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1. 发明申请

WO2008048322A1 MOUSE MODELS TO STUDY CACHEXIA 审中-公开
标题翻译：鼠标模型研究CACHEXIA
公开(公告)号：WO2008048322A1
公开(公告)日：2008-04-24
申请号：PCT/US2006/060067
申请日：2006-10-19
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027 , A61K35/12 , C12Q1/00 , G01N33/574 , A61K51/00 , A61M36/14 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/469 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18 , G01N27/26
CPC分类号： A01K67/02 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K35/36 , A61K35/55 , A61K49/0004 , G01N33/5088
摘要： Embodiments of the invention provide mouse tumor models involving either the B16 mouse melanoma or MXT mouse mammary tumor, untreated or treated with chemotherapy and/or anti-cachectic agents, for the study of tumor-generated or cancer therapy-generated cachexia-inducing signals and mechanisms. Other embodiments of the invention also provide additional models, including pre-treatment of mouse skin with anti-cachectic proteins prior to tumor implantation, for the study of anti-cachectic signals and mechanisms generated by the skin. To reduce or reverse tumor- and chemotherapy- induced cachexia, embodiments of the invention use the human proteins placental alkaline phosphatase, transferrin, α 1 -antitrypsin preparations or combinations thereof as well as chemically synthesized CCDTHT orN,N-diethyl-N-methyl-2-[(9-oxo-9H- thioxanthen-2-yl)methoxy]-ethanaminium iodide or CCDTΗT-like compounds.
摘要翻译：本发明的实施方案提供了涉及B16小鼠黑素瘤或MXT小鼠乳腺肿瘤，未经治疗或用化学疗法和/或抗恶病质药物治疗的小鼠肿瘤模型，用于研究肿瘤产生或癌症治疗产生的恶病质诱导信号，以及机制。本发明的其它实施方案还提供另外的模型，包括在肿瘤植入之前用抗恶病质蛋白预处理小鼠皮肤，用于研究抗恶病质信号和由皮肤产生的机制。为了减少或逆转肿瘤和化疗引起的恶病质，本发明的实施方案使用人类蛋白质胎盘碱性磷酸酶，转铁蛋白，1抗 - 胰蛋白酶制剂或其组合以及化学合成的CCDTHT或N，N - 二乙基-N-甲基-2 - [（9-氧代-9H-噻吨-2-基）甲氧基] - 碘化铵或CCDT-T样化合物。

2. 发明申请

WO2007145672A2 COMBINATIONS OF HUMAN PROTEINS TO ENHANCE VIABILITY OF STEM CELLS AND PROGENITOR CELLS 审中-公开
标题翻译：人类蛋白质组合增强干细胞和祖细胞的可能性
公开(公告)号：WO2007145672A2
公开(公告)日：2007-12-21
申请号：PCT/US2006/060956
申请日：2006-11-16
申请人： Zoltan Laboratories LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/46 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0663 , C12N5/0018 , C12N5/0653 , C12N5/0658 , C12N2501/70
摘要： Embodiments of the present invention include the use of placental alkaline phosphatase and other members of the alkaline phosphatase family alone or in combination with human transferrin and, optionally, human α 1 -antitrypsin to enhance the proliferation and survival of adult or embryonic stem cells and stem cell-derived progenitor cells in vitro and in vivo.
摘要翻译：本发明的实施方案包括使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员单独使用或与人转铁蛋白和任选的人α1 - 抗胰蛋白酶组合以增强其增殖和存活成体或胚胎干细胞和干细胞来源的祖细胞体外和体内。

3. 发明申请

WO2008057120A1 THIOXANTHONE COMPOUNDS TO REVERSE WEIGHT LOSS 审中-公开
标题翻译：硫酮化合物反复重量损失
公开(公告)号：WO2008057120A1
公开(公告)日：2008-05-15
申请号：PCT/US2006/060831
申请日：2006-11-13
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： C07D335/12
CPC分类号： C07D335/12
摘要： One embodiment of the invention uses thioxanthone compounds containing a choline or choline analogue moiety, such as CCcompound1 or [3-(3,4-Dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl]trimethyl-ammonium chloride, to reduce or reverse body weight loss in various mouse models of human tumors. Another embodiment of the invention discloses a method for reducing or reversing cachexia or disease-induced body weight loss in human and other mammals using thioxanthone compounds containing a choline analogue moiety.
摘要翻译：本发明的一个实施方案使用含有胆碱或胆碱类似物部分的噻吨酮化合物，例如CC化合物1或[3-（3,4-二甲基-9-氧代-9H-噻吨-2-基氧基）-2-羟丙基]三甲基铵氯化物，以减少或逆转人类肿瘤的各种小鼠模型中的体重减轻。本发明的另一个实施方案公开了一种使用含有胆碱类似物部分的噻吨酮化合物来减少或逆转人类和其它哺乳动物的恶病质或疾病引起的体重减轻的方法。

4. 发明申请

WO2007081654A3 COMPOSITIONS AND METHODS TO ENHANCE VIABILITY AND FUNCTION OF ISLET CELLS 审中-公开
公开(公告)号：WO2007081654A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/062458
申请日：2006-12-21
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/46
摘要： This invention uses placental alkaline phosphatase ("PALP"), and other members of the alkaline phosphatase family, to reduce the death and thereby maintain or enhance the viability and function of insulin-producing islet β-cells including insulin secretion. PALP may be administered to a patient that has received transplanted islet cells to protect the transplanted islets against ROS-mediated attacks by the patient's immune system. Transferrin and other promoters of islet survival may also be used to enhance the effects of PALP on islet viability both in vivo and in vitro .

5. 发明申请

WO2007075199A1 USE OF ALKALINE PHOSPHATASE TO MAINTAIN HEALTHY TISSUE MASS IN MAMMALS 审中-公开
标题翻译：碱性磷酸酶对母体健康组织质量的使用
公开(公告)号：WO2007075199A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/030753
申请日：2006-08-08
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , C12Y301/03001
摘要： Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, adipose and other tissues. The ability of alkaline phosphatase to selectively enhance the survival of healthy cells and increase protein synthesis has many therapeutic applications. The use of alkaline phosphatase may prevent the loss of body weight and muscle mass typically experienced by diseased (such as cancer) or aging patients, or developing fetuses subjected to harmful conditions, or by patients who are treated with a toxic therapy including chemotherapy.
摘要翻译：本发明的实施方案涉及使用胎盘碱性磷酸酶和碱性磷酸酶家族的其它成员来增强肌肉中的蛋白质合成以及肌肉，脂肪和其它组织中非癌分化细胞的存活。碱性磷酸酶选择性增强健康细胞存活和增加蛋白质合成的能力有很多治疗应用。碱性磷酸酶的使用可以防止患病（例如癌症）或老化患者或发展中的有胎儿患有体重和肌肉量的损失，或通过包括化疗在内的有毒疗法治疗的患者。

6. 发明申请

WO2009015207A1 SMALL MOLECULES FOR THE PROTECTION OF PANCREATIC CELLS 审中-公开
标题翻译：用于保护胰腺细胞的小分子
公开(公告)号：WO2009015207A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/070892
申请日：2008-07-23
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/445
摘要： Embodiments of the present invention include the in vivo and in vitro use of a family of anticancer heterocyclic compounds containing a quaternary ammonium group as exemplified by the thioxanthone and thioxanthene compounds [3-(3,4-dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxypropyl] trimethylammonium chloride, or CCcompound1, N,N,-diethyl-N-methyl-2-[9-oxo-9H-thioxanthen-2-yl)methoxy] ethanaminium iodide, or CCcompound3, and N,N,N-trimethyl-3-(9H-thioxanthen-9-ylidene)-propane-1-aminium iodide, or CCcompound19 to maintain and increase viability of normal endocrine and exocrine pancreatic cells under pathological conditions, such as type 1 and type 2 diabetes, pancreatitis, pancreatic cancer, or during and after islet transplant, or in preparation for transplant of isolated islet cells via (i) direct contact with these cells, and/or via (ii) enhancing survival and proliferation of endogenous or transplanted adult stem cells, and/or via (iii) reducing viability of pancreatic cancer cells.
摘要翻译：本发明的实施方案包括体内和体外使用含有季铵基的抗癌杂环化合物家族，例如噻吨酮和噻吨酮化合物[3-（3,4-二甲基-9-氧代-9H-噻吨） -2-羟基丙基]三甲基氯化铵或CC化合物1，N，N， - 二乙基-N-甲基-2- [9-氧代-9H-噻吨-2-基）甲氧基]乙胺碘化物，或CCcompound3，和N，N，N-三甲基-3-（9H-噻吨-9-亚基） - 丙烷-1-碘鎓碘化物或CCcompound19，以在病理条件下维持和增加正常内分泌和外分泌胰腺细胞的活力，例如1型胰岛炎，胰腺癌或胰岛移植期间或之后，或通过（i）直接接触这些细胞，和/或通过（ii）增强内源性或内源性细胞的存活和增殖来准备移植分离的胰岛细胞移植的成体干细胞，和/或通过（iii）降低胰腺癌的活力c 厄尔。

7. 发明申请

WO2008118164A1 COMPOUNDS TO PROMOTE REGENERATION OF BONE MARROW 审中-公开
标题翻译：促进骨骼再生的化合物
公开(公告)号：WO2008118164A1
公开(公告)日：2008-10-02
申请号：PCT/US2007/064761
申请日：2007-03-23
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61P7/00 , A61K31/352 , A61K31/357 , A61K31/382 , A61K31/385 , A61K31/39 , A61K31/473 , A61K31/4985 , A61K31/536 , A61K31/5415 , A61K33/04
CPC分类号： A61K45/06 , A61K31/352 , A61K31/357 , A61K31/382 , A61K31/385 , A61K31/39 , A61K31/4985 , A61K31/536 , A61K31/5415 , A61K2300/00
摘要： Embodiments of the present invention include the use of heterocyclic trialkyl ammonium-containing compounds to promote regeneration of bone marrow from endogenous or exogenous stem/progenitor cells and to normalize blood cell and platelet counts.
摘要翻译：本发明的实施方案包括使用含杂环三烷基铵的化合物来促进骨髓从内源性或外源性干/祖细胞再生并使血细胞和血小板计数正常化。

8. 发明申请

WO2007032818A2 COMPOUNDS AND COMPOSITIONS TO CONTROL ABNORMAL CELL GROWTH 审中-公开
标题翻译：化合物和组合物来控制异常细胞生长
公开(公告)号：WO2007032818A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/027860
申请日：2006-07-19
申请人： ZOLTAN LABORATORIES LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K31/382 , C07D335/08
CPC分类号： C07D335/08 , C07D335/16
摘要： A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide (CCDTHT) was shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. CCDTHT had even greater effects on tumor volume, body weight, and survival when administered to animals together with the human protein placental alkaline phosphatase. These trialkylammonium group-containing compounds and alkaline phosphatases, particularly in combination with each other and other therapies, may be used to treat cancer and other cell proliferative diseases.
摘要翻译：通常含有三烷基铵基团的一类化合物已被合成并被表征为抗癌化合物。在各种肿瘤模型中显示了该类代表N，N-二乙基-N-甲基-2 - [（9-氧代-9H-噻吨-2-基）甲氧基]乙胺碘化物（CCDTHT）以减少肿瘤体积，增强其他化学治疗剂（包括顺铂）的作用，减少化疗引起的体重减轻，并增加用有毒量的顺铂共同处理的动物的存活。当与人类蛋白质胎盘碱性磷酸酶一起施用于动物时，CCDTHT对肿瘤体积，体重和存活有更大的影响。这些含三烷基铵基的化合物和碱性磷酸酶，特别是彼此组合和其它疗法可用于治疗癌症和其它细胞增殖性疾病。

9. 发明申请

WO2008105872A1 DRUG COMBINATIONS TO TREAT DRUG RESISTANT TUMORS 审中-公开
标题翻译：药物联合治疗耐药性肿瘤
公开(公告)号：WO2008105872A1
公开(公告)日：2008-09-04
申请号：PCT/US2007/062953
申请日：2007-02-28
申请人： CANCURE LABORATORIES, LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K31/335 , A61K31/35 , C07D311/00 , C07D311/82
CPC分类号： A61K31/335 , A61K31/35 , C07D311/82
摘要： Embodiments of the invention provide a method and composition for treating or reducing multiple drug resistance in cancers. Embodiments of the invention also provide for a xanthene compound to inhibit multidrug resistance protein 1.
摘要翻译：本发明的实施方案提供了用于治疗或降低癌症中多种耐药性的方法和组合物。本发明的实施方案还提供了呫吨化合物抑制多药耐药性蛋白质1。

10. 发明申请

WO2007008376A3 USE OF ONE OR MORE METAL CARRIERS TO SELECTIVELY KILL MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2007008376A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/024608
申请日：2006-06-23
申请人： CANCURE LABORATORIES, LLC , KISS, Zoltan
发明人： KISS, Zoltan
IPC分类号： A61K38/02 , C07C333/14
摘要： Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.

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