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1. 发明申请

WO2007084361A3 COATED MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：涂层医疗装置及其制造方法
公开(公告)号：WO2007084361A3
公开(公告)日：2007-10-04
申请号：PCT/US2007000814
申请日：2007-01-11
申请人： BOSTON SCIENT LTD , JANG EUN-HYUN
发明人： JANG EUN-HYUN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/606 , A61L2300/61
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that comprises at least one polymer and a biologically active material that is present in at least two different forms. The coating may include more than one coating layer. Preferably, the coating is capable of releasing the different forms of the biologically active material in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译：本发明一般涉及具有完全或部分涂覆有包含两种或多种形式的生物活性材料的涂层的药物洗脱表面的涂覆医疗装置，优选支架。特别地，本发明涉及具有包含至少两种不同形式的至少一种聚合物和生物活性材料的涂层的涂覆医疗装置。涂层可以包括多于一个的涂层。优选地，涂层能够以不同的速率和/或在不同的时间段以不同的量释放不同形式的生物活性材料。本发明还涉及制造方法和使用涂覆的医疗装置的方法。

2. 发明申请

WO2003047494A3 REVERSE MICELLE COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2003047494A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038474
申请日：2002-12-03
申请人： DOR BIOPHARMA INC. , CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
发明人： CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
IPC分类号： A61K9/10
摘要： The invention relates to reverse micelle compositions and method s for drug delivery suitable for promoting the transmucosal absorption of biologically active molecules, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and othe polar solvents to form stable reverse micelles. When administered as pharmaceutical to mucosal surfaces following oral or intrasanal administration, biologically active molecules principally solubilized in the hydrophilic phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions described in this invention may comprise monoglycerides and/or their transesterified products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrophilic moieties.

3. 发明申请

WO2007084396A2 HALOFUGINONE DELIVERING VASCULAR MEDICAL DEVICES 审中-公开
标题翻译： HALOFUGINONE递送血管医疗器械
公开(公告)号：WO2007084396A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000891
申请日：2007-01-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , JANG, Eun-hyun , SONG, Young-ho , HERRMANN, Robert, A. , SINGHAL, Anurag , PIRES, Brad , SAATI, Andrew
发明人： JANG, Eun-hyun , SONG, Young-ho , HERRMANN, Robert, A. , SINGHAL, Anurag , PIRES, Brad , SAATI, Andrew
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416
摘要： A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 μg and 0.2 μg of halofuginone per mm 2 of stent surface area.
摘要翻译：提供了包含卤夫酮的医疗装置。医疗装置适于植入或插入血管，并且其提供累积的体内14天释放，其位于支架表面积的每平方毫米2范围内的0.02μg至0.2μg卤伏文酮之间。

4. 发明申请

WO2007084361A2 COATED MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：涂覆的医疗装置及其制造方法
公开(公告)号：WO2007084361A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000814
申请日：2007-01-11
申请人： BOSTON SCIENTIFIC SCIMED, INC. , JANG, Eun-Hyun
发明人： JANG, Eun-Hyun
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/606 , A61L2300/61
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that comprises at least one polymer and a biologically active material that is present in at least two different forms. The coating may include more than one coating layer. Preferably, the coating is capable of releasing the different forms of the biologically active material in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译：本发明一般涉及具有完全或部分涂覆有包含两种或更多种形式的生物活性物质的涂层的药物洗脱表面的涂覆医疗装置，优选支架。特别地，本发明涉及具有包含至少一种聚合物和以至少两种不同形式存在的生物活性物质的涂层的涂覆的医疗装置。该涂层可以包括多于一个的涂层。优选地，涂层能够以不同的量，不同的速率和/或不同的时间段释放不同形式的生物活性物质。本发明还涉及制造涂层医疗装置的方法和使用方法。

5. 发明申请

WO2007012012A3 MEDICAL DEVICES CONTAINING STERILISATION RADIATION RESISTANT PHENOXY POLYMERS 审中-公开
公开(公告)号：WO2007012012A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/028053
申请日：2006-07-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ZHONG, Sheng-Ping , MA, Enxin , JANG, Eun-Hyun
发明人： ZHONG, Sheng-Ping , MA, Enxin , JANG, Eun-Hyun
IPC分类号： A61L27/18 , A61L27/34 , A61L27/44 , A61L29/06 , A61L29/08 , A61L29/12 , A61L31/06 , A61L31/10 , A61L31/12
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.

6. 发明申请

WO2007097867A1 EXTENDABLE ROLLED DELIVERY SYSTEM 审中-公开
标题翻译：可扩展的滚动系统
公开(公告)号：WO2007097867A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/001902
申请日：2007-01-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SINGHAL, Anurag , HERRMANN, Robert , JANG, Eun-hyun , SONG, Young-ho
发明人： SINGHAL, Anurag , HERRMANN, Robert , JANG, Eun-hyun , SONG, Young-ho
IPC分类号： A61F2/00 , A61M31/00 , A61M25/00
CPC分类号： A61M25/0082 , A61M25/0074 , A61M31/00
摘要： The present invention relates to a device and method for delivery of a patch (150), graft, implant, therapeutic agent, or other device onto tissue using a rolled delivery mechanism (110). In one embodiment, a rolled delivery mechanism is provided for delivering a patch to tissue when the rolled delivery mechanism is unrolled. In another embodiment, a rolled delivery mechanism is provided for delivering therapeutic agent to a target tissue.
摘要翻译：本发明涉及一种用于使用轧制递送机构（110）将贴片（150），移植物，植入物，治疗剂或其它装置递送到组织上的装置和方法。在一个实施方案中，提供了一种轧制递送机构，用于在轧制的递送机构展开时将补片递送到组织。在另一个实施例中，提供了一种轧制递送机构，用于将治疗剂递送至靶组织。

7. 发明申请

WO2007012012A2 MEDICAL DEVICES CONTAINING RADIATION RESISTANT POLYMERS 审中-公开
标题翻译：包含耐辐射聚合物的医疗器械
公开(公告)号：WO2007012012A2
公开(公告)日：2007-01-25
申请号：PCT/US2006028053
申请日：2006-07-19
申请人： BOSTON SCIENT SCIMED INC , ZHONG SHENG-PING , MA ENXIN , JANG EUN-HYUN
发明人： ZHONG SHENG-PING , MA ENXIN , JANG EUN-HYUN
CPC分类号： A61L31/10 , C08L71/02 , C08L63/04
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译：本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。

8. 发明申请

WO03047493A3 STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：稳定的反胶束组合物及其用途
公开(公告)号：WO03047493A3
公开(公告)日：2003-10-16
申请号：PCT/US0238473
申请日：2002-12-03
申请人： DOR BIOPHARMA INC , CONSTANTINIDES PANOS P , LIANG LIKAN , JANG EUN-HYUN
发明人： CONSTANTINIDES PANOS P , LIANG LIKAN , JANG EUN-HYUN
IPC分类号： A61K8/14 , A61K9/107 , A61K9/48 , A61K31/727 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/48 , A61Q19/00 , A61K9/127 , A61F13/00 , A61K9/20
CPC分类号： A61K31/727 , A61K8/0291 , A61K9/107 , A61K9/1075 , A61K9/4891 , A61K38/09 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61Q19/00
摘要： The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physiclally stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.
摘要翻译：本发明涉及用于药物递送的组合物和方法，所述组合物和方法适于促进药物，特别是具有差的内在生物利用度的药物如肽，蛋白质，疫苗和核酸的透粘膜吸收。本发明的递送系统优选包含脂肪酸酯及其亲水性衍生物，其与水和其它极性溶剂缔合以形成在胃肠液，水和其它亲水性溶剂存在下物理稳定的反胶束。这种稳定的反胶束由聚合物或非聚合物与两亲物的适宜混合物形成。使用这些方法制备的胶束经历相变更慢，导致药物释放曲线延迟和持续吸收。当作为药物在口服或鼻内给药后粘膜表面施用时，主要溶解在水相中的治疗分子被粘膜酶和其他粘膜降解过程保护免于消化，并被吸收细胞机制吸收并到达适当的身体隔室。反胶束组合物可包含含有C 6 -C 12脂肪酸链的甘油单酯，甘油二酯和/或其酯交换产物，其中酯基由亲水部分组成。

9. 发明申请

WO03047494A2 REVERSE MICELLE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：反相MICELLE组合物及其用途
公开(公告)号：WO03047494A2
公开(公告)日：2003-06-12
申请号：PCT/US0238474
申请日：2002-12-03
申请人： DOR BIOPHARMA INC , CONSTANTINIDES PANOS P , LIANG LIKAN , JANG EUN-HYUN
发明人： CONSTANTINIDES PANOS P , LIANG LIKAN , JANG EUN-HYUN
IPC分类号： A61K8/14 , A61K9/107 , A61K47/48 , A61K49/00 , A61Q19/00 , A61J
CPC分类号： A61K8/0291 , A61K9/1075 , A61K49/0004 , A61Q19/00
摘要： The invention relates to reverse micelle compositions and method s for drug delivery suitable for promoting the transmucosal absorption of biologically active molecules, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and othe polar solvents to form stable reverse micelles. When administered as pharmaceutical to mucosal surfaces following oral or intrasanal administration, biologically active molecules principally solubilized in the hydrophilic phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions described in this invention may comprise monoglycerides and/or their transesterified products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrophilic moieties.
摘要翻译：本发明涉及用于药物递送的反胶束组合物和方法，其适用于促进生物活性分子的经粘膜吸收，特别是具有差的内在生物利用度的药物，例如肽，蛋白质，疫苗和核酸。本发明的递送系统优选包含与水和极性溶剂缔合的脂肪酸酯及其亲水性衍生物以形成稳定的反胶束。当口服或体内给药后作为药物施用于粘膜表面时，主要溶解在亲水相中的生物活性分子被保护不被粘膜酶和其它粘膜降解过程消化，并被吸收细胞机制吸收并达到适当的身体隔室。本发明中描述的反胶束组合物可以包含含有C 6 -C 12脂肪酸链的单酸甘油酯和/或其酯交换产物，其中酯基组由亲水部分组成。

10. 发明申请

WO2007084396A3 HALOFUGINONE DELIVERING VASCULAR MEDICAL DEVICES 审中-公开
标题翻译： HALOFUGINONE递送血管医疗器械
公开(公告)号：WO2007084396A3
公开(公告)日：2008-06-19
申请号：PCT/US2007000891
申请日：2007-01-12
申请人： BOSTON SCIENT SCIMED INC , JANG EUN-HYUN , SONG YOUNG-HO , HERRMANN ROBERT A , SINGHAL ANURAG , PIRES BRAD , SAATI ANDREW
发明人： JANG EUN-HYUN , SONG YOUNG-HO , HERRMANN ROBERT A , SINGHAL ANURAG , PIRES BRAD , SAATI ANDREW
IPC分类号： A61L31/16 , A61L31/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416
摘要： A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 µg and 0.2 µg of halofuginone per mm 2 of stent surface area.
摘要翻译：提供了包含卤夫酮的医疗装置。医疗装置适于植入或插入血管，并且其提供累积的体内14天释放，其位于支架表面积的每平方毫米2范围内的0.02μg至0.2μg卤伏文酮之间。

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