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1. 发明申请

WO2009142571A8 PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 审中-公开
公开(公告)号：WO2009142571A8
公开(公告)日：2009-11-26
申请号：PCT/SE2009/000267
申请日：2009-05-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
发明人： BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.

2. 发明申请

WO2009011655A1 SPLROPIPERIDINE COMPOUNDS, A PROCESS OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THE TREATMENT OF AIRWAY DISEASES, INFLAMMATORY DISEASES, COPD OR ASTHMA 审中-公开
标题翻译：雷朋哌啶化合物，其制备方法，含有它们的药物组合物及其在治疗气道疾病，炎性疾病，COPD或ASTHMA中的用途
公开(公告)号：WO2009011655A1
公开(公告)日：2009-01-22
申请号：PCT/SE2008/050878
申请日：2008-07-16
申请人： ASTRAZENECA AB , HEMMERLING, Martin , IVANOVA, Svetlana , MENSONIDES-HARSEMA, Marguerite , SCHULZ, Håkan
发明人： HEMMERLING, Martin , IVANOVA, Svetlana , MENSONIDES-HARSEMA, Marguerite , SCHULZ, Håkan
IPC分类号： C07D491/107 , A61K31/438 , A61P11/00
CPC分类号： C07C231/02 , C07C235/60 , C07D211/48 , C07D301/00 , C07D303/24 , C07D491/10 , C07D491/107
摘要： The present invention relates to new polymorphs of compounds 2-{2-Chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid, and the hydrochloride and sodium hydroxide salts thereof,and compound 2-{2-Chloro-5-{[(2R)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid. The invention further relates to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention also relates to processes for the preparation of said compounds.
摘要翻译：本发明涉及化合物2- {2-氯-5 - {[（2S）-3-（5-氯-1'H，3H-螺[1-苯并呋喃-2,4'-哌啶] -1'-基）-2-羟丙基]氧基} -4 - [（甲基氨基）羰基]苯氧基} -2-甲基丙酸及其盐酸盐和氢氧化钠盐，以及化合物2- {2-氯-5- {[（2R）-3-（5-氯-1'H，3H-螺[1-苯并呋喃-2,4'-哌啶] -1'-基）-2-羟丙基]氧基} -4 - [（甲基氨基）羰基]苯氧基} -2-甲基丙酸。本发明还涉及含有所述化合物的药物组合物和所述化合物在治疗中的用途。本发明还涉及制备所述化合物的方法。

3. 发明申请

WO2008076048A1 INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 审中-公开
标题翻译：用于治疗葡萄糖激素受体介导的疾病的吲哚酚酯和酰胺衍生物
公开(公告)号：WO2008076048A1
公开(公告)日：2008-06-26
申请号：PCT/SE2007/001136
申请日：2007-12-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译：式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物

4. 发明申请

WO2004016615A1 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY 审中-公开
标题翻译： PYRAZOLO（4,3c）作为ITK激酶活性的抑制剂的氰基化合物
公开(公告)号：WO2004016615A1
公开(公告)日：2004-02-26
申请号：PCT/SE2003/001278
申请日：2003-08-13
申请人： ASTRAZENECA AB , DAHMEN, Jan , HEMMERLING, Martin , KLINGSTEDT, Tomas , SJÖ, Peter
发明人： DAHMEN, Jan , HEMMERLING, Martin , KLINGSTEDT, Tomas , SJÖ, Peter
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： There are provided novel compounds of formula (I) wherein R and X are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.
摘要翻译：提供新的式（I）化合物，其中R和X如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是激酶Itk的抑制剂。

5. 发明申请

WO2008063116A1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS 审中-公开
标题翻译：用作GLUCOCORTICOID调节剂的吲哚磺酰胺衍生物
公开(公告)号：WO2008063116A1
公开(公告)日：2008-05-29
申请号：PCT/SE2007/001031
申请日：2007-11-22
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , BERGER, Markus , BERGSTRÖM, Lena , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
发明人： BERGER, Markus , BERGSTRÖM, Lena , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
IPC分类号： C07D231/56 , A61K31/416 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D401/04 , C07D401/14
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
摘要翻译：式（I）化合物或其药学上可接受的盐; 包含它们的组合物，其制备方法及其在药物治疗中的用途（例如调节温血动物中的糖皮质激素受体）。

6. 发明申请

WO2007053082A1 NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA 审中-公开
标题翻译：可用于治疗COPD和ASTHMA的新一代 - 苯基-4-哌啶胺
公开(公告)号：WO2007053082A1
公开(公告)日：2007-05-10
申请号：PCT/SE2006/001227
申请日：2006-10-31
申请人： ASTRAZENECA AB , HEMMERLING, Martin , HOSSAIN, Nafizal , IVANOVA, Svetlana , MUSSIE, Tesfaledet , SHAMOVSKY, Igor , SJÖHOLM, Åsa
发明人： HEMMERLING, Martin , HOSSAIN, Nafizal , IVANOVA, Svetlana , MUSSIE, Tesfaledet , SHAMOVSKY, Igor , SJÖHOLM, Åsa
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/454 , A61P11/00 , A61P11/06 , C07D401/12
CPC分类号： C07D211/58 , C07D211/72 , C07D401/12
摘要： The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such as chronic obstructive pulmonary disease and asthma. The compounds are inhibitors of the CCRl receptor.
摘要翻译：本发明提供了通式（I）的1-苄基-4-哌啶胺，其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物可用于治疗呼吸系统疾病，如慢性阻塞性肺疾病和哮喘。这些化合物是CCR1受体的抑制剂。

7. 发明申请

WO2004027836A2 DIE CARRIER 审中-公开
标题翻译： DIE承运人
公开(公告)号：WO2004027836A2
公开(公告)日：2004-04-01
申请号：PCT/US0326415
申请日：2003-08-19
申请人： AEHR TEST SYSTEMS , MALATHONG SEANG P , HEMMERLING MARTIN A
发明人： MALATHONG SEANG P , HEMMERLING MARTIN A
IPC分类号： H01R33/76 , G01R1/04 , H01L21/00
CPC分类号： G01R1/0466
摘要： A die carrier is disclosed which is specifically designed for use in a TSOP socket. More specifically, the die carrier has a carrier substrate with carrier contacts thereon that are dimensioned specifically to match the positioning of the upper and lower socket contacts. The carrier substrate, being 145 microns thick, can also fit between the upper and lower socket contacts. A carrier base support component is located below a portion only of the carrier substrate, and does not impair insertion of the carrier substrate into the relatively small spacing between the upper and lower socket contacts. Damage to the carrier substrate is avoided by clamping edges of the carrier substrate from opposing sides between the upper and lower socket contacts. There are no screws or nuts within the carrier base support component that may increase its size and prevent it from being inserted into the socket. A double-sided, robust electrical connection is made by each respective pair of upper and lower socket contacts.
摘要翻译：公开了专门设计用于TSOP插座的模具载体。更具体地，模具载体具有其上具有载体接触的载体基板，其尺寸特别地匹配上部和下部插座触头的定位。 145μm厚的载体衬底也可以装配在上和下插座触点之间。载体基部支撑部件位于仅载体基板的一部分的下方，并且不会妨碍载体基板在上部和下部插座触点之间相对小的间隔中的插入。通过将载体基板的边缘从上部和下部插座触头之间的相对侧夹紧来避免对载体基板的损坏。载体基座支撑部件内没有螺丝或螺母，可能会增加其尺寸并防止其插入插座。双面，坚固的电气连接由每对相应的上，下插座触点组成。

8. 发明申请

WO2009142571A1 PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 审中-公开
标题翻译：苯并噻唑啉衍生物衍生物
公开(公告)号：WO2009142571A1
公开(公告)日：2009-11-26
申请号：PCT/SE2009000267
申请日：2009-05-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AG , BERGER MARKUS , DAHMEN JAN , EDMAN KARL , ERIKSSON ANDERS , HANSSON THOMAS , HEMMERLING MARTIN , HOSSAIN NAFIZAL , KLINGSTEDT TOMAS , LEPISTOE MATTI , NILSSON STINABRITT , REHWINKEL HARTMUT
发明人： BAYER SCHERING PHARMA AG , BERGER MARKUS , DAHMEN JAN , EDMAN KARL , ERIKSSON ANDERS , HANSSON THOMAS , HEMMERLING MARTIN , HOSSAIN NAFIZAL , KLINGSTEDT TOMAS , LEPISTOE MATTI , NILSSON STINABRITT , REHWINKEL HARTMUT
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译：式Ia化合物：（Ia）本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。

9. 发明申请

WO2009142569A1 PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES 审中-公开
标题翻译：苯基或吡啶基取代的吲哚衍生物
公开(公告)号：WO2009142569A1
公开(公告)日：2009-11-26
申请号：PCT/SE2009/000265
申请日：2009-05-20
申请人： ASTRAZENECA AB , BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN Karl , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN, Nafizal , JOHANSSON, Henrik , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN Karl , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN, Nafizal , JOHANSSON, Henrik , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D231/56 , A61K31/416 , A61K31/422 , A61K31/4439 , A61K31/444 , A61P11/00 , A61P29/00 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: Formula (la) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译：式Ia化合物：式（Ia）本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。

10. 发明申请

WO2009011653A1 A PROCESS FOR THE PREPARATION OF INTERMEDIATES AND THEIR US IN THE SYNTHESIS OF SPIROPIPERIDINE COMPOUNDS 审中-公开
标题翻译：中间体的制备方法及其在螺吡啶化合物合成中的应用
公开(公告)号：WO2009011653A1
公开(公告)日：2009-01-22
申请号：PCT/SE2008/050876
申请日：2008-07-16
申请人： ASTRAZENECA AB , COOPER, Martin , ELKINS, Barry , GIBSON, Scott , GU, Eric , HASSALL, Ian , HEMMERLING, Martin , IVANOVA, Svetlana , JOSEFSSON, Bo-Göran , MENSONIDES-HARSEMA, Marguerite , MERIFIELD, Eric , PAVEY, John , ROGERS, Mike , ZHENGYU, Wang
发明人： COOPER, Martin , ELKINS, Barry , GIBSON, Scott , GU, Eric , HASSALL, Ian , HEMMERLING, Martin , IVANOVA, Svetlana , JOSEFSSON, Bo-Göran , MENSONIDES-HARSEMA, Marguerite , MERIFIELD, Eric , PAVEY, John , ROGERS, Mike , ZHENGYU, Wang
IPC分类号： C07D491/107 , A61K31/438 , C07C235/60 , C07D211/48 , C07D301/00 , C07D303/24
CPC分类号： C07C231/02 , C07C235/60 , C07D211/48 , C07D301/00 , C07D303/16 , C07D303/24 , C07D491/10 , C07D491/107
摘要： The present invention relates to new processes for the preparation of compounds of formula I, especially the compound 2-{2-Chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1- benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-5 [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid and to new intermediates useful in the preparation thereof.
摘要翻译：本发明涉及制备式I化合物的新方法，特别是化合物2- {2-氯-5 - {[（2S）-3-（5-氯-1'H，3H-螺[1 - 苯并呋喃-2,4'-哌啶] -1'-基）-2-羟丙基]氧基} -4- [[（甲基氨基）羰基]苯氧基} -2-甲基丙酸和可用于其制备的新中间体。

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