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1. 发明申请

WO2012065953A1 SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP INHIBITORS 审中-公开
标题翻译：作为NEP抑制剂的取代的碳酰胆碱乙酸衍生物
公开(公告)号：WO2012065953A1
公开(公告)日：2012-05-24
申请号：PCT/EP2011/070066
申请日：2011-11-14
申请人： NOVARTIS AG , KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , KSANDER, Gary Michael , LIU, Qian , MOGI, Muneto , SCHIERING, Nikolaus , SUN, Robert
发明人： KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , KSANDER, Gary Michael , LIU, Qian , MOGI, Muneto , SCHIERING, Nikolaus , SUN, Robert
IPC分类号： C07C235/36 , C07C235/40 , C07D207/16 , C07D213/55 , C07D257/04 , C07D307/52 , C07D235/00 , A61K31/192 , A61P9/08 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/437 , A61K31/4402
CPC分类号： C07C233/52 , C07C233/63 , C07C237/22 , C07C2601/08 , C07D207/16 , C07D213/55 , C07D257/04 , C07D295/185 , C07D307/52 , C07D471/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，B，X，m和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供了本发明化合物的药物组合物，以及药理活性剂和本发明化合物的组合。

2. 发明申请

WO2010136493A1 SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS 审中-公开
标题翻译：取代的氨基酸衍生物作为NEPRILYSIN抑制剂
公开(公告)号：WO2010136493A1
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057247
申请日：2010-05-26
申请人： NOVARTIS AG , COPPOLA, Gary Mark , IWAKI, Yuki , KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , KSANDER, Gary Michael , MOGI, Muneto , SUN, Robert
发明人： COPPOLA, Gary Mark , IWAKI, Yuki , KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , KSANDER, Gary Michael , MOGI, Muneto
IPC分类号： C07D213/82 , C07D239/36 , C07D261/18 , C07D271/06 , C07C233/47 , A61K31/21 , A61K31/435
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I' or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , B 1 , X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物或其药学上可接受的盐，其中R1，R2，R3，R5，B1，X和n如本文所定义。本发明还涉及制备本发明化合物及其治疗用途的方法。本发明还提供药理活性剂和药物组合物的组合。

3. 发明申请

WO2010136474A2 SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS 审中-公开
标题翻译：作为NEPRILYSIN抑制剂的取代的氨基嘌呤衍生物
公开(公告)号：WO2010136474A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010057213
申请日：2010-05-26
申请人： NOVARTIS AG , COPPOLA GARY MARK , IWAKI YUKI , KARKI RAJESHRI GANESH , KAWANAMI TOSHIO , KSANDER GARY MICHAEL , MOGI MUNETO , SUN ROBERT
发明人： COPPOLA GARY MARK , IWAKI YUKI , KARKI RAJESHRI GANESH , KAWANAMI TOSHIO , KSANDER GARY MICHAEL , MOGI MUNETO , SUN ROBERT
IPC分类号： C07C233/45
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula (I') or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I'）化合物或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

4. 发明申请

WO2013016197A1 TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 审中-公开
标题翻译：四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途
公开(公告)号：WO2013016197A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047617
申请日：2012-07-20
申请人： NOVARTIS AG , GELIN, Christine , FLYER, Alec , ADAMS, Christopher, Michael , DARSIGNY, Veronique , HURLEY, Timothy, Brian , KARKI, Rajeshri, Ganesh , JI, Nan , KAWANAMI, Toshio , MEREDITH, Erik , SERRANO-WU, Michael, H. , RAO, Chang , SOLOVAY, Catherine , LEE, George, Tien-san , TOWLER, Christopher , HAR, Denis , SHEN, Lichun , HU, Bin , JIANG, Xinglong , CAPPACI-DANIEL, Christina
发明人： GELIN, Christine , FLYER, Alec , ADAMS, Christopher, Michael , DARSIGNY, Veronique , HURLEY, Timothy, Brian , KARKI, Rajeshri, Ganesh , JI, Nan , KAWANAMI, Toshio , MEREDITH, Erik , SERRANO-WU, Michael, H. , RAO, Chang , SOLOVAY, Catherine , LEE, George, Tien-san , TOWLER, Christopher , HAR, Denis , SHEN, Lichun , HU, Bin , JIANG, Xinglong , CAPPACI-DANIEL, Christina
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P27/02 , A61P37/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

5. 发明申请

WO2009059943A1 4-BENZYLAMINO-1-CARBOXYACYL-PIPERIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLIPIDEMIA OR ARTERIOSCLEROSIS 审中-公开
标题翻译： 4-苄氧基-1-羧氧基 - 哌啶衍生物作为CETP抑制剂用于治疗疾病如高脂血症或类风湿性心脏病
公开(公告)号：WO2009059943A1
公开(公告)日：2009-05-14
申请号：PCT/EP2008/064859
申请日：2008-11-03
申请人： NOVARTIS AG , MOGI, Muneto , YAMADA, Ken , YASOSHIMA, Kayo , KAWANAMI, Toshio , UMEMURA, Ichiro , IWAKI, Yuki , QIN, Hongbo , IMASE, Hidetomo
发明人： MOGI, Muneto , YAMADA, Ken , YASOSHIMA, Kayo , KAWANAMI, Toshio , UMEMURA, Ichiro , IWAKI, Yuki , QIN, Hongbo , IMASE, Hidetomo
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5377 , A61P3/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译：本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

6. 发明申请

WO2015066241A1 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF 审中-公开
标题翻译： 2-苄基 - 苯并咪唑补体因子B抑制剂及其用途
公开(公告)号：WO2015066241A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063009
申请日：2014-10-29
申请人： NOVARTIS AG , ADAMS, Christopher , EHARA, Takeru , JENDZA, Keith , JI, Nan , KAWANAMI, Toshio , MAINOLFI, Nello , POWERS, James J. , SERRANO-WU, Michael , ZHANG, Chun
发明人： ADAMS, Christopher , EHARA, Takeru , JENDZA, Keith , JI, Nan , KAWANAMI, Toshio , MAINOLFI, Nello , POWERS, James J. , SERRANO-WU, Michael , ZHANG, Chun
IPC分类号： C07D235/12 , A61K31/4184 , C07D235/14 , A61P27/02
CPC分类号： C07D235/12 , A61K31/4184 , A61K45/06 , C07D235/14 , A61K2300/00
摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物，其用于制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

7. 发明申请

WO2011061271A1 SUBSTITUTED CARBAMOYLMETHYLAMINO ACETIC ACID DERIVATIVES AS NOVEL NEP INHIBITORS 审中-公开
标题翻译：作为新型NEP抑制剂的取代的氨基甲酰氨基乙酸衍生物
公开(公告)号：WO2011061271A1
公开(公告)日：2011-05-26
申请号：PCT/EP2010/067781
申请日：2010-11-18
申请人： NOVARTIS AG , IWAKI, Yuki , KAWANAMI, Toshio , KSANDER, Gary Michael , MOGI, Muneto
发明人： IWAKI, Yuki , KAWANAMI, Toshio , KSANDER, Gary Michael , MOGI, Muneto
IPC分类号： C07D231/40 , C07D257/06 , C07D261/14 , A61K31/41 , A61K31/42 , A61K31/415 , A61P7/10
CPC分类号： A61K31/41 , A61K31/42 , A61K45/00 , C07D231/40 , C07D257/06 , C07D261/14
摘要： The present invention provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 6 , A 1 , A 2 , X 1 , s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）的化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R6，A1，A2，X1，s和m如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

8. 发明申请

WO2009071509A1 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS 审中-公开
标题翻译：作为CETP抑制剂的1,2-取代-4-苄氧基 - 吡咯烷衍生物用于治疗疾病如HYPERLI PIDEMIA或ARTERIOSCLEROSIS
公开(公告)号：WO2009071509A1
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066537
申请日：2008-12-01
申请人： NOVARTIS AG , MOGI, Muneto , KAWANAMI, Toshio , YAMADA, Ken , YASOSHIMA, Kayo , IMASE, Hidetomo , MIYAKE, Takahiro , OHMORI, Osamu
发明人： MOGI, Muneto , KAWANAMI, Toshio , YAMADA, Ken , YASOSHIMA, Kayo , IMASE, Hidetomo , MIYAKE, Takahiro , OHMORI, Osamu
IPC分类号： C07D207/14 , C07D403/12 , C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/40 , A61P3/06
CPC分类号： C07D207/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译：本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的疾病或疾病或响应于CETP的抑制。

9. 发明申请

WO1997028409A1 ELECTRIC FURNACE 审中-公开
标题翻译：电炉
公开(公告)号：WO1997028409A1
公开(公告)日：1997-08-07
申请号：PCT/JP1997000217
申请日：1997-01-30
申请人： NIKKATO CORP. , NAKATANI, Masanori , ABE, Takeshi , KAWANAMI, Toshio
发明人： NIKKATO CORP.
IPC分类号： F27D11/02
CPC分类号： H05B3/64 , F27B17/00 , F27D11/02 , H05B3/141 , H05B3/62
摘要： An electric furnace comprising a heating element formed of lanthanum chromite based hollow ceramics and opened at both ends thereof and having such terminal portions that a cross-sectional area of the ceramics at surfaces of both ends thereof perpendicular to a lengthwise direction are made larger than that of the ceramics at a surface of a central portion thereof perpendicular to the lengthwise direction and having electrodes for high temperature and metallic lead wires mounted to the terminal portions to make an intermediate portion between the terminal portions a heating portion, a heat insulator fitted over the heating element, and a hollow ceramics body mounted in a hollow portion of the heating element with a hollow portion thereof serving as an effective heating chamber. The electric furnace is a small-sized one which is stably usable even at 1400 DEG C or higher, and is excellent in durability, profitability and handling property.
摘要翻译：一种电炉，包括由亚铬酸镧基中空陶瓷形成并在其两端开口的加热元件，并且具有这样的端部，使得其两端的表面垂直于纵向方向的陶瓷的横截面积大于的陶瓷在垂直于长度方向的中心部分的表面上并且具有安装到端子部分的高温金属引线的电极，以在端子部分之间形成加热部分的中间部分，加热元件和安装在加热元件的中空部分中的中空陶瓷体，其中空部分用作有效加热室。电炉是小型的，即使在1400℃以上也能够稳定地使用，耐久性，盈利性和处理性优异。

10. 发明申请

WO2014143638A1 2-(1H-INDOL-4-YLMETHYL)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBONITRILE DERIVATIVES AS COMPLEMENT FACTOR B INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES 审中-公开
标题翻译： 2-（1H-吲哚-4-基甲基）-3H-咪唑并[4,5-B]吡啶-6-羰基衍生物作为用于治疗眼病的补充因子B抑制剂
公开(公告)号：WO2014143638A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/026875
申请日：2014-03-13
申请人： NOVARTIS AG , ADAMS, Christopher Michael , BABU, Charles , CAPPARELLI, Michael Paul , DING, Jian , EHARA, Takeru , JENDZA, Keith , JI, Nan , KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , MAINOLFI, Nello , POWERS, James J. , SERRANO-WU, Michael H. , XUE, Liang , ZHANG, Chun
发明人： ADAMS, Christopher Michael , BABU, Charles , CAPPARELLI, Michael Paul , DING, Jian , EHARA, Takeru , JENDZA, Keith , JI, Nan , KARKI, Rajeshri Ganesh , KAWANAMI, Toshio , MAINOLFI, Nello , POWERS, James J. , SERRANO-WU, Michael H. , XUE, Liang , ZHANG, Chun
IPC分类号： C07D471/04 , A61K31/437 , A61P27/02
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
摘要翻译：本发明提供式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。本发明还提供药物组合物和药理活性剂的组合。

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