过提供具有整合在其中的自动混合器的染色装置，染色或可以自动执行需要混合不溶性试剂（如水基和油基试剂）或不溶性试剂的处理方法，而不需要在更加自动化的过程中进行人工交互或手动执行某些工艺步骤，而且质量可以提供染色过程的可能性，因为可以提供试剂的所需程度，或者可以达到恶化混合物的最佳施用时间窗。

8. 发明申请

WO2006042324A2 PHARMACEUTICAL COMPOSITION APPLICABLE TO BODY TISSUE 审中-公开
标题翻译：适用于身体组织的药物组合物
公开(公告)号：WO2006042324A2
公开(公告)日：2006-04-20
申请号：PCT/US2005037074
申请日：2005-10-12
申请人： QLT USA INC , EBMEIER MATHEW , LATHROP ROBERT
发明人： EBMEIER MATHEW , LATHROP ROBERT
IPC分类号： A61K9/08 , A61K31/135 , A61K47/38 , A61P31/10
CPC分类号： A61K9/7015 , A61K9/0014 , A61K31/045 , A61K31/125 , A61K31/137 , A61K31/496 , A61K31/717 , A61K47/08 , A61K47/10 , A61K47/38
摘要： The present invention provides a non-water soluble, film-forming composition which adheres to body tissue and forms a pharmaceutical carrier to provide localized delivery of an antifungal agent to a treatment site. The composition will typically include: (a) an alkyl cellulose; (b) a hydroxyalkyl cellulose; (c) a pharmaceutically acceptable polar protic solvent; (d) an antifungal agent selected from the group of naftifine, ciclopirox, terbinafine, pharmaceutically acceptable salts thereof, and combinations thereof; (e) an glycol ether; (f) an antipruritic agent selected from the group of camphor, menthol, butamben picrate, metacresol, benzyl alcohol, camphorated metacresol, juniper tar, phenol, phenolate sodium, resorcinol, camphorated metacresol, carbolic acid, and combinations,; and (g) a solubility enhancing agent, a surfactant, a wetting agent, or a combination thereof. The present invention also provides for the use of the composition composition of the present invention, in treating a fungal infection (e.g., nail fungus) in a mammal afflicted with such an infection.
摘要翻译：本发明提供了一种非水溶性成膜组合物，其粘附于身体组织并形成药物载体以提供抗真菌剂向治疗部位的局部递送。组合物通常包括：（a）烷基纤维素; （b）羟烷基纤维素; （c）药学上可接受的极性质子溶剂; （d）选自脱头芬，环吡酮，特比萘芬，其药学上可接受的盐及其组合的抗真菌剂; （e）乙二醇醚; （f）选自樟脑，薄荷醇，苦丁酸苦参酸，甲酚，苯甲醇，樟脑甲醇，杜松子焦油，苯酚，苯酚钠，间苯二酚，樟脑甲酚，卡拉酸及其组合的止痒剂。和（g）增溶溶剂，表面活性剂，润湿剂或其组合。本发明还提供本发明的组合物组合物在治疗患有这种感染的哺乳动物中的真菌感染（例如指甲真菌）中的用途。

9. 发明申请

WO0195762A3 WORKSURFACE SYSTEM 审中-公开
标题翻译：工作表系统
公开(公告)号：WO0195762A3
公开(公告)日：2003-09-18
申请号：PCT/US0118978
申请日：2001-06-12
申请人： MILLER HERMAN INC , DUVIER JOHN , BOTTOM LISA , BRANSEN BRADLEY , LATHROP ROBERT , GARTLAND PAUL , MOOREHART JACK
发明人： DUVIER JOHN , BOTTOM LISA , BRANSEN BRADLEY , LATHROP ROBERT , GARTLAND PAUL , MOOREHART JACK
IPC分类号： A47B9/00 , A47B9/16 , A47B17/03 , A47B17/00 , A47B37/00
CPC分类号： A47B17/033 , A47B9/00 , A47B9/16 , A47B2037/005
摘要： A height-adjustable worksurface assembly (14) having a leg. The leg has a top portion (32) and bottom portion (34). The top portion (32) includes a connection member for connection to a worksurface. A first arm (48) is attached to the top portion of the leg and extends downward to an elbow (68). A second arm (110) is attached to the elbow and extends downward to the bottom portion of the leg. The leg has feet (96) that rest on a base surface. The top worksurface connection member, the elbow and the feet are generally aligned in a single vertical plane when the worksurface is positioned at different heights.
摘要翻译：具有腿的高度可调的工作面组件（14）。腿具有顶部（32）和底部（34）。顶部（32）包括用于连接到工作台面的连接构件。第一臂（48）附接到腿的顶部并向下延伸到肘部（68）。第二臂（110）附接到肘部并且向下延伸到腿部的底部。腿部具有搁置在基面上的脚部（96）。当工件表面位于不同的高度时，顶部工作面连接构件，肘部和脚部通常对准在单个垂直平面中。

10. 发明申请

WO2006050303A3 INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH METRONIDAZOLE COMPOSITIONS 审中-公开
标题翻译：用METRONIDAZOLE组合物治疗阴道感染的腹腔内治疗
公开(公告)号：WO2006050303A3
公开(公告)日：2006-10-19
申请号：PCT/US2005039349
申请日：2005-10-26
申请人： QLT USA INC , EBMEIER MATHEW , LATHROP ROBERT
发明人： EBMEIER MATHEW , LATHROP ROBERT
IPC分类号： A61K9/00 , A61K31/4164 , A61P31/04
CPC分类号： A61K9/0034 , A61K31/4164
摘要： The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.
摘要翻译：本发明提供了适用于治疗细菌性阴道病的缓冲非流动组合物。组合物包含浓度为约0.50％（w / w）至约1.50％（w / w）的甲硝唑。甲硝唑与缓冲系统一起存在于生理上可耐受的培养基中。缓冲系统为组合物提供约5.0至约6.0范围内的酸性缓冲pH值。本发明还提供了抑制微生物的方法。该方法包括使微生物与有效量的本发明组合物接触一段有效抑制微生物的时间。本发明还提供了一种在人类患者中治疗细菌性阴道病的方法。该方法包括对需要这种治疗的患者的阴道内施用有效量的本发明的组合物。每天至少一次将组合物引入阴道至少一天的时间。

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