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    • 4. 发明申请
    • USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI
    • 用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法
    • WO2008074473A2
    • 2008-06-26
    • PCT/EP2007011127
    • 2007-12-18
    • BASF SEREINDL ANDREASLANG CHRISTINEBOETTNER MEWESVEEN MARKUS
    • REINDL ANDREASLANG CHRISTINEBOETTNER MEWESVEEN MARKUS
    • A61K35/74A61P1/02
    • C12N1/20A23G3/366A23G4/123A23L33/135A61K8/99A61K35/747A61Q11/00C12R1/225
    • The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
    • 本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途,其特征在于能够特异性结合属于变形链球菌链球菌属的细菌,其中特异性结合是 (i)耐热处理; 和/或(ii)抗蛋白酶处理; 和/或(iii)钙依赖性; 和/或(iv)在4.5至8.5之间的pH范围内形成; 和/或(v)在唾液存在下形成,用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。 优选地,可以如下测定特异性结合:(a)将所述微生物生长至固定相; (b)将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; (c)在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤(b)中获得的混合物; 和(d)通过颗粒的发生检测聚集体。 本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法,包括给予属于所述乳酸菌群的微生物,其特征在于,所述微生物能够特异性结合属于 变体链球菌或所述微生物的突变体,衍生物,类似物或片段。