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1. 发明申请

WO2012054364A3 BICYCLIC DIAMINES AS JANUS KINASE INHIBITORS 审中-公开
标题翻译：作为JANUS KINASE INHIBITORS的双相DIAMINES
公开(公告)号：WO2012054364A3
公开(公告)日：2014-04-10
申请号：PCT/US2011056498
申请日：2011-10-17
申请人： MERCK SHARP & DOHME , GUERIN DAVID JOSEPH , BRUBAKER JASON D , MARTINEZ MICHELLE , JUNG JOON O , ANTHONY NEVILLE J , SCOTT MARK E , CAMMARANO CAROLYN MICHELE , HOFFMAN DAWN MARIE MAMPREIAN , WOO HYUN CHONG , DINSMORE CHRISTOPHER J , JONES PHILIP
发明人： GUERIN DAVID JOSEPH , BRUBAKER JASON D , MARTINEZ MICHELLE , JUNG JOON O , ANTHONY NEVILLE J , SCOTT MARK E , CAMMARANO CAROLYN MICHELE , HOFFMAN DAWN MARIE MAMPREIAN , WOO HYUN CHONG , DINSMORE CHRISTOPHER J , JONES PHILIP
IPC分类号： A61K31/34 , A61K31/44
CPC分类号： C07D471/04 , A61K31/519 , C07D519/00
摘要： The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为Jak抑制剂的式I化合物，因此可用于治疗Jak介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

2. 发明申请

WO2012009000A3 NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开
标题翻译：新型掺杂的吡唑衍生物及其作为代谢谷氨酸受体的独立调节剂
公开(公告)号：WO2012009000A3
公开(公告)日：2013-04-18
申请号：PCT/US2011001206
申请日：2011-07-11
申请人： ADDEX PHARMACEUTICALS SA , MERCK SHARP & DOHME , BOLEA CHRISTELLE , CELANIRE SYLVAIN , TANG LAM , JONES PHILIP , LIVERTON NIGEL J , SOLL RICHARD , DONG JINCHAO , LEI ZHIYU , LIU FUQUING , KONG YANLING , JU YI , ZHANG HAOYONG , WEI JIEPING , WEI QAIOXIN , ZHANG MINGXIANG , LUO YUNFU
发明人： BOLEA CHRISTELLE , CELANIRE SYLVAIN , TANG LAM , JONES PHILIP , LIVERTON NIGEL J , SOLL RICHARD , DONG JINCHAO , LEI ZHIYU , LIU FUQUING , KONG YANLING , JU YI , ZHANG HAOYONG , WEI JIEPING , WEI QAIOXIN , ZHANG MINGXIANG , LUO YUNFU
IPC分类号： A01N43/42
CPC分类号： C07D513/12 , A23L27/2056 , A23L33/10 , A23V2002/00 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2059 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/55 , A61K45/06 , C07D513/04 , C07D513/14 , A61K2300/00 , A23V2200/16 , A23V2200/322 , A23V2200/328
摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
摘要翻译：本发明涉及新的式（I）化合物，其中M，A和Y如式（I）所定义; 本发明化合物是代谢型谷氨酸受体的调节剂 - 亚型4（“mGluR4”），其可用于治疗或预防中枢神经系统疾病以及由mGluR4受体调节的其它病症。本发明还涉及药物组合物和这些化合物在制备药物中的用途，以及这些化合物用于预防和治疗涉及mGluR4的疾病的用途。

3. 发明申请

WO2012158305A2 TEMPERATURE-MEASURING APPARATUS WITH TEMPERATURE-SENSITIVE DEVICE 审中-公开
标题翻译：温度测量装置与温度敏感器件
公开(公告)号：WO2012158305A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/034460
申请日：2012-04-20
申请人： LEELYNN JONES TECHNOLOGIES, INC. , JONES, Philip, Lee
发明人： JONES, Philip, Lee
IPC分类号： G01K5/48
CPC分类号： G01K5/66 , G01K5/70
摘要： The present disclosure relates generally to a temperature-measuring apparatus having a base, an elongated temperature-sensitive strip having multiple layers with different coefficients of thermal expansion, and a conversion component configured to produce temperature data based on a position of a distal portion of the strip. Certain embodiments relate to temperature- measuring apparatuses employing two or more elongated temperature- sensitive strips with a guide configured to limit bending of the distal portions of the strips. Certain embodiments relate to temperature-measuring apparatuses with one or more calibration members to alter the sensitivity and/or a temperature measurement of the apparatuses.
摘要翻译：本公开总体上涉及一种温度测量装置，其具有底座，具有不同热膨胀系数的多层的细长温度敏感条，以及转换部件，该转换部件被配置为基于所述基部的远端部分的位置产生温度数据跳闸。某些实施例涉及采用两个或更多细长的温度敏感条带的温度测量装置，其中引导件配置成限制条的远端部分的弯曲。某些实施例涉及具有一个或多个校准构件的温度测量装置，以改变设备的灵敏度和/或温度测量。

4. 发明申请

WO2011036453A1 METHODS OF ANALYSING HOMEOSTATIC STATE IN CELL SYSTEMS 审中-公开
标题翻译：细胞系统分析家庭状态的方法
公开(公告)号：WO2011036453A1
公开(公告)日：2011-03-31
申请号：PCT/GB2010/001789
申请日：2010-09-22
申请人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ENTERPRISE LIMITED , SIMONS, Benjamin David , KLEIN, Allon , JONES, Philip Howlett
发明人： SIMONS, Benjamin David , KLEIN, Allon , JONES, Philip Howlett
IPC分类号： G06F19/10 , G01N33/50
CPC分类号： G06F19/10 , G01N33/5011 , G01N33/5017 , G01N33/5026 , G01N33/5073
摘要： The invention relates to a method of analysing the homeostatic balance of a population of cells, which includes the following steps: a) label one or more cells in the population b) incubate the cells for a time t c) determine the clone size distribution of labelled cells at time t d) determine if the clone size distribution of (c) conforms to the scaling formula (I): where P n (t) is the probability of finding a surviving clone which has n progenitor cells at time t, formula (II) denotes the average number of dividing cells in surviving clones at time t and formula (III): wherein if the clone size distribution conforms to the scaling form above, the cells are identified as being in a normal steady-state homeostatic balance; if the clone size distribution does not conform to the scaling form above, the cells are identified as not being in a normal steady-state homeostatic balance.
摘要翻译：本发明涉及一种分析细胞群体的稳态平衡的方法，其包括以下步骤：a）标记群体中的一个或多个细胞b）孵育细胞一段时间tc）确定标记的细胞的克隆大小分布细胞在时间td）确定（c）的克隆大小分布是否符合缩放公式（I）：其中Pn（t）是在时间t找到具有n个祖细胞的存活克隆的概率，式（II）表示在时间t的存活克隆中的分裂细胞的平均数目和式（III）：其中如果克隆大小分布符合上述结垢形式，则细胞被鉴定为处于正常稳态稳态平衡中; 如果克隆大小分布不符合上述缩放形式，则细胞被鉴定为不处于正常的稳态稳态平衡。

5. 发明申请

WO2010001170A3 DOOR LATCH FACE PLATE ASSEMBLY 审中-公开
标题翻译：门锁板面板组件
公开(公告)号：WO2010001170A3
公开(公告)日：2010-03-11
申请号：PCT/GB2009050774
申请日：2009-07-02
申请人： HEELEY PETER , JONES PHILIP DAVID
发明人： HEELEY PETER , JONES PHILIP DAVID
IPC分类号： E05B15/02
CPC分类号： E05B15/02 , E05B63/0056
摘要： A face plate assembly comprising two face plates (1,2) for positioning on opposite sides of a door (D) and mounting handles (9,10) for coupling to a latch and/or lock mechanism mounted within an edge of the door (D), one or more screw threaded fasteners (50) slidably mounted on a first one of the face plates (2), on the inside thereof, so as to be adjacent the door (D) when the first face plate (2) is positioned thereagainst, the or each screw threaded fastener (50) being slidably adjustable along the first face plate (2) for aligning with a fixing hole through the door (D), and a fixing plate (14) for positioning on the opposite side of the door (D) to the first face plate (2), said fixing plate (14) having one or more slots (20,21) therethrough corresponding to the path of adjustment of the screw threader fasteners (50) along the first face plate (2), whereby the first face plate (2) and the fixing plate (14) can be clamped to opposite sides of the door (D) by one or more screw fastening members (53) extending through the slot(s) in the fixing plate (14) and the fixing hole(s) in the door (D) and engaging with the screw threaded fastener(s) (50) of the first face plate (2), the second one of the face plates (1) being fastenable to the fixing plate (14).
摘要翻译：一种面板组件，包括用于定位在门（D）的相对侧上的两个面板（1,2）和用于联接到安装在门的边缘内的闩锁和/或锁定机构的手柄（9,10） D），一个或多个螺纹紧固件（50）可滑动地安装在第一面板（2）的内侧上，以便当第一面板（2）为所述螺钉或每个螺纹紧固件（50）可沿着第一面板（2）可滑动地调节，用于与通过门（D）的固定孔对准，以及固定板（14），用于定位在相对侧所述门（D）到所述第一面板（2），所述固定板（14）具有穿过其中的一个或多个狭槽（20,21），所述狭槽（20,21）沿着所述螺纹拧紧器（50）沿着所述第一面板（2），由此第一面板（2）和固定板（14）可以通过一个或多个螺丝紧固件夹紧到门（D）的相对侧延伸穿过固定板（14）中的狭槽的定位构件（53）和门（D）中的固定孔，并与第一面板的螺纹紧固件（50）接合（2），所述面板（1）中的第二个可固定到所述固定板（14）。

6. 发明申请

WO2010023480A1 SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS 审中-公开
标题翻译：饱和双环杂环衍生物作为SMO拮抗剂
公开(公告)号：WO2010023480A1
公开(公告)日：2010-03-04
申请号：PCT/GB2009/051079
申请日：2009-08-28
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , BRANCA, Danila , FERRIGNO, Federica , HERNANDO, Jose, Ignacio, Martin , JONES, Philip , KINZEL, Olaf , MALANCONA, Savina , MURAGLIA, Ester , PALUMBI, Maria, Cecilia , PESCATORE, Giovanna , SCARPELLI, Rita
发明人： BRANCA, Danila , FERRIGNO, Federica , HERNANDO, Jose, Ignacio, Martin , JONES, Philip , KINZEL, Olaf , MALANCONA, Savina , MURAGLIA, Ester , PALUMBI, Maria, Cecilia , PESCATORE, Giovanna , SCARPELLI, Rita
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smoantagonists。因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症上胃肠道

7. 发明申请

WO2009056503A1 METHOD AND CORRESPONDING RECEIVER FOR ESTIMATING CELL GEOMETRY IN A SYNCHRONOUS CDMA COMMUNICATION SYSTEM 审中-公开
标题翻译：用于在同步CDMA通信系统中估计小区几何的方法和对应接收机
公开(公告)号：WO2009056503A1
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064471
申请日：2008-10-24
申请人： ICERA INC , LUSCHI, Carlo , ALLPRESS, Steve , JONES, Philip
发明人： LUSCHI, Carlo , ALLPRESS, Steve , JONES, Philip
IPC分类号： H04B17/00 , H04L1/20 , H04B1/707 , H04L25/02 , H04L25/03
CPC分类号： H04B17/345 , H04B1/7115 , H04B17/27 , H04B17/318 , H04B17/336 , H04L25/0212 , H04L25/0224 , H04L25/03019
摘要： A method and corresponding receiver for processing signals received over a wireless communication channel by a receiver in a wireless cellular network. The method comprises: receiving a sequence of signal samples; using the received sequence of samples to estimate at least one channel coefficient for at least one transmission path of the signal; generating an estimate of an orthogonality factor ( β ) based on the at least one channel coefficient; generating an estimate of the disturbance ( σ i 2 ) on the at least one estimated channel coefficient; generating an estimate of input signal power ( σ o 2 ) using the received sequence; using the estimated orthogonality factor, estimated disturbance and estimated input signal power to generate an estimate of cell geometry; and using the estimate of cell geometry in processing received data samples.
摘要翻译：一种用于处理由无线蜂窝网络中的接收机在无线通信信道上接收的信号的方法和相应的接收机。该方法包括：接收信号样本序列; 使用所接收的样本序列估计所述信号的至少一个传输路径的至少一个信道系数; 基于所述至少一个信道系数产生正交因子（β）的估计; 产生对所述至少一个估计的信道系数的扰动估计（s i 2）; 使用所接收的序列生成输入信号功率的估计（s o 2）; 使用估计的正交因子，估计的干扰和估计的输入信号功率来产生小区几何的估计; 并且在处理所接收的数据样本时使用小区几何的估计。

8. 发明申请

WO2009010725A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO2009010725A2
公开(公告)日：2009-01-22
申请号：PCT/GB2008/002387
申请日：2008-07-11
申请人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ENTERPRISE LIMITED , JONES, Philip, Howlett , SIMONS, Benjamin, David , KLEIN, Allon
发明人： JONES, Philip, Howlett , SIMONS, Benjamin, David , KLEIN, Allon
CPC分类号： G01N33/5073
摘要： The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cells; (i) the proportion of stem cells, proliferating cells and differentiated cells in said cell population; or (ii) the size of stem cell clusters in said cell population; or (iii) the separation of stem cell clusters in said cell population; and comparing said at least one characteristic to a reference value, wherein a difference between the determined value and the reference value indicates an altered behaviour in said population of cells. Preferably the cells are mammalian, more preferably human epithelial cells, more preferably human epidermal cells.
摘要翻译：本发明涉及一种检测细胞群体中改变的行为的方法，所述方法包括确定细胞群体的以下特征中的至少一个; （i）所述细胞群体中干细胞，增殖细胞和分化细胞的比例; 或（ii）所述细胞群体中的干细胞簇的大小; 或（iii）在所述细胞群中分离干细胞簇; 以及将所述至少一个特性与参考值进行比较，其中所述确定值与所述参考值之间的差表示所述细胞群体中的改变的行为。优选地，细胞是哺乳动物，更优选人上皮细胞，更优选人表皮细胞。

9. 发明申请

WO2008084261A1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS 审中-公开
标题翻译：作为聚（ADP-RIBOSE）聚合酶（PARP）抑制剂的酰胺取代的吲哚
公开(公告)号：WO2008084261A1
公开(公告)日：2008-07-17
申请号：PCT/GB2008/050018
申请日：2008-01-08
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , JONES, Philip , ONTORIA ONTORIA, Jesus, Maria , SCARPELLI, Rita , SCHULTZ-FADEMRECHT, Carsten
发明人： JONES, Philip , ONTORIA ONTORIA, Jesus, Maria , SCARPELLI, Rita , SCHULTZ-FADEMRECHT, Carsten
IPC分类号： C07D401/10 , A61K31/4439 , A61P35/00 , A61P29/00
CPC分类号： C07D401/10 , A61K31/4439
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerat ive diseases, retroviral infection, retinal damage or skin senescence and UV- induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，立体异构体或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤或皮肤衰老以及紫外线诱发的皮肤损伤，以及用于癌症治疗的化学和/或放射增敏剂。

10. 发明申请

WO2008041037A1 FUSED INDOLES AND INDAZOLES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) 审中-公开
标题翻译：作为聚（ADP-RIBOSE）聚合酶（PARP）的抑制剂的熔融吲哚和吲哚
公开(公告)号：WO2008041037A1
公开(公告)日：2008-04-10
申请号：PCT/GB2007/050613
申请日：2007-10-04
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , BRANCA, Danila , JONES, Philip , KOCH, Uwe , MURAGLIA, Ester , ORVIETO, Federica
发明人： BRANCA, Danila , JONES, Philip , KOCH, Uwe , MURAGLIA, Ester , ORVIETO, Federica
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性病症，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

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