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    • 4. 发明申请
    • DNA ANALYSIS DEVICE USING NANO PORE STRUCTURE, ANALYSIS METHOD AND PCR QUANTITATIVE DETECTING DEVICE
    • 使用纳米孔结构的DNA分析装置,分析方法和PCR定量检测装置
    • WO2011162582A3
    • 2012-05-03
    • PCT/KR2011004653
    • 2011-06-27
    • SNU R&DB FOUNDATIONKIM KI BUMKIM HYUN MILEE MIN HYUN
    • KIM KI BUMKIM HYUN MILEE MIN HYUN
    • C12Q1/68B82Y15/00B82Y40/00G01N27/26
    • B82Y15/00G01N33/48721
    • Provided are a DNA analysis device using a nano pore structure, a DNA analysis method and a PCR quantitative detecting device. A DNA analysis device using a nano pore structure according to an embodiment of the present invention includes: a chamber receiving a solution and having a first area and a second area; a first electrode positioned in the first area; a second electrode positioned in the second area, facing the first electrode; a nano pore film positioned between the first electrode and the second electrode and having a conductive layer and nano pores penetrating the conductive layer; and an electric signal section electrically connected to the conductive layer, the first electrode and the second electrode, applying first electric signals thereto and receiving second electric signals therefrom, wherein DNA in the solution is detected using the second electric signals.
    • 提供使用纳米孔结构的DNA分析装置,DNA分析方法和PCR定量检测装置。 根据本发明的实施方案的使用纳米孔结构的DNA分析装置包括:容纳溶液并具有第一区域和第二区域的室; 位于所述第一区域中的第一电极; 位于所述第二区域中的面向所述第一电极的第二电极; 位于所述第一电极和所述第二电极之间并具有穿透所述导电层的导电层和纳米孔的纳米孔膜; 以及电连接到所述导电层,所述第一电极和所述第二电极的电信号部分,向其施加第一电信号并从其接收第二电信号,其中使用所述第二电信号检测所述溶液中的DNA。
    • 6. 发明申请
    • HYBRID OF ITRACONAZOLE, CYCLOSPORINE OR CARVEDILOL WITH A LAYERED SILICATE AND A PROCESS FOR PREPARING THE SAME
    • 具有层状硅酸盐的异烟肼,环磷酰胺或卡维地洛的混合物及其制备方法
    • WO2004009120A1
    • 2004-01-29
    • PCT/KR2003/001449
    • 2003-07-22
    • NANOHYBRID CO., LTD.PARK, Tae-UnJUNG, HyunKIM, Hyun-MiCHOY, Jin-HoLEE, Chi-Won
    • PARK, Tae-UnJUNG, HyunKIM, Hyun-MiCHOY, Jin-HoLEE, Chi-Won
    • A61K47/02
    • A61K31/403A61K9/143A61K31/496A61K38/13
    • The present invention provides the hybrids wherein itraconazole, cyclosporine or carvedilol are intercalated into the interlayers and/or absorbed onto the surfaces of layered silicates. The hybrids according to the present invention enable the maximization of bioavailability of drugs by dissolving the drugs from the layered silicates. Furthermore, the present invention provides the preparing methods of the hybrids. The process comprises: (1) dispersing a layered silicate in an aqueous solution to form an aqueous solution containing the layered silicate; (2) dissolving a drug in a organic solvent to form an organic solution containing the drug, the organic solvent having a solubility higher than that in the aqueous solution; and (3) mixing and hybridizing in the inerrface of the aqueous solution containing the layered silicate and the organic phase solution containing the drug in order to intercalate the drug into the interlayers of the layered silicate and/or to absorb the drug onto the surface of the layered silicate.
    • 本发明提供了伊曲康唑,环孢菌素或卡维地洛插入中间层和/或吸收到层状硅酸盐表面上的杂交体。 根据本发明的杂交体能够通过从层状硅酸盐中溶解药物使药物的生物利用度最大化。 此外,本发明提供了杂种的制备方法。 该方法包括:(1)将层状硅酸盐分散在水溶液中以形成含有层状硅酸盐的水溶液; (2)将药物溶解在有机溶剂中以形成含有药物的有机溶液,所述有机溶剂的溶解度高于所述水溶液中的溶解度; 和(3)在含有层状硅酸盐的水溶液和含有药物的有机相溶液的表面中混合和杂交,以将药物插入层状硅酸盐的夹层中和/或将药物吸收到 层状硅酸盐。