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1. 发明申请

WO2007084396A3 HALOFUGINONE DELIVERING VASCULAR MEDICAL DEVICES 审中-公开
标题翻译： HALOFUGINONE递送血管医疗器械
公开(公告)号：WO2007084396A3
公开(公告)日：2008-06-19
申请号：PCT/US2007000891
申请日：2007-01-12
申请人： BOSTON SCIENT SCIMED INC , JANG EUN-HYUN , SONG YOUNG-HO , HERRMANN ROBERT A , SINGHAL ANURAG , PIRES BRAD , SAATI ANDREW
发明人： JANG EUN-HYUN , SONG YOUNG-HO , HERRMANN ROBERT A , SINGHAL ANURAG , PIRES BRAD , SAATI ANDREW
IPC分类号： A61L31/16 , A61L31/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416
摘要： A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 µg and 0.2 µg of halofuginone per mm 2 of stent surface area.
摘要翻译：提供了包含卤夫酮的医疗装置。医疗装置适于植入或插入血管，并且其提供累积的体内14天释放，其位于支架表面积的每平方毫米2范围内的0.02μg至0.2μg卤伏文酮之间。

2. 发明申请

WO2009076592A3 MEDICAL DEVICES HAVING POROUS COMPONENT FOR CONTROLLED DIFFUSION 审中-公开
标题翻译：具有用于控制扩散的多元组件的医疗装置
公开(公告)号：WO2009076592A3
公开(公告)日：2010-04-22
申请号：PCT/US2008086560
申请日：2008-12-12
申请人： BOSTON SCIENT SCIMED INC , SINGAL ANURAG , HERRMANN ROBERT A , XU YIXIN , SONG YOUNG-HO
发明人： SINGAL ANURAG , HERRMANN ROBERT A , XU YIXIN , SONG YOUNG-HO
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L29/14 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）具有一个或多个凹陷的基底，其含有至少一种治疗剂，和（b）设置在基底上的多孔膜，一个或多个凹陷，其调节化学物质在含治疗剂的凹陷和装置的外部之间的运输。基板和多孔膜由各自具有不同热膨胀系数的不同材料形成。此外，衬底和多孔膜中的一个至少部分地围绕另一个。本发明的其他方面涉及制造这种医疗装置的方法，以及使用这种医疗装置的治疗方法。

3. 发明申请

WO2006049823A2 ANTI-THROMBOGENIC AND ANTI-RESTENOTIC VASCULAR MEDICAL DEVICES 审中-公开
标题翻译：抗血栓形成和抗肿瘤血管性医疗装置
公开(公告)号：WO2006049823A2
公开(公告)日：2006-05-11
申请号：PCT/US2005036622
申请日：2005-10-12
申请人： BOSTON SCIENT SCIMED INC , HERRMANN ROBERT A
发明人： HERRMANN ROBERT A
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/61
摘要： A medical device is provided which is adapted for implantation or insertion into the vasculature. The medical device comprises the following: (a) a medical device substrate; (b) a lower polymeric layer, provided over the substrate, which comprises a nitric oxide donor and a polymer; and (c) an upper polymeric layer, provided over the lower polymer layer, which comprises a polymer and an anti-restenotic agent.
摘要翻译：提供适于植入或插入脉管系统的医疗装置。该医疗装置包括：（a）医疗器械基板; （b）提供在基底上的下聚合物层，其包含一氧化氮供体和聚合物; 和（c）设置在下聚合物层上的上聚合物层，其包含聚合物和抗再狭窄剂。

4. 发明申请

WO2009151876A3 CODED HETEROFUNCTIONAL SUTURES AND METHODS 审中-公开
标题翻译：编码的异常方法和方法
公开(公告)号：WO2009151876A3
公开(公告)日：2010-04-22
申请号：PCT/US2009044274
申请日：2009-05-16
申请人： ANGIOTECH PHARM INC , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H , D AGOSTINO WILLIAM L
发明人： AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H , D AGOSTINO WILLIAM L
IPC分类号： A61B17/064
CPC分类号： A61B17/06166 , A61B90/92 , A61B90/94 , A61B2017/06176
摘要： A marked heterofunctional surgical filament. The filament comprises two or more sections having different features, and the different sections of the filament are provided with markers in order that they may be identified and differentiated. The filament may have retainers on the surface of one or more sections such that the filament can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of filament such as the presence and/orientation of retainers. The markers may be utilized to indicate conditions of the filament such as tension. The markers may be directly readable or be machine-readable. The surgical filament is thin and flexible and may be used for suturing.
摘要翻译：标记异型手术丝。灯丝包括具有不同特征的两个或更多个部分，并且灯丝的不同部分设置有标记，以便它们可以被鉴定和分化。长丝可以在一个或多个部分的表面上具有保持器，使得细丝可以接合并保持组织而没有结。标记可用于表示细丝部分的固定特征，例如保持器的存在和/取向。标记可以用于指示细丝的状况，例如张力。标记可以是直接可读的或机器可读的。外科手术细丝薄而柔软，可用于缝合。

5. 发明申请

WO2009129251A3 SELF-RETAINING SUTURES WITH BI-DIRECTIONAL RETAINERS OR UNI-DIRECTIONAL RETAINERS 审中-公开
标题翻译：具有双向定位器或单向定位器的自保持式缝合线
公开(公告)号：WO2009129251A3
公开(公告)日：2009-12-23
申请号：PCT/US2009040545
申请日：2009-04-14
申请人： ANGIOTECH PHARM INC , GORALTCHOUK ALEXEI , DRUBETSKY LEV , CUMMINGS GERALD F , HERRMANN ROBERT A , NAIMAGON ALEXANDER
发明人： GORALTCHOUK ALEXEI , DRUBETSKY LEV , CUMMINGS GERALD F , HERRMANN ROBERT A , NAIMAGON ALEXANDER
IPC分类号： A61B17/064
CPC分类号： A61B17/06166 , A61B17/08 , A61B2017/00526 , A61B2017/06176 , A61B2017/081
摘要： Provided herein are sutures for use in a procedure applied to tissue, and methods for forming such sutures. Some sutures include bi-directional retainers, each of which can be deployed in two directions, but once deployed in one direction, resist motion in the opposite direction. Other sutures include uni-directional retainers that are conical in shape, and include tissue engaging protrusions that extend from edges and/or angled walls of the conical retainers.
摘要翻译：本文提供了用于应用于组织的手术中的缝合线以及形成这种缝合线的方法。一些缝合线包括双向保持器，每个保持器都可以在两个方向上展开，但一旦展开在一个方向上，就会阻止相反方向的运动。其他缝合线包括圆锥形的单向保持器，并且包括从锥形保持器的边缘和/或成角度的壁延伸的组织接合突起。

6. 发明申请

WO2009105663A3 METHOD AND APPARATUS FOR ELEVATING RETAINERS ON SELF-RETAINING SUTURES 审中-公开
标题翻译：用于在自保留缝隙上提起固定器的方法和设备
公开(公告)号：WO2009105663A3
公开(公告)日：2009-12-03
申请号：PCT/US2009034703
申请日：2009-02-20
申请人： ANGIOTECH PHARM INC , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , DRUBETSKY LEV , GROSS JEFFREY MENDEL , D AGOSTINO WILLIAM L , GONZALEZ RESENDIZ CARLOS
发明人： GORALTCHOUK ALEXEI , HERRMANN ROBERT A , DRUBETSKY LEV , GROSS JEFFREY MENDEL , D AGOSTINO WILLIAM L , GONZALEZ RESENDIZ CARLOS
IPC分类号： A61B17/068 , A61B17/03 , A61B17/06
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00867 , A61B2017/00871 , A61B2017/00995 , A61B2017/06176 , D02J3/10 , Y10T83/02
摘要： A method and device to elevate retainers on a suture thread to a desired angle such that the retainers can retain the desired elevation. The retainers can be elevated using an apparatus having at least one roller and at least one bending bar, wherein the bending bar contacts the retainers adjacent to the at least one roller to apply a force to the retainers. The retainers can also be elevated using a tube-shaped apparatus which allows the retainers on a suture thread to be bent by the inner surface of the tube-shaped apparatus. In various embodiments of the invention, a suture can be made up of an inner core and a coating that upon a stimuli increases the protrusion of the retainers away from the suture core thereby ensuring that the suture is held securely in place, preventing wound separation and dehiscence. In an embodiment of the invention, the application of the coating to the outer face of the retainer and attractive forces between the coating at different points results in the distension of the retainers away from the suture core. In an alternative embodiment of the invention, the coating inserts into the cut associated with the retainer and repulsive or expansive forces result in a pushing out of the cut and thereby the distending of the retainers away from the suture core.
摘要翻译：一种将缝合线上的保持器升高到期望角度的方法和装置，使得保持器能够保持期望的高度。可以使用具有至少一个滚子和至少一个弯曲杆的装置升高保持器，其中弯曲杆接触与至少一个滚子相邻的保持器以向保持器施加力。保持器也可以使用管状装置升高，该装置允许缝合线上的保持器被管状装置的内表面弯曲。在本发明的各种实施例中，缝合线可以由内芯和涂层组成，所述内芯和涂层在刺激时增加保持器远离缝合线芯的突出，由此确保缝合线牢固地保持在位，防止伤口分离和裂开。在本发明的一个实施例中，将涂层施加到保持器的外表面以及不同点处的涂层之间的吸引力导致保持器远离缝合线芯延伸。在本发明的可选实施例中，涂层插入与保持器相关联的切口中，并且排斥力或膨胀力导致切口的推出并且因此保持器远离缝合线芯扩张。

7. 发明申请

WO2009042841A3 SELF-RETAINING SUTURES INCLUDING TISSUE RETAINERS HAVING IMPROVED STRENGTH 审中-公开
标题翻译：自我固定的缝合物，包括具有改善的强度的组织固定器
公开(公告)号：WO2009042841A3
公开(公告)日：2009-05-22
申请号：PCT/US2008077813
申请日：2008-09-26
申请人： ANGIOTECH PHARM INC , HERRMANN ROBERT A , GORALTCHOUK ALEXEI , DRUBETSKY LEV
发明人： HERRMANN ROBERT A , GORALTCHOUK ALEXEI , DRUBETSKY LEV
IPC分类号： A61L17/04 , A61B17/04
CPC分类号： B26D3/08 , A61B17/06166 , A61B2017/00526 , A61B2017/06176 , A61L17/005 , A61L2300/43 , B26D1/0006 , B26D1/25 , B26D2001/002 , B26D2001/0053 , B26D2001/006 , B26F3/08 , Y10T83/0333 , Y10T83/0341
摘要： An embodiment of a suture for use in a surgical procedure applied to tissue comprises an elongated body having a first end and a second end, and a plurality of retainers arranged along a portion of the elongated body. The retainers substantially yield to motion of the elongated body within the tissue when the elongated body is drawn at the first end and resist motion of the elongated within the tissue when the elongated body is drawn at the second end. The retainers include an upper surface and a lower surface, the upper surface extending from a periphery of the elongated body and the lower surface having at least two facets.
摘要翻译：用于应用于组织的外科手术中的缝合线的实施例包括具有第一端和第二端的细长主体以及沿细长主体的一部分布置的多个保持器。当细长主体在第一端被拉动时，保持器基本上屈服于细长主体在组织内的运动，并且当细长主体在第二端被拉动时阻止细长在组织内的运动。保持器包括上表面和下表面，上表面从细长主体的周边延伸，并且下表面具有至少两个小平面。

8. 发明申请

WO2011090628A2 BIDIRECTIONAL SELF-RETAINING SUTURES WITH LASER-MARKED AND/OR NON-LASER MARKED INDICIA AND METHODS 审中-公开
标题翻译：具有激光标记和/或非激光标记的指标的双向自保留方法和方法
公开(公告)号：WO2011090628A2
公开(公告)日：2011-07-28
申请号：PCT/US2010060889
申请日：2010-12-16
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
IPC分类号： A61B17/04 , D02G3/34 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/0469 , A61B34/30 , A61B90/90 , A61B90/92 , A61B90/94 , A61B90/98 , A61B2017/00115 , A61B2017/00526 , A61B2017/06009 , A61B2017/06014 , A61B2017/06057 , A61B2017/06176 , A61B2090/064 , A61B2090/0809 , A61B2090/365
摘要： A marked heterofunctional suture thread has two or more sections having different features. One or more sections of the suture thread are provided with laser-marked and non-laser marked indicia in order that they may be identified and differentiated from other sections. The suture thread may have retainers on the surface of one or more sections such that the suture thread can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of suture thread such as the presence and/orientation of retainers. In particular embodiments, laser-marked and non-laser marked indicia are used to identify the transition section of a bidirectional self-retaining suture.
摘要翻译：标记的异型功能缝合线具有两个或多个具有不同特征的部分。缝合线的一个或多个部分设置有激光标记和非激光标记的标记，以便它们可以被识别并且与其它部分区分开。缝合线可以在一个或多个部分的表面上具有保持器，使得缝合线可以接合并保持组织而没有结。标记可以用于指示缝合线的一部分的固定特征，例如保持器的存在和/取向。在特定实施例中，使用激光标记和非激光标记标记来识别双向自固位缝合线的过渡部分。

9. 发明申请

WO2009132284A3 SHAPE-MEMORY SELF-RETAINING SUTURES, METHODS OF MANUFACTURE, AND METHODS OF USE 审中-公开
标题翻译：形状记忆自保留方法，制造方法和使用方法
公开(公告)号：WO2009132284A3
公开(公告)日：2010-02-25
申请号：PCT/US2009041685
申请日：2009-04-24
申请人： ANGIOTECH PHARM INC , GORALTCHOUK ALEXEI , LAI JOHN , HERRMANN ROBERT A
发明人： GORALTCHOUK ALEXEI , LAI JOHN , HERRMANN ROBERT A
IPC分类号： A61L17/10 , A61B17/064
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00792 , A61B2017/00867 , A61B2017/06057 , A61B2017/06176 , A61L17/00 , A61L2400/16 , D01F6/00 , D06M11/83 , D06M15/00
摘要： A self-retaining suture comprises a filament. The filament has retainers on the surface such that the filament can engage and retain tissue without knots. The filament comprises one or more materials at least one of which is a shape-memory polymer or shape-memory alloy. The shape-memory material is used to cause the shape of the retainers and or the filament to transition from a first configuration to a second configuration in response to a transition stimulus. The transition stimulus may be applied before, during, or after deployment of the suture in tissue. In particular, the shape-memory material may be used to enhance the formation, elevation and/or deployment of the retainers. Methods for manufacturing the filament and retainers are also described.
摘要翻译：自固定缝合线包括细丝。灯丝在表面上具有保持器，使得灯丝可以接合并保持组织而不发出结。长丝包括一种或多种材料，其中至少一种是形状记忆聚合物或形状记忆合金。形状记忆材料用于使保持器和/或细丝的形状响应于转换刺激从第一配置转变到第二配置。转移刺激可以在缝合线在组织中展开之前，之中或之后施用。特别地，形状记忆材料可以用于增强保持器的形成，升高和/或部署。还描述了制造丝和保持器的方法。

10. 发明申请

WO2009086172A3 SELF-RETAINING SUTURES WITH HEAT-CONTACT MEDIATED RETAINERS 审中-公开
标题翻译：具有热接触介质保持器的自保护套
公开(公告)号：WO2009086172A3
公开(公告)日：2009-09-24
申请号：PCT/US2008087788
申请日：2008-12-19
申请人： ANGIOTECH PHARM INC , GORALTCHOUK ALEXEI , DRUBETSKY LEV , CUMMINGS GERALD F , HERRMANN ROBERT A , NAIMAGON ALEXANDER
发明人： GORALTCHOUK ALEXEI , DRUBETSKY LEV , CUMMINGS GERALD F , HERRMANN ROBERT A , NAIMAGON ALEXANDER
IPC分类号： A61B17/064 , A61B17/04 , A61B17/068
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/06176 , A61B2017/0619
摘要： Provided herein are sutures to be used in a procedure applied to tissue, and methods for forming such sutures. A suture can include an elongated suture body and a plurality of heat-contact mediated retainers extending from and along the elongated suture body. The heat-contact mediated retainers can be formed by temporarily contacting the elongated suture body with one or more heated element.
摘要翻译：本文提供了用于施用于组织的程序中的缝线以及用于形成这种缝合线的方法。缝合线可以包括细长的缝线体和从细长的缝合线本体延伸的多个热接触介质保持器。热接触介质保持器可以通过将细长的缝合线主体与一个或多个加热元件暂时接触而形成。

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