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1. 发明申请

WO2016198048A3 OMEGA-3 AND/OR OMEGA-6 FATTY ACID(S) IN IMPAIRED SPHINGOLIPID METABOLISM 审中-公开
标题翻译： ω-3和/或ω-6脂肪酸（S）受损鞘脂代谢的存在
公开(公告)号：WO2016198048A3
公开(公告)日：2017-02-02
申请号：PCT/DE2016100265
申请日：2016-06-10
申请人： K D PHARMA BEXBACH GMBH
发明人： HARTMANN TOBIAS , GRIMM MARCUS OTTO WALTER , FLOSS THOMAS , WITTMANN ANKE
IPC分类号： A61P15/08 , A61K31/202 , G01N33/00
CPC分类号： A61K31/202 , A61K2300/00
摘要： The invention relates to an application of omega-3 and/or omega-6 fatty acid(s) for the therapeutic treatment of the human or animal body in the case of an impaired sphingolipid metabolism, in particular in the case of impaired sphingolipid synthesis and/or excessive sphingolipid degradation. In an embodiment of the invention, the agent is applied in the case of missing, reduced and/or defective formation of a sphingomyelin synthase enzyme in the body, in particular the enzyme sphingomyelin synthase 1 or the enzyme sphingomyelin synthase 2. The application has proved to be useful in the case of a defect of the sphingomyelin synthase 1 gene or of the sphingomyelin synthase 2 gene. The omega-3 and/or omega-6 fatty acid(s) preferably comprise(s) polyunsaturated omega-3 and/or omega-6 fatty acid(s), preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. The invention further relates to a method for determining a cause of a disease in an animal or a human being and to a device for carrying out the method.
摘要翻译：本发明涉及一种在impairers鞘脂合成和/或神经鞘脂过度降解为具有受损的鞘脂代谢的治疗性治疗人体或动物体的使用ω-3和/或ω-6脂肪酸（一个或多个），特别是。在本发明的一个实施方案中，该试剂在没有施加，减少和/或在主体中的鞘磷脂合成酶的错误形成，特别是酶鞘磷脂合成酶1或酶鞘磷脂合酶2中的应用已被证明是在鞘磷脂的缺陷的情况下，有利的合酶1个基因或鞘磷脂合酶2基因。 ω-3和/或ω-6脂肪酸（一个或多个）优选包括多不饱和的ω-3和/或ω-6脂肪酸（一个或多个），优选EPA，DHA，DPA，ETA，21：5N3和/ 或SDA。本发明还涉及一种用于确定在动物或人类以及用于执行该方法的装置的疾病的病因。

2. 发明申请

WO2009065395A2 NOVEL USE OF OMEGA-3-FATTY ACID(S) 审中-公开
标题翻译：的新用途ω-3脂肪酸（N）
公开(公告)号：WO2009065395A2
公开(公告)日：2009-05-28
申请号：PCT/DE2008001928
申请日：2008-11-18
申请人： K D PHARMA BEXBACH GMBH , KRUMBHOLZ RUDOLF , KRUMBHOLZ KARIN , KRUMBHOLZ CHRISTINE , SCHIRRA NORBERT , LEMBKE PETER
发明人： KRUMBHOLZ RUDOLF , KRUMBHOLZ KARIN , KRUMBHOLZ CHRISTINE , SCHIRRA NORBERT , LEMBKE PETER
IPC分类号： A61K31/202 , A61K45/06 , A61P29/00
CPC分类号： A61K45/06 , A61K31/202 , A61K2300/00
摘要： The invention relates to the use of omega-3-fatty acid(s) in means for pain relief. Said means preferably comprise highly unsaturated omega-3-fatty acid(s) that contain, above all, EPA and/or DHA. Preferably, the omega-3-fatty acid is administered in a high dose of more than 2g, in particular more than 3 to 4g, for pain relief.
摘要翻译：本发明涉及在一个代理使用ω-3脂肪酸（一个或多个），用于缓解疼痛。优选地，含有特别是EPA和/或DHA的手段的高度不饱和的ω-3脂肪酸（一个或多个）。优选地，用于疼痛管理是在高剂量超过2克的ω-3脂肪酸，特别是超过3至4G施用。

3. 发明申请

WO2007147554A3 IMPROVED CROMATOGRAPHY PROCESS FOR RECOVERING A SUBSTANCE OR A GROUP OF SUBSTANCES FROM A MIXTURE 审中-公开
标题翻译：用于从混合物中回收物质或一组物质的改进的克隆过程
公开(公告)号：WO2007147554A3
公开(公告)日：2008-03-13
申请号：PCT/EP2007005379
申请日：2007-06-19
申请人： K D PHARMA BEXBACH GMBH , KRUMBHOLZ RUDOLF , LEMBKE PETER , SCHIRRA NORBERT
发明人： KRUMBHOLZ RUDOLF , LEMBKE PETER , SCHIRRA NORBERT
IPC分类号： B01D15/16 , B01D15/40 , G01N30/28
CPC分类号： G01N30/28 , B01D15/161 , B01D15/163 , B01D15/40 , B01J20/286 , G01N30/02 , G01N30/32 , G01N30/8658 , G01N30/8689 , G01N2030/3076
摘要： Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and "reversed phase" phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.
摘要翻译：用于改进用于从混合物中回收目标脂肪酸或其衍生物或一组目标脂肪酸或其衍生物的制备型间歇超临界流体色谱分离的性能的方法，其特征在于所述超临界流体色谱分离采用带有选自氧化铝或氧化铝，氧化钛或氧化钛，硅胶或硅胶，氨基丙基改性硅胶，二醇改性硅胶，苯基改性硅胶的固定相的色谱柱和“反相”相，前者又选自RP 18，RP 8和RP 3组成，并且所述超临界流体色谱分离还采用选自乙烯，丙烷，氨的流动相，二氧化氮和二氧化碳，其中在所述方法中，在所述混合物在色谱上运行期间在色谱柱中，在目标脂肪酸或其衍生物洗脱期间，将压力和/或温度梯度施加到色谱柱。

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