专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010068242A1 PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的前列腺素（PGI2）受体的调节剂的吡咯烷基取代的碳酸衍生物
公开(公告)号：WO2010068242A1
公开(公告)日：2010-06-17
申请号：PCT/US2009/006251
申请日：2009-11-24
申请人： ARENA PHARMACEUTICALS, INC. , TRAN, Thuy-Anh , IBARRA, Jason, B. , SHIN, Young-Jun , ULLMAN, Brett , ZOU, Ning , ZENG, Xi
发明人： TRAN, Thuy-Anh , IBARRA, Jason, B. , SHIN, Young-Jun , ULLMAN, Brett , ZOU, Ning , ZENG, Xi
IPC分类号： C07D231/12 , C07D231/18 , C07D231/54 , C07D231/56 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/415 , A61K31/4155 , A61K31/416 , A61P9/00 , A61P11/00
CPC分类号： C07D409/04 , A61P9/00 , A61P11/00 , C07D231/12 , C07D231/18 , C07D231/54 , C07D231/56 , C07D401/04 , C07D405/04
摘要： Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
摘要翻译：式Ia的吡唑衍生物及其药物组合物，其调节PGI 2受体的活性。本发明的化合物及其药物组合物涉及可用于治疗肺动脉高压（PAH）和相关疾病的方法; 血小板聚集; 冠状动脉疾病; 心肌梗死; 短暂性脑缺血发作; 心绞痛; 行程; 缺血再灌注损伤; 再狭窄; 房颤; 在血管成形术或冠状动脉旁路手术个体或患有心房颤动的个体中血凝块形成; 动脉粥样硬化; 动脉粥样硬化; 哮喘或其症状; 糖尿病性相关疾病如糖尿病性周围神经病变，糖尿病性肾病或糖尿病性视网膜病变; 青光眼或其他眼睛异常眼内疾病; 高血压; 炎; 银屑病; 牛皮癣关节炎类风湿关节炎; 克罗恩病; 移植排斥反应多发性硬化症系统性红斑狼疮（SLE）; 溃疡性结肠炎缺血再灌注损伤; 再狭窄; 动脉粥样硬化; 粉刺; 1型糖尿病; 2型糖尿病; 败血症; 和慢性阻塞性肺疾病（COPD）。

2. 发明申请

WO2006065600A2 N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为治疗与相关疾病有关的5HT2C受体有效的调节剂的N-二异丙基和N-芳基乙酰胆碱衍生物
公开(公告)号：WO2006065600A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/044293
申请日：2005-12-09
申请人： ARENA PHARMACEUTICALS, INC. , SMITH, Brian, M. , SANTORA, Vincent, J. , HAYASHI, Rena , IBARRA, Jason, B. , SCHULTZ, Jeffrey, A. , ESTRADA, Scott, A.
发明人： SMITH, Brian, M. , SANTORA, Vincent, J. , HAYASHI, Rena , IBARRA, Jason, B. , SCHULTZ, Jeffrey, A. , ESTRADA, Scott, A.
IPC分类号： C07D295/06 , C07D295/08 , A61K31/496 , A61P3/00 , C07D213/38 , C07D307/52 , C07D333/20
CPC分类号： C07D295/073 , C07D213/38 , C07D295/096 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT 2c receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT 2c receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及式（Ia）的某些二芳基和芳基杂芳基哌嗪衍生物，其为5HT 2C受体的调节剂

3. 发明申请

WO2007061741A3 MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
公开(公告)号：WO2007061741A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/044479
申请日：2006-11-16
申请人： ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent J. , COVEL, Jonathan A. , HAYASHI, Rena , WEBB, Robert R. , REN, Albert S. , CHEN, Weichao G. , DUFFIELD, Jonathan J. , IBARRA, Jason B. , PULLEY, Michelle , SEMPLE, Graeme , WEINHOUSE, Michael I.
发明人： SANTORA, Vincent J. , COVEL, Jonathan A. , HAYASHI, Rena , WEBB, Robert R. , REN, Albert S. , CHEN, Weichao G. , DUFFIELD, Jonathan J. , IBARRA, Jason B. , PULLEY, Michelle , SEMPLE, Graeme , WEINHOUSE, Michael I.
IPC分类号： C07D209/52 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/10 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/04 , A61K31/403 , A61K31/422 , A61K31/4402 , A61K31/4406 , A61K31/4409
摘要： The present invention relates to certain fused heterobicyclic derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, motion sickness and vertigo, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.

4. 发明申请

WO2006065600A3 N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为治疗与相关疾病有关的5HT2C受体有效的调节剂的N-二异丙基和N-芳基乙酰胆碱衍生物
公开(公告)号：WO2006065600A3
公开(公告)日：2006-08-03
申请号：PCT/US2005044293
申请日：2005-12-09
申请人： ARENA PHARM INC , SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
发明人： SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
IPC分类号： C07D295/06 , A61K31/496 , A61P3/00 , C07D213/38 , C07D295/08 , C07D307/52 , C07D333/20
CPC分类号： C07D295/073 , C07D213/38 , C07D295/096 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT 2c
摘要翻译：本发明涉及式（Ia）的某些二芳基和芳基杂芳基哌嗪衍生物，其是5HT 2C的调节剂，

5. 发明申请

WO2006065706A1 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5HT2C受体的调节剂的N-取代二氮杂双环衍生物哌嗪衍生物
公开(公告)号：WO2006065706A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/044815
申请日：2005-12-09
申请人： ARENA PHARMACEUTICALS, INC. , SMITH, Brian M. , SANTORA, Vincent J. , HAYASHI, Rena , IBARRA, Jason B. , SCHULTZ, Jeffrey A. , ESTRADA, Scott A.
发明人： SMITH, Brian M. , SANTORA, Vincent J. , HAYASHI, Rena , IBARRA, Jason B. , SCHULTZ, Jeffrey A. , ESTRADA, Scott A.
IPC分类号： C07D295/06 , C07D213/38 , C07D213/74 , C07D307/52 , C07D333/20 , A61K31/495 , A61K31/501 , A61K31/506 , A61P3/04 , A61P15/10 , A61P25/28 , A61P25/00
CPC分类号： C07D213/38 , C07D213/74 , C07D295/033 , C07D295/073 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及作为5HT 2C受体的调节剂的式（Ia）的某些N-联芳基和N-芳基杂芳基2-取代的哌嗪衍生物。因此，本发明的化合物可用于治疗5HT 2C受体相关疾病或障碍，如肥胖，阿尔茨海默病，勃起功能障碍和相关疾病。

6. 发明申请

WO2010077275A1 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的前列腺素（PGI2）受体的调节剂
公开(公告)号：WO2010077275A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/006408
申请日：2009-12-07
申请人： ARENA PHARMACEUTICALS, INC. , TRAN, Thuy-Anh , HAYASHI, Rena , IBARRA, Jason B. , ULLMAN, Brett , ZOU, Ning
发明人： TRAN, Thuy-Anh , HAYASHI, Rena , IBARRA, Jason B. , ULLMAN, Brett , ZOU, Ning
IPC分类号： C07D237/14 , C07D401/04 , C07D403/04 , C07D409/04 , C07D253/07 , A61K31/50 , A61K31/501 , A61K31/53 , A61P11/08
CPC分类号： C07D237/14 , C07D253/07 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
摘要翻译：式Ia的环己烷衍生物及其药物组合物，其调节PGI 2受体的活性。本发明的化合物及其药物组合物涉及可用于治疗肺动脉高压（PAH）和相关疾病的方法; 血小板聚集; 冠状动脉疾病; 心肌梗死; 短暂性脑缺血发作; 心绞痛; 行程; 缺血再灌注损伤; 再狭窄; 房颤; 在血管成形术或冠状动脉旁路手术个体或患有心房颤动的个体中血凝块形成; 动脉粥样硬化; 动脉粥样硬化; 哮喘或其症状; 糖尿病性相关疾病如糖尿病性周围神经病变，糖尿病性肾病或糖尿病性视网膜病变; 青光眼或其他眼睛异常眼内疾病; 高血压; 炎; 银屑病; 牛皮癣关节炎类风湿关节炎; 克罗恩病; 移植排斥反应多发性硬化症系统性红斑狼疮（SLE）; 溃疡性结肠炎缺血再灌注损伤; 再狭窄; 动脉粥样硬化; 粉刺; 1型糖尿病; 2型糖尿病; 败血症; 和慢性阻塞性肺疾病（COPD）。

7. 发明申请

WO2008048609A1 BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的组胺H3受体的联苯磺隆和苯并噻吩磺酸盐调节剂
公开(公告)号：WO2008048609A1
公开(公告)日：2008-04-24
申请号：PCT/US2007/022086
申请日：2007-10-16
申请人： ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent, J. , HART, Ryan, M. , IBARRA, Jason, B. , PARK, Douglas, M. , REN, Albert, S. , SEMPLE, Graeme , SCHULTZ, Jeffrey, A. , SMITH, Brian , SMITH, Jeffrey
发明人： SANTORA, Vincent, J. , HART, Ryan, M. , IBARRA, Jason, B. , PARK, Douglas, M. , REN, Albert, S. , SEMPLE, Graeme , SCHULTZ, Jeffrey, A. , SMITH, Brian , SMITH, Jeffrey
IPC分类号： C07D207/06 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D417/10 , A61K31/506 , A61P25/28
CPC分类号： C07D207/06 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D417/10
摘要： The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3- receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要翻译：本发明涉及式（Ia）的某些联苯磺酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。本发明的化合物及其药物组合物涉及可用于治疗组胺H3相关疾病例如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如发作性睡眠，工作综合征，作为药物副作用的睡意，维持警惕以完成任务等，猝倒，睡眠过多，嗜睡症，时差，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默氏病等。

8. 发明申请

WO2006065706A9 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5HT2C受体的调节剂的2-取代的2-取代的哌嗪衍生物
公开(公告)号：WO2006065706A9
公开(公告)日：2007-07-26
申请号：PCT/US2005044815
申请日：2005-12-09
申请人： ARENA PHARM INC , SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
发明人： SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
IPC分类号： C07D295/06 , A61K31/495 , A61K31/501 , A61K31/506 , A61P3/04 , A61P15/10 , A61P25/00 , A61P25/28 , C07D213/38 , C07D213/74 , C07D307/52 , C07D333/20
CPC分类号： C07D213/38 , C07D213/74 , C07D295/033 , C07D295/073 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及作为5HT 2C受体的调节剂的式（Ia）的某些N-联芳基和N-芳基杂芳基2-取代的哌嗪衍生物。因此，本发明的化合物可用于治疗5HT 2C受体相关疾病或病症，如肥胖，阿尔茨海默病，勃起功能障碍和相关疾病。

9. 发明申请

WO2009058300A1 BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的组胺H3受体的调节剂的联苯衍生物
公开(公告)号：WO2009058300A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012272
申请日：2008-10-29
申请人： ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
发明人： SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
IPC分类号： C07D403/10 , C07D405/10 , C07D413/10 , A61K31/422 , A61K31/4025 , A61K31/5355 , A61P37/08
CPC分类号： C07D413/10 , C07D403/10 , C07D405/10
摘要： Biphenyl derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 histamine receptor. (Ia) Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness, such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.
摘要翻译：式（Ia）的联苯衍生物及其药物组合物，其调节H3组胺受体的活性。（Ia）本发明化合物及其药物组合物涉及可用于治疗组胺H3相关疾病如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如发作性睡病的方法注意力缺陷多动障碍（ADHD），偏头痛综合征，转移综合征，嗜睡作为药物的副作用，维持警惕以帮助完成任务等，猝死，睡眠过多，嗜睡症，时差，睡眠呼吸暂停等），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默病，疼痛等。

10. 发明申请

WO2008005338A1 MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的组胺H3受体的调节剂
公开(公告)号：WO2008005338A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015139
申请日：2007-06-28
申请人： ARENA PHARMACEUTICALS, INC. , PARK, Douglas, M. , SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
发明人： SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
IPC分类号： C07D207/06 , C07D207/12 , C07D207/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D419/10 , A61K31/4025 , A61K31/4439 , A61K31/40 , A61K31/541 , A61K31/4409 , A61K31/5377
CPC分类号： C07D405/12 , C07D207/06 , C07D207/12 , C07D207/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D419/10
摘要： The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要翻译：本发明涉及式（Ia）的某些联苯磺酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。化合物及其药物组合物涉及可用于治疗组胺H3-受体相关疾病的方法，例如认知障碍，癫痫症，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症，例如发作性睡病，睡眠不足，嗜睡症，射精滞后，睡眠呼吸暂停等，注意缺陷多动障碍（ADHD），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默氏病等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式