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1. 发明申请

WO2012022728A3 NOVEL BIOSENSORS AND THEIR USE 审中-公开
标题翻译：新的生物传感器及其用途
公开(公告)号：WO2012022728A3
公开(公告)日：2015-06-18
申请号：PCT/EP2011064059
申请日：2011-08-16
申请人： EVOCATAL GMBH , JAEGER KARL ERICH , DREPPER THOMAS , ENDRES STEPHAN , POTZKEI JANKO , HECK ACHIM , CIRCOLONE FRANCO
发明人： JAEGER KARL ERICH , DREPPER THOMAS , ENDRES STEPHAN , POTZKEI JANKO , HECK ACHIM , CIRCOLONE FRANCO
IPC分类号： G01N33/542 , G01N33/58
CPC分类号： C12Q1/02 , C07K14/00 , C12Q1/008 , G01N33/542 , G01N33/582 , Y10S435/968 , Y10T436/147777 , Y10T436/153333 , Y10T436/209163
摘要： The present invention relates to an FRET donor/acceptor pair for use as biosensor, comprising at least two fluorescence proteins, where at least one fluorescence protein is stable with respect to a parameter to be detected by the biosensor and at least one fluorescence protein is not stable.
摘要翻译：本发明涉及一种FRET供体 - 受体对用作包括至少两个荧光蛋白的生物传感器中，至少一个荧光蛋白是稳定的由待检测生物传感器和至少一个参数不稳定对面之一。

2. 发明申请

WO2012022727A1 LOV-DOMÄNEN PROTEIN ZUR PHOTOSENSIBLEN DESFUNKTIONALISIERUNG 审中-公开
标题翻译： LOV结构域蛋白用于光敏DESFUNKTIONALISIERUNG
公开(公告)号：WO2012022727A1
公开(公告)日：2012-02-23
申请号：PCT/EP2011/064058
申请日：2011-08-16
申请人： EVOCATAL GMBH , JAEGER, Karl, Erich , DREPPER, Thomas , ENDRES, Stephan , POTZKEI, Janko
发明人： JAEGER, Karl, Erich , DREPPER, Thomas , ENDRES, Stephan , POTZKEI, Janko
IPC分类号： G01N33/58
CPC分类号： C12N13/00 , C07K14/21 , C07K14/32 , G01N33/582
摘要： Die vorliegende Erfindung betrifft die Verwendung eines Proteins umfassend eine LOV-Domäne zur photosensiblen Desfunktionalisierung eines Moleküls sowie eine Methode zur photosensiblen Desfunktionalisierung eines Zielmoleküls.
摘要翻译：本发明涉及使用包含LOV域到一个分子的光敏Desfunktionalisierung以及为感光Desfunktionalisierung的靶分子的方法的蛋白质。

3. 发明申请

WO0068258A3 COMPOUNDS EXHIBITING AN ANTIBIOTIC ACTIVITY 审中-公开
标题翻译：抗生素效果LINKS
公开(公告)号：WO0068258A3
公开(公告)日：2002-02-14
申请号：PCT/EP0004089
申请日：2000-05-06
申请人： STUDIENGESELLSCHAFT KOHLE MBH , REETZ MANFRED , KUEHLING KLAUS , MEHLHORN HEINZ , JAEGER KARL ERICH
发明人： REETZ MANFRED , KUEHLING KLAUS , MEHLHORN HEINZ , JAEGER KARL-ERICH
IPC分类号： A23K20/195 , A23L33/18 , A61K35/56 , A61K38/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , C07K14/435 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , A61K38/17 , C12N15/63
CPC分类号： C07K14/43504 , A23K20/195 , A23L33/18 , A61K38/00 , Y10S435/888 , Y10S930/19
摘要： The invention relates to compounds exhibiting an antibiotic activity which are extracted from body fluids of mollusks, namely from certain West African snails. The invention also relates to medicaments comprising these compounds and to the application thereof for producing a medicament used to control infectious pathogens in humans and animals.
摘要翻译：本发明涉及包含这些化合物具有抗菌活性的化合物，这是从软体动物的体液得到即某些西非蜗牛，，药物组合物，以及它们用于控制在人类和动物感染性病原体的药物中的用途。

4. 发明申请

WO2013020831A1 VERWENDUNG VON FMN-BINDENDEN FLUORESZENZPROTEINEN (FBFP) ALS NEUARTIGE SEKRETIONSMARKER 审中-公开
标题翻译： FMN结合蛋白荧光作为新颖分泌标记USE（FBFP）
公开(公告)号：WO2013020831A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/064776
申请日：2012-07-27
申请人： EVOCATAL GMBH , DREPPER, Thomas , JAEGER, Karl-Erich , POTZKEI, Janko
发明人： DREPPER, Thomas , JAEGER, Karl-Erich , POTZKEI, Janko
IPC分类号： C07K14/195
CPC分类号： G01N33/52 , C07K14/195 , C07K14/245 , C12Q1/68
摘要： Zur Untersuchung von Protein-Protein Interaktionen, Proteinfaltungen und Proteinlokalisation sowie bei der Sekretion von Proteinen werden in der Biotechnologie und in der Grundlagenforschung in vivo Reporterproteine eingesetzt. Um Fluoreszenzreporter als Marker für Sekretionsprozesse nutzen zu können, wurden von uns erstmals FMN-bindende Fluoreszenproteine (FbFP) entwickelt. Die neuen Fluoreszenzmarker lassen sich wie GFP in verschiedenen Bakterien exprimieren. Durch die Bindung des Chromophors FMN entsteht so ein cyan-grün fluoreszierendes Protein, das sich in vivo mit allen gängigen spektroskopischen und mikroskopischen Verfahren nachweisen lässt. Im Gegensatz zu GFP kann dieses Protein überraschender Weise auch über den Sec-Weg sekretiert und im Periplasma in den fluoreszenzaktiven Zustand überführt werden.
摘要翻译：对于蛋白质 - 蛋白质相互作用，蛋白质折叠和蛋白定位的调查以及蛋白质的分泌体内报道蛋白的生物技术和基础研究使用。使用荧光报告作为分泌过程的标志，我们首次FMN结合Fluoreszenproteine（FbFP）开发。新的荧光标记物可以在不同的细菌，如GFP表达。由发色团FMN结果的结合是青色的绿色荧光蛋白可在体内与所有标准光谱和显微技术来检测。相反GFP这种蛋白质，出人意料的是，也可以通过Sec途径分泌，并在周质中被转化成荧光激活状态。

5. 发明申请

WO2012022728A2 NEUE BIOSENSOREN UND DEREN VERWENDUNG 审中-公开
标题翻译：新的生物传感器及其用途
公开(公告)号：WO2012022728A2
公开(公告)日：2012-02-23
申请号：PCT/EP2011/064059
申请日：2011-08-16
申请人： EVOCATAL GMBH , JAEGER, Karl Erich , DREPPER, Thomas , ENDRES, Stephan , POTZKEI, Janko , HECK, Achim , CIRCOLONE, Franco
发明人： JAEGER, Karl Erich , DREPPER, Thomas , ENDRES, Stephan , POTZKEI, Janko , HECK, Achim , CIRCOLONE, Franco
IPC分类号： G01N33/542 , G01N33/58
CPC分类号： C12Q1/02 , C07K14/00 , C12Q1/008 , G01N33/542 , G01N33/582 , Y10S435/968 , Y10T436/147777 , Y10T436/153333 , Y10T436/209163
摘要： Die vorliegende Erfindung betrifft ein FRET-Donor-Akzeptor-Paar zur Verwendung als Biosensor umfassend mindestens zwei Fluoreszenzproteine, wobei wenigstens ein Fluoreszenzprotein gegenber einem durch den Biosensor zur detektierenden Parameter stabil und mindestens eins nicht stabil ist.
摘要翻译：本发明涉及一种FRET供体 - 受体对用作包括至少两个荧光蛋白的生物传感器中，至少一个荧光蛋白是稳定的由待检测生物传感器和至少一个参数不稳定对面之一。

6. 发明申请

WO2007128441A3 A NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 审中-公开
标题翻译：一个生产精细和特种化学品的新一批产品
公开(公告)号：WO2007128441A3
公开(公告)日：2008-02-28
申请号：PCT/EP2007003772
申请日：2007-04-27
申请人： B R A I N AG , ELEND CHRISTIAN , JAEGER KARL-ERICH , LEGGEWIE CHRISTIAN , SCHMEISSER CHRISTEL , STREIT WOLFGANG
发明人： ELEND CHRISTIAN , JAEGER KARL-ERICH , LEGGEWIE CHRISTIAN , SCHMEISSER CHRISTEL , STREIT WOLFGANG
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E. C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6 and 8; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5 and 7; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxyl esterase activity which polynucleotide is at least 65% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6 and 8; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (T) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host, genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a polypeptide comprising the amino acid sequence encoded by a polynucleotide of the present invention or which is obtainable by the process of the present invention. Moreover, the present invention relates to a process for producing said polypeptide and for producing bacteria expressing said polypeptide. Finally, the present invention relates to a composition comprising the polynucleotide of the present invention, the vector of the present invention, the host of the present invention, the polypeptide of the present invention, the antibody of the present invention and/or one or more primers of the present invention.
摘要翻译：本发明涉及编码具有羧基酯酶[E. 3.1.1.1]活性，其中编码序列选自（a）编码SEQ ID NO：2,4,6和8中任一个所示氨基酸序列的多核苷酸; （b）具有或包含编码酶的核苷酸序列的多核苷酸，其中所述核酸序列如SEQ ID NO：1,3,5和7中任一个所示; （c）具有或包含编码由（a）或（b）的多核苷酸编码的酶的片段或衍生物的核苷酸序列的多核苷酸，其中在所述衍生物中，与氨基酸相比，一个或多个氨基酸残基被保守取代（a）的顺序; （d）编码具有羧基酯酶活性的酶的多核苷酸与编码如SEQ ID NO：2,4,6和8之一所示的酶的多核苷酸至少65％相同; （e）具有或包含核苷酸序列的多核苷酸，其互补链与（a）至（d）中任一项所定义的多核苷酸杂交; 和（T）具有或包含与（d）或（e）的多核苷酸的核苷酸序列退化的核苷酸序列的多核苷酸; 或（a）至（f）的这种多核苷酸或其片段的互补链用作特异性探针或引物。本发明还涉及用本发明的多核苷酸或本发明的载体进行遗传工程改造的宿主。本发明还涉及包含由本发明的多核苷酸编码或可通过本发明的方法获得的氨基酸序列的多肽。此外，本发明涉及生产所述多肽和产生表达所述多肽的细菌的方法。最后，本发明涉及包含本发明的多核苷酸，本发明的载体，本发明的宿主，本发明的多肽，本发明的抗体和/或一种或多种的组合物本发明的引物。

7. 发明申请

WO2007128441A2 A NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 审中-公开
标题翻译：一个生产精细和特种化学品的新一批产品
公开(公告)号：WO2007128441A2
公开(公告)日：2007-11-15
申请号：PCT/EP2007/003772
申请日：2007-04-27
申请人： B.R.A.I.N. AG , ELEND, Christian , JAEGER, Karl-Erich , LEGGEWIE, Christian , SCHMEISSER, Christel , STREIT, Wolfgang
发明人： ELEND, Christian , JAEGER, Karl-Erich , LEGGEWIE, Christian , SCHMEISSER, Christel , STREIT, Wolfgang
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E. C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6 and 8; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5 and 7; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxyl esterase activity which polynucleotide is at least 65% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6 and 8; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (T) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host, genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a polypeptide comprising the amino acid sequence encoded by a polynucleotide of the present invention or which is obtainable by the process of the present invention. Moreover, the present invention relates to a process for producing said polypeptide and for producing bacteria expressing said polypeptide. Finally, the present invention relates to a composition comprising the polynucleotide of the present invention, the vector of the present invention, the host of the present invention, the polypeptide of the present invention, the antibody of the present invention and/or one or more primers of the present invention.
摘要翻译：本发明涉及编码具有羧基酯酶[E. 3.1.1.1]活性，其中编码序列选自（a）编码SEQ ID NO：2,4,6和8中任一个所示氨基酸序列的多核苷酸; （b）具有或包含编码酶的核苷酸序列的多核苷酸，其中所述核酸序列如SEQ ID NO：1,3,5和7中任一个所示; （c）具有或包含编码由（a）或（b）的多核苷酸编码的酶的片段或衍生物的核苷酸序列的多核苷酸，其中在所述衍生物中，与氨基酸相比，一个或多个氨基酸残基被保守取代（a）的顺序; （d）编码具有羧基酯酶活性的酶的多核苷酸与编码如SEQ ID NO：2,4,6和8之一所示的酶的多核苷酸至少65％相同; （e）具有或包含核苷酸序列的多核苷酸，其互补链与（a）至（d）中任一项所定义的多核苷酸杂交; 和（T）具有或包含与（d）或（e）的多核苷酸的核苷酸序列退化的核苷酸序列的多核苷酸; 或（a）至（f）的这种多核苷酸或其片段的互补链用作特异性探针或引物。本发明还涉及用本发明的多核苷酸或本发明的载体进行遗传工程改造的宿主。本发明还涉及包含由本发明的多核苷酸编码或可通过本发明的方法获得的氨基酸序列的多肽。此外，本发明涉及生产所述多肽和产生表达所述多肽的细菌的方法。最后，本发明涉及包含本发明的多核苷酸，本发明的载体，本发明的宿主，本发明的多肽，本发明的抗体和/或一种或多种的组合物本发明的引物。

8. 发明申请

WO2006133900A9 LIPASE PRODUCTION METHOD 审中-公开
标题翻译：用于生产脂肪酶
公开(公告)号：WO2006133900A9
公开(公告)日：2007-03-08
申请号：PCT/EP2006005668
申请日：2006-06-13
申请人： BASF AG , BESELIN ANKE , ROSENAU FRANK , JAEGER KARL-ERICH , BREUER MICHAEL , HAUER BERNHARD
发明人： BESELIN ANKE , ROSENAU FRANK , JAEGER KARL-ERICH , BREUER MICHAEL , HAUER BERNHARD
IPC分类号： C12N9/52
CPC分类号： C12N9/52 , C12N9/20
摘要： The invention relates to novel proteins, in particular, exhibiting a protease activity and promoting the production of extracellular lipases by bacteria, in particular, by Burkholderia-type bacteria, to coding nucleic acid sequences, expression constructs containing them, host modified thereby, to a method for producing proteins exhibiting a protease activity and to a lipase production method, in particular by Burkholderia-type bacteria.
摘要翻译：本发明涉及的特别是伯克霍尔德氏菌属，含有这些表达构建体的核酸编码的序列，宿主经转化与之新的蛋白质，特别是具有蛋白酶活性，其通过细菌促进生产细胞外脂肪酶的，用于制备具有蛋白酶活性以及方法的蛋白质的用于生产脂酶的方法，特别是通过伯克霍尔德氏菌属的细菌。

9. 发明申请

WO2007017181A3 USE OF ESTERASES FOR SEPARATING PLASTICS 审中-公开
标题翻译：使用酯类物质切割塑料
公开(公告)号：WO2007017181A3
公开(公告)日：2007-08-02
申请号：PCT/EP2006007693
申请日：2006-08-03
申请人： HENKEL KGAA , MICHELS ANDREAS , PUETZ ANDRE , MAURER KARL-HEINZ , EGGERT THORSTEN , JAEGER KARL-ERICH
发明人： MICHELS ANDREAS , PUETZ ANDRE , MAURER KARL-HEINZ , EGGERT THORSTEN , JAEGER KARL-ERICH
IPC分类号： C12N9/18 , C12N5/10 , C12N15/63
CPC分类号： C12N9/18
摘要： The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and corresponding washing and cleaning methods, in addition to additional technical areas of application. The invention also relates to the use of esterases for protecting against or reducing and/or preventing pilling, preferably in textiles, particularly plastic fibres, more preferably polyester fibres, in addition to the use of esterases for separating the plastics, in particular, polyester compounds. The invention further relates to novel esterases and to sufficiently related proteins and to derivatives thereof, agents containing them and to the use thereof.
摘要翻译：本发明涉及含有酯酶剂，以及涉及它们用于纤维的整理，特别是人造纤维，洗涤和含有酯酶和相应的洗涤和清洁方法和其他技术应用的清洁剂的用途。更具体地说，它涉及使用酯酶的用于防止或减少或防止起球，优选在纺织品，特别是塑料纤维，特别优选聚酯纤维，以及用于塑料裂解使用酯酶，特别是聚酯化合物。它还涉及新的酯酶和足够相关的蛋白质及其衍生物，含有它们的试剂及其用途。

10. 发明申请

WO9905288A3 METHOD FOR PRODUCING AND IDENTIFYING NEW HYDROLASES HAVING IMPROVED PROPERTIES 审中-公开
标题翻译：工艺性能得到改善的制备与鉴定新HYDRO阅读
公开(公告)号：WO9905288A3
公开(公告)日：1999-07-08
申请号：PCT/EP9804612
申请日：1998-07-23
申请人： STUDIENGESELLSCHAFT KOHLE MBH , REETZ MANFRED T , ZONTA ALBIN , SCHIMOSSEK KLAUS , LIEBETON KLAUS , JAEGER KARL ERICH
发明人： REETZ MANFRED T , ZONTA ALBIN , SCHIMOSSEK KLAUS , LIEBETON KLAUS , JAEGER KARL-ERICH
IPC分类号： C12N15/09 , C12N1/21 , C12N9/16 , C12N9/20 , C12N15/10 , C12N15/55 , C12P21/02 , C12Q1/44
CPC分类号： C12N15/102 , C12N9/20 , C12Q1/44
摘要： The invention relates to a method for producing and identifying hydrolase mutants having improved properties regarding stereoselectivity and site selectivity, catalytic activity or stability during chemical reactions.
摘要翻译：本发明涉及用于制备和具有改进的与化学反应相对于立体声或区域选择性，催化活性或稳定性性质水解酶突变体的识别的处理。

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