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1. 发明申请

WO2009046136A3 MICROFLUIDIC INTEGRATION WITH NANOSENSOR PLATFORM 审中-公开
公开(公告)号：WO2009046136A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/078491
申请日：2008-10-01
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , ZHOU, Chongwu , THOMPSON, Mark, E. , COTE, Richard, James , KARTALOV, Emil, P.
发明人： ZHOU, Chongwu , THOMPSON, Mark, E. , COTE, Richard, James , KARTALOV, Emil, P.
IPC分类号： G01N33/00
摘要： The present invention describes microfluidics being employed to achieve multiplex surface functionalization of nanosensor chips by selectively delivering probe molecules to individual nanosensors in an array, and microfluidics being employed to achieve delivery of a solution containing multiple analytes over individual nanosensors in an array, where each nanosensor was previously configured with a specific capture molecule.

2. 发明申请

WO2011146881A1 PAN-ANTIBODY ASSAYS - PRINCIPLES, METHODS, AND DEVICES 审中-公开
标题翻译： PAN抗体测定 - 原理，方法和设备
公开(公告)号：WO2011146881A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037408
申请日：2011-05-20
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , EMERSON, Jane F. , KARTALOV, Emil P.
发明人： EMERSON, Jane F. , KARTALOV, Emil P.
IPC分类号： G01N33/53
CPC分类号： G01N33/6845 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , C40B60/12
摘要： The present invention includes methods, assays, and devices for assaying a sample to detect the presence, absence, or level of at least one analyte in a biological sample using a pan-antibody panel or multiplexed immunoassay, wherein at least one analyte is detected by two or more antibodies. Certain embodiments include the use of a microfluidic device in the immunoassay. Further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is determined for a diagnostic or a scientific purpose. Still further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is indicative of a condition or disease. Yet further embodiments of the invention include incorporating additional diagnostic techniques (e.g., PCR, RT-PCR, and DNA hybridization arrays) to the assays, device, and methods.
摘要翻译：本发明包括用于测定样品以使用泛抗体面板或多重免疫测定来检测生物样品中至少一种分析物的存在，不存在或水平的方法，测定和装置，其中至少一种分析物被两种或更多种抗体。某些实施方案包括在免疫测定中使用微流体装置。本发明的其它实施方案包括用于检测为诊断或科学目的确定的至少一种分析物的存在，不存在或水平的测定，方法和装置。本发明的另外的实施方案包括检测指示病症或疾病的至少一种分析物的存在，不存在或水平的测定，方法和装置。本发明的另外的实施方案包括将其它诊断技术（例如，PCR，RT-PCR和DNA杂交阵列）结合到测定，装置和方法中。

3. 发明申请

WO2009046136A2 MICROFLUIDIC INTEGRATION WITH NANOSENSOR PLATFORM 审中-公开
标题翻译：微纳流体与纳米传感器平台的集成
公开(公告)号：WO2009046136A2
公开(公告)日：2009-04-09
申请号：PCT/US2008078491
申请日：2008-10-01
申请人： UNIV SOUTHERN CALIFORNIA , ZHOU CHONGWU , THOMPSON MARK E , COTE RICHARD JAMES , KARTALOV EMIL P
发明人： ZHOU CHONGWU , THOMPSON MARK E , COTE RICHARD JAMES , KARTALOV EMIL P
IPC分类号： C12M3/00
CPC分类号： C12Q1/6825 , B82Y15/00 , B82Y30/00 , C12Q1/6827 , C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , G01N27/4146 , C12Q2565/607 , C12Q2565/519 , C12Q2537/164 , C12Q2522/101 , C12Q2522/10 , C12Q2523/125 , C12Q2563/155 , C12Q2565/631
摘要： The present invention describes microfluidics being employed to achieve multiplex surface functionalization of nanosensor chips by selectively delivering probe molecules to individual nanosensors in an array, and microfluidics being employed to achieve delivery of a solution containing multiple analytes over individual nanosensors in an array, where each nanosensor was previously configured with a specific capture molecule.
摘要翻译：本发明描述了微流体，用于通过选择性地将探针分子递送到阵列中的单个纳米传感器来实现纳米传感器芯片的多重表面官能化，并且微流体用于实现在阵列中的单个纳米传感器上递送含有多个分析物的溶液，其中每个纳米传感器以前配置了特定的捕获分子。

4. 发明申请

WO2013116780A1 SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS 审中-公开
标题翻译：多重生物化学测定中的信号编码和解码
公开(公告)号：WO2013116780A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024509
申请日：2013-02-01
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
发明人： KARTALOV, Emil, P. , RAJAGOPAL, Aditya , SCHERER, Axel
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
摘要： This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
摘要翻译：本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。

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