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1. 发明申请

WO2008019887A3 PROBIOTIC MICROORGANISMS FOR THE REDUCTION OF MANURE ODOR 审中-公开
标题翻译：用于减少臭味的生物微生物
公开(公告)号：WO2008019887A3
公开(公告)日：2008-09-12
申请号：PCT/EP2007007337
申请日：2007-08-20
申请人： BASF SE , LANG CHRISTINE , RITTMANN STEFANIE , BOLOTINA NATALIA , VEEN MARKUS , BOETTNER MEWES , BUDDE ECKHARD , KUENKEL ANDREAS , PFEIFFER ANGELIKA-MARIA
发明人： LANG CHRISTINE , RITTMANN STEFANIE , BOLOTINA NATALIA , VEEN MARKUS , BOETTNER MEWES , BUDDE ECKHARD , KUENKEL ANDREAS , PFEIFFER ANGELIKA-MARIA
IPC分类号： C12N1/16 , A23L29/00 , A61K35/66 , A61K35/74 , C12N1/20 , C12R1/225 , C12R1/23 , C12R1/25 , C12R1/645 , C12R1/74
CPC分类号： C12R1/225 , A23L29/065 , A23V2002/00 , A23Y2220/00 , A61K35/747 , A61K36/064 , A61K36/07 , C12R1/23 , C12R1/25 , C12R1/645 , C12R1/72 , A23V2200/3204
摘要： Described are microorganism which are able to reduce the generation of feces odor by decreasing the amount of at least one of the compounds methyl mercaptan, a sulphide compound, cadavarine, putrescine, indole or skatole, and wherein said decrease in the amount of said compounds is independent of the growth of the microorganism. Also described are compositions, comprising such microorganisms, e.g. food, feed or pharmaceutical compositions and the use of such microorganisms for suppressing feces odor or the preparation of foodstuff or feedstuff, as well as corresponding methods for the production of food or feed composition and additives for food, feed or drinks.
摘要翻译：描述了能够通过减少化合物中的至少一种化合物甲硫醇，硫化物化合物，卡那霉素，腐胺，吲哚或粪便来减少粪便气味的产生的微生物，并且其中所述化合物的量的减少是独立于微生物的生长。还描述了包含这样的微生物的组合物，例如。食品，饲料或药物组合物以及这些微生物用于抑制粪便气味或食品或饲料的制备，以及用于生产食品，饲料组合物和用于食品，饲料或饮料的添加剂的相应方法。

2. 发明申请

WO2006136420A2 METHODS AND MEANS FOR PROTECTING THE SKIN AGAINST PATHOGENIC MICROORGANISMS 审中-公开
标题翻译：保护皮肤病原微生物的方法和手段
公开(公告)号：WO2006136420A2
公开(公告)日：2006-12-28
申请号：PCT/EP2006006030
申请日：2006-06-22
申请人： ORGANOBALANCE GMBH , LANG CHRISTINE , HEILMANN ANDREAS , VEEN MARKUS , BUDDE ECKHARD , BOETTNER MEWES , REINDL ANDREAS , KNOELL ROLF
发明人： LANG CHRISTINE , HEILMANN ANDREAS , VEEN MARKUS , BUDDE ECKHARD , BOETTNER MEWES , REINDL ANDREAS , KNOELL ROLF
IPC分类号： C12N1/20 , A61K35/74 , C12N1/38
CPC分类号： A61K35/747 , A01N63/00 , A61K8/99 , A61K9/0014 , A61K35/74 , A61K2035/11 , A61Q17/005 , A61Q19/00 , C12R1/225 , C12R1/24
摘要： Described are microorganisms which are, in a first aspect, able to to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.
摘要翻译：描述的是微生物，其在第一方面能够刺激常驻皮肤微生物菌群的微生物的生长并且不刺激瞬时致病微菌群的微生物的生长。在第二方面，描述了能够抑制瞬时致病性皮肤微菌群的微生物生长并且不抑制常驻皮肤微菌群微生物生长的微生物。还描述了包含这种微生物的组合物以及这些微生物在化妆品，预防或治疗应用中的用途。

3. 发明申请

WO2009124694A3 SYNTHESIS OF POLYUNSATURATED FATTY ACIDS IN YEAST 审中-公开
标题翻译：聚合脂肪酸在YEAST中的合成
公开(公告)号：WO2009124694A3
公开(公告)日：2010-01-14
申请号：PCT/EP2009002481
申请日：2009-04-03
申请人： ORGANOBALANCE GMBH , VAN LENGERICH BERNHARD , BOETTNER MEWES , RIECHERS SEAN-PATRICK , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL
发明人： VAN LENGERICH BERNHARD , BOETTNER MEWES , RIECHERS SEAN-PATRICK , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL
IPC分类号： C12P7/64 , A23K1/16 , A23L1/30 , C12N1/18
CPC分类号： C12P7/6472 , A23K20/158 , A23L33/12 , C11B1/10 , C12N1/18 , C12N9/0083 , C12N9/1029 , C12P7/6427
摘要： Described is a method of providing an organism belonging to the genus Saccharomyces, which is capable of producing polyunsaturated fatty acids (PUFAs) comprising the steps of subjecting such an organism, which does not produce PUFAs, to a mutagenesis step and selecting a Saccharomyces organism, which is capable of accumulating at least 15% of the cellular dry weight as lipids; and genetically modifying the Saccharomyces organism selected in step (a) so that it is capable of synthesizing PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid. Also described are organisms obtained by such a method, as well as a method for the synthesis of PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid comprising culturing such an organism.
摘要翻译：描述了提供属于酵母属（Saccharomyces）的生物体的方法，其能够产生多不饱和脂肪酸（PUFA），包括以下步骤：使不产生PUFA的生物体进行诱变步骤并选择酵母属生物，其能够作为脂质积聚至少15％的细胞干重; 和遗传修饰在步骤（a）中选择的酵母属生物体，使得其能够合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸。还描述了通过这种方法获得的生物体，以及用于合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸的方法，其包括培养这种生物体。

4. 发明申请

WO2008128522A3 MICROORGANISM FOR THE PRODUCTION OF SUCCINIC ACID 审中-公开
标题翻译：菌对琥珀酸生产
公开(公告)号：WO2008128522A3
公开(公告)日：2009-04-02
申请号：PCT/DE2008000670
申请日：2008-04-16
申请人： ORGANO BALANCE GMBH , LANG CHRISTINE , VEEN MARKUS , BOETTNER MEWES , RAAB ANDREAS
发明人： LANG CHRISTINE , VEEN MARKUS , BOETTNER MEWES , RAAB ANDREAS
IPC分类号： C12P7/46 , C12N1/19 , C12N9/04 , C12N9/88
CPC分类号： C12P7/46 , C12N1/18 , C12N9/0006 , C12N9/88
摘要： The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising "PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3" are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.
摘要翻译：本发明涉及一种分离的遗传修饰的微生物，其中所述基因IDH1和基因SDH2中的至少一个，并且是第一启动子DIC1，其由培养添加剂压抑到培养生长介质，并且是活性在没有培养添加剂的控制下，对其中的基因基“PYC1，ACS1，CIT1，ACO1，ICL1，MSL1和CIT2任选MDH3”是这样的微生物的组成性活性，以及用途，特别是用于生产琥珀酸。

5. 发明申请

WO2006027265A1 MEANS AND METHODS FOR PREVENTING AND/OR TREATING CARIES 审中-公开
标题翻译：用于预防和/或治疗卡车的方法和方法
公开(公告)号：WO2006027265A1
公开(公告)日：2006-03-16
申请号：PCT/EP2005/009724
申请日：2005-09-09
申请人： BASF AKTIENGESELLSCHAFT , KAESLER, Bruno , KNÖLL, Rolf , BOETTNER, Mewes , BUDDE, Eckhard , LANG, Christine , RYSER, Martin , VEEN, Markus
发明人： KAESLER, Bruno , KNÖLL, Rolf , BOETTNER, Mewes , BUDDE, Eckhard , LANG, Christine , RYSER, Martin , VEEN, Markus
IPC分类号： C12N1/20 , C12R1/225 , A61K35/74 , A23L1/03
CPC分类号： A61K8/99 , A23G3/366 , A23G4/123 , A23K50/10 , A23K50/30 , A23K50/40 , A23K50/50 , A23K50/70 , A23K50/75 , A23K50/80 , A23L7/10 , A23L33/135 , A23V2002/00 , A23Y2220/63 , A23Y2220/73 , A23Y2240/49 , A61K8/0216 , A61K8/042 , A61K8/60 , A61K35/747 , A61Q11/00 , C12N1/20 , C12R1/225 , A23V2200/312 , A23V2200/3204
摘要： The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.
摘要翻译：本发明涉及属于该乳酸菌群的微生物，其特征在于能够特异性结合变形链球菌，其特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成。优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变形链球菌混合; （c）在允许形成所述微生物和变形链球菌的聚集体的条件下培养步骤（b）中获得的混合物，和（d）通过颗粒的发生检测聚集体。本发明的另一方面是所述微生物的类似物或片段，其被热灭活或冻干，其中所述类似物或片段保留特异性结合变形链球菌的能力。此外，本发明包括用于食品，饲料或饮料的组合物和添加剂，其包含特异性结合变形链球菌的乳酸菌群的微生物或其类似物或片段。此外，本发明提供了所述微生物或其所述类似物或其片段用于制备抗焦虑药物或药物组合物或抗癌食品或饲料的用途以及用于生产所述组合物或食物或饲料的方法。

6. 发明申请

WO2008074473A2 USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI 审中-公开
标题翻译：用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法
公开(公告)号：WO2008074473A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007011127
申请日：2007-12-18
申请人： BASF SE , REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
发明人： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
IPC分类号： A61K35/74 , A61P1/02
CPC分类号： C12N1/20 , A23G3/366 , A23G4/123 , A23L33/135 , A61K8/99 , A61K35/747 , A61Q11/00 , C12R1/225
摘要： The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
摘要翻译：本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途，其特征在于能够特异性结合属于变形链球菌链球菌属的细菌，其中特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成，用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; （c）在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤（b）中获得的混合物; 和（d）通过颗粒的发生检测聚集体。本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法，包括给予属于所述乳酸菌群的微生物，其特征在于，所述微生物能够特异性结合属于变体链球菌或所述微生物的突变体，衍生物，类似物或片段。

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