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1. 发明申请

WO2003047494A3 REVERSE MICELLE COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2003047494A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038474
申请日：2002-12-03
申请人： DOR BIOPHARMA INC. , CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
发明人： CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
IPC分类号： A61K9/10
摘要： The invention relates to reverse micelle compositions and method s for drug delivery suitable for promoting the transmucosal absorption of biologically active molecules, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and othe polar solvents to form stable reverse micelles. When administered as pharmaceutical to mucosal surfaces following oral or intrasanal administration, biologically active molecules principally solubilized in the hydrophilic phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions described in this invention may comprise monoglycerides and/or their transesterified products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrophilic moieties.

2. 发明申请

WO2003047493A2 STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：稳定的反相MICELLE组合物及其用途
公开(公告)号：WO2003047493A2
公开(公告)日：2003-06-12
申请号：PCT/US2002/038473
申请日：2002-12-03
申请人： DOR BIOPHARMA INC. , CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
发明人： CONSTANTINIDES, Panos, P. , LIANG, Likan , JANG, Eun-Hyun
IPC分类号： A61J
CPC分类号： A61K31/727 , A61K8/0291 , A61K9/107 , A61K9/1075 , A61K9/4891 , A61K38/09 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61Q19/00
摘要： The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physiclally stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.
摘要翻译：本发明涉及用于药物递送的组合物和方法，其适用于促进药物，特别是具有差的内在生物利用度的药物（例如肽，蛋白质，疫苗和核酸）的经粘膜吸收。本发明的递送系统优选包括脂肪酸酯及其亲水性衍生物，其与水和其它极性溶剂缔合以形成反胶束，其在胃肠液，水和其它亲水溶剂存在下被物理稳定化。这种稳定的反胶束由聚合物或非聚合物与两亲物的合适混合物形成。使用这些方法制备的胶束进行相变更慢，导致延迟的药物释放曲线和持续吸收。当口服摄取或鼻内给药后作为药物施用于粘膜表面时，主要溶解在水相中的治疗分子被保护不被粘膜酶和其它粘膜降解过程消化，并被吸收细胞机制吸收并达到适当的身体隔室。反胶束组合物可以包含含有C6-C12脂肪酸链的单 - ，二 - 甘油酯和/或其酯交换产物，其中酯基组由亲水部分组成。

3. 发明申请

WO2007084361A2 COATED MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：涂覆的医疗装置及其制造方法
公开(公告)号：WO2007084361A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000814
申请日：2007-01-11
申请人： BOSTON SCIENTIFIC SCIMED, INC. , JANG, Eun-Hyun
发明人： JANG, Eun-Hyun
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/606 , A61L2300/61
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that comprises at least one polymer and a biologically active material that is present in at least two different forms. The coating may include more than one coating layer. Preferably, the coating is capable of releasing the different forms of the biologically active material in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译：本发明一般涉及具有完全或部分涂覆有包含两种或更多种形式的生物活性物质的涂层的药物洗脱表面的涂覆医疗装置，优选支架。特别地，本发明涉及具有包含至少一种聚合物和以至少两种不同形式存在的生物活性物质的涂层的涂覆的医疗装置。该涂层可以包括多于一个的涂层。优选地，涂层能够以不同的量，不同的速率和/或不同的时间段释放不同形式的生物活性物质。本发明还涉及制造涂层医疗装置的方法和使用方法。

4. 发明申请

WO2007012012A3 MEDICAL DEVICES CONTAINING STERILISATION RADIATION RESISTANT PHENOXY POLYMERS 审中-公开
公开(公告)号：WO2007012012A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/028053
申请日：2006-07-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ZHONG, Sheng-Ping , MA, Enxin , JANG, Eun-Hyun
发明人： ZHONG, Sheng-Ping , MA, Enxin , JANG, Eun-Hyun
IPC分类号： A61L27/18 , A61L27/34 , A61L27/44 , A61L29/06 , A61L29/08 , A61L29/12 , A61L31/06 , A61L31/10 , A61L31/12
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.

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