专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009010725A2 METHODS 审中-公开
标题翻译：方法
公开(公告)号：WO2009010725A2
公开(公告)日：2009-01-22
申请号：PCT/GB2008/002387
申请日：2008-07-11
申请人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ENTERPRISE LIMITED , JONES, Philip, Howlett , SIMONS, Benjamin, David , KLEIN, Allon
发明人： JONES, Philip, Howlett , SIMONS, Benjamin, David , KLEIN, Allon
CPC分类号： G01N33/5073
摘要： The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cells; (i) the proportion of stem cells, proliferating cells and differentiated cells in said cell population; or (ii) the size of stem cell clusters in said cell population; or (iii) the separation of stem cell clusters in said cell population; and comparing said at least one characteristic to a reference value, wherein a difference between the determined value and the reference value indicates an altered behaviour in said population of cells. Preferably the cells are mammalian, more preferably human epithelial cells, more preferably human epidermal cells.
摘要翻译：本发明涉及一种检测细胞群体中改变的行为的方法，所述方法包括确定细胞群体的以下特征中的至少一个; （i）所述细胞群体中干细胞，增殖细胞和分化细胞的比例; 或（ii）所述细胞群体中的干细胞簇的大小; 或（iii）在所述细胞群中分离干细胞簇; 以及将所述至少一个特性与参考值进行比较，其中所述确定值与所述参考值之间的差表示所述细胞群体中的改变的行为。优选地，细胞是哺乳动物，更优选人上皮细胞，更优选人表皮细胞。

2. 发明申请

WO2007101979A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2007101979A2
公开(公告)日：2007-09-13
申请号：PCT/GB2007/000675
申请日：2007-02-27
申请人： MEDICAL RESERACH COUNCIL , CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED , JONES, Philip, Howlett , SIMON, Benjamin, David
发明人： JONES, Philip, Howlett , SIMON, Benjamin, David
CPC分类号： G01N33/5011 , A61K49/0006 , A61K49/0008 , G01N33/5014 , G01N33/5088 , G01N33/574
摘要： The invention relates to a method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at at least one time point t , wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behaviour of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviours, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.
摘要翻译：本发明涉及一种评估生物系统中靶细胞群的增殖或分化行为的方法，所述方法包括以下步骤： [a]在至少一个时间点t测量所述细胞的至少一种增殖特征的值，其中所述增殖特征是克隆大小分布; [b]将在[a]中测量的克隆大小分布与通过方程预测或描述的对应时间点t处的参考克隆大小分布进行比较; 其中[a]的测量的克隆大小分布与[b]的预测或描述的克隆大小分布之间的差异表示所述细胞的增殖或分化行为改变。本发明还涉及评估上述行为的结垢形式，参数值以及对细胞增殖和/或分化的推断效应的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式