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1. 发明申请

WO2007009019A3 PROTEIN COMPOSITIONS FOR PROMOTING WOUND HEALING AND SKIN REGENERATION 审中-公开
标题翻译：促进愈合和皮肤再生的蛋白质组合物
公开(公告)号：WO2007009019A3
公开(公告)日：2009-05-07
申请号：PCT/US2006027155
申请日：2006-07-12
申请人： ESSENTIAL SKINCARE LLC , KISS ZOLTAN
发明人： KISS ZOLTAN
IPC分类号： A61K38/00
CPC分类号： A61K38/1741 , A61K38/40 , A61K38/465 , A61K38/57 , C12Y301/03001 , A61K2300/00
摘要： Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell suspensions are described. The methods include the steps of administering to an area of wounded or non-wounded skin therapeutically effective amounts of 1-antitrypsin, alkaline phosphatase (such as placental alkaline phosphatase), transferrin, and 1-acid glycoprotein in compositions that contain at least two of these proteins, or their active derivatives, as the major active components. The compositions can be administered topically and/or by injection, or both. The invention also provides regimens for restoring or maintaining the strength and thickness of wounded, non-wounded and transplanted skin as well as developing new skin from skin cell suspensions comprising periodically administering one or more compositions topically and/or by injection.
摘要翻译：描述了刺激增殖和抑制伤口和未受伤的表皮和真皮细胞以及移植的哺乳动物皮肤和移植的皮肤细胞悬浮液中的细胞死亡的方法。所述方法包括以下步骤：在组合物中给予受伤或非伤口皮肤的治疗有效量的1-抗胰蛋白酶，碱性磷酸酶（例如胎盘碱性磷酸酶），转铁蛋白和1-酸性糖蛋白的步骤，所述组合物含有至少两种这些蛋白质或其活性衍生物作为主要活性成分。组合物可以局部施用和/或通过注射或两者施用。本发明还提供了恢复或维持受伤的，未受伤的和移植的皮肤的强度和厚度以及从皮肤细胞悬浮液开发新皮肤的方案，包括局部地和/或通过注射周期性地施用一种或多种组合物。

2. 发明申请

WO2008105872A1 DRUG COMBINATIONS TO TREAT DRUG RESISTANT TUMORS 审中-公开
标题翻译：药物联合治疗耐药性肿瘤
公开(公告)号：WO2008105872A1
公开(公告)日：2008-09-04
申请号：PCT/US2007/062953
申请日：2007-02-28
申请人： CANCURE LABORATORIES, LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K31/335 , A61K31/35 , C07D311/00 , C07D311/82
CPC分类号： A61K31/335 , A61K31/35 , C07D311/82
摘要： Embodiments of the invention provide a method and composition for treating or reducing multiple drug resistance in cancers. Embodiments of the invention also provide for a xanthene compound to inhibit multidrug resistance protein 1.
摘要翻译：本发明的实施方案提供了用于治疗或降低癌症中多种耐药性的方法和组合物。本发明的实施方案还提供了呫吨化合物抑制多药耐药性蛋白质1。

3. 发明申请

WO2008057120A1 THIOXANTHONE COMPOUNDS TO REVERSE WEIGHT LOSS 审中-公开
标题翻译：硫酮化合物反复重量损失
公开(公告)号：WO2008057120A1
公开(公告)日：2008-05-15
申请号：PCT/US2006/060831
申请日：2006-11-13
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： C07D335/12
CPC分类号： C07D335/12
摘要： One embodiment of the invention uses thioxanthone compounds containing a choline or choline analogue moiety, such as CCcompound1 or [3-(3,4-Dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethyl-ammonium chloride, to reduce or reverse body weight loss in various mouse models of human tumors. Another embodiment of the invention discloses a method for reducing or reversing cachexia or disease-induced body weight loss in human and other mammals using thioxanthone compounds containing a choline analogue moiety.
摘要翻译：本发明的一个实施方案使用含有胆碱或胆碱类似物部分的噻吨酮化合物，例如CC化合物1或[3-（3,4-二甲基-9-氧代-9H-噻吨-2-基氧基）-2-羟丙基]三甲基铵氯化物，以减少或逆转人类肿瘤的各种小鼠模型中的体重减轻。本发明的另一个实施方案公开了一种使用含有胆碱类似物部分的噻吨酮化合物来减少或逆转人类和其它哺乳动物的恶病质或疾病引起的体重减轻的方法。

4. 发明申请

WO2007081654A2 COMPOSITIONS AND METHODS TO ENHANCE VIABILITY AND FUNCTION OF ISLET CELLS 审中-公开
标题翻译：用于增强ISLET细胞的可能性和功能的组合物和方法
公开(公告)号：WO2007081654A2
公开(公告)日：2007-07-19
申请号：PCT/US2006062458
申请日：2006-12-21
申请人： ZOLTAN LAB LLC , KISS ZOLTAN
发明人： KISS ZOLTAN
IPC分类号： A61K38/46 , A61K35/37
CPC分类号： A61K38/465 , A61K38/40 , C12Y301/03001 , A61K2300/00
摘要： This invention uses placental alkaline phosphatase ("PALP"), and other members of the alkaline phosphatase family, to reduce the death and thereby maintain or enhance the viability and function of insulin-producing islet ß-cells including insulin secretion. PALP may be administered to a patient that has received transplanted islet cells to protect the transplanted islets against ROS-mediated attacks by the patient's immune system. Transferrin and other promoters of islet survival may also be used to enhance the effects of PALP on islet viability both in vivo and in vitro.
摘要翻译：本发明使用胎盘碱性磷酸酶（“PALP”）和碱性磷酸酶家族的其他成员来减少死亡，从而维持或增强胰岛素产生胰岛β细胞（包括胰岛素分泌）的存活力和功能。可以向接受移植的胰岛细胞的患者施用PALP以保护移植的胰岛免受患者的免疫系统的ROS介导的攻击。转铁蛋白和胰岛存活的其他启动子也可用于增强PALP对体内和体外胰岛活力的影响。

5. 发明申请

WO2007008376A3 USE OF ONE OR MORE METAL CARRIERS TO SELECTIVELY KILL MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2007008376A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/024608
申请日：2006-06-23
申请人： CANCURE LABORATORIES, LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/02 , C07C333/14
摘要： Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.

6. 发明申请

WO2002072136A1 COMPOSITIONS AND METHODS FOR STIMULATING WOUND HEALING AND FIBROBLAST PROLIFERATION 审中-公开
标题翻译：用于刺激伤口愈合和成纤维细胞增殖的组合物和方法
公开(公告)号：WO2002072136A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007350
申请日：2002-03-11
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/46
CPC分类号： A61K38/28 , A61K38/1858 , A61K38/30 , A61K38/465 , C12Y301/03001 , A61K2300/00
摘要： It has been found that placenta alkaline phosphatase interacts synergistically with growth factors and corresponding serum factors to stimulate the proliferation of adult fibroblast cells. Furthermore, this stimulation of fibroblast proliferation does not result in a corresponding stimulation of collagen synthesis. Thus, wound healing compositions can be formulated that improve wound healing without increasing scar formation. Compositions for wound healing can include placental alkaline phosphatase and a gel-forming material. In some embodiments, compositions include placental alkaline phosphatase and serum/growth factors. In addition to wound healing applications, compositions with placental alkaline phosphatase can also be used in cell sulturing of adult fibroblast cells.
摘要翻译：已经发现胎盘碱性磷酸酶与生长因子和相应的血清因子协同作用，以刺激成体成纤维细胞的增殖。此外，对成纤维细胞增殖的这种刺激不会导致胶原合成的相应刺激。因此，可以配制伤口愈合组合物，其可改善伤口愈合而不增加瘢痕形成。用于伤口愈合的组合物可以包括胎盘碱性磷酸酶和凝胶形成材料。在一些实施方案中，组合物包括胎盘碱性磷酸酶和血清/生长因子。除了伤口愈合应用之外，具有胎盘碱性磷酸酶的组合物也可用于成体成纤维细胞的细胞培养。

7. 发明申请

WO2008048322A1 MOUSE MODELS TO STUDY CACHEXIA 审中-公开
标题翻译：鼠标模型研究CACHEXIA
公开(公告)号：WO2008048322A1
公开(公告)日：2008-04-24
申请号：PCT/US2006/060067
申请日：2006-10-19
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027 , A61K35/12 , C12Q1/00 , G01N33/574 , A61K51/00 , A61M36/14 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/469 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18 , G01N27/26
CPC分类号： A01K67/02 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K35/36 , A61K35/55 , A61K49/0004 , G01N33/5088
摘要： Embodiments of the invention provide mouse tumor models involving either the B16 mouse melanoma or MXT mouse mammary tumor, untreated or treated with chemotherapy and/or anti-cachectic agents, for the study of tumor-generated or cancer therapy-generated cachexia-inducing signals and mechanisms. Other embodiments of the invention also provide additional models, including pre-treatment of mouse skin with anti-cachectic proteins prior to tumor implantation, for the study of anti-cachectic signals and mechanisms generated by the skin. To reduce or reverse tumor- and chemotherapy- induced cachexia, embodiments of the invention use the human proteins placental alkaline phosphatase, transferrin, α 1 -antitrypsin preparations or combinations thereof as well as chemically synthesized CCDTHT orN,N-diethyl-N-methyl-2-[(9-oxo-9H- thioxanthen-2-yl)methoxy]-ethanaminium iodide or CCDTΗT-like compounds.
摘要翻译：本发明的实施方案提供了涉及B16小鼠黑素瘤或MXT小鼠乳腺肿瘤，未经治疗或用化学疗法和/或抗恶病质药物治疗的小鼠肿瘤模型，用于研究肿瘤产生或癌症治疗产生的恶病质诱导信号，以及机制。本发明的其它实施方案还提供另外的模型，包括在肿瘤植入之前用抗恶病质蛋白预处理小鼠皮肤，用于研究抗恶病质信号和由皮肤产生的机制。为了减少或逆转肿瘤和化疗引起的恶病质，本发明的实施方案使用人类蛋白质胎盘碱性磷酸酶，转铁蛋白，1抗 - 胰蛋白酶制剂或其组合以及化学合成的CCDTHT或N，N - 二乙基-N-甲基-2 - [（9-氧代-9H-噻吨-2-基）甲氧基] - 碘化铵或CCDT-T样化合物。

8. 发明申请

WO2007145672A2 COMBINATIONS OF HUMAN PROTEINS TO ENHANCE VIABILITY OF STEM CELLS AND PROGENITOR CELLS 审中-公开
标题翻译：人类蛋白质组合增强干细胞和祖细胞的可能性
公开(公告)号：WO2007145672A2
公开(公告)日：2007-12-21
申请号：PCT/US2006/060956
申请日：2006-11-16
申请人： Zoltan Laboratories LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/46 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0663 , C12N5/0018 , C12N5/0653 , C12N5/0658 , C12N2501/70
摘要： Embodiments of the present invention include the use of placental alkaline phosphatase and other members of the alkaline phosphatase family alone or in combination with human transferrin and, optionally, human α 1 -antitrypsin to enhance the proliferation and survival of adult or embryonic stem cells and stem cell-derived progenitor cells in vitro and in vivo.
摘要翻译：本发明的实施方案包括使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员单独使用或与人转铁蛋白和任选的人α1 - 抗胰蛋白酶组合以增强其增殖和存活成体或胚胎干细胞和干细胞来源的祖细胞体外和体内。

9. 发明申请

WO2007076505A3 TRANSFERRIN AND TRANSFERRIN-BASED COMPOSITIONS FOR DIABETES TREATMENT 审中-公开
标题翻译：用于糖尿病治疗的转铁蛋白和转铁蛋白组合物
公开(公告)号：WO2007076505A3
公开(公告)日：2007-12-21
申请号：PCT/US2006062612
申请日：2006-12-27
申请人： ESSENTIAL SKINCARE LLC , KISS ZOLTAN
发明人： KISS ZOLTAN
IPC分类号： A61K38/40 , A61K31/155 , A61K31/17 , A61K31/426 , A61K31/70
CPC分类号： A61K38/40 , A61K31/155 , A61K31/17 , A61K31/426 , A61K31/70 , A61K35/39 , A61K38/28
摘要： Embodiments of the present invention use transferrin or active derivatives to control or stabilize abnormally elevated levels of blood glucose in mammals, particularly humans. Embodiments of the invention also provide methods for enhancing survival of islet -cells in vivo and in vitro. In other embodiments, transferrin or active derivatives are used in combination with anti-diabetic medicaments or performing an insulin elevating procedure. In yet another embodiment the invention includes administering transferrin or an active derivative to reduce weight loss induced by type 1 diabetic condition.
摘要翻译：本发明的实施方案使用转铁蛋白或活性衍生物来控制或稳定哺乳动物特别是人类中异常升高的血糖水平。本发明的实施方案还提供了用于增强胰岛细胞在体内和体外存活的方法。在其他实施方案中，转铁蛋白或活性衍生物与抗糖尿病药物联合使用或进行胰岛素升高手术。在又一个实施方案中，本发明包括施用转铁蛋白或活性衍生物以减少由1型糖尿病病症诱导的体重减轻。

10. 发明申请

WO2005055956A3 METHOD FOR IMPROVING INSULIN SENSITIVITY BY ADMINISTERING AN INHIBITOR OF ANTITRYPSIN 审中-公开
标题翻译：通过施用抗抑郁剂抑制胰岛素敏感性的方法
公开(公告)号：WO2005055956A3
公开(公告)日：2006-08-10
申请号：PCT/US2004041508
申请日：2004-12-09
申请人： ESSENTIAL SKINCARE LLC , KISS ZOLTAN
发明人： KISS ZOLTAN
IPC分类号： A61K31/195 , A61K20060101 , A61K31/19 , A61K31/575 , A61K45/06
CPC分类号： A61K31/19 , A61K31/575 , A61K45/06
摘要： Methods of delaying the onset or treating the progression of Type 2 diabetes in subjects that have increased blood levels of an inflammation marker protein. In one embodiment, the method includes administering an inhibitor OF a 1 -antitrypsin (AT) to the subject, and optionally co-administering an anti-diabetic medicament or anti-inflammatory agent to the subject. Treatment regimens provided by the invention may be used to delay the onset of or to cotnrol Type 2 diabetes. The invention provides for the use of an inhibitor of a 1 -antitrypsin, such as gemfibrozil (GF), for the manufacture of a medicament for the uses described herein. The invention further provides combinations of agents for treating or delaying the progression or onset of diabetes, comprising an inhibitor of a 1 -antitrypsin and an anti-inflammatory agent and/or an anti-diabetic medicament.
摘要翻译：在具有增加炎症标记蛋白的血液水平的受试者中延迟发作或治疗2型糖尿病进展的方法。在一个实施方案中，所述方法包括向受试者施用1抗 - 胰蛋白酶抑制剂（AT），以及任选地向受试者共同施用抗糖尿病药物或抗炎剂。本发明提供的治疗方案可以用于延迟2型糖尿病的发作。本发明提供了用于制备用于本文所述用途的药物的1抗 - 抗胰蛋白酶抑制剂如吉非贝齐（GF）的用途。本发明进一步提供了用于治疗或延缓糖尿病进展或发作的药剂的组合，其包含1抗 - 抗胰蛋白酶抑制剂和抗炎剂和/或抗糖尿病药物。

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