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1. 发明申请

WO2003089015A3 RAPID STERILIZATION AND VACCINE PREPARATION 审中-公开
公开(公告)号：WO2003089015A3
公开(公告)日：2003-10-30
申请号：PCT/US2002/025231
申请日：2002-08-07
申请人： BOSTON BIOMEDICA, INC. , BRADLEY, David, W. , LAUGHARN, James, A., Jr. , HESS, Robert, A.
发明人： BRADLEY, David, W. , LAUGHARN, James, A., Jr. , HESS, Robert, A.
IPC分类号： C12N7/04
摘要： The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about -40 °C to about 95 °C, or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.

2. 发明申请

WO2003089015A2 RAPID STERILIZATION AND VACCINE PREPARATION 审中-公开
标题翻译：快速灭菌和疫苗制备
公开(公告)号：WO2003089015A2
公开(公告)日：2003-10-30
申请号：PCT/US2002/025231
申请日：2002-08-07
申请人： BOSTON BIOMEDICA, INC. , BRADLEY, David, W. , LAUGHARN, James, A., Jr. , HESS, Robert, A.
发明人： BRADLEY, David, W. , LAUGHARN, James, A., Jr. , HESS, Robert, A.
IPC分类号： A61L
CPC分类号： A61L2/02 , A23L3/0155 , A61L2/0011
摘要： The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about -40 °C to about 95 °C, or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.
摘要翻译：本发明基于这样的发现，即生物和非生物材料可以通过在相对较高和较低的压力之间重复循环而被灭菌，去污染或消毒。压力循环可以在低，环境温度或升高的温度（例如约-40℃至约95℃或中间范围）下进行。基于这一发现的新方法可用于例如疫苗的制备，血浆或血清，植物，动物和人体组织的消毒，痰液，尿液，粪便，水和腹水的消毒，军事的净化设备，食品和饮料生产以及医疗设备的消毒。新方法也可以纳入生产过程或研究程序。

3. 发明申请

WO0230561A3 APPARATUS FOR ASSAY, SYNTHESIS AND STORAGE, AND METHODS OF MANUFACTURE, USE, AND MANIPULATION THEREOF 审中-公开
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：WO0230561A3
公开(公告)日：2003-05-22
申请号：PCT/US0131770
申请日：2001-10-10
申请人： BIOTROVE INC , HESS ROBERT A , KANIGAN TANYA S , BRENAN COLIN J H , OZBAL CAN , LINTON JOHN DUDLEY
发明人： HESS ROBERT A , KANIGAN TANYA S , BRENAN COLIN J H , OZBAL CAN , LINTON JOHN DUDLEY
IPC分类号： G01N21/78 , B01D61/00 , B01D71/20 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C12M1/00 , C12N5/02 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B60/14 , G01N30/46 , G01N30/60 , G01N30/82 , G01N30/84 , G01N35/02 , G01N37/00
CPC分类号： G01N30/466 , B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C40B60/14 , G01N30/6095 , G01N30/82 , G01N2030/8417 , Y10T29/301 , Y10T29/49938
摘要： The invention features methods of making devices, or "platens" having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analizying the contents of the array, including assaying of physical properties of the samples. In various embodiments, the reagents can be contained within the through-holes by capillary action, attached to the walls of the through-hole. The porous material can be, for example, a gel, a bead, sintered glass, or particulate matter, or can be the inner wall of a ghrough-hole that has been chemically etched. In particular embodiments, the arrays can include invidual molecules, complexes of molecules, viruses, cells, groups of cells, pieces of tissue, or small particles or beads. The members of the arrays can aslo, for example, function as transducers that report the presence of an analyte (e.g., by providing an easily detected signal), or they can function as selective binding agents for the retention of analytes of interest. Using these methods, arrays corresponding to a large plurality of human genes (e.g., using nucleic acid probes) can also be prepared.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。在各种实施方案中，试剂可通过毛细管作用包含在通孔内，附着在通孔的壁上。多孔材料可以是例如凝胶，珠粒，烧结玻璃或颗粒物质，或者可以是经化学蚀刻的孔洞的内壁。在具体实施方案中，阵列可以包括隐窝分子，分子复合物，病毒，细胞，细胞群，组织块或小颗粒或珠粒。例如，阵列的成员可以作为报告分析物的存在（例如通过提供容易检测到的信号）的换能器起作用，或者它们可以用作保留感兴趣分析物的选择性结合剂。使用这些方法，也可以制备对应于大量人类基因（例如使用核酸探针）的阵列。

4. 发明申请

WO02056824A3 PRESSURE CYCLING INACTIVATION OF PATHOGENS IN BIOLOGICAL MATERIALS USED FOR THERAPEUTICS OR VACCINES 审中-公开
标题翻译：用于治疗或疫苗的生物材料中病原体的压力循环灭活
公开(公告)号：WO02056824A3
公开(公告)日：2003-03-13
申请号：PCT/US0141623
申请日：2001-08-08
申请人： BOSTON BIOMEDICA INC , HESS ROBERT A , MANAK MARK M , DUSING SANDRA K
发明人： HESS ROBERT A , MANAK MARK M , DUSING SANDRA K
IPC分类号： A61L2/00 , A01N1/00 , A61K35/14 , C12N7/04 , C12Q1/70 , G01N33/53
CPC分类号： A61L2/0011
摘要： The invention is based on the discovery that viruses, bacteria or fungi present in biological materials can be inactivated without substantial loss of protein function, using high pressure at temperatures above or below room temperature (e.g., below 0 DEG C or above 30 DEG C). The new methods can be used to decontaminate recombinant protein solutions, serum, plasma, and other biological materials, which can be contaminated with viruses such as parvoviruses (e.g., human parvovirus, porcine parvovirus, and murine parvovirus) and retroviruses such as human immunodeficiency virus (HIV), herpesviruses (e.g., herpes simplex virus, HSV), flaviviruses (e.g., hepatitis C virus, HCV), reoviruses, and picornaviruses,bacteria (e.g., Bacillus, Enterococcus, Staphylococcus, Listeria, Pseudomonas) or fungi (e.g., Candida).
摘要翻译：本发明基于以下发现：使用在高于或低于室温（例如低于0℃或高于30℃）的温度下使用高压的蛋白质功能的实质性损失可以灭活生物材料中存在的病毒，细菌或真菌，。新方法可用于去除重组蛋白质溶液，血清，血浆和其他生物材料，其可被病毒如细小病毒（例如，人细小病毒，猪细小病毒和鼠细小病毒）和逆转录病毒如人类免疫缺陷病毒（HIV），疱疹病毒（例如单纯疱疹病毒，HSV），黄病毒（例如丙型肝炎病毒，HCV），呼肠孤病毒和小核糖核酸病毒，细菌（例如芽孢杆菌，肠球菌，葡萄球菌，李斯特菌，假单胞菌）或真菌念珠菌）。

5. 发明申请

WO1998000032A1 PRESSURE-MEDIATED BINDING OF BIOMOLECULAR COMPLEXES 审中-公开
标题翻译：压力介导的生物分子复合物的结合
公开(公告)号：WO1998000032A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011198
申请日：1997-07-01
申请人： BIOSEQ, INC. , LITT, Gerald, J. , LAUGHARN, James, A., Jr. , GREEN, David, J. , HESS, Robert, A. , PAULUS, Henry
发明人： BIOSEQ, INC.
IPC分类号： A23J01/00
CPC分类号： G01N33/5306 , B01J3/00 , C11B7/005 , G01N33/50 , G01N33/53 , G01N33/543
摘要： The invention relates to (1) pressure-mediated dissociation of an analyte complexed with an endogenous binding partner to enable detection of a complex formed from the analyte and an exogenous binding factor, (2) pressure-mediated association of an analyte and an exogenous binding partner to enable more rapid and/or more sensitive detection of an analyte, and (3) pressure-mediated association and dissociation of biomolecular complexes to enable separation of one biomolecule from a complex mixture. Pressure can be used to improve assays by dissociating endogenous analyte complexes and improving assay speed and sensitivity by associating the analyte molecules with exogenously supplied binding partners. Pressure can also be used to improve the separation of compounds from contaminated mixtures.
摘要翻译：本发明涉及（1）与内源结合配偶体复合的分析物的压力介导的解离，以能够检测由分析物形成的复合物和外源性结合因子，（2）压力介导的分析物缔合和外源结合合作伙伴能够更快速和/或更敏感地检测分析物，和（3）压力介导的生物分子复合物的缔合和解离，以使一个生物分子与复杂混合物分离。压力可用于通过解离内源性分析物复合物来改进测定，并通过将分析物分子与外源提供的结合配偶体相关联来提高测定速度和灵敏度。压力也可用于改善化合物与污染混合物的分离。

6. 发明申请

WO2017004328A1 VEHICLE DISPLAY 审中-公开
标题翻译：车辆显示
公开(公告)号：WO2017004328A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040300
申请日：2016-06-30
申请人： BAE SYSTEMS CONTROLS INC. , HESS, Robert A.
发明人： HESS, Robert A.
IPC分类号： G06F3/041 , G06F3/045 , B64C19/00 , B64D45/00
CPC分类号： B64D11/00152 , B32B2369/00 , B32B2405/00 , B64D11/00155 , B64D11/0624 , G06F1/16 , Y02T50/46
摘要： The present disclosure includes a hardened tablet for use within an aircraft cabin, the hardened tablet including a processor, a touch screen, a memory, a tablet and a protective layer applied to the touch screen of the tablet, the protective layer comprising a bonding material and a laminate. The protective layer of the hardened tablet is selected from the group consisting of a polycarbonate and a chemically strengthened glass. The thickness of the polycarbonate protective layer is between about 0.5 mm and about 1.6 mm. The bonding material is selected from the group consisting of an adhesive tape and an optically clear adhesive. In one embodiment, the protective layer includes a polycarbonate of a thickness of about 0.02" to about 0.04" and the bonding material is an optically clear adhesive.
摘要翻译：本公开内容包括用于飞机机舱内的硬化片剂，所述硬化片剂包括施加到片剂的触摸屏的处理器，触摸屏，存储器，片剂和保护层，所述保护层包括接合材料和层压板。硬化片剂的保护层选自聚碳酸酯和化学强化玻璃。聚碳酸酯保护层的厚度在约0.5mm至约1.6mm之间。接合材料选自粘合带和光学透明粘合剂。在一个实施方案中，保护层包括厚度为约0.02“至约0.04”的聚碳酸酯，并且粘合材料为光学透明粘合剂。

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